Amino acid dipepetide frequency for Vibrio phage ValSw4_1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.767AlaAla: 6.767 ± 0.796
0.677AlaCys: 0.677 ± 0.162
4.356AlaAsp: 4.356 ± 0.456
5.372AlaGlu: 5.372 ± 0.527
2.538AlaPhe: 2.538 ± 0.367
4.695AlaGly: 4.695 ± 0.376
1.48AlaHis: 1.48 ± 0.292
4.864AlaIle: 4.864 ± 0.712
6.217AlaLys: 6.217 ± 0.576
8.29AlaLeu: 8.29 ± 0.599
1.988AlaMet: 1.988 ± 0.32
4.949AlaAsn: 4.949 ± 0.527
3.468AlaPro: 3.468 ± 0.451
3.511AlaGln: 3.511 ± 0.508
4.568AlaArg: 4.568 ± 0.48
4.187AlaSer: 4.187 ± 0.501
4.23AlaThr: 4.23 ± 0.566
5.118AlaVal: 5.118 ± 0.838
0.465AlaTrp: 0.465 ± 0.144
2.834AlaTyr: 2.834 ± 0.336
0.0AlaXaa: 0.0 ± 0.0
Cys
0.634CysAla: 0.634 ± 0.151
0.296CysCys: 0.296 ± 0.131
0.381CysAsp: 0.381 ± 0.151
0.634CysGlu: 0.634 ± 0.198
0.55CysPhe: 0.55 ± 0.187
0.931CysGly: 0.931 ± 0.238
0.465CysHis: 0.465 ± 0.148
0.804CysIle: 0.804 ± 0.175
0.888CysLys: 0.888 ± 0.215
1.396CysLeu: 1.396 ± 0.26
0.211CysMet: 0.211 ± 0.097
0.296CysAsn: 0.296 ± 0.118
0.55CysPro: 0.55 ± 0.152
0.634CysGln: 0.634 ± 0.182
0.55CysArg: 0.55 ± 0.173
0.592CysSer: 0.592 ± 0.163
0.508CysThr: 0.508 ± 0.162
0.592CysVal: 0.592 ± 0.181
0.127CysTrp: 0.127 ± 0.069
0.508CysTyr: 0.508 ± 0.124
0.0CysXaa: 0.0 ± 0.0
Asp
5.414AspAla: 5.414 ± 0.517
0.55AspCys: 0.55 ± 0.18
3.595AspAsp: 3.595 ± 0.429
4.695AspGlu: 4.695 ± 0.568
2.495AspPhe: 2.495 ± 0.351
4.145AspGly: 4.145 ± 0.41
1.903AspHis: 1.903 ± 0.357
3.257AspIle: 3.257 ± 0.361
3.849AspLys: 3.849 ± 0.389
7.444AspLeu: 7.444 ± 0.485
1.565AspMet: 1.565 ± 0.25
2.876AspAsn: 2.876 ± 0.306
3.257AspPro: 3.257 ± 0.442
2.58AspGln: 2.58 ± 0.362
2.538AspArg: 2.538 ± 0.301
3.637AspSer: 3.637 ± 0.37
3.384AspThr: 3.384 ± 0.387
4.018AspVal: 4.018 ± 0.428
0.592AspTrp: 0.592 ± 0.153
2.622AspTyr: 2.622 ± 0.396
0.0AspXaa: 0.0 ± 0.0
Glu
5.879GluAla: 5.879 ± 0.606
0.677GluCys: 0.677 ± 0.178
4.314GluAsp: 4.314 ± 0.36
3.976GluGlu: 3.976 ± 0.523
3.257GluPhe: 3.257 ± 0.338
4.018GluGly: 4.018 ± 0.461
1.565GluHis: 1.565 ± 0.275
5.075GluIle: 5.075 ± 0.429
3.468GluLys: 3.468 ± 0.52
6.81GluLeu: 6.81 ± 0.532
1.523GluMet: 1.523 ± 0.23
2.834GluAsn: 2.834 ± 0.41
1.48GluPro: 1.48 ± 0.246
3.088GluGln: 3.088 ± 0.409
3.511GluArg: 3.511 ± 0.515
4.356GluSer: 4.356 ± 0.442
4.991GluThr: 4.991 ± 0.461
4.737GluVal: 4.737 ± 0.396
0.846GluTrp: 0.846 ± 0.184
2.411GluTyr: 2.411 ± 0.282
0.0GluXaa: 0.0 ± 0.0
Phe
2.665PheAla: 2.665 ± 0.339
0.592PheCys: 0.592 ± 0.185
2.665PheAsp: 2.665 ± 0.413
2.495PheGlu: 2.495 ± 0.334
1.057PhePhe: 1.057 ± 0.201
2.072PheGly: 2.072 ± 0.229
0.634PheHis: 0.634 ± 0.179
3.045PheIle: 3.045 ± 0.418
2.622PheLys: 2.622 ± 0.364
2.876PheLeu: 2.876 ± 0.39
0.761PheMet: 0.761 ± 0.178
2.749PheAsn: 2.749 ± 0.301
0.804PhePro: 0.804 ± 0.248
1.1PheGln: 1.1 ± 0.193
1.353PheArg: 1.353 ± 0.226
2.918PheSer: 2.918 ± 0.304
2.834PheThr: 2.834 ± 0.33
2.157PheVal: 2.157 ± 0.29
0.0PheTrp: 0.0 ± 0.0
1.269PheTyr: 1.269 ± 0.227
0.0PheXaa: 0.0 ± 0.0
Gly
4.653GlyAla: 4.653 ± 0.477
0.761GlyCys: 0.761 ± 0.154
4.483GlyAsp: 4.483 ± 0.571
4.356GlyGlu: 4.356 ± 0.367
2.834GlyPhe: 2.834 ± 0.307
4.737GlyGly: 4.737 ± 0.657
0.846GlyHis: 0.846 ± 0.237
3.13GlyIle: 3.13 ± 0.385
3.891GlyLys: 3.891 ± 0.478
5.921GlyLeu: 5.921 ± 0.561
1.311GlyMet: 1.311 ± 0.226
2.665GlyAsn: 2.665 ± 0.316
0.0GlyPro: 0.0 ± 0.0
1.946GlyGln: 1.946 ± 0.285
3.637GlyArg: 3.637 ± 0.511
4.06GlySer: 4.06 ± 0.461
3.13GlyThr: 3.13 ± 0.436
5.075GlyVal: 5.075 ± 0.484
0.719GlyTrp: 0.719 ± 0.17
2.834GlyTyr: 2.834 ± 0.293
0.0GlyXaa: 0.0 ± 0.0
His
1.607HisAla: 1.607 ± 0.236
0.211HisCys: 0.211 ± 0.109
1.311HisAsp: 1.311 ± 0.245
1.692HisGlu: 1.692 ± 0.287
0.508HisPhe: 0.508 ± 0.135
1.142HisGly: 1.142 ± 0.221
0.381HisHis: 0.381 ± 0.133
1.269HisIle: 1.269 ± 0.258
1.607HisLys: 1.607 ± 0.248
2.284HisLeu: 2.284 ± 0.323
0.296HisMet: 0.296 ± 0.134
0.719HisAsn: 0.719 ± 0.182
1.184HisPro: 1.184 ± 0.223
0.508HisGln: 0.508 ± 0.137
1.142HisArg: 1.142 ± 0.251
1.269HisSer: 1.269 ± 0.229
0.931HisThr: 0.931 ± 0.178
1.269HisVal: 1.269 ± 0.245
0.042HisTrp: 0.042 ± 0.042
0.804HisTyr: 0.804 ± 0.17
0.0HisXaa: 0.0 ± 0.0
Ile
4.695IleAla: 4.695 ± 0.595
0.804IleCys: 0.804 ± 0.231
5.414IleAsp: 5.414 ± 0.532
4.822IleGlu: 4.822 ± 0.398
1.438IlePhe: 1.438 ± 0.264
3.257IleGly: 3.257 ± 0.364
1.015IleHis: 1.015 ± 0.221
3.13IleIle: 3.13 ± 0.388
4.23IleLys: 4.23 ± 0.464
3.891IleLeu: 3.891 ± 0.437
1.311IleMet: 1.311 ± 0.178
3.764IleAsn: 3.764 ± 0.376
3.341IlePro: 3.341 ± 0.326
2.538IleGln: 2.538 ± 0.272
3.764IleArg: 3.764 ± 0.331
4.145IleSer: 4.145 ± 0.38
4.018IleThr: 4.018 ± 0.428
3.257IleVal: 3.257 ± 0.311
0.254IleTrp: 0.254 ± 0.098
1.903IleTyr: 1.903 ± 0.27
0.0IleXaa: 0.0 ± 0.0
Lys
5.456LysAla: 5.456 ± 0.545
0.888LysCys: 0.888 ± 0.194
4.314LysAsp: 4.314 ± 0.522
4.441LysGlu: 4.441 ± 0.491
2.707LysPhe: 2.707 ± 0.338
3.976LysGly: 3.976 ± 0.37
1.438LysHis: 1.438 ± 0.181
3.045LysIle: 3.045 ± 0.369
5.118LysLys: 5.118 ± 0.785
5.795LysLeu: 5.795 ± 0.59
1.607LysMet: 1.607 ± 0.259
2.834LysAsn: 2.834 ± 0.358
3.976LysPro: 3.976 ± 0.432
2.326LysGln: 2.326 ± 0.329
3.553LysArg: 3.553 ± 0.435
3.722LysSer: 3.722 ± 0.352
4.822LysThr: 4.822 ± 0.473
4.568LysVal: 4.568 ± 0.446
0.634LysTrp: 0.634 ± 0.174
2.284LysTyr: 2.284 ± 0.291
0.0LysXaa: 0.0 ± 0.0
Leu
8.205LeuAla: 8.205 ± 0.665
0.761LeuCys: 0.761 ± 0.144
5.583LeuAsp: 5.583 ± 0.492
6.006LeuGlu: 6.006 ± 0.491
2.918LeuPhe: 2.918 ± 0.36
5.287LeuGly: 5.287 ± 0.474
1.903LeuHis: 1.903 ± 0.362
7.148LeuIle: 7.148 ± 0.529
6.302LeuLys: 6.302 ± 0.61
6.81LeuLeu: 6.81 ± 0.558
2.284LeuMet: 2.284 ± 0.291
6.471LeuAsn: 6.471 ± 0.573
3.172LeuPro: 3.172 ± 0.404
2.792LeuGln: 2.792 ± 0.319
4.526LeuArg: 4.526 ± 0.379
6.217LeuSer: 6.217 ± 0.518
6.514LeuThr: 6.514 ± 0.613
5.668LeuVal: 5.668 ± 0.469
0.846LeuTrp: 0.846 ± 0.19
2.242LeuTyr: 2.242 ± 0.28
0.0LeuXaa: 0.0 ± 0.0
Met
2.242MetAla: 2.242 ± 0.278
0.465MetCys: 0.465 ± 0.146
0.931MetAsp: 0.931 ± 0.19
0.931MetGlu: 0.931 ± 0.239
0.888MetPhe: 0.888 ± 0.19
1.269MetGly: 1.269 ± 0.296
0.55MetHis: 0.55 ± 0.18
1.438MetIle: 1.438 ± 0.21
1.819MetLys: 1.819 ± 0.282
2.326MetLeu: 2.326 ± 0.304
0.381MetMet: 0.381 ± 0.114
1.142MetAsn: 1.142 ± 0.261
0.888MetPro: 0.888 ± 0.212
0.381MetGln: 0.381 ± 0.119
1.523MetArg: 1.523 ± 0.286
2.326MetSer: 2.326 ± 0.294
1.65MetThr: 1.65 ± 0.293
1.48MetVal: 1.48 ± 0.252
0.211MetTrp: 0.211 ± 0.095
0.338MetTyr: 0.338 ± 0.124
0.0MetXaa: 0.0 ± 0.0
Asn
4.272AsnAla: 4.272 ± 0.384
0.465AsnCys: 0.465 ± 0.152
3.384AsnAsp: 3.384 ± 0.316
3.849AsnGlu: 3.849 ± 0.345
2.369AsnPhe: 2.369 ± 0.39
3.384AsnGly: 3.384 ± 0.36
0.634AsnHis: 0.634 ± 0.167
2.58AsnIle: 2.58 ± 0.331
3.045AsnLys: 3.045 ± 0.319
4.526AsnLeu: 4.526 ± 0.495
1.438AsnMet: 1.438 ± 0.27
2.284AsnAsn: 2.284 ± 0.272
2.961AsnPro: 2.961 ± 0.336
1.819AsnGln: 1.819 ± 0.259
2.284AsnArg: 2.284 ± 0.34
2.622AsnSer: 2.622 ± 0.375
3.511AsnThr: 3.511 ± 0.384
3.68AsnVal: 3.68 ± 0.424
0.423AsnTrp: 0.423 ± 0.145
1.819AsnTyr: 1.819 ± 0.291
0.0AsnXaa: 0.0 ± 0.0
Pro
2.453ProAla: 2.453 ± 0.338
0.592ProCys: 0.592 ± 0.159
3.172ProAsp: 3.172 ± 0.386
3.849ProGlu: 3.849 ± 0.432
1.227ProPhe: 1.227 ± 0.265
0.0ProGly: 0.0 ± 0.0
0.761ProHis: 0.761 ± 0.17
1.903ProIle: 1.903 ± 0.248
3.341ProLys: 3.341 ± 0.402
3.426ProLeu: 3.426 ± 0.441
0.55ProMet: 0.55 ± 0.16
2.326ProAsn: 2.326 ± 0.433
1.353ProPro: 1.353 ± 0.215
1.269ProGln: 1.269 ± 0.22
2.538ProArg: 2.538 ± 0.341
2.792ProSer: 2.792 ± 0.436
2.242ProThr: 2.242 ± 0.277
2.918ProVal: 2.918 ± 0.383
0.211ProTrp: 0.211 ± 0.101
1.776ProTyr: 1.776 ± 0.375
0.0ProXaa: 0.0 ± 0.0
Gln
3.341GlnAla: 3.341 ± 0.508
0.296GlnCys: 0.296 ± 0.132
1.988GlnAsp: 1.988 ± 0.241
2.369GlnGlu: 2.369 ± 0.349
1.142GlnPhe: 1.142 ± 0.254
2.961GlnGly: 2.961 ± 0.35
0.761GlnHis: 0.761 ± 0.2
2.072GlnIle: 2.072 ± 0.277
1.946GlnLys: 1.946 ± 0.351
3.468GlnLeu: 3.468 ± 0.403
0.973GlnMet: 0.973 ± 0.199
1.057GlnAsn: 1.057 ± 0.164
1.142GlnPro: 1.142 ± 0.194
1.1GlnGln: 1.1 ± 0.289
2.199GlnArg: 2.199 ± 0.349
2.072GlnSer: 2.072 ± 0.302
2.369GlnThr: 2.369 ± 0.314
2.115GlnVal: 2.115 ± 0.254
0.381GlnTrp: 0.381 ± 0.133
1.269GlnTyr: 1.269 ± 0.229
0.0GlnXaa: 0.0 ± 0.0
Arg
5.372ArgAla: 5.372 ± 0.643
0.508ArgCys: 0.508 ± 0.176
3.553ArgAsp: 3.553 ± 0.392
3.976ArgGlu: 3.976 ± 0.513
2.453ArgPhe: 2.453 ± 0.375
3.68ArgGly: 3.68 ± 0.318
1.142ArgHis: 1.142 ± 0.234
3.595ArgIle: 3.595 ± 0.513
3.257ArgLys: 3.257 ± 0.478
5.287ArgLeu: 5.287 ± 0.345
0.973ArgMet: 0.973 ± 0.187
1.903ArgAsn: 1.903 ± 0.292
1.692ArgPro: 1.692 ± 0.32
1.776ArgGln: 1.776 ± 0.29
3.214ArgArg: 3.214 ± 0.356
3.045ArgSer: 3.045 ± 0.384
2.199ArgThr: 2.199 ± 0.308
3.341ArgVal: 3.341 ± 0.364
0.381ArgTrp: 0.381 ± 0.132
2.411ArgTyr: 2.411 ± 0.352
0.0ArgXaa: 0.0 ± 0.0
Ser
4.737SerAla: 4.737 ± 0.521
0.677SerCys: 0.677 ± 0.213
3.511SerAsp: 3.511 ± 0.45
4.272SerGlu: 4.272 ± 0.542
2.876SerPhe: 2.876 ± 0.392
4.568SerGly: 4.568 ± 0.417
1.311SerHis: 1.311 ± 0.24
3.849SerIle: 3.849 ± 0.457
4.822SerLys: 4.822 ± 0.445
5.625SerLeu: 5.625 ± 0.456
1.65SerMet: 1.65 ± 0.242
3.003SerAsn: 3.003 ± 0.389
1.988SerPro: 1.988 ± 0.328
1.946SerGln: 1.946 ± 0.287
3.426SerArg: 3.426 ± 0.36
3.553SerSer: 3.553 ± 0.464
4.018SerThr: 4.018 ± 0.451
3.595SerVal: 3.595 ± 0.398
0.423SerTrp: 0.423 ± 0.146
2.622SerTyr: 2.622 ± 0.396
0.0SerXaa: 0.0 ± 0.0
Thr
4.906ThrAla: 4.906 ± 0.582
0.592ThrCys: 0.592 ± 0.163
3.849ThrAsp: 3.849 ± 0.363
4.018ThrGlu: 4.018 ± 0.477
1.903ThrPhe: 1.903 ± 0.282
4.06ThrGly: 4.06 ± 0.351
1.184ThrHis: 1.184 ± 0.234
3.299ThrIle: 3.299 ± 0.318
4.399ThrLys: 4.399 ± 0.46
5.837ThrLeu: 5.837 ± 0.572
1.565ThrMet: 1.565 ± 0.206
3.214ThrAsn: 3.214 ± 0.368
3.722ThrPro: 3.722 ± 0.439
1.396ThrGln: 1.396 ± 0.274
3.214ThrArg: 3.214 ± 0.389
3.511ThrSer: 3.511 ± 0.59
3.849ThrThr: 3.849 ± 0.455
4.61ThrVal: 4.61 ± 0.391
0.508ThrTrp: 0.508 ± 0.157
2.495ThrTyr: 2.495 ± 0.354
0.0ThrXaa: 0.0 ± 0.0
Val
3.511ValAla: 3.511 ± 0.314
1.142ValCys: 1.142 ± 0.235
3.891ValAsp: 3.891 ± 0.403
4.822ValGlu: 4.822 ± 0.443
2.284ValPhe: 2.284 ± 0.293
3.553ValGly: 3.553 ± 0.392
1.184ValHis: 1.184 ± 0.221
3.976ValIle: 3.976 ± 0.369
4.568ValLys: 4.568 ± 0.405
4.906ValLeu: 4.906 ± 0.505
1.438ValMet: 1.438 ± 0.269
3.891ValAsn: 3.891 ± 0.427
2.157ValPro: 2.157 ± 0.333
2.242ValGln: 2.242 ± 0.29
3.68ValArg: 3.68 ± 0.445
5.202ValSer: 5.202 ± 0.447
4.779ValThr: 4.779 ± 0.504
4.441ValVal: 4.441 ± 0.547
0.423ValTrp: 0.423 ± 0.134
2.834ValTyr: 2.834 ± 0.417
0.0ValXaa: 0.0 ± 0.0
Trp
0.508TrpAla: 0.508 ± 0.135
0.169TrpCys: 0.169 ± 0.086
0.55TrpAsp: 0.55 ± 0.128
0.338TrpGlu: 0.338 ± 0.105
0.169TrpPhe: 0.169 ± 0.092
0.677TrpGly: 0.677 ± 0.183
0.169TrpHis: 0.169 ± 0.079
0.634TrpIle: 0.634 ± 0.172
0.592TrpLys: 0.592 ± 0.154
0.761TrpLeu: 0.761 ± 0.183
0.211TrpMet: 0.211 ± 0.091
0.55TrpAsn: 0.55 ± 0.134
0.0TrpPro: 0.0 ± 0.0
0.508TrpGln: 0.508 ± 0.138
0.381TrpArg: 0.381 ± 0.133
0.338TrpSer: 0.338 ± 0.125
0.381TrpThr: 0.381 ± 0.133
0.508TrpVal: 0.508 ± 0.15
0.127TrpTrp: 0.127 ± 0.06
0.338TrpTyr: 0.338 ± 0.13
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.299TyrAla: 3.299 ± 0.384
0.423TyrCys: 0.423 ± 0.15
3.172TyrAsp: 3.172 ± 0.407
1.903TyrGlu: 1.903 ± 0.282
1.057TyrPhe: 1.057 ± 0.21
2.58TyrGly: 2.58 ± 0.272
0.846TyrHis: 0.846 ± 0.168
2.876TyrIle: 2.876 ± 0.349
1.523TyrLys: 1.523 ± 0.267
3.976TyrLeu: 3.976 ± 0.424
1.1TyrMet: 1.1 ± 0.218
1.819TyrAsn: 1.819 ± 0.267
1.565TyrPro: 1.565 ± 0.226
1.565TyrGln: 1.565 ± 0.236
2.157TyrArg: 2.157 ± 0.237
1.903TyrSer: 1.903 ± 0.315
1.776TyrThr: 1.776 ± 0.284
1.776TyrVal: 1.776 ± 0.275
0.296TyrTrp: 0.296 ± 0.117
1.607TyrTyr: 1.607 ± 0.277
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 107 proteins (23644 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski