Amino acid dipepetide frequency for Dysgonomonas macrotermitis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.461AlaAla: 4.461 ± 0.08	0.695AlaCys: 0.695 ± 0.027	3.857AlaAsp: 3.857 ± 0.06	3.897AlaGlu: 3.897 ± 0.055	2.97AlaPhe: 2.97 ± 0.051	4.597AlaGly: 4.597 ± 0.066	0.972AlaHis: 0.972 ± 0.032	5.024AlaIle: 5.024 ± 0.065	4.311AlaLys: 4.311 ± 0.058	5.837AlaLeu: 5.837 ± 0.076	1.483AlaMet: 1.483 ± 0.035	3.265AlaAsn: 3.265 ± 0.058	1.97AlaPro: 1.97 ± 0.039	2.472AlaGln: 2.472 ± 0.047	2.366AlaArg: 2.366 ± 0.043	4.37AlaSer: 4.37 ± 0.064	3.556AlaThr: 3.556 ± 0.057	3.987AlaVal: 3.987 ± 0.067	0.69AlaTrp: 0.69 ± 0.023	2.812AlaTyr: 2.812 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.549CysAla: 0.549 ± 0.022	0.149CysCys: 0.149 ± 0.013	0.484CysAsp: 0.484 ± 0.021	0.51CysGlu: 0.51 ± 0.021	0.534CysPhe: 0.534 ± 0.02	0.731CysGly: 0.731 ± 0.024	0.194CysHis: 0.194 ± 0.014	0.873CysIle: 0.873 ± 0.027	0.573CysLys: 0.573 ± 0.021	0.854CysLeu: 0.854 ± 0.025	0.196CysMet: 0.196 ± 0.013	0.502CysAsn: 0.502 ± 0.018	0.396CysPro: 0.396 ± 0.018	0.267CysGln: 0.267 ± 0.015	0.375CysArg: 0.375 ± 0.015	0.725CysSer: 0.725 ± 0.026	0.534CysThr: 0.534 ± 0.02	0.546CysVal: 0.546 ± 0.021	0.124CysTrp: 0.124 ± 0.01	0.433CysTyr: 0.433 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.646AspAla: 3.646 ± 0.055	0.515AspCys: 0.515 ± 0.02	2.932AspAsp: 2.932 ± 0.056	3.702AspGlu: 3.702 ± 0.049	3.12AspPhe: 3.12 ± 0.045	4.096AspGly: 4.096 ± 0.063	0.779AspHis: 0.779 ± 0.024	5.093AspIle: 5.093 ± 0.056	4.735AspLys: 4.735 ± 0.071	5.025AspLeu: 5.025 ± 0.07	1.521AspMet: 1.521 ± 0.032	3.582AspAsn: 3.582 ± 0.059	1.992AspPro: 1.992 ± 0.044	1.538AspGln: 1.538 ± 0.034	2.391AspArg: 2.391 ± 0.043	3.555AspSer: 3.555 ± 0.056	2.913AspThr: 2.913 ± 0.047	3.352AspVal: 3.352 ± 0.051	0.847AspTrp: 0.847 ± 0.024	3.004AspTyr: 3.004 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	4.058GluAla: 4.058 ± 0.062	0.465GluCys: 0.465 ± 0.017	3.405GluAsp: 3.405 ± 0.051	4.221GluGlu: 4.221 ± 0.068	2.484GluPhe: 2.484 ± 0.042	3.629GluGly: 3.629 ± 0.052	0.993GluHis: 0.993 ± 0.029	4.968GluIle: 4.968 ± 0.069	5.409GluLys: 5.409 ± 0.081	5.531GluLeu: 5.531 ± 0.068	1.673GluMet: 1.673 ± 0.037	3.89GluAsn: 3.89 ± 0.052	1.616GluPro: 1.616 ± 0.035	2.31GluGln: 2.31 ± 0.044	2.676GluArg: 2.676 ± 0.05	3.607GluSer: 3.607 ± 0.052	3.367GluThr: 3.367 ± 0.054	3.763GluVal: 3.763 ± 0.048	0.789GluTrp: 0.789 ± 0.026	2.99GluTyr: 2.99 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	2.957PheAla: 2.957 ± 0.047	0.546PheCys: 0.546 ± 0.017	3.113PheAsp: 3.113 ± 0.048	2.752PheGlu: 2.752 ± 0.044	2.454PhePhe: 2.454 ± 0.044	3.171PheGly: 3.171 ± 0.053	0.764PheHis: 0.764 ± 0.025	3.591PheIle: 3.591 ± 0.06	2.732PheLys: 2.732 ± 0.054	4.06PheLeu: 4.06 ± 0.064	1.149PheMet: 1.149 ± 0.031	2.657PheAsn: 2.657 ± 0.049	1.612PhePro: 1.612 ± 0.035	1.243PheGln: 1.243 ± 0.029	1.934PheArg: 1.934 ± 0.039	3.829PheSer: 3.829 ± 0.059	2.911PheThr: 2.911 ± 0.045	3.006PheVal: 3.006 ± 0.05	0.576PheTrp: 0.576 ± 0.022	2.12PheTyr: 2.12 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	4.009GlyAla: 4.009 ± 0.062	0.69GlyCys: 0.69 ± 0.024	3.494GlyAsp: 3.494 ± 0.051	3.687GlyGlu: 3.687 ± 0.052	3.265GlyPhe: 3.265 ± 0.053	4.609GlyGly: 4.609 ± 0.068	1.097GlyHis: 1.097 ± 0.03	5.743GlyIle: 5.743 ± 0.07	4.964GlyLys: 4.964 ± 0.064	5.734GlyLeu: 5.734 ± 0.063	1.662GlyMet: 1.662 ± 0.041	3.796GlyAsn: 3.796 ± 0.062	1.087GlyPro: 1.087 ± 0.027	2.088GlyGln: 2.088 ± 0.039	2.571GlyArg: 2.571 ± 0.05	4.257GlySer: 4.257 ± 0.063	4.275GlyThr: 4.275 ± 0.072	4.391GlyVal: 4.391 ± 0.07	0.943GlyTrp: 0.943 ± 0.029	3.482GlyTyr: 3.482 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	0.9HisAla: 0.9 ± 0.027	0.199HisCys: 0.199 ± 0.013	0.818HisAsp: 0.818 ± 0.026	0.849HisGlu: 0.849 ± 0.025	0.919HisPhe: 0.919 ± 0.022	1.026HisGly: 1.026 ± 0.03	0.348HisHis: 0.348 ± 0.015	1.452HisIle: 1.452 ± 0.032	0.987HisLys: 0.987 ± 0.026	1.514HisLeu: 1.514 ± 0.037	0.359HisMet: 0.359 ± 0.018	0.966HisAsn: 0.966 ± 0.031	0.825HisPro: 0.825 ± 0.024	0.527HisGln: 0.527 ± 0.02	0.646HisArg: 0.646 ± 0.022	1.006HisSer: 1.006 ± 0.027	0.971HisThr: 0.971 ± 0.033	0.861HisVal: 0.861 ± 0.024	0.202HisTrp: 0.202 ± 0.012	0.798HisTyr: 0.798 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.358IleAla: 5.358 ± 0.077	0.898IleCys: 0.898 ± 0.028	5.03IleAsp: 5.03 ± 0.072	5.228IleGlu: 5.228 ± 0.065	3.362IlePhe: 3.362 ± 0.059	5.041IleGly: 5.041 ± 0.08	1.319IleHis: 1.319 ± 0.034	5.926IleIle: 5.926 ± 0.079	5.205IleLys: 5.205 ± 0.069	7.01IleLeu: 7.01 ± 0.096	1.464IleMet: 1.464 ± 0.029	4.545IleAsn: 4.545 ± 0.057	3.41IlePro: 3.41 ± 0.047	2.556IleGln: 2.556 ± 0.044	3.3IleArg: 3.3 ± 0.053	5.898IleSer: 5.898 ± 0.065	4.626IleThr: 4.626 ± 0.064	4.854IleVal: 4.854 ± 0.063	0.883IleTrp: 0.883 ± 0.032	3.376IleTyr: 3.376 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	4.728LysAla: 4.728 ± 0.063	0.464LysCys: 0.464 ± 0.021	4.68LysAsp: 4.68 ± 0.064	5.798LysGlu: 5.798 ± 0.086	2.443LysPhe: 2.443 ± 0.042	4.524LysGly: 4.524 ± 0.064	1.232LysHis: 1.232 ± 0.033	5.255LysIle: 5.255 ± 0.069	5.531LysLys: 5.531 ± 0.071	5.65LysLeu: 5.65 ± 0.066	2.044LysMet: 2.044 ± 0.036	4.246LysAsn: 4.246 ± 0.064	2.305LysPro: 2.305 ± 0.039	2.676LysGln: 2.676 ± 0.045	2.87LysArg: 2.87 ± 0.036	4.186LysSer: 4.186 ± 0.064	4.033LysThr: 4.033 ± 0.057	4.424LysVal: 4.424 ± 0.061	0.816LysTrp: 0.816 ± 0.024	3.513LysTyr: 3.513 ± 0.057	0.0LysXaa: 0.0 ± 0.0
Leu	5.64LeuAla: 5.64 ± 0.073	0.991LeuCys: 0.991 ± 0.027	4.998LeuAsp: 4.998 ± 0.063	4.929LeuGlu: 4.929 ± 0.055	4.621LeuPhe: 4.621 ± 0.073	5.382LeuGly: 5.382 ± 0.072	1.421LeuHis: 1.421 ± 0.032	6.556LeuIle: 6.556 ± 0.083	6.539LeuLys: 6.539 ± 0.068	8.644LeuLeu: 8.644 ± 0.111	2.076LeuMet: 2.076 ± 0.041	5.191LeuAsn: 5.191 ± 0.058	3.72LeuPro: 3.72 ± 0.054	2.981LeuGln: 2.981 ± 0.05	3.562LeuArg: 3.562 ± 0.056	7.267LeuSer: 7.267 ± 0.088	5.189LeuThr: 5.189 ± 0.06	4.885LeuVal: 4.885 ± 0.067	1.043LeuTrp: 1.043 ± 0.027	3.82LeuTyr: 3.82 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	1.614MetAla: 1.614 ± 0.034	0.175MetCys: 0.175 ± 0.011	1.284MetAsp: 1.284 ± 0.029	1.447MetGlu: 1.447 ± 0.032	0.969MetPhe: 0.969 ± 0.026	1.534MetGly: 1.534 ± 0.037	0.37MetHis: 0.37 ± 0.017	1.606MetIle: 1.606 ± 0.033	2.364MetLys: 2.364 ± 0.037	2.09MetLeu: 2.09 ± 0.037	0.6MetMet: 0.6 ± 0.023	1.409MetAsn: 1.409 ± 0.03	1.005MetPro: 1.005 ± 0.031	0.89MetGln: 0.89 ± 0.027	0.997MetArg: 0.997 ± 0.027	1.55MetSer: 1.55 ± 0.034	1.339MetThr: 1.339 ± 0.032	1.296MetVal: 1.296 ± 0.033	0.219MetTrp: 0.219 ± 0.013	0.887MetTyr: 0.887 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.37AsnAla: 3.37 ± 0.051	0.477AsnCys: 0.477 ± 0.021	2.992AsnAsp: 2.992 ± 0.051	3.273AsnGlu: 3.273 ± 0.051	2.424AsnPhe: 2.424 ± 0.046	3.997AsnGly: 3.997 ± 0.066	0.896AsnHis: 0.896 ± 0.026	5.146AsnIle: 5.146 ± 0.064	4.273AsnLys: 4.273 ± 0.068	5.033AsnLeu: 5.033 ± 0.071	1.386AsnMet: 1.386 ± 0.032	3.784AsnAsn: 3.784 ± 0.08	2.711AsnPro: 2.711 ± 0.049	1.922AsnGln: 1.922 ± 0.04	2.443AsnArg: 2.443 ± 0.043	3.73AsnSer: 3.73 ± 0.062	3.628AsnThr: 3.628 ± 0.051	3.251AsnVal: 3.251 ± 0.052	0.74AsnTrp: 0.74 ± 0.024	2.69AsnTyr: 2.69 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	2.372ProAla: 2.372 ± 0.049	0.268ProCys: 0.268 ± 0.016	2.559ProAsp: 2.559 ± 0.047	2.92ProGlu: 2.92 ± 0.047	1.783ProPhe: 1.783 ± 0.037	2.041ProGly: 2.041 ± 0.046	0.626ProHis: 0.626 ± 0.021	2.412ProIle: 2.412 ± 0.043	2.0ProLys: 2.0 ± 0.038	3.003ProLeu: 3.003 ± 0.046	0.736ProMet: 0.736 ± 0.023	1.847ProAsn: 1.847 ± 0.042	0.829ProPro: 0.829 ± 0.029	1.388ProGln: 1.388 ± 0.034	1.132ProArg: 1.132 ± 0.032	2.449ProSer: 2.449 ± 0.044	1.969ProThr: 1.969 ± 0.037	2.829ProVal: 2.829 ± 0.039	0.39ProTrp: 0.39 ± 0.016	1.663ProTyr: 1.663 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	2.215GlnAla: 2.215 ± 0.043	0.225GlnCys: 0.225 ± 0.013	1.653GlnAsp: 1.653 ± 0.033	2.057GlnGlu: 2.057 ± 0.044	1.396GlnPhe: 1.396 ± 0.03	1.873GlnGly: 1.873 ± 0.031	0.494GlnHis: 0.494 ± 0.02	2.689GlnIle: 2.689 ± 0.047	2.628GlnLys: 2.628 ± 0.043	3.179GlnLeu: 3.179 ± 0.053	0.935GlnMet: 0.935 ± 0.023	2.097GlnAsn: 2.097 ± 0.046	1.11GlnPro: 1.11 ± 0.033	1.419GlnGln: 1.419 ± 0.036	1.385GlnArg: 1.385 ± 0.032	2.245GlnSer: 2.245 ± 0.039	2.076GlnThr: 2.076 ± 0.042	1.972GlnVal: 1.972 ± 0.044	0.407GlnTrp: 0.407 ± 0.018	1.526GlnTyr: 1.526 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.227ArgAla: 2.227 ± 0.046	0.339ArgCys: 0.339 ± 0.018	2.123ArgAsp: 2.123 ± 0.039	2.409ArgGlu: 2.409 ± 0.047	2.079ArgPhe: 2.079 ± 0.042	2.152ArgGly: 2.152 ± 0.042	0.716ArgHis: 0.716 ± 0.022	3.561ArgIle: 3.561 ± 0.057	3.165ArgLys: 3.165 ± 0.048	3.827ArgLeu: 3.827 ± 0.057	1.104ArgMet: 1.104 ± 0.03	2.32ArgAsn: 2.32 ± 0.04	1.267ArgPro: 1.267 ± 0.03	1.374ArgGln: 1.374 ± 0.034	1.656ArgArg: 1.656 ± 0.037	2.259ArgSer: 2.259 ± 0.038	2.154ArgThr: 2.154 ± 0.041	2.292ArgVal: 2.292 ± 0.039	0.559ArgTrp: 0.559 ± 0.022	2.028ArgTyr: 2.028 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	4.203SerAla: 4.203 ± 0.058	0.685SerCys: 0.685 ± 0.023	4.174SerAsp: 4.174 ± 0.064	3.912SerGlu: 3.912 ± 0.061	3.669SerPhe: 3.669 ± 0.054	5.144SerGly: 5.144 ± 0.072	1.096SerHis: 1.096 ± 0.033	5.35SerIle: 5.35 ± 0.069	4.312SerLys: 4.312 ± 0.055	6.425SerLeu: 6.425 ± 0.077	1.415SerMet: 1.415 ± 0.035	3.646SerAsn: 3.646 ± 0.056	2.396SerPro: 2.396 ± 0.045	2.196SerGln: 2.196 ± 0.037	2.554SerArg: 2.554 ± 0.045	4.708SerSer: 4.708 ± 0.078	3.854SerThr: 3.854 ± 0.057	4.549SerVal: 4.549 ± 0.057	0.833SerTrp: 0.833 ± 0.026	3.253SerTyr: 3.253 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	3.807ThrAla: 3.807 ± 0.063	0.447ThrCys: 0.447 ± 0.02	3.732ThrAsp: 3.732 ± 0.06	3.477ThrGlu: 3.477 ± 0.056	2.768ThrPhe: 2.768 ± 0.045	4.547ThrGly: 4.547 ± 0.063	0.966ThrHis: 0.966 ± 0.031	4.759ThrIle: 4.759 ± 0.067	3.379ThrLys: 3.379 ± 0.049	5.268ThrLeu: 5.268 ± 0.059	1.053ThrMet: 1.053 ± 0.031	3.019ThrAsn: 3.019 ± 0.056	2.626ThrPro: 2.626 ± 0.044	1.867ThrGln: 1.867 ± 0.039	1.89ThrArg: 1.89 ± 0.039	3.923ThrSer: 3.923 ± 0.058	3.555ThrThr: 3.555 ± 0.075	3.881ThrVal: 3.881 ± 0.058	0.645ThrTrp: 0.645 ± 0.023	2.676ThrTyr: 2.676 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	3.975ValAla: 3.975 ± 0.063	0.728ValCys: 0.728 ± 0.025	3.61ValAsp: 3.61 ± 0.062	3.661ValGlu: 3.661 ± 0.057	3.028ValPhe: 3.028 ± 0.051	3.858ValGly: 3.858 ± 0.064	0.87ValHis: 0.87 ± 0.025	4.732ValIle: 4.732 ± 0.064	4.201ValLys: 4.201 ± 0.054	5.458ValLeu: 5.458 ± 0.076	1.347ValMet: 1.347 ± 0.034	3.541ValAsn: 3.541 ± 0.055	2.187ValPro: 2.187 ± 0.042	1.854ValGln: 1.854 ± 0.035	2.375ValArg: 2.375 ± 0.04	4.702ValSer: 4.702 ± 0.07	3.65ValThr: 3.65 ± 0.063	4.086ValVal: 4.086 ± 0.068	0.741ValTrp: 0.741 ± 0.023	2.727ValTyr: 2.727 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.8TrpAla: 0.8 ± 0.026	0.142TrpCys: 0.142 ± 0.01	0.744TrpAsp: 0.744 ± 0.027	0.682TrpGlu: 0.682 ± 0.023	0.576TrpPhe: 0.576 ± 0.019	0.964TrpGly: 0.964 ± 0.027	0.232TrpHis: 0.232 ± 0.015	0.941TrpIle: 0.941 ± 0.026	0.888TrpLys: 0.888 ± 0.024	1.086TrpLeu: 1.086 ± 0.026	0.349TrpMet: 0.349 ± 0.016	0.802TrpAsn: 0.802 ± 0.025	0.256TrpPro: 0.256 ± 0.015	0.484TrpGln: 0.484 ± 0.02	0.504TrpArg: 0.504 ± 0.022	0.717TrpSer: 0.717 ± 0.028	0.669TrpThr: 0.669 ± 0.024	0.731TrpVal: 0.731 ± 0.025	0.186TrpTrp: 0.186 ± 0.012	0.529TrpTyr: 0.529 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.705TyrAla: 2.705 ± 0.049	0.452TyrCys: 0.452 ± 0.017	2.655TyrAsp: 2.655 ± 0.047	2.432TyrGlu: 2.432 ± 0.044	2.312TyrPhe: 2.312 ± 0.043	2.929TyrGly: 2.929 ± 0.051	0.788TyrHis: 0.788 ± 0.027	3.614TyrIle: 3.614 ± 0.049	3.221TyrLys: 3.221 ± 0.055	4.225TyrLeu: 4.225 ± 0.057	1.093TyrMet: 1.093 ± 0.028	3.064TyrAsn: 3.064 ± 0.053	1.896TyrPro: 1.896 ± 0.04	1.53TyrGln: 1.53 ± 0.036	1.984TyrArg: 1.984 ± 0.041	3.39TyrSer: 3.39 ± 0.055	3.016TyrThr: 3.016 ± 0.058	2.375TyrVal: 2.375 ± 0.046	0.646TyrTrp: 0.646 ± 0.022	2.498TyrTyr: 2.498 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4009 proteins (1390717 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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