Amino acid dipepetide frequency for Hydromonas duriensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.693AlaAla: 10.693 ± 0.18
1.084AlaCys: 1.084 ± 0.043
5.098AlaAsp: 5.098 ± 0.091
4.951AlaGlu: 4.951 ± 0.084
3.737AlaPhe: 3.737 ± 0.074
7.148AlaGly: 7.148 ± 0.126
2.885AlaHis: 2.885 ± 0.075
5.359AlaIle: 5.359 ± 0.099
5.05AlaLys: 5.05 ± 0.108
10.935AlaLeu: 10.935 ± 0.166
2.818AlaMet: 2.818 ± 0.065
3.668AlaAsn: 3.668 ± 0.09
3.872AlaPro: 3.872 ± 0.087
6.192AlaGln: 6.192 ± 0.123
5.128AlaArg: 5.128 ± 0.095
5.732AlaSer: 5.732 ± 0.116
5.138AlaThr: 5.138 ± 0.128
7.007AlaVal: 7.007 ± 0.114
1.312AlaTrp: 1.312 ± 0.046
2.81AlaTyr: 2.81 ± 0.073
0.0AlaXaa: 0.0 ± 0.0
Cys
1.036CysAla: 1.036 ± 0.041
0.124CysCys: 0.124 ± 0.013
0.56CysAsp: 0.56 ± 0.024
0.529CysGlu: 0.529 ± 0.028
0.404CysPhe: 0.404 ± 0.027
0.84CysGly: 0.84 ± 0.038
0.291CysHis: 0.291 ± 0.021
0.558CysIle: 0.558 ± 0.03
0.382CysLys: 0.382 ± 0.027
0.927CysLeu: 0.927 ± 0.037
0.215CysMet: 0.215 ± 0.017
0.286CysAsn: 0.286 ± 0.02
0.483CysPro: 0.483 ± 0.03
0.368CysGln: 0.368 ± 0.023
0.377CysArg: 0.377 ± 0.024
0.601CysSer: 0.601 ± 0.034
0.539CysThr: 0.539 ± 0.033
0.834CysVal: 0.834 ± 0.043
0.141CysTrp: 0.141 ± 0.014
0.243CysTyr: 0.243 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
5.948AspAla: 5.948 ± 0.122
0.524AspCys: 0.524 ± 0.026
3.05AspAsp: 3.05 ± 0.08
3.611AspGlu: 3.611 ± 0.084
2.331AspPhe: 2.331 ± 0.066
3.978AspGly: 3.978 ± 0.086
0.879AspHis: 0.879 ± 0.039
3.284AspIle: 3.284 ± 0.071
2.953AspLys: 2.953 ± 0.071
5.046AspLeu: 5.046 ± 0.086
1.555AspMet: 1.555 ± 0.05
2.226AspAsn: 2.226 ± 0.087
1.727AspPro: 1.727 ± 0.055
1.252AspGln: 1.252 ± 0.042
1.85AspArg: 1.85 ± 0.06
2.892AspSer: 2.892 ± 0.074
2.852AspThr: 2.852 ± 0.069
4.799AspVal: 4.799 ± 0.086
0.956AspTrp: 0.956 ± 0.039
1.754AspTyr: 1.754 ± 0.053
0.0AspXaa: 0.0 ± 0.0
Glu
5.412GluAla: 5.412 ± 0.131
0.469GluCys: 0.469 ± 0.028
2.328GluAsp: 2.328 ± 0.062
2.564GluGlu: 2.564 ± 0.075
2.026GluPhe: 2.026 ± 0.06
3.186GluGly: 3.186 ± 0.076
1.791GluHis: 1.791 ± 0.052
3.031GluIle: 3.031 ± 0.078
2.975GluLys: 2.975 ± 0.076
5.661GluLeu: 5.661 ± 0.125
1.471GluMet: 1.471 ± 0.046
2.041GluAsn: 2.041 ± 0.062
1.976GluPro: 1.976 ± 0.063
3.394GluGln: 3.394 ± 0.077
3.578GluArg: 3.578 ± 0.085
2.838GluSer: 2.838 ± 0.068
2.858GluThr: 2.858 ± 0.067
3.881GluVal: 3.881 ± 0.091
0.784GluTrp: 0.784 ± 0.03
1.635GluTyr: 1.635 ± 0.056
0.0GluXaa: 0.0 ± 0.0
Phe
3.696PheAla: 3.696 ± 0.073
0.465PheCys: 0.465 ± 0.027
2.652PheAsp: 2.652 ± 0.07
2.43PheGlu: 2.43 ± 0.062
1.818PhePhe: 1.818 ± 0.066
3.175PheGly: 3.175 ± 0.075
0.745PheHis: 0.745 ± 0.033
2.37PheIle: 2.37 ± 0.067
2.284PheLys: 2.284 ± 0.055
3.419PheLeu: 3.419 ± 0.081
1.037PheMet: 1.037 ± 0.038
1.972PheAsn: 1.972 ± 0.054
1.302PhePro: 1.302 ± 0.037
1.045PheGln: 1.045 ± 0.036
1.405PheArg: 1.405 ± 0.045
2.761PheSer: 2.761 ± 0.062
2.303PheThr: 2.303 ± 0.069
2.797PheVal: 2.797 ± 0.067
0.567PheTrp: 0.567 ± 0.029
1.302PheTyr: 1.302 ± 0.05
0.0PheXaa: 0.0 ± 0.0
Gly
6.489GlyAla: 6.489 ± 0.128
0.749GlyCys: 0.749 ± 0.032
3.51GlyAsp: 3.51 ± 0.096
3.877GlyGlu: 3.877 ± 0.076
3.247GlyPhe: 3.247 ± 0.074
5.193GlyGly: 5.193 ± 0.128
1.781GlyHis: 1.781 ± 0.058
4.076GlyIle: 4.076 ± 0.078
3.578GlyLys: 3.578 ± 0.092
7.377GlyLeu: 7.377 ± 0.101
2.127GlyMet: 2.127 ± 0.063
2.334GlyAsn: 2.334 ± 0.085
1.347GlyPro: 1.347 ± 0.052
3.289GlyGln: 3.289 ± 0.085
3.45GlyArg: 3.45 ± 0.084
4.081GlySer: 4.081 ± 0.119
3.853GlyThr: 3.853 ± 0.115
6.342GlyVal: 6.342 ± 0.113
1.001GlyTrp: 1.001 ± 0.04
2.298GlyTyr: 2.298 ± 0.065
0.0GlyXaa: 0.0 ± 0.0
His
2.656HisAla: 2.656 ± 0.07
0.237HisCys: 0.237 ± 0.02
1.378HisAsp: 1.378 ± 0.042
1.265HisGlu: 1.265 ± 0.044
1.08HisPhe: 1.08 ± 0.041
1.665HisGly: 1.665 ± 0.047
0.865HisHis: 0.865 ± 0.042
1.648HisIle: 1.648 ± 0.047
0.968HisLys: 0.968 ± 0.039
2.445HisLeu: 2.445 ± 0.061
0.645HisMet: 0.645 ± 0.032
0.987HisAsn: 0.987 ± 0.039
1.406HisPro: 1.406 ± 0.045
1.046HisGln: 1.046 ± 0.039
1.2HisArg: 1.2 ± 0.041
1.413HisSer: 1.413 ± 0.05
1.416HisThr: 1.416 ± 0.05
1.843HisVal: 1.843 ± 0.055
0.328HisTrp: 0.328 ± 0.024
0.855HisTyr: 0.855 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
6.19IleAla: 6.19 ± 0.097
0.571IleCys: 0.571 ± 0.032
3.676IleAsp: 3.676 ± 0.072
3.994IleGlu: 3.994 ± 0.09
1.977IlePhe: 1.977 ± 0.06
4.346IleGly: 4.346 ± 0.102
1.333IleHis: 1.333 ± 0.041
2.994IleIle: 2.994 ± 0.07
3.228IleLys: 3.228 ± 0.083
4.978IleLeu: 4.978 ± 0.098
1.272IleMet: 1.272 ± 0.05
2.735IleAsn: 2.735 ± 0.079
2.373IlePro: 2.373 ± 0.063
2.239IleGln: 2.239 ± 0.061
2.615IleArg: 2.615 ± 0.064
3.51IleSer: 3.51 ± 0.086
3.196IleThr: 3.196 ± 0.072
3.864IleVal: 3.864 ± 0.067
0.611IleTrp: 0.611 ± 0.032
1.416IleTyr: 1.416 ± 0.047
0.0IleXaa: 0.0 ± 0.0
Lys
4.86LysAla: 4.86 ± 0.085
0.298LysCys: 0.298 ± 0.021
2.694LysAsp: 2.694 ± 0.069
2.541LysGlu: 2.541 ± 0.066
1.46LysPhe: 1.46 ± 0.042
3.388LysGly: 3.388 ± 0.073
1.206LysHis: 1.206 ± 0.038
3.006LysIle: 3.006 ± 0.067
3.055LysLys: 3.055 ± 0.092
4.433LysLeu: 4.433 ± 0.091
1.645LysMet: 1.645 ± 0.048
2.632LysAsn: 2.632 ± 0.071
2.427LysPro: 2.427 ± 0.104
2.327LysGln: 2.327 ± 0.06
2.686LysArg: 2.686 ± 0.061
3.169LysSer: 3.169 ± 0.07
3.36LysThr: 3.36 ± 0.076
3.528LysVal: 3.528 ± 0.079
0.565LysTrp: 0.565 ± 0.027
1.312LysTyr: 1.312 ± 0.056
0.0LysXaa: 0.0 ± 0.0
Leu
10.126LeuAla: 10.126 ± 0.152
0.998LeuCys: 0.998 ± 0.041
5.412LeuAsp: 5.412 ± 0.088
4.899LeuGlu: 4.899 ± 0.091
3.869LeuPhe: 3.869 ± 0.084
6.889LeuGly: 6.889 ± 0.104
2.308LeuHis: 2.308 ± 0.069
5.613LeuIle: 5.613 ± 0.099
5.496LeuLys: 5.496 ± 0.113
9.77LeuLeu: 9.77 ± 0.153
2.696LeuMet: 2.696 ± 0.076
4.953LeuAsn: 4.953 ± 0.098
4.874LeuPro: 4.874 ± 0.096
3.935LeuGln: 3.935 ± 0.068
4.999LeuArg: 4.999 ± 0.087
7.493LeuSer: 7.493 ± 0.133
6.119LeuThr: 6.119 ± 0.098
6.421LeuVal: 6.421 ± 0.113
1.152LeuTrp: 1.152 ± 0.039
2.445LeuTyr: 2.445 ± 0.066
0.001LeuXaa: 0.001 ± 0.001
Met
2.643MetAla: 2.643 ± 0.055
0.239MetCys: 0.239 ± 0.018
1.288MetAsp: 1.288 ± 0.043
1.015MetGlu: 1.015 ± 0.039
0.98MetPhe: 0.98 ± 0.04
2.071MetGly: 2.071 ± 0.064
0.622MetHis: 0.622 ± 0.028
1.265MetIle: 1.265 ± 0.045
1.394MetLys: 1.394 ± 0.047
2.768MetLeu: 2.768 ± 0.067
0.94MetMet: 0.94 ± 0.038
1.35MetAsn: 1.35 ± 0.051
1.354MetPro: 1.354 ± 0.046
1.209MetGln: 1.209 ± 0.037
1.626MetArg: 1.626 ± 0.054
2.165MetSer: 2.165 ± 0.051
1.816MetThr: 1.816 ± 0.049
1.798MetVal: 1.798 ± 0.047
0.315MetTrp: 0.315 ± 0.023
0.547MetTyr: 0.547 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
4.355AsnAla: 4.355 ± 0.106
0.38AsnCys: 0.38 ± 0.023
2.301AsnAsp: 2.301 ± 0.062
2.38AsnGlu: 2.38 ± 0.084
1.512AsnPhe: 1.512 ± 0.055
3.173AsnGly: 3.173 ± 0.104
0.999AsnHis: 0.999 ± 0.042
2.541AsnIle: 2.541 ± 0.066
2.006AsnLys: 2.006 ± 0.055
3.815AsnLeu: 3.815 ± 0.081
1.059AsnMet: 1.059 ± 0.043
1.997AsnAsn: 1.997 ± 0.083
2.254AsnPro: 2.254 ± 0.058
2.007AsnGln: 2.007 ± 0.059
1.912AsnArg: 1.912 ± 0.054
2.44AsnSer: 2.44 ± 0.086
2.588AsnThr: 2.588 ± 0.075
2.916AsnVal: 2.916 ± 0.07
0.622AsnTrp: 0.622 ± 0.031
1.175AsnTyr: 1.175 ± 0.043
0.0AsnXaa: 0.0 ± 0.0
Pro
4.058ProAla: 4.058 ± 0.104
0.38ProCys: 0.38 ± 0.022
2.327ProAsp: 2.327 ± 0.054
2.81ProGlu: 2.81 ± 0.069
1.686ProPhe: 1.686 ± 0.052
1.65ProGly: 1.65 ± 0.049
1.112ProHis: 1.112 ± 0.043
2.506ProIle: 2.506 ± 0.062
2.156ProLys: 2.156 ± 0.055
4.065ProLeu: 4.065 ± 0.082
1.193ProMet: 1.193 ± 0.038
2.071ProAsn: 2.071 ± 0.048
1.305ProPro: 1.305 ± 0.043
1.623ProGln: 1.623 ± 0.05
1.702ProArg: 1.702 ± 0.052
2.653ProSer: 2.653 ± 0.062
2.517ProThr: 2.517 ± 0.074
3.25ProVal: 3.25 ± 0.082
0.481ProTrp: 0.481 ± 0.026
1.298ProTyr: 1.298 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
5.043GlnAla: 5.043 ± 0.123
0.393GlnCys: 0.393 ± 0.025
1.942GlnAsp: 1.942 ± 0.052
1.936GlnGlu: 1.936 ± 0.056
1.606GlnPhe: 1.606 ± 0.05
2.926GlnGly: 2.926 ± 0.07
1.286GlnHis: 1.286 ± 0.046
2.462GlnIle: 2.462 ± 0.066
2.294GlnLys: 2.294 ± 0.065
4.851GlnLeu: 4.851 ± 0.108
1.228GlnMet: 1.228 ± 0.04
1.912GlnAsn: 1.912 ± 0.058
1.777GlnPro: 1.777 ± 0.054
2.191GlnGln: 2.191 ± 0.06
2.441GlnArg: 2.441 ± 0.067
2.616GlnSer: 2.616 ± 0.061
2.746GlnThr: 2.746 ± 0.07
3.223GlnVal: 3.223 ± 0.069
0.628GlnTrp: 0.628 ± 0.028
1.344GlnTyr: 1.344 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
4.929ArgAla: 4.929 ± 0.094
0.375ArgCys: 0.375 ± 0.027
2.666ArgAsp: 2.666 ± 0.07
2.994ArgGlu: 2.994 ± 0.077
2.202ArgPhe: 2.202 ± 0.063
2.987ArgGly: 2.987 ± 0.067
1.336ArgHis: 1.336 ± 0.044
3.2ArgIle: 3.2 ± 0.075
1.966ArgLys: 1.966 ± 0.059
5.383ArgLeu: 5.383 ± 0.101
1.449ArgMet: 1.449 ± 0.05
1.815ArgAsn: 1.815 ± 0.052
1.83ArgPro: 1.83 ± 0.052
2.185ArgGln: 2.185 ± 0.06
2.592ArgArg: 2.592 ± 0.083
2.478ArgSer: 2.478 ± 0.054
2.587ArgThr: 2.587 ± 0.058
3.799ArgVal: 3.799 ± 0.089
0.718ArgTrp: 0.718 ± 0.033
1.775ArgTyr: 1.775 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
5.816SerAla: 5.816 ± 0.125
0.563SerCys: 0.563 ± 0.031
3.209SerAsp: 3.209 ± 0.072
3.243SerGlu: 3.243 ± 0.064
2.515SerPhe: 2.515 ± 0.055
4.919SerGly: 4.919 ± 0.129
1.5SerHis: 1.5 ± 0.045
3.703SerIle: 3.703 ± 0.079
3.098SerLys: 3.098 ± 0.078
5.949SerLeu: 5.949 ± 0.105
1.726SerMet: 1.726 ± 0.051
2.748SerAsn: 2.748 ± 0.085
2.522SerPro: 2.522 ± 0.063
2.489SerGln: 2.489 ± 0.065
2.845SerArg: 2.845 ± 0.073
4.204SerSer: 4.204 ± 0.152
3.831SerThr: 3.831 ± 0.112
4.314SerVal: 4.314 ± 0.091
0.769SerTrp: 0.769 ± 0.039
1.631SerTyr: 1.631 ± 0.05
0.0SerXaa: 0.0 ± 0.0
Thr
5.507ThrAla: 5.507 ± 0.112
0.537ThrCys: 0.537 ± 0.034
2.947ThrAsp: 2.947 ± 0.068
2.9ThrGlu: 2.9 ± 0.071
2.085ThrPhe: 2.085 ± 0.049
4.363ThrGly: 4.363 ± 0.116
1.65ThrHis: 1.65 ± 0.056
3.326ThrIle: 3.326 ± 0.076
2.317ThrLys: 2.317 ± 0.066
6.071ThrLeu: 6.071 ± 0.113
1.266ThrMet: 1.266 ± 0.04
2.092ThrAsn: 2.092 ± 0.067
3.275ThrPro: 3.275 ± 0.08
2.881ThrGln: 2.881 ± 0.065
2.732ThrArg: 2.732 ± 0.062
3.353ThrSer: 3.353 ± 0.105
3.268ThrThr: 3.268 ± 0.113
4.376ThrVal: 4.376 ± 0.117
0.727ThrTrp: 0.727 ± 0.037
1.519ThrTyr: 1.519 ± 0.051
0.0ThrXaa: 0.0 ± 0.0
Val
7.275ValAla: 7.275 ± 0.107
0.833ValCys: 0.833 ± 0.039
4.113ValAsp: 4.113 ± 0.132
4.035ValGlu: 4.035 ± 0.107
3.019ValPhe: 3.019 ± 0.065
5.111ValGly: 5.111 ± 0.101
1.644ValHis: 1.644 ± 0.048
3.994ValIle: 3.994 ± 0.08
3.623ValLys: 3.623 ± 0.075
8.009ValLeu: 8.009 ± 0.113
2.058ValMet: 2.058 ± 0.059
3.018ValAsn: 3.018 ± 0.079
3.006ValPro: 3.006 ± 0.07
2.954ValGln: 2.954 ± 0.064
3.545ValArg: 3.545 ± 0.079
4.725ValSer: 4.725 ± 0.089
4.043ValThr: 4.043 ± 0.079
5.734ValVal: 5.734 ± 0.11
0.999ValTrp: 0.999 ± 0.039
1.963ValTyr: 1.963 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
1.114TrpAla: 1.114 ± 0.036
0.164TrpCys: 0.164 ± 0.015
0.571TrpAsp: 0.571 ± 0.028
0.476TrpGlu: 0.476 ± 0.028
0.647TrpPhe: 0.647 ± 0.032
0.842TrpGly: 0.842 ± 0.035
0.425TrpHis: 0.425 ± 0.023
0.646TrpIle: 0.646 ± 0.032
0.455TrpLys: 0.455 ± 0.028
1.85TrpLeu: 1.85 ± 0.058
0.399TrpMet: 0.399 ± 0.027
0.427TrpAsn: 0.427 ± 0.024
0.417TrpPro: 0.417 ± 0.024
0.947TrpGln: 0.947 ± 0.034
0.927TrpArg: 0.927 ± 0.04
0.753TrpSer: 0.753 ± 0.037
0.564TrpThr: 0.564 ± 0.032
1.053TrpVal: 1.053 ± 0.045
0.226TrpTrp: 0.226 ± 0.02
0.386TrpTyr: 0.386 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.77TyrAla: 2.77 ± 0.072
0.353TyrCys: 0.353 ± 0.022
1.746TyrAsp: 1.746 ± 0.058
1.447TyrGlu: 1.447 ± 0.047
1.343TyrPhe: 1.343 ± 0.053
2.15TyrGly: 2.15 ± 0.06
0.69TyrHis: 0.69 ± 0.033
1.538TyrIle: 1.538 ± 0.047
1.315TyrLys: 1.315 ± 0.038
2.715TyrLeu: 2.715 ± 0.063
0.602TyrMet: 0.602 ± 0.026
1.172TyrAsn: 1.172 ± 0.039
1.313TyrPro: 1.313 ± 0.039
1.275TyrGln: 1.275 ± 0.044
1.654TyrArg: 1.654 ± 0.058
1.716TyrSer: 1.716 ± 0.052
1.599TyrThr: 1.599 ± 0.049
1.922TyrVal: 1.922 ± 0.049
0.39TyrTrp: 0.39 ± 0.025
0.923TyrTyr: 0.923 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.001XaaLeu: 0.001 ± 0.001
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.003XaaXaa: 0.003 ± 0.003
Statistics based on 2252 proteins (707475 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski