Amino acid dipepetide frequency for Anaeroglobus geminatus F0357

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.589AlaAla: 12.589 ± 0.256
1.297AlaCys: 1.297 ± 0.054
5.809AlaAsp: 5.809 ± 0.106
6.485AlaGlu: 6.485 ± 0.129
3.629AlaPhe: 3.629 ± 0.097
8.364AlaGly: 8.364 ± 0.144
1.623AlaHis: 1.623 ± 0.053
4.223AlaIle: 4.223 ± 0.104
4.58AlaLys: 4.58 ± 0.095
8.506AlaLeu: 8.506 ± 0.164
2.627AlaMet: 2.627 ± 0.069
2.515AlaAsn: 2.515 ± 0.075
2.754AlaPro: 2.754 ± 0.069
2.467AlaGln: 2.467 ± 0.074
4.212AlaArg: 4.212 ± 0.101
3.939AlaSer: 3.939 ± 0.09
4.009AlaThr: 4.009 ± 0.099
10.118AlaVal: 10.118 ± 0.173
0.717AlaTrp: 0.717 ± 0.034
3.401AlaTyr: 3.401 ± 0.085
0.0AlaXaa: 0.0 ± 0.0
Cys
1.072CysAla: 1.072 ± 0.044
0.256CysCys: 0.256 ± 0.022
0.613CysAsp: 0.613 ± 0.04
0.717CysGlu: 0.717 ± 0.037
0.532CysPhe: 0.532 ± 0.031
1.417CysGly: 1.417 ± 0.052
0.304CysHis: 0.304 ± 0.026
1.024CysIle: 1.024 ± 0.046
0.623CysLys: 0.623 ± 0.038
1.181CysLeu: 1.181 ± 0.053
0.403CysMet: 0.403 ± 0.029
0.461CysAsn: 0.461 ± 0.03
0.691CysPro: 0.691 ± 0.04
0.225CysGln: 0.225 ± 0.021
1.124CysArg: 1.124 ± 0.052
0.739CysSer: 0.739 ± 0.036
0.759CysThr: 0.759 ± 0.04
0.761CysVal: 0.761 ± 0.039
0.085CysTrp: 0.085 ± 0.013
0.345CysTyr: 0.345 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
4.508AspAla: 4.508 ± 0.115
0.689AspCys: 0.689 ± 0.033
2.951AspAsp: 2.951 ± 0.088
3.873AspGlu: 3.873 ± 0.09
2.419AspPhe: 2.419 ± 0.07
5.024AspGly: 5.024 ± 0.109
0.884AspHis: 0.884 ± 0.039
4.479AspIle: 4.479 ± 0.101
3.412AspLys: 3.412 ± 0.083
4.578AspLeu: 4.578 ± 0.102
1.776AspMet: 1.776 ± 0.052
2.039AspAsn: 2.039 ± 0.063
1.898AspPro: 1.898 ± 0.059
0.892AspGln: 0.892 ± 0.043
2.749AspArg: 2.749 ± 0.08
2.583AspSer: 2.583 ± 0.068
3.384AspThr: 3.384 ± 0.081
4.062AspVal: 4.062 ± 0.08
0.549AspTrp: 0.549 ± 0.033
2.297AspTyr: 2.297 ± 0.077
0.0AspXaa: 0.0 ± 0.0
Glu
6.299GluAla: 6.299 ± 0.145
0.661GluCys: 0.661 ± 0.039
3.296GluAsp: 3.296 ± 0.076
5.324GluGlu: 5.324 ± 0.12
2.141GluPhe: 2.141 ± 0.058
4.138GluGly: 4.138 ± 0.084
1.306GluHis: 1.306 ± 0.051
4.506GluIle: 4.506 ± 0.102
5.324GluLys: 5.324 ± 0.103
5.945GluLeu: 5.945 ± 0.117
1.907GluMet: 1.907 ± 0.062
2.782GluAsn: 2.782 ± 0.079
2.016GluPro: 2.016 ± 0.058
2.069GluGln: 2.069 ± 0.067
4.252GluArg: 4.252 ± 0.115
2.611GluSer: 2.611 ± 0.079
3.666GluThr: 3.666 ± 0.091
3.937GluVal: 3.937 ± 0.095
0.549GluTrp: 0.549 ± 0.034
2.132GluTyr: 2.132 ± 0.052
0.0GluXaa: 0.0 ± 0.0
Phe
3.449PheAla: 3.449 ± 0.072
0.691PheCys: 0.691 ± 0.038
2.196PheAsp: 2.196 ± 0.068
1.899PheGlu: 1.899 ± 0.066
2.073PhePhe: 2.073 ± 0.074
3.266PheGly: 3.266 ± 0.089
0.809PheHis: 0.809 ± 0.044
3.007PheIle: 3.007 ± 0.087
1.741PheLys: 1.741 ± 0.053
3.784PheLeu: 3.784 ± 0.112
1.282PheMet: 1.282 ± 0.054
1.483PheAsn: 1.483 ± 0.054
1.463PhePro: 1.463 ± 0.052
0.82PheGln: 0.82 ± 0.037
2.073PheArg: 2.073 ± 0.071
2.88PheSer: 2.88 ± 0.089
2.559PheThr: 2.559 ± 0.065
2.734PheVal: 2.734 ± 0.092
0.451PheTrp: 0.451 ± 0.03
1.402PheTyr: 1.402 ± 0.056
0.0PheXaa: 0.0 ± 0.0
Gly
7.003GlyAla: 7.003 ± 0.131
1.179GlyCys: 1.179 ± 0.05
3.911GlyAsp: 3.911 ± 0.094
4.44GlyGlu: 4.44 ± 0.097
3.009GlyPhe: 3.009 ± 0.08
6.028GlyGly: 6.028 ± 0.116
1.625GlyHis: 1.625 ± 0.061
6.233GlyIle: 6.233 ± 0.11
5.468GlyLys: 5.468 ± 0.113
6.78GlyLeu: 6.78 ± 0.132
2.445GlyMet: 2.445 ± 0.071
3.034GlyAsn: 3.034 ± 0.078
2.062GlyPro: 2.062 ± 0.064
2.178GlyGln: 2.178 ± 0.068
4.663GlyArg: 4.663 ± 0.105
4.398GlySer: 4.398 ± 0.1
5.334GlyThr: 5.334 ± 0.1
5.308GlyVal: 5.308 ± 0.116
0.661GlyTrp: 0.661 ± 0.034
2.964GlyTyr: 2.964 ± 0.065
0.0GlyXaa: 0.0 ± 0.0
His
1.579HisAla: 1.579 ± 0.055
0.374HisCys: 0.374 ± 0.03
1.166HisAsp: 1.166 ± 0.046
1.137HisGlu: 1.137 ± 0.043
0.79HisPhe: 0.79 ± 0.04
1.684HisGly: 1.684 ± 0.053
0.488HisHis: 0.488 ± 0.031
1.765HisIle: 1.765 ± 0.061
1.146HisLys: 1.146 ± 0.042
1.658HisLeu: 1.658 ± 0.054
0.569HisMet: 0.569 ± 0.032
0.842HisAsn: 0.842 ± 0.042
0.906HisPro: 0.906 ± 0.039
0.472HisGln: 0.472 ± 0.024
1.164HisArg: 1.164 ± 0.051
0.993HisSer: 0.993 ± 0.043
1.266HisThr: 1.266 ± 0.05
1.546HisVal: 1.546 ± 0.061
0.212HisTrp: 0.212 ± 0.02
0.711HisTyr: 0.711 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
5.93IleAla: 5.93 ± 0.119
1.035IleCys: 1.035 ± 0.046
3.856IleAsp: 3.856 ± 0.085
3.727IleGlu: 3.727 ± 0.088
2.635IlePhe: 2.635 ± 0.069
5.673IleGly: 5.673 ± 0.109
1.411IleHis: 1.411 ± 0.056
4.937IleIle: 4.937 ± 0.134
3.482IleLys: 3.482 ± 0.084
6.135IleLeu: 6.135 ± 0.116
1.986IleMet: 1.986 ± 0.062
2.482IleAsn: 2.482 ± 0.08
3.01IlePro: 3.01 ± 0.089
1.608IleGln: 1.608 ± 0.052
3.72IleArg: 3.72 ± 0.082
3.897IleSer: 3.897 ± 0.096
4.108IleThr: 4.108 ± 0.091
5.022IleVal: 5.022 ± 0.112
0.536IleTrp: 0.536 ± 0.031
2.216IleTyr: 2.216 ± 0.07
0.0IleXaa: 0.0 ± 0.0
Lys
5.343LysAla: 5.343 ± 0.121
0.468LysCys: 0.468 ± 0.031
3.519LysAsp: 3.519 ± 0.099
5.247LysGlu: 5.247 ± 0.113
1.562LysPhe: 1.562 ± 0.055
4.189LysGly: 4.189 ± 0.085
1.085LysHis: 1.085 ± 0.049
3.943LysIle: 3.943 ± 0.078
4.816LysLys: 4.816 ± 0.106
4.512LysLeu: 4.512 ± 0.093
1.584LysMet: 1.584 ± 0.047
2.824LysAsn: 2.824 ± 0.073
1.866LysPro: 1.866 ± 0.061
1.772LysGln: 1.772 ± 0.057
3.41LysArg: 3.41 ± 0.078
2.867LysSer: 2.867 ± 0.07
3.515LysThr: 3.515 ± 0.075
3.675LysVal: 3.675 ± 0.08
0.475LysTrp: 0.475 ± 0.029
2.13LysTyr: 2.13 ± 0.065
0.0LysXaa: 0.0 ± 0.0
Leu
8.766LeuAla: 8.766 ± 0.141
1.347LeuCys: 1.347 ± 0.048
4.696LeuAsp: 4.696 ± 0.1
5.26LeuGlu: 5.26 ± 0.121
3.823LeuPhe: 3.823 ± 0.117
6.446LeuGly: 6.446 ± 0.134
2.15LeuHis: 2.15 ± 0.068
5.696LeuIle: 5.696 ± 0.124
5.138LeuLys: 5.138 ± 0.102
8.237LeuLeu: 8.237 ± 0.153
2.369LeuMet: 2.369 ± 0.068
3.082LeuAsn: 3.082 ± 0.082
4.167LeuPro: 4.167 ± 0.087
3.034LeuGln: 3.034 ± 0.09
5.153LeuArg: 5.153 ± 0.096
5.612LeuSer: 5.612 ± 0.11
5.647LeuThr: 5.647 ± 0.099
5.643LeuVal: 5.643 ± 0.11
0.752LeuTrp: 0.752 ± 0.04
3.106LeuTyr: 3.106 ± 0.084
0.0LeuXaa: 0.0 ± 0.0
Met
2.62MetAla: 2.62 ± 0.068
0.26MetCys: 0.26 ± 0.026
1.542MetAsp: 1.542 ± 0.061
1.975MetGlu: 1.975 ± 0.064
0.803MetPhe: 0.803 ± 0.04
1.98MetGly: 1.98 ± 0.064
0.564MetHis: 0.564 ± 0.031
1.734MetIle: 1.734 ± 0.058
2.292MetLys: 2.292 ± 0.069
2.288MetLeu: 2.288 ± 0.073
0.776MetMet: 0.776 ± 0.043
1.408MetAsn: 1.408 ± 0.052
1.437MetPro: 1.437 ± 0.058
0.836MetGln: 0.836 ± 0.039
1.494MetArg: 1.494 ± 0.056
1.638MetSer: 1.638 ± 0.062
1.964MetThr: 1.964 ± 0.063
1.588MetVal: 1.588 ± 0.055
0.184MetTrp: 0.184 ± 0.018
0.945MetTyr: 0.945 ± 0.041
0.0MetXaa: 0.0 ± 0.0
Asn
2.997AsnAla: 2.997 ± 0.084
0.523AsnCys: 0.523 ± 0.038
1.883AsnAsp: 1.883 ± 0.065
2.189AsnGlu: 2.189 ± 0.06
1.387AsnPhe: 1.387 ± 0.047
3.257AsnGly: 3.257 ± 0.077
0.706AsnHis: 0.706 ± 0.037
2.962AsnIle: 2.962 ± 0.073
2.159AsnLys: 2.159 ± 0.068
3.172AsnLeu: 3.172 ± 0.077
1.08AsnMet: 1.08 ± 0.039
1.439AsnAsn: 1.439 ± 0.059
1.805AsnPro: 1.805 ± 0.065
0.809AsnGln: 0.809 ± 0.038
2.235AsnArg: 2.235 ± 0.071
1.874AsnSer: 1.874 ± 0.065
2.268AsnThr: 2.268 ± 0.079
2.67AsnVal: 2.67 ± 0.071
0.343AsnTrp: 0.343 ± 0.026
1.242AsnTyr: 1.242 ± 0.05
0.0AsnXaa: 0.0 ± 0.0
Pro
3.563ProAla: 3.563 ± 0.078
0.455ProCys: 0.455 ± 0.033
2.557ProAsp: 2.557 ± 0.071
3.102ProGlu: 3.102 ± 0.075
1.839ProPhe: 1.839 ± 0.065
2.692ProGly: 2.692 ± 0.075
0.899ProHis: 0.899 ± 0.042
1.839ProIle: 1.839 ± 0.059
1.553ProLys: 1.553 ± 0.058
3.738ProLeu: 3.738 ± 0.077
0.938ProMet: 0.938 ± 0.05
1.115ProAsn: 1.115 ± 0.046
1.163ProPro: 1.163 ± 0.051
1.245ProGln: 1.245 ± 0.05
1.518ProArg: 1.518 ± 0.05
1.907ProSer: 1.907 ± 0.059
1.745ProThr: 1.745 ± 0.06
4.149ProVal: 4.149 ± 0.084
0.374ProTrp: 0.374 ± 0.03
1.568ProTyr: 1.568 ± 0.057
0.0ProXaa: 0.0 ± 0.0
Gln
2.793GlnAla: 2.793 ± 0.081
0.275GlnCys: 0.275 ± 0.019
1.345GlnAsp: 1.345 ± 0.053
1.87GlnGlu: 1.87 ± 0.062
1.069GlnPhe: 1.069 ± 0.048
1.896GlnGly: 1.896 ± 0.06
0.525GlnHis: 0.525 ± 0.031
1.934GlnIle: 1.934 ± 0.058
1.846GlnLys: 1.846 ± 0.057
2.397GlnLeu: 2.397 ± 0.065
0.838GlnMet: 0.838 ± 0.037
1.067GlnAsn: 1.067 ± 0.049
0.934GlnPro: 0.934 ± 0.041
1.059GlnGln: 1.059 ± 0.052
1.673GlnArg: 1.673 ± 0.061
1.356GlnSer: 1.356 ± 0.057
1.4GlnThr: 1.4 ± 0.056
1.831GlnVal: 1.831 ± 0.057
0.287GlnTrp: 0.287 ± 0.022
1.153GlnTyr: 1.153 ± 0.046
0.0GlnXaa: 0.0 ± 0.0
Arg
4.291ArgAla: 4.291 ± 0.09
0.746ArgCys: 0.746 ± 0.034
2.734ArgAsp: 2.734 ± 0.078
3.817ArgGlu: 3.817 ± 0.09
2.356ArgPhe: 2.356 ± 0.071
3.246ArgGly: 3.246 ± 0.085
1.391ArgHis: 1.391 ± 0.049
4.298ArgIle: 4.298 ± 0.092
3.454ArgLys: 3.454 ± 0.082
5.505ArgLeu: 5.505 ± 0.108
1.634ArgMet: 1.634 ± 0.053
2.323ArgAsn: 2.323 ± 0.068
2.189ArgPro: 2.189 ± 0.075
2.065ArgGln: 2.065 ± 0.074
4.158ArgArg: 4.158 ± 0.107
2.798ArgSer: 2.798 ± 0.084
3.18ArgThr: 3.18 ± 0.073
3.447ArgVal: 3.447 ± 0.083
0.488ArgTrp: 0.488 ± 0.031
2.047ArgTyr: 2.047 ± 0.058
0.0ArgXaa: 0.0 ± 0.0
Ser
4.626SerAla: 4.626 ± 0.099
0.656SerCys: 0.656 ± 0.044
2.719SerAsp: 2.719 ± 0.075
3.014SerGlu: 3.014 ± 0.078
2.533SerPhe: 2.533 ± 0.066
4.711SerGly: 4.711 ± 0.104
1.128SerHis: 1.128 ± 0.047
3.079SerIle: 3.079 ± 0.076
2.436SerLys: 2.436 ± 0.072
5.512SerLeu: 5.512 ± 0.097
1.384SerMet: 1.384 ± 0.052
1.518SerAsn: 1.518 ± 0.06
1.971SerPro: 1.971 ± 0.056
1.389SerGln: 1.389 ± 0.051
3.001SerArg: 3.001 ± 0.088
2.658SerSer: 2.658 ± 0.073
2.552SerThr: 2.552 ± 0.079
4.707SerVal: 4.707 ± 0.099
0.488SerTrp: 0.488 ± 0.028
1.91SerTyr: 1.91 ± 0.054
0.0SerXaa: 0.0 ± 0.0
Thr
6.544ThrAla: 6.544 ± 0.145
0.637ThrCys: 0.637 ± 0.039
3.425ThrAsp: 3.425 ± 0.071
3.782ThrGlu: 3.782 ± 0.092
2.15ThrPhe: 2.15 ± 0.069
5.687ThrGly: 5.687 ± 0.114
1.085ThrHis: 1.085 ± 0.047
3.239ThrIle: 3.239 ± 0.081
2.62ThrLys: 2.62 ± 0.072
5.074ThrLeu: 5.074 ± 0.097
1.411ThrMet: 1.411 ± 0.051
1.783ThrAsn: 1.783 ± 0.064
2.461ThrPro: 2.461 ± 0.076
1.282ThrGln: 1.282 ± 0.049
2.531ThrArg: 2.531 ± 0.065
2.384ThrSer: 2.384 ± 0.065
2.927ThrThr: 2.927 ± 0.085
6.163ThrVal: 6.163 ± 0.127
0.52ThrTrp: 0.52 ± 0.03
2.1ThrTyr: 2.1 ± 0.069
0.0ThrXaa: 0.0 ± 0.0
Val
6.358ValAla: 6.358 ± 0.131
1.19ValCys: 1.19 ± 0.051
3.99ValAsp: 3.99 ± 0.098
4.219ValGlu: 4.219 ± 0.097
3.373ValPhe: 3.373 ± 0.075
5.157ValGly: 5.157 ± 0.112
1.444ValHis: 1.444 ± 0.052
5.3ValIle: 5.3 ± 0.109
4.184ValLys: 4.184 ± 0.093
7.143ValLeu: 7.143 ± 0.137
2.08ValMet: 2.08 ± 0.062
2.915ValAsn: 2.915 ± 0.077
3.495ValPro: 3.495 ± 0.075
2.141ValGln: 2.141 ± 0.062
4.399ValArg: 4.399 ± 0.082
4.528ValSer: 4.528 ± 0.101
4.925ValThr: 4.925 ± 0.108
5.427ValVal: 5.427 ± 0.117
0.584ValTrp: 0.584 ± 0.036
2.791ValTyr: 2.791 ± 0.071
0.0ValXaa: 0.0 ± 0.0
Trp
0.617TrpAla: 0.617 ± 0.037
0.076TrpCys: 0.076 ± 0.013
0.49TrpAsp: 0.49 ± 0.034
0.532TrpGlu: 0.532 ± 0.031
0.367TrpPhe: 0.367 ± 0.027
0.625TrpGly: 0.625 ± 0.037
0.24TrpHis: 0.24 ± 0.021
0.52TrpIle: 0.52 ± 0.03
0.525TrpLys: 0.525 ± 0.033
0.923TrpLeu: 0.923 ± 0.048
0.219TrpMet: 0.219 ± 0.019
0.407TrpAsn: 0.407 ± 0.026
0.341TrpPro: 0.341 ± 0.025
0.451TrpGln: 0.451 ± 0.028
0.555TrpArg: 0.555 ± 0.027
0.497TrpSer: 0.497 ± 0.033
0.391TrpThr: 0.391 ± 0.027
0.49TrpVal: 0.49 ± 0.03
0.085TrpTrp: 0.085 ± 0.012
0.346TrpTyr: 0.346 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.916TyrAla: 2.916 ± 0.069
0.516TyrCys: 0.516 ± 0.032
2.347TyrAsp: 2.347 ± 0.072
2.251TyrGlu: 2.251 ± 0.068
1.572TyrPhe: 1.572 ± 0.056
3.242TyrGly: 3.242 ± 0.081
0.801TyrHis: 0.801 ± 0.033
2.69TyrIle: 2.69 ± 0.076
2.004TyrLys: 2.004 ± 0.059
3.056TyrLeu: 3.056 ± 0.078
1.017TyrMet: 1.017 ± 0.043
1.481TyrAsn: 1.481 ± 0.046
1.328TyrPro: 1.328 ± 0.055
0.733TyrGln: 0.733 ± 0.044
2.086TyrArg: 2.086 ± 0.074
1.835TyrSer: 1.835 ± 0.06
2.209TyrThr: 2.209 ± 0.071
2.366TyrVal: 2.366 ± 0.064
0.356TyrTrp: 0.356 ± 0.025
1.367TyrTyr: 1.367 ± 0.062
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2148 proteins (542794 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski