Amino acid dipepetide frequency for Tolypocladium paradoxum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.757AlaAla: 11.757 ± 0.081	1.197AlaCys: 1.197 ± 0.02	5.053AlaAsp: 5.053 ± 0.044	5.556AlaGlu: 5.556 ± 0.049	3.178AlaPhe: 3.178 ± 0.032	6.774AlaGly: 6.774 ± 0.054	2.025AlaHis: 2.025 ± 0.02	4.016AlaIle: 4.016 ± 0.035	4.281AlaLys: 4.281 ± 0.041	8.29AlaLeu: 8.29 ± 0.056	2.318AlaMet: 2.318 ± 0.024	3.07AlaAsn: 3.07 ± 0.026	5.677AlaPro: 5.677 ± 0.052	3.792AlaGln: 3.792 ± 0.035	6.208AlaArg: 6.208 ± 0.041	8.106AlaSer: 8.106 ± 0.055	5.646AlaThr: 5.646 ± 0.041	6.173AlaVal: 6.173 ± 0.047	1.285AlaTrp: 1.285 ± 0.018	2.121AlaTyr: 2.121 ± 0.025	0.001AlaXaa: 0.001 ± 0.0
Cys	1.079CysAla: 1.079 ± 0.02	0.278CysCys: 0.278 ± 0.01	0.702CysAsp: 0.702 ± 0.014	0.604CysGlu: 0.604 ± 0.013	0.549CysPhe: 0.549 ± 0.014	1.016CysGly: 1.016 ± 0.018	0.379CysHis: 0.379 ± 0.01	0.652CysIle: 0.652 ± 0.013	0.497CysLys: 0.497 ± 0.012	1.288CysLeu: 1.288 ± 0.02	0.277CysMet: 0.277 ± 0.008	0.425CysAsn: 0.425 ± 0.011	0.787CysPro: 0.787 ± 0.015	0.455CysGln: 0.455 ± 0.011	0.884CysArg: 0.884 ± 0.014	0.949CysSer: 0.949 ± 0.015	0.681CysThr: 0.681 ± 0.015	0.858CysVal: 0.858 ± 0.016	0.212CysTrp: 0.212 ± 0.008	0.323CysTyr: 0.323 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	5.765AspAla: 5.765 ± 0.046	0.669AspCys: 0.669 ± 0.014	4.985AspAsp: 4.985 ± 0.054	4.798AspGlu: 4.798 ± 0.043	2.166AspPhe: 2.166 ± 0.025	4.841AspGly: 4.841 ± 0.035	1.211AspHis: 1.211 ± 0.014	2.677AspIle: 2.677 ± 0.028	2.581AspLys: 2.581 ± 0.03	4.911AspLeu: 4.911 ± 0.036	1.44AspMet: 1.44 ± 0.016	1.775AspAsn: 1.775 ± 0.023	3.233AspPro: 3.233 ± 0.023	1.781AspGln: 1.781 ± 0.019	3.276AspArg: 3.276 ± 0.039	4.004AspSer: 4.004 ± 0.031	2.688AspThr: 2.688 ± 0.026	4.036AspVal: 4.036 ± 0.029	0.888AspTrp: 0.888 ± 0.013	1.408AspTyr: 1.408 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	5.899GluAla: 5.899 ± 0.048	0.617GluCys: 0.617 ± 0.013	4.054GluAsp: 4.054 ± 0.039	4.768GluGlu: 4.768 ± 0.047	1.851GluPhe: 1.851 ± 0.021	3.663GluGly: 3.663 ± 0.029	1.455GluHis: 1.455 ± 0.019	2.397GluIle: 2.397 ± 0.025	3.068GluLys: 3.068 ± 0.032	5.164GluLeu: 5.164 ± 0.042	1.449GluMet: 1.449 ± 0.019	1.834GluAsn: 1.834 ± 0.021	3.045GluPro: 3.045 ± 0.036	2.462GluGln: 2.462 ± 0.028	4.056GluArg: 4.056 ± 0.04	4.008GluSer: 4.008 ± 0.036	3.235GluThr: 3.235 ± 0.034	3.401GluVal: 3.401 ± 0.029	0.84GluTrp: 0.84 ± 0.014	1.522GluTyr: 1.522 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.15PheAla: 3.15 ± 0.032	0.558PheCys: 0.558 ± 0.011	2.253PheAsp: 2.253 ± 0.025	1.991PheGlu: 1.991 ± 0.022	1.493PhePhe: 1.493 ± 0.024	2.803PheGly: 2.803 ± 0.033	0.867PheHis: 0.867 ± 0.011	1.54PheIle: 1.54 ± 0.022	1.372PheLys: 1.372 ± 0.018	3.213PheLeu: 3.213 ± 0.036	0.768PheMet: 0.768 ± 0.014	1.291PheAsn: 1.291 ± 0.018	1.829PhePro: 1.829 ± 0.021	1.267PheGln: 1.267 ± 0.015	2.027PheArg: 2.027 ± 0.023	2.723PheSer: 2.723 ± 0.027	1.907PheThr: 1.907 ± 0.024	2.451PheVal: 2.451 ± 0.027	0.613PheTrp: 0.613 ± 0.014	1.001PheTyr: 1.001 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	6.298GlyAla: 6.298 ± 0.047	0.944GlyCys: 0.944 ± 0.017	4.117GlyAsp: 4.117 ± 0.032	3.826GlyGlu: 3.826 ± 0.031	2.727GlyPhe: 2.727 ± 0.029	6.46GlyGly: 6.46 ± 0.062	1.903GlyHis: 1.903 ± 0.022	3.312GlyIle: 3.312 ± 0.034	3.383GlyLys: 3.383 ± 0.03	6.241GlyLeu: 6.241 ± 0.043	1.689GlyMet: 1.689 ± 0.021	2.434GlyAsn: 2.434 ± 0.024	3.875GlyPro: 3.875 ± 0.036	2.815GlyGln: 2.815 ± 0.029	5.007GlyArg: 5.007 ± 0.041	5.995GlySer: 5.995 ± 0.047	3.983GlyThr: 3.983 ± 0.036	4.503GlyVal: 4.503 ± 0.04	1.181GlyTrp: 1.181 ± 0.016	2.001GlyTyr: 2.001 ± 0.025	0.001GlyXaa: 0.001 ± 0.0
His	2.151HisAla: 2.151 ± 0.024	0.36HisCys: 0.36 ± 0.01	1.469HisAsp: 1.469 ± 0.021	1.357HisGlu: 1.357 ± 0.017	0.855HisPhe: 0.855 ± 0.015	2.073HisGly: 2.073 ± 0.021	0.983HisHis: 0.983 ± 0.019	1.072HisIle: 1.072 ± 0.015	0.867HisLys: 0.867 ± 0.014	2.286HisLeu: 2.286 ± 0.028	0.53HisMet: 0.53 ± 0.01	0.738HisAsn: 0.738 ± 0.012	1.721HisPro: 1.721 ± 0.021	1.058HisGln: 1.058 ± 0.017	1.793HisArg: 1.793 ± 0.023	1.742HisSer: 1.742 ± 0.019	1.159HisThr: 1.159 ± 0.017	1.633HisVal: 1.633 ± 0.021	0.333HisTrp: 0.333 ± 0.009	0.623HisTyr: 0.623 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	3.79IleAla: 3.79 ± 0.032	0.684IleCys: 0.684 ± 0.013	2.494IleAsp: 2.494 ± 0.025	2.357IleGlu: 2.357 ± 0.025	1.657IlePhe: 1.657 ± 0.02	2.832IleGly: 2.832 ± 0.03	1.075IleHis: 1.075 ± 0.016	1.959IleIle: 1.959 ± 0.03	1.915IleLys: 1.915 ± 0.025	3.932IleLeu: 3.932 ± 0.038	0.963IleMet: 0.963 ± 0.015	1.481IleAsn: 1.481 ± 0.019	2.611IlePro: 2.611 ± 0.022	1.587IleGln: 1.587 ± 0.018	2.657IleArg: 2.657 ± 0.024	3.132IleSer: 3.132 ± 0.031	2.301IleThr: 2.301 ± 0.026	2.869IleVal: 2.869 ± 0.031	0.632IleTrp: 0.632 ± 0.013	1.152IleTyr: 1.152 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.41LysAla: 4.41 ± 0.042	0.473LysCys: 0.473 ± 0.011	2.651LysAsp: 2.651 ± 0.028	2.847LysGlu: 2.847 ± 0.032	1.338LysPhe: 1.338 ± 0.021	2.865LysGly: 2.865 ± 0.032	1.11LysHis: 1.11 ± 0.014	1.852LysIle: 1.852 ± 0.023	3.002LysLys: 3.002 ± 0.039	3.869LysLeu: 3.869 ± 0.034	1.043LysMet: 1.043 ± 0.016	1.451LysAsn: 1.451 ± 0.021	2.728LysPro: 2.728 ± 0.027	1.777LysGln: 1.777 ± 0.022	3.358LysArg: 3.358 ± 0.035	3.103LysSer: 3.103 ± 0.029	2.631LysThr: 2.631 ± 0.021	2.599LysVal: 2.599 ± 0.029	0.605LysTrp: 0.605 ± 0.013	1.157LysTyr: 1.157 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	8.668LeuAla: 8.668 ± 0.053	1.284LeuCys: 1.284 ± 0.02	5.347LeuAsp: 5.347 ± 0.038	5.223LeuGlu: 5.223 ± 0.042	3.111LeuPhe: 3.111 ± 0.038	6.272LeuGly: 6.272 ± 0.039	2.267LeuHis: 2.267 ± 0.028	3.303LeuIle: 3.303 ± 0.033	3.727LeuLys: 3.727 ± 0.035	8.327LeuLeu: 8.327 ± 0.075	1.777LeuMet: 1.777 ± 0.023	2.757LeuAsn: 2.757 ± 0.026	5.586LeuPro: 5.586 ± 0.04	3.715LeuGln: 3.715 ± 0.038	6.288LeuArg: 6.288 ± 0.043	6.95LeuSer: 6.95 ± 0.047	4.517LeuThr: 4.517 ± 0.036	5.812LeuVal: 5.812 ± 0.047	1.164LeuTrp: 1.164 ± 0.017	2.186LeuTyr: 2.186 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.608MetAla: 2.608 ± 0.025	0.253MetCys: 0.253 ± 0.008	1.381MetAsp: 1.381 ± 0.016	1.291MetGlu: 1.291 ± 0.017	0.734MetPhe: 0.734 ± 0.014	1.59MetGly: 1.59 ± 0.02	0.499MetHis: 0.499 ± 0.01	0.857MetIle: 0.857 ± 0.015	0.964MetLys: 0.964 ± 0.015	1.927MetLeu: 1.927 ± 0.02	0.602MetMet: 0.602 ± 0.012	0.715MetAsn: 0.715 ± 0.011	1.47MetPro: 1.47 ± 0.019	0.886MetGln: 0.886 ± 0.016	1.425MetArg: 1.425 ± 0.02	1.89MetSer: 1.89 ± 0.023	1.325MetThr: 1.325 ± 0.017	1.382MetVal: 1.382 ± 0.019	0.276MetTrp: 0.276 ± 0.008	0.519MetTyr: 0.519 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.001AsnAla: 3.001 ± 0.026	0.424AsnCys: 0.424 ± 0.009	1.789AsnAsp: 1.789 ± 0.019	1.696AsnGlu: 1.696 ± 0.022	1.194AsnPhe: 1.194 ± 0.019	2.831AsnGly: 2.831 ± 0.026	0.76AsnHis: 0.76 ± 0.015	1.652AsnIle: 1.652 ± 0.021	1.426AsnLys: 1.426 ± 0.018	2.886AsnLeu: 2.886 ± 0.03	0.829AsnMet: 0.829 ± 0.013	1.182AsnAsn: 1.182 ± 0.017	2.208AsnPro: 2.208 ± 0.026	1.14AsnGln: 1.14 ± 0.016	1.909AsnArg: 1.909 ± 0.021	2.331AsnSer: 2.331 ± 0.024	1.769AsnThr: 1.769 ± 0.024	2.153AsnVal: 2.153 ± 0.025	0.505AsnTrp: 0.505 ± 0.011	0.886AsnTyr: 0.886 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	6.322ProAla: 6.322 ± 0.05	0.641ProCys: 0.641 ± 0.014	3.437ProAsp: 3.437 ± 0.029	3.723ProGlu: 3.723 ± 0.037	2.009ProPhe: 2.009 ± 0.021	4.519ProGly: 4.519 ± 0.039	1.423ProHis: 1.423 ± 0.021	2.168ProIle: 2.168 ± 0.024	2.55ProLys: 2.55 ± 0.03	4.888ProLeu: 4.888 ± 0.041	1.185ProMet: 1.185 ± 0.02	2.013ProAsn: 2.013 ± 0.022	5.918ProPro: 5.918 ± 0.072	2.606ProGln: 2.606 ± 0.03	4.322ProArg: 4.322 ± 0.04	6.094ProSer: 6.094 ± 0.048	3.841ProThr: 3.841 ± 0.036	3.777ProVal: 3.777 ± 0.03	0.797ProTrp: 0.797 ± 0.014	1.41ProTyr: 1.41 ± 0.02	0.001ProXaa: 0.001 ± 0.0
Gln	3.783GlnAla: 3.783 ± 0.035	0.43GlnCys: 0.43 ± 0.011	2.164GlnAsp: 2.164 ± 0.025	2.19GlnGlu: 2.19 ± 0.025	1.216GlnPhe: 1.216 ± 0.018	2.63GlnGly: 2.63 ± 0.027	1.176GlnHis: 1.176 ± 0.02	1.572GlnIle: 1.572 ± 0.019	1.756GlnLys: 1.756 ± 0.025	3.483GlnLeu: 3.483 ± 0.035	0.906GlnMet: 0.906 ± 0.016	1.269GlnAsn: 1.269 ± 0.018	2.844GlnPro: 2.844 ± 0.035	2.612GlnGln: 2.612 ± 0.053	2.98GlnArg: 2.98 ± 0.028	2.94GlnSer: 2.94 ± 0.031	2.19GlnThr: 2.19 ± 0.027	2.258GlnVal: 2.258 ± 0.023	0.544GlnTrp: 0.544 ± 0.011	1.033GlnTyr: 1.033 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	5.807ArgAla: 5.807 ± 0.039	0.894ArgCys: 0.894 ± 0.016	3.985ArgAsp: 3.985 ± 0.038	4.005ArgGlu: 4.005 ± 0.041	2.263ArgPhe: 2.263 ± 0.023	4.556ArgGly: 4.556 ± 0.042	1.959ArgHis: 1.959 ± 0.023	2.729ArgIle: 2.729 ± 0.027	3.314ArgLys: 3.314 ± 0.031	6.193ArgLeu: 6.193 ± 0.047	1.457ArgMet: 1.457 ± 0.018	2.213ArgAsn: 2.213 ± 0.022	4.326ArgPro: 4.326 ± 0.044	2.999ArgGln: 2.999 ± 0.028	6.558ArgArg: 6.558 ± 0.074	5.094ArgSer: 5.094 ± 0.045	3.417ArgThr: 3.417 ± 0.03	3.778ArgVal: 3.778 ± 0.033	0.997ArgTrp: 0.997 ± 0.013	1.611ArgTyr: 1.611 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	7.124SerAla: 7.124 ± 0.046	0.939SerCys: 0.939 ± 0.018	4.062SerAsp: 4.062 ± 0.037	3.701SerGlu: 3.701 ± 0.031	2.801SerPhe: 2.801 ± 0.031	5.629SerGly: 5.629 ± 0.038	1.923SerHis: 1.923 ± 0.021	3.379SerIle: 3.379 ± 0.03	3.374SerLys: 3.374 ± 0.028	6.947SerLeu: 6.947 ± 0.05	1.777SerMet: 1.777 ± 0.02	2.613SerAsn: 2.613 ± 0.027	5.704SerPro: 5.704 ± 0.051	3.166SerGln: 3.166 ± 0.031	5.563SerArg: 5.563 ± 0.043	8.381SerSer: 8.381 ± 0.075	5.092SerThr: 5.092 ± 0.046	4.5SerVal: 4.5 ± 0.035	1.103SerTrp: 1.103 ± 0.017	1.8SerTyr: 1.8 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	5.465ThrAla: 5.465 ± 0.04	0.762ThrCys: 0.762 ± 0.014	2.644ThrAsp: 2.644 ± 0.025	2.796ThrGlu: 2.796 ± 0.028	1.948ThrPhe: 1.948 ± 0.023	4.128ThrGly: 4.128 ± 0.035	1.226ThrHis: 1.226 ± 0.017	2.545ThrIle: 2.545 ± 0.029	2.362ThrLys: 2.362 ± 0.028	4.895ThrLeu: 4.895 ± 0.036	1.239ThrMet: 1.239 ± 0.017	1.798ThrAsn: 1.798 ± 0.022	4.233ThrPro: 4.233 ± 0.038	1.933ThrGln: 1.933 ± 0.022	3.386ThrArg: 3.386 ± 0.031	4.82ThrSer: 4.82 ± 0.043	3.89ThrThr: 3.89 ± 0.054	3.581ThrVal: 3.581 ± 0.032	0.802ThrTrp: 0.802 ± 0.016	1.416ThrTyr: 1.416 ± 0.021	0.001ThrXaa: 0.001 ± 0.0
Val	6.105ValAla: 6.105 ± 0.044	0.897ValCys: 0.897 ± 0.016	4.068ValAsp: 4.068 ± 0.032	3.849ValGlu: 3.849 ± 0.031	2.457ValPhe: 2.457 ± 0.025	4.327ValGly: 4.327 ± 0.034	1.484ValHis: 1.484 ± 0.018	2.596ValIle: 2.596 ± 0.03	2.766ValLys: 2.766 ± 0.028	5.773ValLeu: 5.773 ± 0.047	1.382ValMet: 1.382 ± 0.017	2.036ValAsn: 2.036 ± 0.021	3.827ValPro: 3.827 ± 0.032	2.379ValGln: 2.379 ± 0.027	3.83ValArg: 3.83 ± 0.034	4.549ValSer: 4.549 ± 0.034	3.338ValThr: 3.338 ± 0.03	4.73ValVal: 4.73 ± 0.046	0.88ValTrp: 0.88 ± 0.015	1.661ValTyr: 1.661 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.218TrpAla: 1.218 ± 0.018	0.203TrpCys: 0.203 ± 0.007	0.896TrpAsp: 0.896 ± 0.017	0.828TrpGlu: 0.828 ± 0.013	0.517TrpPhe: 0.517 ± 0.011	0.899TrpGly: 0.899 ± 0.014	0.382TrpHis: 0.382 ± 0.01	0.671TrpIle: 0.671 ± 0.013	0.704TrpLys: 0.704 ± 0.011	1.363TrpLeu: 1.363 ± 0.018	0.361TrpMet: 0.361 ± 0.009	0.572TrpAsn: 0.572 ± 0.013	0.669TrpPro: 0.669 ± 0.014	0.569TrpGln: 0.569 ± 0.011	1.052TrpArg: 1.052 ± 0.017	0.997TrpSer: 0.997 ± 0.015	0.904TrpThr: 0.904 ± 0.017	0.854TrpVal: 0.854 ± 0.013	0.278TrpTrp: 0.278 ± 0.008	0.4TrpTyr: 0.4 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.123TyrAla: 2.123 ± 0.026	0.388TyrCys: 0.388 ± 0.01	1.583TyrAsp: 1.583 ± 0.019	1.383TyrGlu: 1.383 ± 0.018	1.054TyrPhe: 1.054 ± 0.016	1.986TyrGly: 1.986 ± 0.025	0.698TyrHis: 0.698 ± 0.013	1.131TyrIle: 1.131 ± 0.018	0.962TyrLys: 0.962 ± 0.017	2.405TyrLeu: 2.405 ± 0.028	0.6TyrMet: 0.6 ± 0.012	0.903TyrAsn: 0.903 ± 0.016	1.351TyrPro: 1.351 ± 0.018	0.976TyrGln: 0.976 ± 0.017	1.578TyrArg: 1.578 ± 0.021	1.769TyrSer: 1.769 ± 0.021	1.355TyrThr: 1.355 ± 0.018	1.585TyrVal: 1.585 ± 0.022	0.403TyrTrp: 0.403 ± 0.009	0.796TyrTyr: 0.796 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.001XaaGln: 0.001 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.107XaaXaa: 0.107 ± 0.028

Statistics based on 8979 proteins (4469941 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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