Amino acid dipepetide frequency for Neomonachus schauinslandi (Hawaiian monk seal) (Monachus schauinslandi)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.342AlaAla: 7.342 ± 0.048	1.426AlaCys: 1.426 ± 0.013	2.967AlaAsp: 2.967 ± 0.015	4.917AlaGlu: 4.917 ± 0.028	2.706AlaPhe: 2.706 ± 0.019	5.032AlaGly: 5.032 ± 0.034	1.578AlaHis: 1.578 ± 0.011	2.712AlaIle: 2.712 ± 0.016	3.398AlaLys: 3.398 ± 0.022	7.387AlaLeu: 7.387 ± 0.041	1.476AlaMet: 1.476 ± 0.011	1.982AlaAsn: 1.982 ± 0.015	4.564AlaPro: 4.564 ± 0.035	3.37AlaGln: 3.37 ± 0.022	3.931AlaArg: 3.931 ± 0.024	5.884AlaSer: 5.884 ± 0.025	3.509AlaThr: 3.509 ± 0.019	4.79AlaVal: 4.79 ± 0.022	0.818AlaTrp: 0.818 ± 0.008	1.538AlaTyr: 1.538 ± 0.011	0.006AlaXaa: 0.006 ± 0.001
Cys	1.281CysAla: 1.281 ± 0.013	0.617CysCys: 0.617 ± 0.012	1.019CysAsp: 1.019 ± 0.012	1.265CysGlu: 1.265 ± 0.013	0.816CysPhe: 0.816 ± 0.008	1.768CysGly: 1.768 ± 0.02	0.654CysHis: 0.654 ± 0.009	0.927CysIle: 0.927 ± 0.009	1.107CysLys: 1.107 ± 0.013	2.127CysLeu: 2.127 ± 0.017	0.405CysMet: 0.405 ± 0.006	0.774CysAsn: 0.774 ± 0.009	1.407CysPro: 1.407 ± 0.018	1.045CysGln: 1.045 ± 0.013	1.305CysArg: 1.305 ± 0.012	1.971CysSer: 1.971 ± 0.015	1.079CysThr: 1.079 ± 0.01	1.285CysVal: 1.285 ± 0.013	0.284CysTrp: 0.284 ± 0.004	0.576CysTyr: 0.576 ± 0.006	0.003CysXaa: 0.003 ± 0.0
Asp	2.9AspAla: 2.9 ± 0.015	1.064AspCys: 1.064 ± 0.012	2.655AspAsp: 2.655 ± 0.017	3.493AspGlu: 3.493 ± 0.018	2.101AspPhe: 2.101 ± 0.012	3.354AspGly: 3.354 ± 0.022	1.128AspHis: 1.128 ± 0.01	2.496AspIle: 2.496 ± 0.015	2.471AspLys: 2.471 ± 0.015	4.997AspLeu: 4.997 ± 0.023	1.115AspMet: 1.115 ± 0.008	1.646AspAsn: 1.646 ± 0.014	3.022AspPro: 3.022 ± 0.017	1.836AspGln: 1.836 ± 0.012	2.537AspArg: 2.537 ± 0.018	4.125AspSer: 4.125 ± 0.021	2.417AspThr: 2.417 ± 0.013	3.012AspVal: 3.012 ± 0.015	0.614AspTrp: 0.614 ± 0.007	1.471AspTyr: 1.471 ± 0.012	0.003AspXaa: 0.003 ± 0.0
Glu	5.462GluAla: 5.462 ± 0.034	1.455GluCys: 1.455 ± 0.021	4.486GluAsp: 4.486 ± 0.019	8.19GluGlu: 8.19 ± 0.048	2.01GluPhe: 2.01 ± 0.013	4.276GluGly: 4.276 ± 0.02	1.498GluHis: 1.498 ± 0.01	3.026GluIle: 3.026 ± 0.018	5.347GluLys: 5.347 ± 0.032	6.477GluLeu: 6.477 ± 0.035	1.645GluMet: 1.645 ± 0.01	3.044GluAsn: 3.044 ± 0.019	3.398GluPro: 3.398 ± 0.025	3.187GluGln: 3.187 ± 0.025	4.172GluArg: 4.172 ± 0.026	4.362GluSer: 4.362 ± 0.021	3.278GluThr: 3.278 ± 0.018	4.136GluVal: 4.136 ± 0.021	0.697GluTrp: 0.697 ± 0.006	1.59GluTyr: 1.59 ± 0.014	0.004GluXaa: 0.004 ± 0.0
Phe	2.003PheAla: 2.003 ± 0.013	0.935PheCys: 0.935 ± 0.008	1.674PheAsp: 1.674 ± 0.012	2.009PheGlu: 2.009 ± 0.014	1.607PhePhe: 1.607 ± 0.014	2.27PheGly: 2.27 ± 0.016	1.026PheHis: 1.026 ± 0.009	1.813PheIle: 1.813 ± 0.015	1.724PheLys: 1.724 ± 0.012	4.073PheLeu: 4.073 ± 0.026	0.769PheMet: 0.769 ± 0.007	1.314PheAsn: 1.314 ± 0.011	2.02PhePro: 2.02 ± 0.014	1.779PheGln: 1.779 ± 0.011	2.007PheArg: 2.007 ± 0.014	3.4PheSer: 3.4 ± 0.019	2.001PheThr: 2.001 ± 0.013	2.123PheVal: 2.123 ± 0.015	0.49PheTrp: 0.49 ± 0.006	1.168PheTyr: 1.168 ± 0.01	0.007PheXaa: 0.007 ± 0.001
Gly	4.859GlyAla: 4.859 ± 0.034	1.286GlyCys: 1.286 ± 0.013	3.175GlyAsp: 3.175 ± 0.022	4.23GlyGlu: 4.23 ± 0.029	2.425GlyPhe: 2.425 ± 0.018	5.52GlyGly: 5.52 ± 0.042	1.714GlyHis: 1.714 ± 0.014	2.696GlyIle: 2.696 ± 0.016	3.774GlyLys: 3.774 ± 0.024	6.087GlyLeu: 6.087 ± 0.033	1.311GlyMet: 1.311 ± 0.011	2.311GlyAsn: 2.311 ± 0.015	4.664GlyPro: 4.664 ± 0.056	2.834GlyGln: 2.834 ± 0.019	3.974GlyArg: 3.974 ± 0.019	5.916GlySer: 5.916 ± 0.028	3.566GlyThr: 3.566 ± 0.021	3.627GlyVal: 3.627 ± 0.019	0.814GlyTrp: 0.814 ± 0.009	1.735GlyTyr: 1.735 ± 0.016	0.007GlyXaa: 0.007 ± 0.001
His	1.35HisAla: 1.35 ± 0.01	0.713HisCys: 0.713 ± 0.009	0.88HisAsp: 0.88 ± 0.008	1.305HisGlu: 1.305 ± 0.009	1.069HisPhe: 1.069 ± 0.008	1.578HisGly: 1.578 ± 0.012	0.91HisHis: 0.91 ± 0.012	1.19HisIle: 1.19 ± 0.011	1.23HisLys: 1.23 ± 0.01	2.917HisLeu: 2.917 ± 0.018	0.572HisMet: 0.572 ± 0.006	0.832HisAsn: 0.832 ± 0.009	1.671HisPro: 1.671 ± 0.013	1.369HisGln: 1.369 ± 0.016	1.616HisArg: 1.616 ± 0.012	2.246HisSer: 2.246 ± 0.013	1.517HisThr: 1.517 ± 0.016	1.499HisVal: 1.499 ± 0.011	0.349HisTrp: 0.349 ± 0.005	0.814HisTyr: 0.814 ± 0.008	0.003HisXaa: 0.003 ± 0.0
Ile	2.5IleAla: 2.5 ± 0.013	1.041IleCys: 1.041 ± 0.009	1.954IleAsp: 1.954 ± 0.012	2.491IleGlu: 2.491 ± 0.016	1.879IlePhe: 1.879 ± 0.016	2.149IleGly: 2.149 ± 0.014	1.322IleHis: 1.322 ± 0.013	2.331IleIle: 2.331 ± 0.018	2.498IleLys: 2.498 ± 0.018	4.48IleLeu: 4.48 ± 0.023	0.985IleMet: 0.985 ± 0.01	1.734IleAsn: 1.734 ± 0.012	2.545IlePro: 2.545 ± 0.013	2.237IleGln: 2.237 ± 0.014	2.337IleArg: 2.337 ± 0.013	3.541IleSer: 3.541 ± 0.02	2.467IleThr: 2.467 ± 0.019	2.414IleVal: 2.414 ± 0.019	0.497IleTrp: 0.497 ± 0.006	1.359IleTyr: 1.359 ± 0.011	0.003IleXaa: 0.003 ± 0.001
Lys	3.999LysAla: 3.999 ± 0.022	1.097LysCys: 1.097 ± 0.012	3.079LysAsp: 3.079 ± 0.018	5.004LysGlu: 5.004 ± 0.031	1.662LysPhe: 1.662 ± 0.011	3.177LysGly: 3.177 ± 0.024	1.362LysHis: 1.362 ± 0.009	2.673LysIle: 2.673 ± 0.019	4.655LysLys: 4.655 ± 0.036	5.049LysLeu: 5.049 ± 0.025	1.428LysMet: 1.428 ± 0.01	2.306LysAsn: 2.306 ± 0.017	3.141LysPro: 3.141 ± 0.024	2.553LysGln: 2.553 ± 0.017	3.293LysArg: 3.293 ± 0.02	3.811LysSer: 3.811 ± 0.022	3.017LysThr: 3.017 ± 0.018	3.355LysVal: 3.355 ± 0.022	0.579LysTrp: 0.579 ± 0.007	1.52LysTyr: 1.52 ± 0.013	0.004LysXaa: 0.004 ± 0.001
Leu	7.016LeuAla: 7.016 ± 0.036	2.159LeuCys: 2.159 ± 0.017	4.732LeuAsp: 4.732 ± 0.019	7.243LeuGlu: 7.243 ± 0.035	3.413LeuPhe: 3.413 ± 0.023	6.109LeuGly: 6.109 ± 0.031	2.683LeuHis: 2.683 ± 0.017	3.779LeuIle: 3.779 ± 0.024	5.657LeuLys: 5.657 ± 0.027	10.855LeuLeu: 10.855 ± 0.059	1.996LeuMet: 1.996 ± 0.014	3.426LeuAsn: 3.426 ± 0.019	6.113LeuPro: 6.113 ± 0.031	5.749LeuGln: 5.749 ± 0.036	6.172LeuArg: 6.172 ± 0.031	7.916LeuSer: 7.916 ± 0.031	5.001LeuThr: 5.001 ± 0.021	5.537LeuVal: 5.537 ± 0.025	1.135LeuTrp: 1.135 ± 0.01	2.53LeuTyr: 2.53 ± 0.015	0.009LeuXaa: 0.009 ± 0.001
Met	1.95MetAla: 1.95 ± 0.013	0.387MetCys: 0.387 ± 0.006	1.264MetAsp: 1.264 ± 0.01	1.824MetGlu: 1.824 ± 0.013	0.722MetPhe: 0.722 ± 0.008	1.29MetGly: 1.29 ± 0.013	0.466MetHis: 0.466 ± 0.006	0.807MetIle: 0.807 ± 0.007	1.409MetLys: 1.409 ± 0.009	1.977MetLeu: 1.977 ± 0.013	0.577MetMet: 0.577 ± 0.007	0.881MetAsn: 0.881 ± 0.009	1.08MetPro: 1.08 ± 0.01	0.901MetGln: 0.901 ± 0.009	1.071MetArg: 1.071 ± 0.009	1.549MetSer: 1.549 ± 0.011	1.102MetThr: 1.102 ± 0.009	1.394MetVal: 1.394 ± 0.009	0.237MetTrp: 0.237 ± 0.004	0.586MetTyr: 0.586 ± 0.007	0.002MetXaa: 0.002 ± 0.0
Asn	1.999AsnAla: 1.999 ± 0.014	0.802AsnCys: 0.802 ± 0.008	1.473AsnAsp: 1.473 ± 0.012	2.142AsnGlu: 2.142 ± 0.015	1.439AsnPhe: 1.439 ± 0.011	2.416AsnGly: 2.416 ± 0.019	0.939AsnHis: 0.939 ± 0.009	2.043AsnIle: 2.043 ± 0.016	2.103AsnLys: 2.103 ± 0.015	3.617AsnLeu: 3.617 ± 0.021	0.896AsnMet: 0.896 ± 0.009	1.451AsnAsn: 1.451 ± 0.014	2.158AsnPro: 2.158 ± 0.014	1.631AsnGln: 1.631 ± 0.013	1.811AsnArg: 1.811 ± 0.012	2.996AsnSer: 2.996 ± 0.019	1.895AsnThr: 1.895 ± 0.014	2.127AsnVal: 2.127 ± 0.014	0.443AsnTrp: 0.443 ± 0.006	1.084AsnTyr: 1.084 ± 0.01	0.003AsnXaa: 0.003 ± 0.0
Pro	5.255ProAla: 5.255 ± 0.036	1.168ProCys: 1.168 ± 0.014	2.845ProAsp: 2.845 ± 0.016	4.604ProGlu: 4.604 ± 0.026	1.96ProPhe: 1.96 ± 0.014	5.694ProGly: 5.694 ± 0.073	1.489ProHis: 1.489 ± 0.013	1.815ProIle: 1.815 ± 0.013	2.763ProLys: 2.763 ± 0.018	5.377ProLeu: 5.377 ± 0.026	1.088ProMet: 1.088 ± 0.009	1.771ProAsn: 1.771 ± 0.013	6.656ProPro: 6.656 ± 0.065	2.93ProGln: 2.93 ± 0.02	3.63ProArg: 3.63 ± 0.021	5.814ProSer: 5.814 ± 0.031	3.107ProThr: 3.107 ± 0.023	3.834ProVal: 3.834 ± 0.022	0.71ProTrp: 0.71 ± 0.009	1.571ProTyr: 1.571 ± 0.017	0.009ProXaa: 0.009 ± 0.001
Gln	3.598GlnAla: 3.598 ± 0.023	0.912GlnCys: 0.912 ± 0.009	2.357GlnAsp: 2.357 ± 0.016	3.948GlnGlu: 3.948 ± 0.025	1.342GlnPhe: 1.342 ± 0.011	2.894GlnGly: 2.894 ± 0.019	1.306GlnHis: 1.306 ± 0.011	1.928GlnIle: 1.928 ± 0.014	2.911GlnLys: 2.911 ± 0.019	4.763GlnLeu: 4.763 ± 0.028	1.124GlnMet: 1.124 ± 0.009	1.791GlnAsn: 1.791 ± 0.014	2.88GlnPro: 2.88 ± 0.021	3.017GlnGln: 3.017 ± 0.03	3.095GlnArg: 3.095 ± 0.023	3.084GlnSer: 3.084 ± 0.018	2.239GlnThr: 2.239 ± 0.013	2.789GlnVal: 2.789 ± 0.016	0.535GlnTrp: 0.535 ± 0.006	1.117GlnTyr: 1.117 ± 0.009	0.005GlnXaa: 0.005 ± 0.001
Arg	4.161ArgAla: 4.161 ± 0.022	1.228ArgCys: 1.228 ± 0.013	2.837ArgAsp: 2.837 ± 0.017	4.18ArgGlu: 4.18 ± 0.028	1.879ArgPhe: 1.879 ± 0.012	3.847ArgGly: 3.847 ± 0.023	1.575ArgHis: 1.575 ± 0.012	2.439ArgIle: 2.439 ± 0.016	3.674ArgLys: 3.674 ± 0.021	5.582ArgLeu: 5.582 ± 0.03	1.193ArgMet: 1.193 ± 0.01	2.116ArgAsn: 2.116 ± 0.013	3.485ArgPro: 3.485 ± 0.02	2.712ArgGln: 2.712 ± 0.017	4.663ArgArg: 4.663 ± 0.03	4.421ArgSer: 4.421 ± 0.037	2.834ArgThr: 2.834 ± 0.017	3.197ArgVal: 3.197 ± 0.018	0.711ArgTrp: 0.711 ± 0.008	1.447ArgTyr: 1.447 ± 0.01	0.006ArgXaa: 0.006 ± 0.001
Ser	5.385SerAla: 5.385 ± 0.025	1.815SerCys: 1.815 ± 0.016	3.844SerAsp: 3.844 ± 0.02	5.153SerGlu: 5.153 ± 0.023	3.009SerPhe: 3.009 ± 0.016	5.721SerGly: 5.721 ± 0.031	2.06SerHis: 2.06 ± 0.013	3.089SerIle: 3.089 ± 0.016	3.992SerLys: 3.992 ± 0.023	8.144SerLeu: 8.144 ± 0.029	1.579SerMet: 1.579 ± 0.011	2.595SerAsn: 2.595 ± 0.017	6.172SerPro: 6.172 ± 0.038	3.799SerGln: 3.799 ± 0.022	4.659SerArg: 4.659 ± 0.033	9.171SerSer: 9.171 ± 0.055	4.338SerThr: 4.338 ± 0.023	4.829SerVal: 4.829 ± 0.024	1.076SerTrp: 1.076 ± 0.01	2.048SerTyr: 2.048 ± 0.015	0.008SerXaa: 0.008 ± 0.001
Thr	3.72ThrAla: 3.72 ± 0.019	1.267ThrCys: 1.267 ± 0.015	2.39ThrAsp: 2.39 ± 0.014	3.437ThrGlu: 3.437 ± 0.018	2.096ThrPhe: 2.096 ± 0.014	3.519ThrGly: 3.519 ± 0.022	1.281ThrHis: 1.281 ± 0.012	2.282ThrIle: 2.282 ± 0.015	2.543ThrLys: 2.543 ± 0.017	5.207ThrLeu: 5.207 ± 0.021	1.088ThrMet: 1.088 ± 0.009	1.671ThrAsn: 1.671 ± 0.014	3.56ThrPro: 3.56 ± 0.021	2.227ThrGln: 2.227 ± 0.014	2.485ThrArg: 2.485 ± 0.014	4.473ThrSer: 4.473 ± 0.026	2.831ThrThr: 2.831 ± 0.025	3.766ThrVal: 3.766 ± 0.021	0.67ThrTrp: 0.67 ± 0.008	1.389ThrTyr: 1.389 ± 0.011	0.005ThrXaa: 0.005 ± 0.001
Val	4.309ValAla: 4.309 ± 0.021	1.431ValCys: 1.431 ± 0.012	2.903ValAsp: 2.903 ± 0.013	3.793ValGlu: 3.793 ± 0.019	2.393ValPhe: 2.393 ± 0.017	3.464ValGly: 3.464 ± 0.018	1.578ValHis: 1.578 ± 0.015	2.853ValIle: 2.853 ± 0.019	3.295ValLys: 3.295 ± 0.023	6.265ValLeu: 6.265 ± 0.03	1.319ValMet: 1.319 ± 0.012	2.206ValAsn: 2.206 ± 0.014	3.704ValPro: 3.704 ± 0.02	2.7ValGln: 2.7 ± 0.017	3.089ValArg: 3.089 ± 0.015	4.789ValSer: 4.789 ± 0.021	3.609ValThr: 3.609 ± 0.026	3.962ValVal: 3.962 ± 0.021	0.71ValTrp: 0.71 ± 0.008	1.575ValTyr: 1.575 ± 0.01	0.005ValXaa: 0.005 ± 0.001
Trp	0.828TrpAla: 0.828 ± 0.008	0.252TrpCys: 0.252 ± 0.005	0.65TrpAsp: 0.65 ± 0.008	0.797TrpGlu: 0.797 ± 0.008	0.45TrpPhe: 0.45 ± 0.006	0.748TrpGly: 0.748 ± 0.008	0.3TrpHis: 0.3 ± 0.005	0.528TrpIle: 0.528 ± 0.007	0.781TrpLys: 0.781 ± 0.007	1.203TrpLeu: 1.203 ± 0.011	0.319TrpMet: 0.319 ± 0.005	0.545TrpAsn: 0.545 ± 0.006	0.535TrpPro: 0.535 ± 0.006	0.526TrpGln: 0.526 ± 0.006	0.742TrpArg: 0.742 ± 0.008	0.853TrpSer: 0.853 ± 0.008	0.652TrpThr: 0.652 ± 0.007	0.685TrpVal: 0.685 ± 0.007	0.195TrpTrp: 0.195 ± 0.004	0.327TrpTyr: 0.327 ± 0.005	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.407TyrAla: 1.407 ± 0.01	0.659TyrCys: 0.659 ± 0.006	1.266TyrAsp: 1.266 ± 0.012	1.709TyrGlu: 1.709 ± 0.014	1.228TyrPhe: 1.228 ± 0.011	1.69TyrGly: 1.69 ± 0.015	0.759TyrHis: 0.759 ± 0.008	1.334TyrIle: 1.334 ± 0.011	1.431TyrLys: 1.431 ± 0.015	2.637TyrLeu: 2.637 ± 0.017	0.592TyrMet: 0.592 ± 0.007	1.069TyrAsn: 1.069 ± 0.008	1.305TyrPro: 1.305 ± 0.011	1.228TyrGln: 1.228 ± 0.009	1.594TyrArg: 1.594 ± 0.013	2.16TyrSer: 2.16 ± 0.013	1.443TyrThr: 1.443 ± 0.011	1.585TyrVal: 1.585 ± 0.012	0.351TyrTrp: 0.351 ± 0.006	0.916TyrTyr: 0.916 ± 0.01	0.002TyrXaa: 0.002 ± 0.0
Xaa	0.008XaaAla: 0.008 ± 0.001	0.003XaaCys: 0.003 ± 0.0	0.004XaaAsp: 0.004 ± 0.001	0.006XaaGlu: 0.006 ± 0.001	0.004XaaPhe: 0.004 ± 0.001	0.008XaaGly: 0.008 ± 0.001	0.003XaaHis: 0.003 ± 0.0	0.003XaaIle: 0.003 ± 0.0	0.005XaaLys: 0.005 ± 0.001	0.009XaaLeu: 0.009 ± 0.001	0.002XaaMet: 0.002 ± 0.0	0.004XaaAsn: 0.004 ± 0.001	0.009XaaPro: 0.009 ± 0.001	0.004XaaGln: 0.004 ± 0.001	0.004XaaArg: 0.004 ± 0.0	0.007XaaSer: 0.007 ± 0.001	0.004XaaThr: 0.004 ± 0.001	0.006XaaVal: 0.006 ± 0.001	0.001XaaTrp: 0.001 ± 0.0	0.002XaaTyr: 0.002 ± 0.0	0.055XaaXaa: 0.055 ± 0.008

Statistics based on 26219 proteins (15552255 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---