Amino acid dipepetide frequency for Alicyclobacillus ferrooxydans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.024AlaAla: 9.024 ± 0.1	0.785AlaCys: 0.785 ± 0.027	4.399AlaAsp: 4.399 ± 0.07	5.378AlaGlu: 5.378 ± 0.076	3.527AlaPhe: 3.527 ± 0.06	7.189AlaGly: 7.189 ± 0.092	1.864AlaHis: 1.864 ± 0.039	5.536AlaIle: 5.536 ± 0.069	4.099AlaLys: 4.099 ± 0.068	9.255AlaLeu: 9.255 ± 0.085	2.672AlaMet: 2.672 ± 0.044	2.928AlaAsn: 2.928 ± 0.06	3.032AlaPro: 3.032 ± 0.056	3.268AlaGln: 3.268 ± 0.076	4.532AlaArg: 4.532 ± 0.07	5.514AlaSer: 5.514 ± 0.082	4.687AlaThr: 4.687 ± 0.071	7.781AlaVal: 7.781 ± 0.088	1.218AlaTrp: 1.218 ± 0.035	2.596AlaTyr: 2.596 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.616CysAla: 0.616 ± 0.023	0.105CysCys: 0.105 ± 0.009	0.498CysAsp: 0.498 ± 0.023	0.463CysGlu: 0.463 ± 0.021	0.321CysPhe: 0.321 ± 0.016	0.871CysGly: 0.871 ± 0.031	0.224CysHis: 0.224 ± 0.016	0.515CysIle: 0.515 ± 0.021	0.283CysLys: 0.283 ± 0.014	0.74CysLeu: 0.74 ± 0.023	0.187CysMet: 0.187 ± 0.011	0.251CysAsn: 0.251 ± 0.014	0.418CysPro: 0.418 ± 0.019	0.286CysGln: 0.286 ± 0.013	0.481CysArg: 0.481 ± 0.019	0.512CysSer: 0.512 ± 0.021	0.498CysThr: 0.498 ± 0.021	0.64CysVal: 0.64 ± 0.025	0.098CysTrp: 0.098 ± 0.009	0.236CysTyr: 0.236 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.534AspAla: 4.534 ± 0.073	0.398AspCys: 0.398 ± 0.02	2.58AspAsp: 2.58 ± 0.059	3.853AspGlu: 3.853 ± 0.067	2.025AspPhe: 2.025 ± 0.041	4.008AspGly: 4.008 ± 0.065	1.095AspHis: 1.095 ± 0.031	3.076AspIle: 3.076 ± 0.053	2.169AspLys: 2.169 ± 0.042	4.887AspLeu: 4.887 ± 0.072	1.232AspMet: 1.232 ± 0.03	1.468AspAsn: 1.468 ± 0.036	2.375AspPro: 2.375 ± 0.043	1.318AspGln: 1.318 ± 0.039	2.755AspArg: 2.755 ± 0.049	2.627AspSer: 2.627 ± 0.047	2.686AspThr: 2.686 ± 0.047	4.738AspVal: 4.738 ± 0.069	0.83AspTrp: 0.83 ± 0.027	1.571AspTyr: 1.571 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	5.487GluAla: 5.487 ± 0.08	0.413GluCys: 0.413 ± 0.016	2.976GluAsp: 2.976 ± 0.057	3.953GluGlu: 3.953 ± 0.072	2.198GluPhe: 2.198 ± 0.048	3.701GluGly: 3.701 ± 0.065	1.521GluHis: 1.521 ± 0.038	3.447GluIle: 3.447 ± 0.054	2.503GluLys: 2.503 ± 0.054	6.085GluLeu: 6.085 ± 0.102	1.735GluMet: 1.735 ± 0.041	1.968GluAsn: 1.968 ± 0.042	2.041GluPro: 2.041 ± 0.047	2.933GluGln: 2.933 ± 0.057	4.274GluArg: 4.274 ± 0.077	3.412GluSer: 3.412 ± 0.06	3.276GluThr: 3.276 ± 0.056	4.652GluVal: 4.652 ± 0.063	0.904GluTrp: 0.904 ± 0.025	1.679GluTyr: 1.679 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.742PheAla: 3.742 ± 0.058	0.38PheCys: 0.38 ± 0.015	2.206PheAsp: 2.206 ± 0.047	2.252PheGlu: 2.252 ± 0.049	1.618PhePhe: 1.618 ± 0.043	3.598PheGly: 3.598 ± 0.054	1.09PheHis: 1.09 ± 0.03	2.306PheIle: 2.306 ± 0.05	1.1PheLys: 1.1 ± 0.03	3.947PheLeu: 3.947 ± 0.072	0.968PheMet: 0.968 ± 0.027	1.233PheAsn: 1.233 ± 0.033	1.694PhePro: 1.694 ± 0.036	1.433PheGln: 1.433 ± 0.035	2.148PheArg: 2.148 ± 0.045	2.622PheSer: 2.622 ± 0.055	2.351PheThr: 2.351 ± 0.049	3.612PheVal: 3.612 ± 0.062	0.612PheTrp: 0.612 ± 0.024	1.241PheTyr: 1.241 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	6.683GlyAla: 6.683 ± 0.104	0.766GlyCys: 0.766 ± 0.025	3.477GlyAsp: 3.477 ± 0.061	3.849GlyGlu: 3.849 ± 0.065	3.522GlyPhe: 3.522 ± 0.058	5.958GlyGly: 5.958 ± 0.089	1.918GlyHis: 1.918 ± 0.044	5.348GlyIle: 5.348 ± 0.076	3.451GlyLys: 3.451 ± 0.057	7.941GlyLeu: 7.941 ± 0.091	2.364GlyMet: 2.364 ± 0.05	2.553GlyAsn: 2.553 ± 0.049	2.616GlyPro: 2.616 ± 0.054	3.191GlyGln: 3.191 ± 0.059	4.162GlyArg: 4.162 ± 0.072	4.691GlySer: 4.691 ± 0.078	5.026GlyThr: 5.026 ± 0.088	6.719GlyVal: 6.719 ± 0.083	1.236GlyTrp: 1.236 ± 0.035	2.758GlyTyr: 2.758 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.986HisAla: 1.986 ± 0.04	0.214HisCys: 0.214 ± 0.015	1.201HisAsp: 1.201 ± 0.036	1.381HisGlu: 1.381 ± 0.036	1.01HisPhe: 1.01 ± 0.03	1.991HisGly: 1.991 ± 0.041	0.785HisHis: 0.785 ± 0.03	1.326HisIle: 1.326 ± 0.031	0.801HisLys: 0.801 ± 0.03	2.421HisLeu: 2.421 ± 0.05	0.637HisMet: 0.637 ± 0.022	0.69HisAsn: 0.69 ± 0.025	1.552HisPro: 1.552 ± 0.034	0.992HisGln: 0.992 ± 0.026	1.53HisArg: 1.53 ± 0.039	1.318HisSer: 1.318 ± 0.036	1.294HisThr: 1.294 ± 0.032	2.062HisVal: 2.062 ± 0.043	0.337HisTrp: 0.337 ± 0.017	0.764HisTyr: 0.764 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.915IleAla: 5.915 ± 0.07	0.552IleCys: 0.552 ± 0.021	3.139IleAsp: 3.139 ± 0.056	3.622IleGlu: 3.622 ± 0.059	1.894IlePhe: 1.894 ± 0.05	5.441IleGly: 5.441 ± 0.075	1.566IleHis: 1.566 ± 0.037	2.975IleIle: 2.975 ± 0.061	1.645IleLys: 1.645 ± 0.041	5.572IleLeu: 5.572 ± 0.082	1.202IleMet: 1.202 ± 0.032	1.652IleAsn: 1.652 ± 0.037	3.092IlePro: 3.092 ± 0.054	2.414IleGln: 2.414 ± 0.047	3.616IleArg: 3.616 ± 0.059	3.507IleSer: 3.507 ± 0.056	3.277IleThr: 3.277 ± 0.058	5.234IleVal: 5.234 ± 0.071	0.692IleTrp: 0.692 ± 0.024	1.594IleTyr: 1.594 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	3.482LysAla: 3.482 ± 0.056	0.252LysCys: 0.252 ± 0.015	2.065LysAsp: 2.065 ± 0.051	2.522LysGlu: 2.522 ± 0.048	1.223LysPhe: 1.223 ± 0.035	2.659LysGly: 2.659 ± 0.042	0.959LysHis: 0.959 ± 0.029	1.971LysIle: 1.971 ± 0.04	1.759LysLys: 1.759 ± 0.045	3.635LysLeu: 3.635 ± 0.054	1.155LysMet: 1.155 ± 0.033	1.408LysAsn: 1.408 ± 0.039	1.8LysPro: 1.8 ± 0.036	1.947LysGln: 1.947 ± 0.041	2.759LysArg: 2.759 ± 0.054	2.557LysSer: 2.557 ± 0.05	2.519LysThr: 2.519 ± 0.045	3.151LysVal: 3.151 ± 0.05	0.586LysTrp: 0.586 ± 0.027	1.205LysTyr: 1.205 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	9.174LeuAla: 9.174 ± 0.093	0.934LeuCys: 0.934 ± 0.031	4.812LeuAsp: 4.812 ± 0.072	5.591LeuGlu: 5.591 ± 0.096	4.206LeuPhe: 4.206 ± 0.071	7.555LeuGly: 7.555 ± 0.085	2.466LeuHis: 2.466 ± 0.046	5.433LeuIle: 5.433 ± 0.082	3.778LeuLys: 3.778 ± 0.064	9.829LeuLeu: 9.829 ± 0.134	2.563LeuMet: 2.563 ± 0.054	3.408LeuAsn: 3.408 ± 0.054	4.604LeuPro: 4.604 ± 0.066	4.125LeuGln: 4.125 ± 0.064	5.792LeuArg: 5.792 ± 0.089	7.15LeuSer: 7.15 ± 0.084	5.957LeuThr: 5.957 ± 0.079	7.738LeuVal: 7.738 ± 0.096	1.307LeuTrp: 1.307 ± 0.037	2.958LeuTyr: 2.958 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.573MetAla: 2.573 ± 0.049	0.192MetCys: 0.192 ± 0.012	1.358MetAsp: 1.358 ± 0.032	1.56MetGlu: 1.56 ± 0.034	1.045MetPhe: 1.045 ± 0.028	1.998MetGly: 1.998 ± 0.043	0.591MetHis: 0.591 ± 0.02	1.406MetIle: 1.406 ± 0.035	1.386MetLys: 1.386 ± 0.034	2.476MetLeu: 2.476 ± 0.049	0.819MetMet: 0.819 ± 0.026	1.182MetAsn: 1.182 ± 0.033	1.201MetPro: 1.201 ± 0.034	1.12MetGln: 1.12 ± 0.032	1.501MetArg: 1.501 ± 0.035	1.851MetSer: 1.851 ± 0.041	1.769MetThr: 1.769 ± 0.041	2.003MetVal: 2.003 ± 0.039	0.35MetTrp: 0.35 ± 0.019	0.746MetTyr: 0.746 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	2.96AsnAla: 2.96 ± 0.056	0.27AsnCys: 0.27 ± 0.017	1.498AsnAsp: 1.498 ± 0.037	1.835AsnGlu: 1.835 ± 0.036	1.196AsnPhe: 1.196 ± 0.035	2.895AsnGly: 2.895 ± 0.06	0.927AsnHis: 0.927 ± 0.029	1.837AsnIle: 1.837 ± 0.038	1.129AsnLys: 1.129 ± 0.032	3.299AsnLeu: 3.299 ± 0.052	0.819AsnMet: 0.819 ± 0.031	1.137AsnAsn: 1.137 ± 0.04	2.187AsnPro: 2.187 ± 0.043	1.644AsnGln: 1.644 ± 0.044	2.082AsnArg: 2.082 ± 0.045	1.929AsnSer: 1.929 ± 0.05	2.013AsnThr: 2.013 ± 0.052	2.655AsnVal: 2.655 ± 0.043	0.55AsnTrp: 0.55 ± 0.021	0.997AsnTyr: 0.997 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	3.389ProAla: 3.389 ± 0.066	0.268ProCys: 0.268 ± 0.016	2.567ProAsp: 2.567 ± 0.047	2.975ProGlu: 2.975 ± 0.048	1.914ProPhe: 1.914 ± 0.038	3.425ProGly: 3.425 ± 0.059	1.009ProHis: 1.009 ± 0.028	2.612ProIle: 2.612 ± 0.046	1.862ProLys: 1.862 ± 0.042	4.06ProLeu: 4.06 ± 0.062	1.142ProMet: 1.142 ± 0.032	1.733ProAsn: 1.733 ± 0.035	1.489ProPro: 1.489 ± 0.04	1.56ProGln: 1.56 ± 0.037	1.89ProArg: 1.89 ± 0.046	3.092ProSer: 3.092 ± 0.062	2.565ProThr: 2.565 ± 0.047	3.859ProVal: 3.859 ± 0.058	0.659ProTrp: 0.659 ± 0.026	1.496ProTyr: 1.496 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	3.813GlnAla: 3.813 ± 0.065	0.251GlnCys: 0.251 ± 0.015	1.768GlnAsp: 1.768 ± 0.036	2.128GlnGlu: 2.128 ± 0.04	1.575GlnPhe: 1.575 ± 0.033	2.866GlnGly: 2.866 ± 0.082	0.928GlnHis: 0.928 ± 0.029	2.408GlnIle: 2.408 ± 0.04	1.688GlnLys: 1.688 ± 0.039	4.053GlnLeu: 4.053 ± 0.06	1.223GlnMet: 1.223 ± 0.031	1.493GlnAsn: 1.493 ± 0.035	1.696GlnPro: 1.696 ± 0.037	2.0GlnGln: 2.0 ± 0.051	2.362GlnArg: 2.362 ± 0.051	2.79GlnSer: 2.79 ± 0.058	2.479GlnThr: 2.479 ± 0.049	3.272GlnVal: 3.272 ± 0.051	0.582GlnTrp: 0.582 ± 0.022	1.156GlnTyr: 1.156 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	4.368ArgAla: 4.368 ± 0.066	0.444ArgCys: 0.444 ± 0.022	3.033ArgAsp: 3.033 ± 0.06	3.773ArgGlu: 3.773 ± 0.064	2.48ArgPhe: 2.48 ± 0.049	3.745ArgGly: 3.745 ± 0.059	1.427ArgHis: 1.427 ± 0.037	3.659ArgIle: 3.659 ± 0.058	2.673ArgLys: 2.673 ± 0.058	5.835ArgLeu: 5.835 ± 0.082	1.801ArgMet: 1.801 ± 0.034	1.986ArgAsn: 1.986 ± 0.045	2.329ArgPro: 2.329 ± 0.042	2.553ArgGln: 2.553 ± 0.049	3.928ArgArg: 3.928 ± 0.069	3.185ArgSer: 3.185 ± 0.054	3.11ArgThr: 3.11 ± 0.048	4.384ArgVal: 4.384 ± 0.062	0.877ArgTrp: 0.877 ± 0.024	1.919ArgTyr: 1.919 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	5.497SerAla: 5.497 ± 0.083	0.453SerCys: 0.453 ± 0.02	3.192SerAsp: 3.192 ± 0.048	3.602SerGlu: 3.602 ± 0.059	2.645SerPhe: 2.645 ± 0.049	5.514SerGly: 5.514 ± 0.093	1.396SerHis: 1.396 ± 0.035	3.712SerIle: 3.712 ± 0.061	2.386SerLys: 2.386 ± 0.038	6.239SerLeu: 6.239 ± 0.07	1.804SerMet: 1.804 ± 0.042	2.169SerAsn: 2.169 ± 0.058	2.745SerPro: 2.745 ± 0.054	2.505SerGln: 2.505 ± 0.048	3.402SerArg: 3.402 ± 0.061	4.45SerSer: 4.45 ± 0.095	3.681SerThr: 3.681 ± 0.072	5.201SerVal: 5.201 ± 0.077	0.848SerTrp: 0.848 ± 0.03	1.843SerTyr: 1.843 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	5.447ThrAla: 5.447 ± 0.071	0.411ThrCys: 0.411 ± 0.018	2.92ThrAsp: 2.92 ± 0.046	3.236ThrGlu: 3.236 ± 0.055	2.318ThrPhe: 2.318 ± 0.052	5.206ThrGly: 5.206 ± 0.076	1.371ThrHis: 1.371 ± 0.032	3.311ThrIle: 3.311 ± 0.067	2.261ThrLys: 2.261 ± 0.044	5.692ThrLeu: 5.692 ± 0.071	1.44ThrMet: 1.44 ± 0.034	2.048ThrAsn: 2.048 ± 0.05	2.91ThrPro: 2.91 ± 0.052	1.943ThrGln: 1.943 ± 0.047	2.898ThrArg: 2.898 ± 0.057	3.792ThrSer: 3.792 ± 0.074	3.461ThrThr: 3.461 ± 0.074	5.097ThrVal: 5.097 ± 0.077	0.849ThrTrp: 0.849 ± 0.031	1.796ThrTyr: 1.796 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	7.044ValAla: 7.044 ± 0.079	0.749ValCys: 0.749 ± 0.025	4.254ValAsp: 4.254 ± 0.061	4.802ValGlu: 4.802 ± 0.082	3.473ValPhe: 3.473 ± 0.053	6.02ValGly: 6.02 ± 0.077	2.026ValHis: 2.026 ± 0.045	5.139ValIle: 5.139 ± 0.068	3.09ValLys: 3.09 ± 0.055	8.651ValLeu: 8.651 ± 0.097	2.235ValMet: 2.235 ± 0.041	2.888ValAsn: 2.888 ± 0.048	3.854ValPro: 3.854 ± 0.054	3.198ValGln: 3.198 ± 0.051	4.548ValArg: 4.548 ± 0.072	5.687ValSer: 5.687 ± 0.078	5.14ValThr: 5.14 ± 0.074	7.3ValVal: 7.3 ± 0.089	1.167ValTrp: 1.167 ± 0.031	2.446ValTyr: 2.446 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	1.028TrpAla: 1.028 ± 0.03	0.129TrpCys: 0.129 ± 0.009	0.657TrpAsp: 0.657 ± 0.023	0.628TrpGlu: 0.628 ± 0.023	0.701TrpPhe: 0.701 ± 0.028	0.96TrpGly: 0.96 ± 0.029	0.336TrpHis: 0.336 ± 0.019	0.947TrpIle: 0.947 ± 0.03	0.596TrpLys: 0.596 ± 0.022	1.711TrpLeu: 1.711 ± 0.044	0.495TrpMet: 0.495 ± 0.021	0.615TrpAsn: 0.615 ± 0.024	0.498TrpPro: 0.498 ± 0.021	0.605TrpGln: 0.605 ± 0.022	0.842TrpArg: 0.842 ± 0.027	0.958TrpSer: 0.958 ± 0.028	0.898TrpThr: 0.898 ± 0.028	1.1TrpVal: 1.1 ± 0.028	0.313TrpTrp: 0.313 ± 0.019	0.42TrpTyr: 0.42 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.522TyrAla: 2.522 ± 0.047	0.275TyrCys: 0.275 ± 0.015	1.622TyrAsp: 1.622 ± 0.042	1.759TyrGlu: 1.759 ± 0.043	1.265TyrPhe: 1.265 ± 0.034	2.63TyrGly: 2.63 ± 0.049	0.792TyrHis: 0.792 ± 0.028	1.637TyrIle: 1.637 ± 0.037	0.956TyrLys: 0.956 ± 0.027	3.055TyrLeu: 3.055 ± 0.053	0.631TyrMet: 0.631 ± 0.019	1.048TyrAsn: 1.048 ± 0.033	1.43TyrPro: 1.43 ± 0.038	1.496TyrGln: 1.496 ± 0.034	2.006TyrArg: 2.006 ± 0.039	1.641TyrSer: 1.641 ± 0.04	1.721TyrThr: 1.721 ± 0.043	2.514TyrVal: 2.514 ± 0.042	0.423TyrTrp: 0.423 ± 0.021	0.957TyrTyr: 0.957 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4142 proteins (1212945 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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