Amino acid dipepetide frequency for Serinicoccus hydrothermalis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.524AlaAla: 18.524 ± 0.192
0.871AlaCys: 0.871 ± 0.03
8.434AlaAsp: 8.434 ± 0.11
8.033AlaGlu: 8.033 ± 0.11
3.069AlaPhe: 3.069 ± 0.054
12.622AlaGly: 12.622 ± 0.117
2.485AlaHis: 2.485 ± 0.054
3.6AlaIle: 3.6 ± 0.068
1.812AlaLys: 1.812 ± 0.053
14.369AlaLeu: 14.369 ± 0.154
2.651AlaMet: 2.651 ± 0.049
1.567AlaAsn: 1.567 ± 0.04
6.243AlaPro: 6.243 ± 0.089
4.474AlaGln: 4.474 ± 0.066
10.025AlaArg: 10.025 ± 0.13
6.006AlaSer: 6.006 ± 0.073
7.28AlaThr: 7.28 ± 0.08
11.631AlaVal: 11.631 ± 0.144
2.09AlaTrp: 2.09 ± 0.048
2.589AlaTyr: 2.589 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
0.807CysAla: 0.807 ± 0.028
0.089CysCys: 0.089 ± 0.01
0.424CysAsp: 0.424 ± 0.021
0.348CysGlu: 0.348 ± 0.019
0.184CysPhe: 0.184 ± 0.015
0.791CysGly: 0.791 ± 0.03
0.17CysHis: 0.17 ± 0.013
0.161CysIle: 0.161 ± 0.013
0.07CysLys: 0.07 ± 0.008
0.576CysLeu: 0.576 ± 0.024
0.105CysMet: 0.105 ± 0.011
0.097CysAsn: 0.097 ± 0.009
0.435CysPro: 0.435 ± 0.021
0.141CysGln: 0.141 ± 0.013
0.497CysArg: 0.497 ± 0.021
0.391CysSer: 0.391 ± 0.023
0.424CysThr: 0.424 ± 0.018
0.516CysVal: 0.516 ± 0.022
0.104CysTrp: 0.104 ± 0.009
0.117CysTyr: 0.117 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
7.994AspAla: 7.994 ± 0.091
0.318AspCys: 0.318 ± 0.019
4.378AspAsp: 4.378 ± 0.094
4.756AspGlu: 4.756 ± 0.08
1.584AspPhe: 1.584 ± 0.04
6.624AspGly: 6.624 ± 0.096
1.506AspHis: 1.506 ± 0.042
1.774AspIle: 1.774 ± 0.045
0.886AspLys: 0.886 ± 0.038
7.71AspLeu: 7.71 ± 0.1
0.858AspMet: 0.858 ± 0.032
0.856AspAsn: 0.856 ± 0.031
4.917AspPro: 4.917 ± 0.076
1.957AspGln: 1.957 ± 0.037
5.032AspArg: 5.032 ± 0.067
2.327AspSer: 2.327 ± 0.05
3.089AspThr: 3.089 ± 0.057
5.864AspVal: 5.864 ± 0.085
1.003AspTrp: 1.003 ± 0.036
1.339AspTyr: 1.339 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
7.982GluAla: 7.982 ± 0.109
0.285GluCys: 0.285 ± 0.017
4.201GluAsp: 4.201 ± 0.074
4.589GluGlu: 4.589 ± 0.074
1.309GluPhe: 1.309 ± 0.035
5.608GluGly: 5.608 ± 0.085
1.958GluHis: 1.958 ± 0.049
2.172GluIle: 2.172 ± 0.051
0.954GluLys: 0.954 ± 0.037
6.87GluLeu: 6.87 ± 0.082
1.003GluMet: 1.003 ± 0.035
0.735GluAsn: 0.735 ± 0.026
3.64GluPro: 3.64 ± 0.075
3.307GluGln: 3.307 ± 0.056
5.72GluArg: 5.72 ± 0.084
2.633GluSer: 2.633 ± 0.052
2.85GluThr: 2.85 ± 0.065
6.157GluVal: 6.157 ± 0.087
0.766GluTrp: 0.766 ± 0.026
0.77GluTyr: 0.77 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
3.201PheAla: 3.201 ± 0.055
0.216PheCys: 0.216 ± 0.013
1.85PheAsp: 1.85 ± 0.045
1.412PheGlu: 1.412 ± 0.04
0.865PhePhe: 0.865 ± 0.032
2.815PheGly: 2.815 ± 0.055
0.515PheHis: 0.515 ± 0.022
0.721PheIle: 0.721 ± 0.03
0.334PheLys: 0.334 ± 0.02
2.51PheLeu: 2.51 ± 0.061
0.394PheMet: 0.394 ± 0.021
0.474PheAsn: 0.474 ± 0.024
1.248PhePro: 1.248 ± 0.042
0.553PheGln: 0.553 ± 0.023
1.439PheArg: 1.439 ± 0.04
1.35PheSer: 1.35 ± 0.034
1.802PheThr: 1.802 ± 0.042
2.532PheVal: 2.532 ± 0.055
0.439PheTrp: 0.439 ± 0.021
0.599PheTyr: 0.599 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
11.168GlyAla: 11.168 ± 0.122
0.697GlyCys: 0.697 ± 0.027
5.539GlyAsp: 5.539 ± 0.077
6.406GlyGlu: 6.406 ± 0.089
2.664GlyPhe: 2.664 ± 0.057
9.086GlyGly: 9.086 ± 0.127
2.216GlyHis: 2.216 ± 0.05
3.578GlyIle: 3.578 ± 0.068
1.648GlyLys: 1.648 ± 0.047
9.894GlyLeu: 9.894 ± 0.11
2.523GlyMet: 2.523 ± 0.045
1.438GlyAsn: 1.438 ± 0.044
4.733GlyPro: 4.733 ± 0.068
3.104GlyGln: 3.104 ± 0.052
7.658GlyArg: 7.658 ± 0.11
5.728GlySer: 5.728 ± 0.079
6.078GlyThr: 6.078 ± 0.069
8.359GlyVal: 8.359 ± 0.091
1.932GlyTrp: 1.932 ± 0.048
2.258GlyTyr: 2.258 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
2.532HisAla: 2.532 ± 0.054
0.149HisCys: 0.149 ± 0.011
1.557HisAsp: 1.557 ± 0.04
1.441HisGlu: 1.441 ± 0.042
0.487HisPhe: 0.487 ± 0.025
2.272HisGly: 2.272 ± 0.046
0.688HisHis: 0.688 ± 0.026
0.461HisIle: 0.461 ± 0.025
0.253HisLys: 0.253 ± 0.016
2.564HisLeu: 2.564 ± 0.055
0.255HisMet: 0.255 ± 0.015
0.311HisAsn: 0.311 ± 0.016
1.697HisPro: 1.697 ± 0.041
0.714HisGln: 0.714 ± 0.028
1.991HisArg: 1.991 ± 0.047
0.837HisSer: 0.837 ± 0.026
1.309HisThr: 1.309 ± 0.038
2.071HisVal: 2.071 ± 0.048
0.334HisTrp: 0.334 ± 0.019
0.44HisTyr: 0.44 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
4.175IleAla: 4.175 ± 0.074
0.26IleCys: 0.26 ± 0.017
2.175IleAsp: 2.175 ± 0.058
2.082IleGlu: 2.082 ± 0.05
0.819IlePhe: 0.819 ± 0.03
3.295IleGly: 3.295 ± 0.061
0.545IleHis: 0.545 ± 0.024
1.036IleIle: 1.036 ± 0.036
0.527IleLys: 0.527 ± 0.025
2.619IleLeu: 2.619 ± 0.057
0.498IleMet: 0.498 ± 0.024
0.635IleAsn: 0.635 ± 0.028
1.843IlePro: 1.843 ± 0.041
0.673IleGln: 0.673 ± 0.023
1.894IleArg: 1.894 ± 0.051
1.709IleSer: 1.709 ± 0.046
2.204IleThr: 2.204 ± 0.048
2.746IleVal: 2.746 ± 0.059
0.363IleTrp: 0.363 ± 0.019
0.58IleTyr: 0.58 ± 0.024
0.0IleXaa: 0.0 ± 0.0
Lys
1.754LysAla: 1.754 ± 0.048
0.061LysCys: 0.061 ± 0.007
0.971LysAsp: 0.971 ± 0.033
0.863LysGlu: 0.863 ± 0.037
0.324LysPhe: 0.324 ± 0.02
1.281LysGly: 1.281 ± 0.043
0.324LysHis: 0.324 ± 0.019
0.617LysIle: 0.617 ± 0.025
0.525LysLys: 0.525 ± 0.032
1.196LysLeu: 1.196 ± 0.035
0.298LysMet: 0.298 ± 0.018
0.328LysAsn: 0.328 ± 0.021
0.748LysPro: 0.748 ± 0.029
0.463LysGln: 0.463 ± 0.022
0.972LysArg: 0.972 ± 0.034
0.747LysSer: 0.747 ± 0.028
0.846LysThr: 0.846 ± 0.034
1.442LysVal: 1.442 ± 0.043
0.141LysTrp: 0.141 ± 0.01
0.292LysTyr: 0.292 ± 0.016
0.0LysXaa: 0.0 ± 0.0
Leu
15.378LeuAla: 15.378 ± 0.152
0.583LeuCys: 0.583 ± 0.023
7.17LeuAsp: 7.17 ± 0.085
5.855LeuGlu: 5.855 ± 0.093
2.317LeuPhe: 2.317 ± 0.054
10.535LeuGly: 10.535 ± 0.115
2.149LeuHis: 2.149 ± 0.048
2.702LeuIle: 2.702 ± 0.06
1.23LeuLys: 1.23 ± 0.042
11.679LeuLeu: 11.679 ± 0.142
1.691LeuMet: 1.691 ± 0.043
1.339LeuAsn: 1.339 ± 0.034
6.085LeuPro: 6.085 ± 0.087
2.56LeuGln: 2.56 ± 0.046
8.57LeuArg: 8.57 ± 0.114
5.236LeuSer: 5.236 ± 0.072
6.79LeuThr: 6.79 ± 0.093
11.174LeuVal: 11.174 ± 0.131
1.381LeuTrp: 1.381 ± 0.04
1.403LeuTyr: 1.403 ± 0.036
0.0LeuXaa: 0.0 ± 0.0
Met
2.311MetAla: 2.311 ± 0.053
0.109MetCys: 0.109 ± 0.011
1.003MetAsp: 1.003 ± 0.026
0.897MetGlu: 0.897 ± 0.036
0.506MetPhe: 0.506 ± 0.024
1.503MetGly: 1.503 ± 0.038
0.369MetHis: 0.369 ± 0.018
0.711MetIle: 0.711 ± 0.026
0.332MetLys: 0.332 ± 0.019
1.948MetLeu: 1.948 ± 0.053
0.374MetMet: 0.374 ± 0.019
0.369MetAsn: 0.369 ± 0.018
1.227MetPro: 1.227 ± 0.032
0.557MetGln: 0.557 ± 0.024
1.455MetArg: 1.455 ± 0.032
1.597MetSer: 1.597 ± 0.04
1.66MetThr: 1.66 ± 0.036
1.668MetVal: 1.668 ± 0.045
0.216MetTrp: 0.216 ± 0.015
0.262MetTyr: 0.262 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
1.705AsnAla: 1.705 ± 0.043
0.106AsnCys: 0.106 ± 0.01
0.834AsnAsp: 0.834 ± 0.027
0.707AsnGlu: 0.707 ± 0.028
0.446AsnPhe: 0.446 ± 0.02
1.252AsnGly: 1.252 ± 0.041
0.332AsnHis: 0.332 ± 0.018
0.551AsnIle: 0.551 ± 0.023
0.25AsnLys: 0.25 ± 0.015
1.511AsnLeu: 1.511 ± 0.044
0.242AsnMet: 0.242 ± 0.018
0.354AsnAsn: 0.354 ± 0.021
1.25AsnPro: 1.25 ± 0.038
0.453AsnGln: 0.453 ± 0.023
0.96AsnArg: 0.96 ± 0.032
0.667AsnSer: 0.667 ± 0.026
0.831AsnThr: 0.831 ± 0.028
1.24AsnVal: 1.24 ± 0.034
0.221AsnTrp: 0.221 ± 0.016
0.353AsnTyr: 0.353 ± 0.015
0.0AsnXaa: 0.0 ± 0.0
Pro
7.144ProAla: 7.144 ± 0.082
0.262ProCys: 0.262 ± 0.016
4.59ProAsp: 4.59 ± 0.067
4.722ProGlu: 4.722 ± 0.078
1.398ProPhe: 1.398 ± 0.034
6.378ProGly: 6.378 ± 0.083
1.276ProHis: 1.276 ± 0.033
1.332ProIle: 1.332 ± 0.039
0.669ProLys: 0.669 ± 0.026
4.832ProLeu: 4.832 ± 0.072
1.127ProMet: 1.127 ± 0.027
0.655ProAsn: 0.655 ± 0.025
2.97ProPro: 2.97 ± 0.064
1.859ProGln: 1.859 ± 0.046
3.882ProArg: 3.882 ± 0.063
2.961ProSer: 2.961 ± 0.056
3.527ProThr: 3.527 ± 0.063
5.623ProVal: 5.623 ± 0.073
1.082ProTrp: 1.082 ± 0.032
0.988ProTyr: 0.988 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
4.084GlnAla: 4.084 ± 0.063
0.154GlnCys: 0.154 ± 0.014
1.963GlnAsp: 1.963 ± 0.044
2.02GlnGlu: 2.02 ± 0.04
0.663GlnPhe: 0.663 ± 0.024
2.729GlnGly: 2.729 ± 0.056
0.723GlnHis: 0.723 ± 0.025
1.229GlnIle: 1.229 ± 0.036
0.354GlnLys: 0.354 ± 0.02
3.205GlnLeu: 3.205 ± 0.062
0.576GlnMet: 0.576 ± 0.024
0.372GlnAsn: 0.372 ± 0.021
1.701GlnPro: 1.701 ± 0.038
1.356GlnGln: 1.356 ± 0.042
2.653GlnArg: 2.653 ± 0.057
1.25GlnSer: 1.25 ± 0.035
1.663GlnThr: 1.663 ± 0.031
3.553GlnVal: 3.553 ± 0.063
0.452GlnTrp: 0.452 ± 0.022
0.405GlnTyr: 0.405 ± 0.018
0.0GlnXaa: 0.0 ± 0.0
Arg
9.423ArgAla: 9.423 ± 0.116
0.526ArgCys: 0.526 ± 0.022
4.566ArgAsp: 4.566 ± 0.079
5.351ArgGlu: 5.351 ± 0.075
1.984ArgPhe: 1.984 ± 0.046
6.246ArgGly: 6.246 ± 0.09
2.088ArgHis: 2.088 ± 0.044
2.643ArgIle: 2.643 ± 0.06
1.104ArgLys: 1.104 ± 0.039
8.14ArgLeu: 8.14 ± 0.107
1.833ArgMet: 1.833 ± 0.036
0.981ArgAsn: 0.981 ± 0.029
4.612ArgPro: 4.612 ± 0.073
2.355ArgGln: 2.355 ± 0.049
7.819ArgArg: 7.819 ± 0.111
4.41ArgSer: 4.41 ± 0.076
4.733ArgThr: 4.733 ± 0.065
6.511ArgVal: 6.511 ± 0.091
1.575ArgTrp: 1.575 ± 0.042
1.574ArgTyr: 1.574 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
6.256SerAla: 6.256 ± 0.073
0.357SerCys: 0.357 ± 0.021
2.752SerAsp: 2.752 ± 0.053
2.615SerGlu: 2.615 ± 0.055
1.521SerPhe: 1.521 ± 0.04
5.96SerGly: 5.96 ± 0.074
0.979SerHis: 0.979 ± 0.031
1.613SerIle: 1.613 ± 0.047
0.721SerLys: 0.721 ± 0.03
4.915SerLeu: 4.915 ± 0.073
1.253SerMet: 1.253 ± 0.037
0.817SerAsn: 0.817 ± 0.032
3.006SerPro: 3.006 ± 0.061
1.389SerGln: 1.389 ± 0.038
3.841SerArg: 3.841 ± 0.062
3.089SerSer: 3.089 ± 0.063
3.584SerThr: 3.584 ± 0.065
4.405SerVal: 4.405 ± 0.054
0.932SerTrp: 0.932 ± 0.028
1.101SerTyr: 1.101 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
7.122ThrAla: 7.122 ± 0.095
0.43ThrCys: 0.43 ± 0.02
3.847ThrAsp: 3.847 ± 0.057
3.445ThrGlu: 3.445 ± 0.061
1.771ThrPhe: 1.771 ± 0.049
6.444ThrGly: 6.444 ± 0.08
1.202ThrHis: 1.202 ± 0.035
1.941ThrIle: 1.941 ± 0.047
0.856ThrLys: 0.856 ± 0.032
6.049ThrLeu: 6.049 ± 0.082
1.155ThrMet: 1.155 ± 0.033
0.947ThrAsn: 0.947 ± 0.03
3.804ThrPro: 3.804 ± 0.051
1.644ThrGln: 1.644 ± 0.042
4.104ThrArg: 4.104 ± 0.067
3.486ThrSer: 3.486 ± 0.061
4.084ThrThr: 4.084 ± 0.074
5.882ThrVal: 5.882 ± 0.075
1.092ThrTrp: 1.092 ± 0.031
1.279ThrTyr: 1.279 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
12.169ValAla: 12.169 ± 0.126
0.693ValCys: 0.693 ± 0.025
6.339ValAsp: 6.339 ± 0.081
6.156ValGlu: 6.156 ± 0.095
2.303ValPhe: 2.303 ± 0.053
8.341ValGly: 8.341 ± 0.105
2.095ValHis: 2.095 ± 0.053
2.942ValIle: 2.942 ± 0.061
1.191ValLys: 1.191 ± 0.04
11.127ValLeu: 11.127 ± 0.132
1.74ValMet: 1.74 ± 0.044
1.392ValAsn: 1.392 ± 0.037
5.237ValPro: 5.237 ± 0.076
2.432ValGln: 2.432 ± 0.046
7.119ValArg: 7.119 ± 0.091
4.798ValSer: 4.798 ± 0.066
5.78ValThr: 5.78 ± 0.085
11.002ValVal: 11.002 ± 0.134
1.19ValTrp: 1.19 ± 0.039
1.434ValTyr: 1.434 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
1.862TrpAla: 1.862 ± 0.046
0.159TrpCys: 0.159 ± 0.012
0.86TrpAsp: 0.86 ± 0.031
0.829TrpGlu: 0.829 ± 0.03
0.505TrpPhe: 0.505 ± 0.023
1.201TrpGly: 1.201 ± 0.042
0.376TrpHis: 0.376 ± 0.019
0.501TrpIle: 0.501 ± 0.023
0.22TrpLys: 0.22 ± 0.016
1.884TrpLeu: 1.884 ± 0.052
0.329TrpMet: 0.329 ± 0.015
0.295TrpAsn: 0.295 ± 0.019
0.813TrpPro: 0.813 ± 0.025
0.564TrpGln: 0.564 ± 0.024
1.387TrpArg: 1.387 ± 0.037
1.052TrpSer: 1.052 ± 0.034
1.021TrpThr: 1.021 ± 0.036
1.478TrpVal: 1.478 ± 0.039
0.467TrpTrp: 0.467 ± 0.025
0.258TrpTyr: 0.258 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.784TyrAla: 2.784 ± 0.049
0.125TyrCys: 0.125 ± 0.011
1.321TyrAsp: 1.321 ± 0.043
0.986TyrGlu: 0.986 ± 0.032
0.55TyrPhe: 0.55 ± 0.026
1.723TyrGly: 1.723 ± 0.04
0.365TyrHis: 0.365 ± 0.019
0.391TyrIle: 0.391 ± 0.021
0.257TyrLys: 0.257 ± 0.016
2.227TyrLeu: 2.227 ± 0.051
0.166TyrMet: 0.166 ± 0.013
0.305TyrAsn: 0.305 ± 0.018
1.07TyrPro: 1.07 ± 0.03
0.55TyrGln: 0.55 ± 0.025
1.455TyrArg: 1.455 ± 0.039
0.83TyrSer: 0.83 ± 0.024
1.027TyrThr: 1.027 ± 0.036
1.627TyrVal: 1.627 ± 0.037
0.28TyrTrp: 0.28 ± 0.017
0.39TyrTyr: 0.39 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3300 proteins (1072852 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski