Amino acid dipepetide frequency for Alginatibacterium sediminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.769AlaAla: 7.769 ± 0.1	1.107AlaCys: 1.107 ± 0.03	4.271AlaAsp: 4.271 ± 0.059	4.607AlaGlu: 4.607 ± 0.076	3.507AlaPhe: 3.507 ± 0.056	5.912AlaGly: 5.912 ± 0.092	1.687AlaHis: 1.687 ± 0.04	6.318AlaIle: 6.318 ± 0.072	5.043AlaLys: 5.043 ± 0.07	10.309AlaLeu: 10.309 ± 0.113	2.792AlaMet: 2.792 ± 0.05	3.504AlaAsn: 3.504 ± 0.06	2.723AlaPro: 2.723 ± 0.054	5.009AlaGln: 5.009 ± 0.07	3.613AlaArg: 3.613 ± 0.063	6.181AlaSer: 6.181 ± 0.087	3.958AlaThr: 3.958 ± 0.057	5.657AlaVal: 5.657 ± 0.073	1.108AlaTrp: 1.108 ± 0.033	2.492AlaTyr: 2.492 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.899CysAla: 0.899 ± 0.03	0.2CysCys: 0.2 ± 0.013	0.69CysAsp: 0.69 ± 0.025	0.702CysGlu: 0.702 ± 0.026	0.586CysPhe: 0.586 ± 0.02	0.871CysGly: 0.871 ± 0.026	0.342CysHis: 0.342 ± 0.019	0.702CysIle: 0.702 ± 0.023	0.44CysLys: 0.44 ± 0.019	1.193CysLeu: 1.193 ± 0.034	0.237CysMet: 0.237 ± 0.015	0.368CysAsn: 0.368 ± 0.018	0.469CysPro: 0.469 ± 0.018	0.496CysGln: 0.496 ± 0.022	0.447CysArg: 0.447 ± 0.02	0.842CysSer: 0.842 ± 0.026	0.403CysThr: 0.403 ± 0.016	0.687CysVal: 0.687 ± 0.026	0.142CysTrp: 0.142 ± 0.011	0.364CysTyr: 0.364 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.52AspAla: 4.52 ± 0.067	0.616AspCys: 0.616 ± 0.027	2.94AspAsp: 2.94 ± 0.058	3.591AspGlu: 3.591 ± 0.063	2.662AspPhe: 2.662 ± 0.045	3.684AspGly: 3.684 ± 0.053	1.1AspHis: 1.1 ± 0.032	3.931AspIle: 3.931 ± 0.061	2.738AspLys: 2.738 ± 0.053	5.648AspLeu: 5.648 ± 0.079	1.294AspMet: 1.294 ± 0.033	2.257AspAsn: 2.257 ± 0.044	2.248AspPro: 2.248 ± 0.039	2.521AspGln: 2.521 ± 0.048	2.147AspArg: 2.147 ± 0.045	3.645AspSer: 3.645 ± 0.059	2.439AspThr: 2.439 ± 0.043	3.51AspVal: 3.51 ± 0.06	0.884AspTrp: 0.884 ± 0.026	2.17AspTyr: 2.17 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	4.9GluAla: 4.9 ± 0.077	0.448GluCys: 0.448 ± 0.016	2.677GluAsp: 2.677 ± 0.048	2.71GluGlu: 2.71 ± 0.055	2.56GluPhe: 2.56 ± 0.046	3.097GluGly: 3.097 ± 0.055	1.736GluHis: 1.736 ± 0.044	3.818GluIle: 3.818 ± 0.055	2.808GluLys: 2.808 ± 0.052	7.686GluLeu: 7.686 ± 0.099	1.507GluMet: 1.507 ± 0.038	2.558GluAsn: 2.558 ± 0.044	1.963GluPro: 1.963 ± 0.042	4.804GluGln: 4.804 ± 0.061	3.247GluArg: 3.247 ± 0.056	3.889GluSer: 3.889 ± 0.063	2.795GluThr: 2.795 ± 0.049	3.892GluVal: 3.892 ± 0.064	0.528GluTrp: 0.528 ± 0.018	1.608GluTyr: 1.608 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.904PheAla: 3.904 ± 0.061	0.576PheCys: 0.576 ± 0.02	3.025PheAsp: 3.025 ± 0.053	3.112PheGlu: 3.112 ± 0.051	1.739PhePhe: 1.739 ± 0.041	3.184PheGly: 3.184 ± 0.052	0.767PheHis: 0.767 ± 0.026	2.726PheIle: 2.726 ± 0.054	2.038PheLys: 2.038 ± 0.044	3.457PheLeu: 3.457 ± 0.059	1.028PheMet: 1.028 ± 0.031	1.902PheAsn: 1.902 ± 0.039	1.369PhePro: 1.369 ± 0.038	1.347PheGln: 1.347 ± 0.033	1.578PheArg: 1.578 ± 0.043	3.631PheSer: 3.631 ± 0.055	2.076PheThr: 2.076 ± 0.04	3.218PheVal: 3.218 ± 0.046	0.587PheTrp: 0.587 ± 0.023	1.376PheTyr: 1.376 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	5.109GlyAla: 5.109 ± 0.078	0.832GlyCys: 0.832 ± 0.026	3.607GlyAsp: 3.607 ± 0.069	4.05GlyGlu: 4.05 ± 0.059	3.459GlyPhe: 3.459 ± 0.049	4.398GlyGly: 4.398 ± 0.084	1.509GlyHis: 1.509 ± 0.033	4.633GlyIle: 4.633 ± 0.067	3.494GlyLys: 3.494 ± 0.056	7.524GlyLeu: 7.524 ± 0.078	1.853GlyMet: 1.853 ± 0.039	2.414GlyAsn: 2.414 ± 0.06	1.821GlyPro: 1.821 ± 0.04	3.07GlyGln: 3.07 ± 0.054	3.011GlyArg: 3.011 ± 0.049	4.326GlySer: 4.326 ± 0.078	2.953GlyThr: 2.953 ± 0.051	4.807GlyVal: 4.807 ± 0.063	0.814GlyTrp: 0.814 ± 0.028	2.37GlyTyr: 2.37 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	1.698HisAla: 1.698 ± 0.036	0.351HisCys: 0.351 ± 0.018	1.039HisAsp: 1.039 ± 0.033	1.126HisGlu: 1.126 ± 0.028	1.1HisPhe: 1.1 ± 0.025	1.521HisGly: 1.521 ± 0.034	0.61HisHis: 0.61 ± 0.024	1.361HisIle: 1.361 ± 0.035	0.934HisLys: 0.934 ± 0.027	2.372HisLeu: 2.372 ± 0.044	0.482HisMet: 0.482 ± 0.02	0.823HisAsn: 0.823 ± 0.023	1.137HisPro: 1.137 ± 0.029	1.425HisGln: 1.425 ± 0.035	1.144HisArg: 1.144 ± 0.029	1.617HisSer: 1.617 ± 0.031	0.939HisThr: 0.939 ± 0.025	1.23HisVal: 1.23 ± 0.032	0.399HisTrp: 0.399 ± 0.017	0.832HisTyr: 0.832 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.898IleAla: 6.898 ± 0.1	0.767IleCys: 0.767 ± 0.027	4.515IleAsp: 4.515 ± 0.056	5.113IleGlu: 5.113 ± 0.057	2.251IlePhe: 2.251 ± 0.042	4.745IleGly: 4.745 ± 0.067	1.237IleHis: 1.237 ± 0.03	3.629IleIle: 3.629 ± 0.061	2.938IleLys: 2.938 ± 0.049	5.421IleLeu: 5.421 ± 0.078	1.324IleMet: 1.324 ± 0.032	2.9IleAsn: 2.9 ± 0.055	2.576IlePro: 2.576 ± 0.045	2.386IleGln: 2.386 ± 0.048	2.813IleArg: 2.813 ± 0.051	5.049IleSer: 5.049 ± 0.078	3.099IleThr: 3.099 ± 0.066	4.517IleVal: 4.517 ± 0.062	0.658IleTrp: 0.658 ± 0.025	1.777IleTyr: 1.777 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	4.651LysAla: 4.651 ± 0.071	0.276LysCys: 0.276 ± 0.016	2.615LysAsp: 2.615 ± 0.046	2.44LysGlu: 2.44 ± 0.04	1.46LysPhe: 1.46 ± 0.036	2.913LysGly: 2.913 ± 0.045	1.251LysHis: 1.251 ± 0.028	2.756LysIle: 2.756 ± 0.045	2.147LysLys: 2.147 ± 0.05	5.377LysLeu: 5.377 ± 0.068	1.164LysMet: 1.164 ± 0.031	1.93LysAsn: 1.93 ± 0.036	2.237LysPro: 2.237 ± 0.05	3.177LysGln: 3.177 ± 0.052	2.73LysArg: 2.73 ± 0.045	3.181LysSer: 3.181 ± 0.05	2.67LysThr: 2.67 ± 0.047	3.53LysVal: 3.53 ± 0.054	0.469LysTrp: 0.469 ± 0.019	1.214LysTyr: 1.214 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	10.552LeuAla: 10.552 ± 0.108	1.287LeuCys: 1.287 ± 0.035	6.296LeuAsp: 6.296 ± 0.078	7.153LeuGlu: 7.153 ± 0.081	4.3LeuPhe: 4.3 ± 0.071	7.384LeuGly: 7.384 ± 0.082	2.103LeuHis: 2.103 ± 0.038	6.649LeuIle: 6.649 ± 0.08	5.582LeuLys: 5.582 ± 0.072	11.459LeuLeu: 11.459 ± 0.134	2.716LeuMet: 2.716 ± 0.048	4.998LeuAsn: 4.998 ± 0.066	4.487LeuPro: 4.487 ± 0.065	4.516LeuGln: 4.516 ± 0.062	4.928LeuArg: 4.928 ± 0.069	9.353LeuSer: 9.353 ± 0.094	4.6LeuThr: 4.6 ± 0.056	7.564LeuVal: 7.564 ± 0.081	1.179LeuTrp: 1.179 ± 0.036	2.553LeuTyr: 2.553 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.373MetAla: 2.373 ± 0.047	0.218MetCys: 0.218 ± 0.013	1.225MetAsp: 1.225 ± 0.034	1.13MetGlu: 1.13 ± 0.03	0.98MetPhe: 0.98 ± 0.033	1.712MetGly: 1.712 ± 0.035	0.508MetHis: 0.508 ± 0.019	1.461MetIle: 1.461 ± 0.033	1.196MetLys: 1.196 ± 0.031	3.052MetLeu: 3.052 ± 0.052	0.693MetMet: 0.693 ± 0.025	1.068MetAsn: 1.068 ± 0.034	1.154MetPro: 1.154 ± 0.03	1.326MetGln: 1.326 ± 0.03	1.326MetArg: 1.326 ± 0.032	1.988MetSer: 1.988 ± 0.04	1.352MetThr: 1.352 ± 0.032	1.708MetVal: 1.708 ± 0.042	0.224MetTrp: 0.224 ± 0.014	0.561MetTyr: 0.561 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.591AsnAla: 3.591 ± 0.066	0.453AsnCys: 0.453 ± 0.021	2.292AsnAsp: 2.292 ± 0.044	2.162AsnGlu: 2.162 ± 0.039	1.7AsnPhe: 1.7 ± 0.038	2.794AsnGly: 2.794 ± 0.054	0.928AsnHis: 0.928 ± 0.024	2.726AsnIle: 2.726 ± 0.051	1.941AsnLys: 1.941 ± 0.045	4.188AsnLeu: 4.188 ± 0.06	1.018AsnMet: 1.018 ± 0.03	1.789AsnAsn: 1.789 ± 0.042	2.128AsnPro: 2.128 ± 0.044	2.381AsnGln: 2.381 ± 0.049	1.938AsnArg: 1.938 ± 0.038	2.963AsnSer: 2.963 ± 0.054	2.052AsnThr: 2.052 ± 0.044	2.499AsnVal: 2.499 ± 0.049	0.607AsnTrp: 0.607 ± 0.02	1.477AsnTyr: 1.477 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	2.817ProAla: 2.817 ± 0.056	0.349ProCys: 0.349 ± 0.019	2.015ProAsp: 2.015 ± 0.04	2.872ProGlu: 2.872 ± 0.061	1.588ProPhe: 1.588 ± 0.039	2.284ProGly: 2.284 ± 0.047	0.763ProHis: 0.763 ± 0.026	2.529ProIle: 2.529 ± 0.044	2.126ProLys: 2.126 ± 0.041	4.027ProLeu: 4.027 ± 0.057	1.029ProMet: 1.029 ± 0.026	1.814ProAsn: 1.814 ± 0.036	1.001ProPro: 1.001 ± 0.031	1.863ProGln: 1.863 ± 0.044	1.418ProArg: 1.418 ± 0.033	2.975ProSer: 2.975 ± 0.05	1.781ProThr: 1.781 ± 0.036	2.606ProVal: 2.606 ± 0.05	0.547ProTrp: 0.547 ± 0.021	1.148ProTyr: 1.148 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	5.113GlnAla: 5.113 ± 0.067	0.501GlnCys: 0.501 ± 0.02	2.321GlnAsp: 2.321 ± 0.04	2.554GlnGlu: 2.554 ± 0.044	2.048GlnPhe: 2.048 ± 0.046	3.198GlnGly: 3.198 ± 0.055	1.523GlnHis: 1.523 ± 0.038	3.152GlnIle: 3.152 ± 0.047	1.984GlnLys: 1.984 ± 0.04	6.683GlnLeu: 6.683 ± 0.098	1.262GlnMet: 1.262 ± 0.029	1.966GlnAsn: 1.966 ± 0.04	1.454GlnPro: 1.454 ± 0.034	4.377GlnGln: 4.377 ± 0.108	3.119GlnArg: 3.119 ± 0.049	3.904GlnSer: 3.904 ± 0.07	2.389GlnThr: 2.389 ± 0.041	3.485GlnVal: 3.485 ± 0.053	0.875GlnTrp: 0.875 ± 0.028	1.333GlnTyr: 1.333 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	3.493ArgAla: 3.493 ± 0.059	0.559ArgCys: 0.559 ± 0.021	2.488ArgAsp: 2.488 ± 0.044	2.888ArgGlu: 2.888 ± 0.054	2.347ArgPhe: 2.347 ± 0.041	2.561ArgGly: 2.561 ± 0.049	1.154ArgHis: 1.154 ± 0.03	3.006ArgIle: 3.006 ± 0.047	2.221ArgLys: 2.221 ± 0.044	5.293ArgLeu: 5.293 ± 0.077	1.14ArgMet: 1.14 ± 0.027	1.889ArgAsn: 1.889 ± 0.04	1.588ArgPro: 1.588 ± 0.034	2.389ArgGln: 2.389 ± 0.047	2.358ArgArg: 2.358 ± 0.04	3.202ArgSer: 3.202 ± 0.045	1.859ArgThr: 1.859 ± 0.04	3.152ArgVal: 3.152 ± 0.05	0.671ArgTrp: 0.671 ± 0.023	1.823ArgTyr: 1.823 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.041SerAla: 6.041 ± 0.068	0.793SerCys: 0.793 ± 0.024	4.021SerAsp: 4.021 ± 0.067	4.278SerGlu: 4.278 ± 0.058	3.477SerPhe: 3.477 ± 0.053	5.163SerGly: 5.163 ± 0.078	1.633SerHis: 1.633 ± 0.034	4.948SerIle: 4.948 ± 0.077	3.601SerLys: 3.601 ± 0.06	8.234SerLeu: 8.234 ± 0.097	1.876SerMet: 1.876 ± 0.034	3.194SerAsn: 3.194 ± 0.052	2.703SerPro: 2.703 ± 0.048	3.94SerGln: 3.94 ± 0.061	3.087SerArg: 3.087 ± 0.049	5.582SerSer: 5.582 ± 0.092	3.288SerThr: 3.288 ± 0.052	4.797SerVal: 4.797 ± 0.069	0.932SerTrp: 0.932 ± 0.026	2.321SerTyr: 2.321 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	3.82ThrAla: 3.82 ± 0.061	0.39ThrCys: 0.39 ± 0.019	2.278ThrAsp: 2.278 ± 0.045	2.477ThrGlu: 2.477 ± 0.042	1.699ThrPhe: 1.699 ± 0.038	3.414ThrGly: 3.414 ± 0.047	1.026ThrHis: 1.026 ± 0.026	3.332ThrIle: 3.332 ± 0.06	2.11ThrLys: 2.11 ± 0.042	5.316ThrLeu: 5.316 ± 0.062	1.08ThrMet: 1.08 ± 0.028	1.849ThrAsn: 1.849 ± 0.039	2.127ThrPro: 2.127 ± 0.042	2.71ThrGln: 2.71 ± 0.044	2.022ThrArg: 2.022 ± 0.042	3.213ThrSer: 3.213 ± 0.061	2.413ThrThr: 2.413 ± 0.05	3.175ThrVal: 3.175 ± 0.065	0.614ThrTrp: 0.614 ± 0.021	1.133ThrTyr: 1.133 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	6.147ValAla: 6.147 ± 0.068	0.788ValCys: 0.788 ± 0.024	4.112ValAsp: 4.112 ± 0.065	4.352ValGlu: 4.352 ± 0.074	3.094ValPhe: 3.094 ± 0.052	4.48ValGly: 4.48 ± 0.063	1.212ValHis: 1.212 ± 0.03	4.575ValIle: 4.575 ± 0.058	3.099ValLys: 3.099 ± 0.051	7.282ValLeu: 7.282 ± 0.098	1.788ValMet: 1.788 ± 0.039	2.837ValAsn: 2.837 ± 0.051	2.422ValPro: 2.422 ± 0.047	2.433ValGln: 2.433 ± 0.044	2.789ValArg: 2.789 ± 0.048	5.286ValSer: 5.286 ± 0.069	3.248ValThr: 3.248 ± 0.063	5.258ValVal: 5.258 ± 0.077	0.728ValTrp: 0.728 ± 0.025	1.965ValTyr: 1.965 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	0.908TrpAla: 0.908 ± 0.028	0.149TrpCys: 0.149 ± 0.01	0.644TrpAsp: 0.644 ± 0.022	0.518TrpGlu: 0.518 ± 0.02	0.612TrpPhe: 0.612 ± 0.023	0.759TrpGly: 0.759 ± 0.027	0.31TrpHis: 0.31 ± 0.017	0.741TrpIle: 0.741 ± 0.024	0.532TrpLys: 0.532 ± 0.02	1.729TrpLeu: 1.729 ± 0.036	0.359TrpMet: 0.359 ± 0.017	0.519TrpAsn: 0.519 ± 0.02	0.501TrpPro: 0.501 ± 0.022	0.938TrpGln: 0.938 ± 0.03	0.665TrpArg: 0.665 ± 0.022	0.838TrpSer: 0.838 ± 0.029	0.528TrpThr: 0.528 ± 0.019	0.813TrpVal: 0.813 ± 0.026	0.214TrpTrp: 0.214 ± 0.012	0.365TrpTyr: 0.365 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.364TyrAla: 2.364 ± 0.04	0.418TyrCys: 0.418 ± 0.019	1.473TyrAsp: 1.473 ± 0.041	1.399TyrGlu: 1.399 ± 0.032	1.47TyrPhe: 1.47 ± 0.034	1.979TyrGly: 1.979 ± 0.04	0.739TyrHis: 0.739 ± 0.026	1.622TyrIle: 1.622 ± 0.039	1.215TyrLys: 1.215 ± 0.027	3.411TyrLeu: 3.411 ± 0.057	0.614TyrMet: 0.614 ± 0.022	1.048TyrAsn: 1.048 ± 0.03	1.444TyrPro: 1.444 ± 0.036	2.132TyrGln: 2.132 ± 0.039	1.7TyrArg: 1.7 ± 0.04	2.246TyrSer: 2.246 ± 0.047	1.356TyrThr: 1.356 ± 0.033	1.79TyrVal: 1.79 ± 0.037	0.461TyrTrp: 0.461 ± 0.021	0.996TyrTyr: 0.996 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3984 proteins (1305717 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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