Amino acid dipepetide frequency for Dentipellis sp. KUC8613

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.933AlaAla: 10.933 ± 0.069
1.381AlaCys: 1.381 ± 0.018
4.52AlaAsp: 4.52 ± 0.03
5.033AlaGlu: 5.033 ± 0.034
3.377AlaPhe: 3.377 ± 0.027
6.189AlaGly: 6.189 ± 0.041
2.613AlaHis: 2.613 ± 0.026
3.947AlaIle: 3.947 ± 0.032
3.747AlaLys: 3.747 ± 0.033
9.88AlaLeu: 9.88 ± 0.056
1.949AlaMet: 1.949 ± 0.018
2.662AlaAsn: 2.662 ± 0.025
8.039AlaPro: 8.039 ± 0.076
3.543AlaGln: 3.543 ± 0.033
6.857AlaArg: 6.857 ± 0.05
8.6AlaSer: 8.6 ± 0.048
5.285AlaThr: 5.285 ± 0.036
6.289AlaVal: 6.289 ± 0.039
1.245AlaTrp: 1.245 ± 0.016
2.169AlaTyr: 2.169 ± 0.022
0.0AlaXaa: 0.0 ± 0.0
Cys
1.514CysAla: 1.514 ± 0.024
0.379CysCys: 0.379 ± 0.009
0.638CysAsp: 0.638 ± 0.012
0.579CysGlu: 0.579 ± 0.01
0.505CysPhe: 0.505 ± 0.01
0.934CysGly: 0.934 ± 0.015
0.446CysHis: 0.446 ± 0.009
0.664CysIle: 0.664 ± 0.012
0.458CysLys: 0.458 ± 0.01
1.385CysLeu: 1.385 ± 0.02
0.301CysMet: 0.301 ± 0.007
0.404CysAsn: 0.404 ± 0.01
1.137CysPro: 1.137 ± 0.02
0.43CysGln: 0.43 ± 0.009
1.172CysArg: 1.172 ± 0.018
1.082CysSer: 1.082 ± 0.014
0.888CysThr: 0.888 ± 0.014
0.899CysVal: 0.899 ± 0.013
0.197CysTrp: 0.197 ± 0.006
0.308CysTyr: 0.308 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
5.488AspAla: 5.488 ± 0.035
0.584AspCys: 0.584 ± 0.011
3.884AspAsp: 3.884 ± 0.038
4.104AspGlu: 4.104 ± 0.037
1.931AspPhe: 1.931 ± 0.019
3.85AspGly: 3.85 ± 0.03
1.139AspHis: 1.139 ± 0.016
2.746AspIle: 2.746 ± 0.024
1.93AspLys: 1.93 ± 0.02
4.651AspLeu: 4.651 ± 0.034
1.172AspMet: 1.172 ± 0.017
1.468AspAsn: 1.468 ± 0.019
3.338AspPro: 3.338 ± 0.03
1.427AspGln: 1.427 ± 0.015
2.819AspArg: 2.819 ± 0.027
3.663AspSer: 3.663 ± 0.03
2.871AspThr: 2.871 ± 0.023
3.966AspVal: 3.966 ± 0.028
0.836AspTrp: 0.836 ± 0.012
1.301AspTyr: 1.301 ± 0.017
0.0AspXaa: 0.0 ± 0.0
Glu
5.031GluAla: 5.031 ± 0.042
0.602GluCys: 0.602 ± 0.012
3.935GluAsp: 3.935 ± 0.033
4.892GluGlu: 4.892 ± 0.048
1.701GluPhe: 1.701 ± 0.02
3.718GluGly: 3.718 ± 0.029
1.43GluHis: 1.43 ± 0.015
2.398GluIle: 2.398 ± 0.023
2.876GluLys: 2.876 ± 0.028
4.819GluLeu: 4.819 ± 0.032
1.245GluMet: 1.245 ± 0.017
1.672GluAsn: 1.672 ± 0.018
2.756GluPro: 2.756 ± 0.025
2.096GluGln: 2.096 ± 0.023
4.076GluArg: 4.076 ± 0.034
3.505GluSer: 3.505 ± 0.03
2.818GluThr: 2.818 ± 0.024
3.36GluVal: 3.36 ± 0.028
0.855GluTrp: 0.855 ± 0.013
1.423GluTyr: 1.423 ± 0.016
0.0GluXaa: 0.0 ± 0.0
Phe
3.375PheAla: 3.375 ± 0.028
0.566PheCys: 0.566 ± 0.011
2.11PheAsp: 2.11 ± 0.021
1.856PheGlu: 1.856 ± 0.019
1.484PhePhe: 1.484 ± 0.02
2.554PheGly: 2.554 ± 0.028
0.898PheHis: 0.898 ± 0.013
1.618PheIle: 1.618 ± 0.016
1.293PheLys: 1.293 ± 0.016
3.364PheLeu: 3.364 ± 0.029
0.713PheMet: 0.713 ± 0.012
1.172PheAsn: 1.172 ± 0.016
2.061PhePro: 2.061 ± 0.022
1.131PheGln: 1.131 ± 0.015
1.991PheArg: 1.991 ± 0.021
2.94PheSer: 2.94 ± 0.03
2.046PheThr: 2.046 ± 0.021
2.498PheVal: 2.498 ± 0.023
0.557PheTrp: 0.557 ± 0.011
0.937PheTyr: 0.937 ± 0.013
0.0PheXaa: 0.0 ± 0.0
Gly
6.014GlyAla: 6.014 ± 0.044
0.847GlyCys: 0.847 ± 0.014
3.272GlyAsp: 3.272 ± 0.025
3.407GlyGlu: 3.407 ± 0.03
2.401GlyPhe: 2.401 ± 0.024
5.496GlyGly: 5.496 ± 0.055
1.675GlyHis: 1.675 ± 0.021
2.944GlyIle: 2.944 ± 0.023
3.138GlyLys: 3.138 ± 0.027
5.478GlyLeu: 5.478 ± 0.033
1.426GlyMet: 1.426 ± 0.02
2.023GlyAsn: 2.023 ± 0.022
3.579GlyPro: 3.579 ± 0.027
2.212GlyGln: 2.212 ± 0.022
4.45GlyArg: 4.45 ± 0.036
5.306GlySer: 5.306 ± 0.043
3.858GlyThr: 3.858 ± 0.028
4.28GlyVal: 4.28 ± 0.033
1.103GlyTrp: 1.103 ± 0.015
1.684GlyTyr: 1.684 ± 0.023
0.0GlyXaa: 0.0 ± 0.0
His
2.982HisAla: 2.982 ± 0.028
0.452HisCys: 0.452 ± 0.009
1.32HisAsp: 1.32 ± 0.014
1.293HisGlu: 1.293 ± 0.015
0.948HisPhe: 0.948 ± 0.013
1.728HisGly: 1.728 ± 0.018
0.995HisHis: 0.995 ± 0.017
1.287HisIle: 1.287 ± 0.015
0.838HisLys: 0.838 ± 0.013
2.652HisLeu: 2.652 ± 0.027
0.533HisMet: 0.533 ± 0.011
0.744HisAsn: 0.744 ± 0.01
2.357HisPro: 2.357 ± 0.025
0.833HisGln: 0.833 ± 0.014
2.043HisArg: 2.043 ± 0.025
2.102HisSer: 2.102 ± 0.025
1.622HisThr: 1.622 ± 0.017
1.795HisVal: 1.795 ± 0.018
0.347HisTrp: 0.347 ± 0.008
0.648HisTyr: 0.648 ± 0.01
0.0HisXaa: 0.0 ± 0.0
Ile
4.037IleAla: 4.037 ± 0.032
0.683IleCys: 0.683 ± 0.01
2.432IleAsp: 2.432 ± 0.022
2.282IleGlu: 2.282 ± 0.02
1.743IlePhe: 1.743 ± 0.019
2.627IleGly: 2.627 ± 0.025
1.157IleHis: 1.157 ± 0.015
2.045IleIle: 2.045 ± 0.022
1.633IleLys: 1.633 ± 0.018
4.136IleLeu: 4.136 ± 0.032
0.837IleMet: 0.837 ± 0.014
1.317IleAsn: 1.317 ± 0.018
3.061IlePro: 3.061 ± 0.027
1.53IleGln: 1.53 ± 0.017
2.659IleArg: 2.659 ± 0.021
3.422IleSer: 3.422 ± 0.027
2.444IleThr: 2.444 ± 0.022
3.082IleVal: 3.082 ± 0.026
0.668IleTrp: 0.668 ± 0.013
1.206IleTyr: 1.206 ± 0.016
0.0IleXaa: 0.0 ± 0.0
Lys
4.043LysAla: 4.043 ± 0.035
0.419LysCys: 0.419 ± 0.009
2.269LysAsp: 2.269 ± 0.024
2.769LysGlu: 2.769 ± 0.029
1.188LysPhe: 1.188 ± 0.017
2.684LysGly: 2.684 ± 0.026
0.993LysHis: 0.993 ± 0.015
1.694LysIle: 1.694 ± 0.02
2.602LysLys: 2.602 ± 0.035
3.362LysLeu: 3.362 ± 0.026
0.834LysMet: 0.834 ± 0.011
1.258LysAsn: 1.258 ± 0.015
2.386LysPro: 2.386 ± 0.025
1.445LysGln: 1.445 ± 0.016
3.104LysArg: 3.104 ± 0.031
2.791LysSer: 2.791 ± 0.024
2.315LysThr: 2.315 ± 0.021
2.339LysVal: 2.339 ± 0.022
0.576LysTrp: 0.576 ± 0.01
1.091LysTyr: 1.091 ± 0.015
0.0LysXaa: 0.0 ± 0.0
Leu
8.977LeuAla: 8.977 ± 0.051
1.452LeuCys: 1.452 ± 0.019
4.922LeuAsp: 4.922 ± 0.033
4.97LeuGlu: 4.97 ± 0.037
3.281LeuPhe: 3.281 ± 0.026
5.447LeuGly: 5.447 ± 0.035
2.742LeuHis: 2.742 ± 0.026
3.518LeuIle: 3.518 ± 0.024
3.559LeuLys: 3.559 ± 0.028
8.625LeuLeu: 8.625 ± 0.055
1.633LeuMet: 1.633 ± 0.017
2.712LeuAsn: 2.712 ± 0.022
6.737LeuPro: 6.737 ± 0.045
3.628LeuGln: 3.628 ± 0.031
6.727LeuArg: 6.727 ± 0.045
8.064LeuSer: 8.064 ± 0.04
5.071LeuThr: 5.071 ± 0.036
5.778LeuVal: 5.778 ± 0.037
1.244LeuTrp: 1.244 ± 0.015
2.292LeuTyr: 2.292 ± 0.018
0.0LeuXaa: 0.0 ± 0.0
Met
1.882MetAla: 1.882 ± 0.019
0.269MetCys: 0.269 ± 0.007
1.143MetAsp: 1.143 ± 0.015
1.062MetGlu: 1.062 ± 0.014
0.68MetPhe: 0.68 ± 0.011
1.246MetGly: 1.246 ± 0.019
0.598MetHis: 0.598 ± 0.01
0.79MetIle: 0.79 ± 0.012
0.828MetLys: 0.828 ± 0.013
1.821MetLeu: 1.821 ± 0.017
0.473MetMet: 0.473 ± 0.009
0.659MetAsn: 0.659 ± 0.013
1.489MetPro: 1.489 ± 0.017
0.853MetGln: 0.853 ± 0.015
1.42MetArg: 1.42 ± 0.017
1.872MetSer: 1.872 ± 0.02
1.146MetThr: 1.146 ± 0.015
1.077MetVal: 1.077 ± 0.016
0.248MetTrp: 0.248 ± 0.006
0.488MetTyr: 0.488 ± 0.009
0.0MetXaa: 0.0 ± 0.0
Asn
3.063AsnAla: 3.063 ± 0.025
0.347AsnCys: 0.347 ± 0.008
1.565AsnAsp: 1.565 ± 0.018
1.529AsnGlu: 1.529 ± 0.018
1.119AsnPhe: 1.119 ± 0.016
2.391AsnGly: 2.391 ± 0.025
0.689AsnHis: 0.689 ± 0.011
1.625AsnIle: 1.625 ± 0.017
1.112AsnLys: 1.112 ± 0.016
2.672AsnLeu: 2.672 ± 0.025
0.678AsnMet: 0.678 ± 0.012
1.077AsnAsn: 1.077 ± 0.018
2.097AsnPro: 2.097 ± 0.021
0.944AsnGln: 0.944 ± 0.014
1.56AsnArg: 1.56 ± 0.017
2.146AsnSer: 2.146 ± 0.022
1.804AsnThr: 1.804 ± 0.018
2.132AsnVal: 2.132 ± 0.02
0.434AsnTrp: 0.434 ± 0.01
0.783AsnTyr: 0.783 ± 0.011
0.0AsnXaa: 0.0 ± 0.0
Pro
7.441ProAla: 7.441 ± 0.057
0.991ProCys: 0.991 ± 0.019
3.293ProAsp: 3.293 ± 0.027
3.569ProGlu: 3.569 ± 0.025
2.401ProPhe: 2.401 ± 0.023
3.968ProGly: 3.968 ± 0.032
2.202ProHis: 2.202 ± 0.027
2.543ProIle: 2.543 ± 0.022
2.276ProLys: 2.276 ± 0.025
6.251ProLeu: 6.251 ± 0.046
1.176ProMet: 1.176 ± 0.014
1.982ProAsn: 1.982 ± 0.019
8.939ProPro: 8.939 ± 0.108
2.536ProGln: 2.536 ± 0.032
5.031ProArg: 5.031 ± 0.053
9.006ProSer: 9.006 ± 0.084
4.681ProThr: 4.681 ± 0.036
4.193ProVal: 4.193 ± 0.034
0.793ProTrp: 0.793 ± 0.012
1.67ProTyr: 1.67 ± 0.021
0.0ProXaa: 0.0 ± 0.0
Gln
3.398GlnAla: 3.398 ± 0.028
0.457GlnCys: 0.457 ± 0.009
1.777GlnAsp: 1.777 ± 0.017
1.991GlnGlu: 1.991 ± 0.02
1.168GlnPhe: 1.168 ± 0.013
2.117GlnGly: 2.117 ± 0.02
1.091GlnHis: 1.091 ± 0.015
1.561GlnIle: 1.561 ± 0.019
1.464GlnLys: 1.464 ± 0.016
3.175GlnLeu: 3.175 ± 0.03
0.797GlnMet: 0.797 ± 0.012
1.179GlnAsn: 1.179 ± 0.015
2.507GlnPro: 2.507 ± 0.03
1.924GlnGln: 1.924 ± 0.043
2.628GlnArg: 2.628 ± 0.023
2.756GlnSer: 2.756 ± 0.027
2.072GlnThr: 2.072 ± 0.022
1.982GlnVal: 1.982 ± 0.017
0.525GlnTrp: 0.525 ± 0.01
1.008GlnTyr: 1.008 ± 0.014
0.0GlnXaa: 0.0 ± 0.0
Arg
7.228ArgAla: 7.228 ± 0.061
1.191ArgCys: 1.191 ± 0.019
3.363ArgAsp: 3.363 ± 0.027
3.841ArgGlu: 3.841 ± 0.033
2.122ArgPhe: 2.122 ± 0.021
4.06ArgGly: 4.06 ± 0.039
2.083ArgHis: 2.083 ± 0.024
2.903ArgIle: 2.903 ± 0.024
3.062ArgLys: 3.062 ± 0.03
6.227ArgLeu: 6.227 ± 0.043
1.428ArgMet: 1.428 ± 0.018
1.911ArgAsn: 1.911 ± 0.018
5.409ArgPro: 5.409 ± 0.065
2.366ArgGln: 2.366 ± 0.018
7.121ArgArg: 7.121 ± 0.062
5.404ArgSer: 5.404 ± 0.04
4.137ArgThr: 4.137 ± 0.031
4.033ArgVal: 4.033 ± 0.025
1.034ArgTrp: 1.034 ± 0.014
1.583ArgTyr: 1.583 ± 0.017
0.0ArgXaa: 0.0 ± 0.0
Ser
8.094SerAla: 8.094 ± 0.045
1.239SerCys: 1.239 ± 0.018
4.057SerAsp: 4.057 ± 0.031
3.733SerGlu: 3.733 ± 0.03
2.928SerPhe: 2.928 ± 0.025
5.355SerGly: 5.355 ± 0.036
2.345SerHis: 2.345 ± 0.023
3.491SerIle: 3.491 ± 0.025
3.03SerLys: 3.03 ± 0.028
7.524SerLeu: 7.524 ± 0.041
1.666SerMet: 1.666 ± 0.02
2.438SerAsn: 2.438 ± 0.023
6.993SerPro: 6.993 ± 0.064
3.009SerGln: 3.009 ± 0.026
6.194SerArg: 6.194 ± 0.053
9.66SerSer: 9.66 ± 0.077
5.862SerThr: 5.862 ± 0.034
4.951SerVal: 4.951 ± 0.033
1.048SerTrp: 1.048 ± 0.016
1.876SerTyr: 1.876 ± 0.02
0.0SerXaa: 0.0 ± 0.0
Thr
5.508ThrAla: 5.508 ± 0.034
0.829ThrCys: 0.829 ± 0.014
2.643ThrAsp: 2.643 ± 0.027
2.55ThrGlu: 2.55 ± 0.025
2.249ThrPhe: 2.249 ± 0.02
3.685ThrGly: 3.685 ± 0.03
1.611ThrHis: 1.611 ± 0.017
2.669ThrIle: 2.669 ± 0.024
2.112ThrLys: 2.112 ± 0.021
5.662ThrLeu: 5.662 ± 0.034
1.085ThrMet: 1.085 ± 0.014
1.767ThrAsn: 1.767 ± 0.02
5.336ThrPro: 5.336 ± 0.04
1.931ThrGln: 1.931 ± 0.02
3.758ThrArg: 3.758 ± 0.03
5.434ThrSer: 5.434 ± 0.04
3.87ThrThr: 3.87 ± 0.031
3.751ThrVal: 3.751 ± 0.025
0.762ThrTrp: 0.762 ± 0.013
1.453ThrTyr: 1.453 ± 0.017
0.0ThrXaa: 0.0 ± 0.0
Val
5.8ValAla: 5.8 ± 0.038
1.016ValCys: 1.016 ± 0.014
3.65ValAsp: 3.65 ± 0.025
3.662ValGlu: 3.662 ± 0.03
2.451ValPhe: 2.451 ± 0.022
3.916ValGly: 3.916 ± 0.032
1.722ValHis: 1.722 ± 0.017
2.68ValIle: 2.68 ± 0.024
2.578ValLys: 2.578 ± 0.025
6.127ValLeu: 6.127 ± 0.038
1.228ValMet: 1.228 ± 0.016
1.92ValAsn: 1.92 ± 0.021
4.506ValPro: 4.506 ± 0.036
2.372ValGln: 2.372 ± 0.023
4.213ValArg: 4.213 ± 0.031
4.972ValSer: 4.972 ± 0.034
3.453ValThr: 3.453 ± 0.026
4.582ValVal: 4.582 ± 0.03
0.945ValTrp: 0.945 ± 0.013
1.67ValTyr: 1.67 ± 0.017
0.0ValXaa: 0.0 ± 0.0
Trp
1.174TrpAla: 1.174 ± 0.015
0.231TrpCys: 0.231 ± 0.006
0.878TrpAsp: 0.878 ± 0.017
0.787TrpGlu: 0.787 ± 0.012
0.494TrpPhe: 0.494 ± 0.009
0.863TrpGly: 0.863 ± 0.014
0.385TrpHis: 0.385 ± 0.008
0.676TrpIle: 0.676 ± 0.011
0.722TrpLys: 0.722 ± 0.015
1.245TrpLeu: 1.245 ± 0.015
0.34TrpMet: 0.34 ± 0.007
0.529TrpAsn: 0.529 ± 0.01
0.697TrpPro: 0.697 ± 0.012
0.493TrpGln: 0.493 ± 0.009
1.131TrpArg: 1.131 ± 0.014
1.009TrpSer: 1.009 ± 0.014
0.89TrpThr: 0.89 ± 0.013
0.835TrpVal: 0.835 ± 0.013
0.27TrpTrp: 0.27 ± 0.007
0.397TrpTyr: 0.397 ± 0.009
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.274TyrAla: 2.274 ± 0.025
0.387TyrCys: 0.387 ± 0.009
1.5TyrAsp: 1.5 ± 0.017
1.298TyrGlu: 1.298 ± 0.014
0.992TyrPhe: 0.992 ± 0.015
1.767TyrGly: 1.767 ± 0.02
0.703TyrHis: 0.703 ± 0.01
1.204TyrIle: 1.204 ± 0.015
0.904TyrLys: 0.904 ± 0.012
2.324TyrLeu: 2.324 ± 0.022
0.529TyrMet: 0.529 ± 0.01
0.871TyrAsn: 0.871 ± 0.012
1.518TyrPro: 1.518 ± 0.02
0.871TyrGln: 0.871 ± 0.014
1.555TyrArg: 1.555 ± 0.019
1.76TyrSer: 1.76 ± 0.019
1.531TyrThr: 1.531 ± 0.016
1.64TyrVal: 1.64 ± 0.018
0.357TyrTrp: 0.357 ± 0.007
0.746TyrTyr: 0.746 ± 0.011
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 14287 proteins (5785676 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski