Amino acid dipepetide frequency for Desulfobacca acetoxidans (strain ATCC 700848 / DSM 11109 / ASRB2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.76AlaAla: 10.76 ± 0.174	1.094AlaCys: 1.094 ± 0.039	4.348AlaAsp: 4.348 ± 0.082	5.585AlaGlu: 5.585 ± 0.082	3.281AlaPhe: 3.281 ± 0.074	7.316AlaGly: 7.316 ± 0.135	1.786AlaHis: 1.786 ± 0.043	5.212AlaIle: 5.212 ± 0.085	3.822AlaLys: 3.822 ± 0.078	10.15AlaLeu: 10.15 ± 0.146	2.231AlaMet: 2.231 ± 0.059	2.476AlaAsn: 2.476 ± 0.049	3.67AlaPro: 3.67 ± 0.07	3.698AlaGln: 3.698 ± 0.067	5.623AlaArg: 5.623 ± 0.097	4.45AlaSer: 4.45 ± 0.07	4.1AlaThr: 4.1 ± 0.067	6.786AlaVal: 6.786 ± 0.084	1.106AlaTrp: 1.106 ± 0.038	2.362AlaTyr: 2.362 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.783CysAla: 0.783 ± 0.03	0.238CysCys: 0.238 ± 0.016	0.445CysAsp: 0.445 ± 0.021	0.571CysGlu: 0.571 ± 0.026	0.475CysPhe: 0.475 ± 0.023	1.249CysGly: 1.249 ± 0.046	0.388CysHis: 0.388 ± 0.026	0.557CysIle: 0.557 ± 0.025	0.38CysLys: 0.38 ± 0.021	1.469CysLeu: 1.469 ± 0.041	0.222CysMet: 0.222 ± 0.015	0.361CysAsn: 0.361 ± 0.021	0.954CysPro: 0.954 ± 0.04	0.723CysGln: 0.723 ± 0.031	0.958CysArg: 0.958 ± 0.035	0.669CysSer: 0.669 ± 0.032	0.543CysThr: 0.543 ± 0.024	0.617CysVal: 0.617 ± 0.034	0.188CysTrp: 0.188 ± 0.014	0.413CysTyr: 0.413 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	3.499AspAla: 3.499 ± 0.059	0.629AspCys: 0.629 ± 0.024	1.969AspAsp: 1.969 ± 0.05	2.65AspGlu: 2.65 ± 0.061	2.533AspPhe: 2.533 ± 0.054	3.079AspGly: 3.079 ± 0.068	1.094AspHis: 1.094 ± 0.039	3.487AspIle: 3.487 ± 0.06	1.981AspLys: 1.981 ± 0.056	6.461AspLeu: 6.461 ± 0.091	1.037AspMet: 1.037 ± 0.037	1.595AspAsn: 1.595 ± 0.051	2.763AspPro: 2.763 ± 0.053	1.879AspGln: 1.879 ± 0.045	3.429AspArg: 3.429 ± 0.066	2.131AspSer: 2.131 ± 0.05	1.918AspThr: 1.918 ± 0.046	2.753AspVal: 2.753 ± 0.054	0.763AspTrp: 0.763 ± 0.032	1.954AspTyr: 1.954 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	6.387GluAla: 6.387 ± 0.11	0.511GluCys: 0.511 ± 0.024	2.713GluAsp: 2.713 ± 0.049	4.669GluGlu: 4.669 ± 0.092	2.202GluPhe: 2.202 ± 0.052	3.853GluGly: 3.853 ± 0.066	1.245GluHis: 1.245 ± 0.039	4.762GluIle: 4.762 ± 0.086	3.851GluLys: 3.851 ± 0.083	6.878GluLeu: 6.878 ± 0.113	1.691GluMet: 1.691 ± 0.038	2.095GluAsn: 2.095 ± 0.054	2.494GluPro: 2.494 ± 0.058	2.417GluGln: 2.417 ± 0.056	3.863GluArg: 3.863 ± 0.069	2.813GluSer: 2.813 ± 0.06	3.083GluThr: 3.083 ± 0.06	5.232GluVal: 5.232 ± 0.091	0.622GluTrp: 0.622 ± 0.028	1.662GluTyr: 1.662 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.103PheAla: 3.103 ± 0.061	0.645PheCys: 0.645 ± 0.028	2.254PheAsp: 2.254 ± 0.054	1.998PheGlu: 1.998 ± 0.046	2.231PhePhe: 2.231 ± 0.059	3.217PheGly: 3.217 ± 0.059	0.906PheHis: 0.906 ± 0.032	2.599PheIle: 2.599 ± 0.063	1.683PheLys: 1.683 ± 0.047	4.942PheLeu: 4.942 ± 0.087	0.868PheMet: 0.868 ± 0.035	1.4PheAsn: 1.4 ± 0.045	2.021PhePro: 2.021 ± 0.046	1.754PheGln: 1.754 ± 0.042	2.387PheArg: 2.387 ± 0.055	2.765PheSer: 2.765 ± 0.061	2.132PheThr: 2.132 ± 0.053	2.202PheVal: 2.202 ± 0.053	0.66PheTrp: 0.66 ± 0.031	1.47PheTyr: 1.47 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	6.179GlyAla: 6.179 ± 0.124	1.134GlyCys: 1.134 ± 0.041	3.457GlyAsp: 3.457 ± 0.089	4.524GlyGlu: 4.524 ± 0.076	3.4GlyPhe: 3.4 ± 0.061	6.384GlyGly: 6.384 ± 0.367	1.531GlyHis: 1.531 ± 0.05	4.792GlyIle: 4.792 ± 0.077	3.913GlyLys: 3.913 ± 0.079	8.855GlyLeu: 8.855 ± 0.11	2.01GlyMet: 2.01 ± 0.049	2.281GlyAsn: 2.281 ± 0.075	2.957GlyPro: 2.957 ± 0.057	3.122GlyGln: 3.122 ± 0.064	5.277GlyArg: 5.277 ± 0.079	4.04GlySer: 4.04 ± 0.108	3.503GlyThr: 3.503 ± 0.092	5.678GlyVal: 5.678 ± 0.075	1.117GlyTrp: 1.117 ± 0.042	2.607GlyTyr: 2.607 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	1.363HisAla: 1.363 ± 0.043	0.351HisCys: 0.351 ± 0.021	0.957HisAsp: 0.957 ± 0.036	0.99HisGlu: 0.99 ± 0.031	1.008HisPhe: 1.008 ± 0.032	1.571HisGly: 1.571 ± 0.056	0.63HisHis: 0.63 ± 0.029	1.234HisIle: 1.234 ± 0.043	0.715HisLys: 0.715 ± 0.028	2.849HisLeu: 2.849 ± 0.065	0.36HisMet: 0.36 ± 0.018	0.717HisAsn: 0.717 ± 0.029	1.5HisPro: 1.5 ± 0.043	0.993HisGln: 0.993 ± 0.032	1.534HisArg: 1.534 ± 0.038	0.981HisSer: 0.981 ± 0.03	1.008HisThr: 1.008 ± 0.032	1.025HisVal: 1.025 ± 0.034	0.307HisTrp: 0.307 ± 0.023	0.84HisTyr: 0.84 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.2IleAla: 5.2 ± 0.083	0.837IleCys: 0.837 ± 0.032	3.257IleAsp: 3.257 ± 0.063	3.34IleGlu: 3.34 ± 0.064	2.769IlePhe: 2.769 ± 0.066	4.498IleGly: 4.498 ± 0.07	1.264IleHis: 1.264 ± 0.039	4.487IleIle: 4.487 ± 0.077	2.999IleLys: 2.999 ± 0.074	6.787IleLeu: 6.787 ± 0.112	1.384IleMet: 1.384 ± 0.043	2.442IleAsn: 2.442 ± 0.068	3.321IlePro: 3.321 ± 0.061	2.221IleGln: 2.221 ± 0.054	3.764IleArg: 3.764 ± 0.064	3.849IleSer: 3.849 ± 0.064	3.399IleThr: 3.399 ± 0.064	3.853IleVal: 3.853 ± 0.086	0.693IleTrp: 0.693 ± 0.028	1.85IleTyr: 1.85 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	4.059LysAla: 4.059 ± 0.073	0.391LysCys: 0.391 ± 0.019	2.236LysAsp: 2.236 ± 0.06	3.333LysGlu: 3.333 ± 0.078	1.593LysPhe: 1.593 ± 0.048	3.121LysGly: 3.121 ± 0.056	0.745LysHis: 0.745 ± 0.028	3.419LysIle: 3.419 ± 0.07	3.232LysLys: 3.232 ± 0.078	4.304LysLeu: 4.304 ± 0.071	1.147LysMet: 1.147 ± 0.035	1.842LysAsn: 1.842 ± 0.049	2.3LysPro: 2.3 ± 0.06	1.624LysGln: 1.624 ± 0.047	2.554LysArg: 2.554 ± 0.058	2.265LysSer: 2.265 ± 0.052	2.667LysThr: 2.667 ± 0.061	3.31LysVal: 3.31 ± 0.069	0.401LysTrp: 0.401 ± 0.022	1.348LysTyr: 1.348 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	12.309LeuAla: 12.309 ± 0.137	1.282LeuCys: 1.282 ± 0.038	5.403LeuAsp: 5.403 ± 0.094	7.467LeuGlu: 7.467 ± 0.12	4.248LeuPhe: 4.248 ± 0.074	8.798LeuGly: 8.798 ± 0.125	2.152LeuHis: 2.152 ± 0.053	6.625LeuIle: 6.625 ± 0.102	5.761LeuLys: 5.761 ± 0.085	12.17LeuLeu: 12.17 ± 0.169	2.419LeuMet: 2.419 ± 0.06	3.843LeuAsn: 3.843 ± 0.069	6.176LeuPro: 6.176 ± 0.091	4.708LeuGln: 4.708 ± 0.085	6.88LeuArg: 6.88 ± 0.11	6.576LeuSer: 6.576 ± 0.097	6.628LeuThr: 6.628 ± 0.099	7.452LeuVal: 7.452 ± 0.103	1.303LeuTrp: 1.303 ± 0.041	2.862LeuTyr: 2.862 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	2.619MetAla: 2.619 ± 0.05	0.161MetCys: 0.161 ± 0.013	0.986MetAsp: 0.986 ± 0.036	1.418MetGlu: 1.418 ± 0.038	0.665MetPhe: 0.665 ± 0.029	1.758MetGly: 1.758 ± 0.049	0.418MetHis: 0.418 ± 0.019	1.332MetIle: 1.332 ± 0.043	1.176MetLys: 1.176 ± 0.039	2.28MetLeu: 2.28 ± 0.057	0.519MetMet: 0.519 ± 0.026	0.816MetAsn: 0.816 ± 0.03	1.193MetPro: 1.193 ± 0.033	0.953MetGln: 0.953 ± 0.034	1.258MetArg: 1.258 ± 0.043	1.223MetSer: 1.223 ± 0.038	1.267MetThr: 1.267 ± 0.043	1.724MetVal: 1.724 ± 0.044	0.174MetTrp: 0.174 ± 0.014	0.45MetTyr: 0.45 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.266AsnAla: 2.266 ± 0.066	0.433AsnCys: 0.433 ± 0.024	1.303AsnAsp: 1.303 ± 0.039	1.419AsnGlu: 1.419 ± 0.044	1.508AsnPhe: 1.508 ± 0.042	1.914AsnGly: 1.914 ± 0.057	0.72AsnHis: 0.72 ± 0.028	2.362AsnIle: 2.362 ± 0.061	1.206AsnLys: 1.206 ± 0.042	4.464AsnLeu: 4.464 ± 0.069	0.629AsnMet: 0.629 ± 0.026	1.154AsnAsn: 1.154 ± 0.045	2.312AsnPro: 2.312 ± 0.045	1.37AsnGln: 1.37 ± 0.044	2.237AsnArg: 2.237 ± 0.054	1.435AsnSer: 1.435 ± 0.042	1.451AsnThr: 1.451 ± 0.043	1.905AsnVal: 1.905 ± 0.047	0.462AsnTrp: 0.462 ± 0.022	1.263AsnTyr: 1.263 ± 0.044	0.0AsnXaa: 0.0 ± 0.0
Pro	4.305ProAla: 4.305 ± 0.067	0.525ProCys: 0.525 ± 0.025	3.05ProAsp: 3.05 ± 0.06	4.584ProGlu: 4.584 ± 0.084	2.014ProPhe: 2.014 ± 0.052	4.261ProGly: 4.261 ± 0.074	1.144ProHis: 1.144 ± 0.031	2.419ProIle: 2.419 ± 0.057	2.096ProLys: 2.096 ± 0.054	5.425ProLeu: 5.425 ± 0.086	1.03ProMet: 1.03 ± 0.031	1.409ProAsn: 1.409 ± 0.043	2.974ProPro: 2.974 ± 0.07	2.326ProGln: 2.326 ± 0.053	2.679ProArg: 2.679 ± 0.054	2.402ProSer: 2.402 ± 0.058	2.372ProThr: 2.372 ± 0.053	3.905ProVal: 3.905 ± 0.069	0.726ProTrp: 0.726 ± 0.027	1.546ProTyr: 1.546 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	4.726GlnAla: 4.726 ± 0.071	0.413GlnCys: 0.413 ± 0.023	2.071GlnAsp: 2.071 ± 0.056	3.699GlnGlu: 3.699 ± 0.077	1.22GlnPhe: 1.22 ± 0.036	3.419GlnGly: 3.419 ± 0.066	0.801GlnHis: 0.801 ± 0.03	2.555GlnIle: 2.555 ± 0.048	2.114GlnLys: 2.114 ± 0.06	3.743GlnLeu: 3.743 ± 0.064	0.939GlnMet: 0.939 ± 0.032	1.186GlnAsn: 1.186 ± 0.034	2.033GlnPro: 2.033 ± 0.047	2.027GlnGln: 2.027 ± 0.055	2.703GlnArg: 2.703 ± 0.052	1.97GlnSer: 1.97 ± 0.066	2.234GlnThr: 2.234 ± 0.053	3.428GlnVal: 3.428 ± 0.059	0.46GlnTrp: 0.46 ± 0.023	0.964GlnTyr: 0.964 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	4.432ArgAla: 4.432 ± 0.079	0.74ArgCys: 0.74 ± 0.03	2.81ArgAsp: 2.81 ± 0.055	4.471ArgGlu: 4.471 ± 0.08	2.937ArgPhe: 2.937 ± 0.059	4.069ArgGly: 4.069 ± 0.075	1.53ArgHis: 1.53 ± 0.038	3.613ArgIle: 3.613 ± 0.068	2.512ArgLys: 2.512 ± 0.054	9.102ArgLeu: 9.102 ± 0.129	1.376ArgMet: 1.376 ± 0.045	1.75ArgAsn: 1.75 ± 0.05	3.136ArgPro: 3.136 ± 0.067	4.023ArgGln: 4.023 ± 0.077	5.236ArgArg: 5.236 ± 0.108	3.062ArgSer: 3.062 ± 0.059	2.689ArgThr: 2.689 ± 0.061	3.976ArgVal: 3.976 ± 0.077	0.834ArgTrp: 0.834 ± 0.032	2.145ArgTyr: 2.145 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	3.925SerAla: 3.925 ± 0.07	0.669SerCys: 0.669 ± 0.028	2.31SerAsp: 2.31 ± 0.055	2.85SerGlu: 2.85 ± 0.052	2.24SerPhe: 2.24 ± 0.051	4.803SerGly: 4.803 ± 0.102	1.19SerHis: 1.19 ± 0.036	2.776SerIle: 2.776 ± 0.066	1.894SerLys: 1.894 ± 0.051	6.487SerLeu: 6.487 ± 0.098	1.144SerMet: 1.144 ± 0.035	1.372SerAsn: 1.372 ± 0.04	3.12SerPro: 3.12 ± 0.053	2.352SerGln: 2.352 ± 0.058	3.792SerArg: 3.792 ± 0.061	2.918SerSer: 2.918 ± 0.067	2.328SerThr: 2.328 ± 0.049	3.206SerVal: 3.206 ± 0.066	0.85SerTrp: 0.85 ± 0.034	1.73SerTyr: 1.73 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	4.643ThrAla: 4.643 ± 0.075	0.593ThrCys: 0.593 ± 0.027	2.308ThrAsp: 2.308 ± 0.052	2.706ThrGlu: 2.706 ± 0.055	2.055ThrPhe: 2.055 ± 0.05	4.663ThrGly: 4.663 ± 0.107	0.983ThrHis: 0.983 ± 0.033	3.087ThrIle: 3.087 ± 0.063	1.73ThrLys: 1.73 ± 0.044	5.785ThrLeu: 5.785 ± 0.082	1.042ThrMet: 1.042 ± 0.035	1.348ThrAsn: 1.348 ± 0.039	3.204ThrPro: 3.204 ± 0.062	1.575ThrGln: 1.575 ± 0.045	2.625ThrArg: 2.625 ± 0.054	2.508ThrSer: 2.508 ± 0.054	2.514ThrThr: 2.514 ± 0.059	3.649ThrVal: 3.649 ± 0.066	0.619ThrTrp: 0.619 ± 0.027	1.496ThrTyr: 1.496 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	6.241ValAla: 6.241 ± 0.093	0.962ValCys: 0.962 ± 0.039	3.45ValAsp: 3.45 ± 0.065	4.322ValGlu: 4.322 ± 0.077	2.873ValPhe: 2.873 ± 0.056	5.252ValGly: 5.252 ± 0.084	1.319ValHis: 1.319 ± 0.036	4.699ValIle: 4.699 ± 0.079	3.276ValLys: 3.276 ± 0.069	7.334ValLeu: 7.334 ± 0.097	1.609ValMet: 1.609 ± 0.042	2.264ValAsn: 2.264 ± 0.05	2.782ValPro: 2.782 ± 0.053	2.555ValGln: 2.555 ± 0.056	4.218ValArg: 4.218 ± 0.074	3.78ValSer: 3.78 ± 0.059	3.441ValThr: 3.441 ± 0.07	5.257ValVal: 5.257 ± 0.099	0.81ValTrp: 0.81 ± 0.03	1.934ValTyr: 1.934 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.902TrpAla: 0.902 ± 0.034	0.156TrpCys: 0.156 ± 0.012	0.557TrpAsp: 0.557 ± 0.023	0.855TrpGlu: 0.855 ± 0.03	0.51TrpPhe: 0.51 ± 0.023	1.099TrpGly: 1.099 ± 0.034	0.305TrpHis: 0.305 ± 0.02	0.648TrpIle: 0.648 ± 0.027	0.495TrpLys: 0.495 ± 0.022	1.622TrpLeu: 1.622 ± 0.053	0.249TrpMet: 0.249 ± 0.015	0.363TrpAsn: 0.363 ± 0.02	0.646TrpPro: 0.646 ± 0.028	0.76TrpGln: 0.76 ± 0.029	1.14TrpArg: 1.14 ± 0.037	0.614TrpSer: 0.614 ± 0.032	0.517TrpThr: 0.517 ± 0.026	0.753TrpVal: 0.753 ± 0.031	0.21TrpTrp: 0.21 ± 0.015	0.345TrpTyr: 0.345 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.158TyrAla: 2.158 ± 0.052	0.442TyrCys: 0.442 ± 0.024	1.717TyrAsp: 1.717 ± 0.051	1.592TyrGlu: 1.592 ± 0.043	1.477TyrPhe: 1.477 ± 0.045	2.439TyrGly: 2.439 ± 0.054	0.783TyrHis: 0.783 ± 0.031	1.55TyrIle: 1.55 ± 0.045	1.055TyrLys: 1.055 ± 0.035	3.957TyrLeu: 3.957 ± 0.071	0.481TyrMet: 0.481 ± 0.021	1.097TyrAsn: 1.097 ± 0.042	1.636TyrPro: 1.636 ± 0.044	1.624TyrGln: 1.624 ± 0.044	2.287TyrArg: 2.287 ± 0.055	1.505TyrSer: 1.505 ± 0.049	1.337TyrThr: 1.337 ± 0.04	1.667TyrVal: 1.667 ± 0.043	0.438TyrTrp: 0.438 ± 0.025	1.189TyrTyr: 1.189 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2859 proteins (919224 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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