Amino acid dipepetide frequency for Methanolobus tindarius DSM 2278

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.357AlaAla: 5.357 ± 0.115	0.854AlaCys: 0.854 ± 0.035	4.233AlaAsp: 4.233 ± 0.084	4.869AlaGlu: 4.869 ± 0.084	2.735AlaPhe: 2.735 ± 0.061	5.344AlaGly: 5.344 ± 0.083	1.124AlaHis: 1.124 ± 0.037	5.7AlaIle: 5.7 ± 0.084	3.988AlaLys: 3.988 ± 0.074	6.203AlaLeu: 6.203 ± 0.095	2.068AlaMet: 2.068 ± 0.053	2.733AlaAsn: 2.733 ± 0.06	1.993AlaPro: 1.993 ± 0.047	1.606AlaGln: 1.606 ± 0.054	2.704AlaArg: 2.704 ± 0.061	4.684AlaSer: 4.684 ± 0.068	3.52AlaThr: 3.52 ± 0.072	5.224AlaVal: 5.224 ± 0.091	0.494AlaTrp: 0.494 ± 0.024	2.173AlaTyr: 2.173 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.698CysAla: 0.698 ± 0.028	0.203CysCys: 0.203 ± 0.017	0.744CysAsp: 0.744 ± 0.033	0.696CysGlu: 0.696 ± 0.031	0.418CysPhe: 0.418 ± 0.022	1.166CysGly: 1.166 ± 0.045	0.303CysHis: 0.303 ± 0.023	0.925CysIle: 0.925 ± 0.04	0.706CysLys: 0.706 ± 0.032	0.855CysLeu: 0.855 ± 0.032	0.323CysMet: 0.323 ± 0.019	0.563CysAsn: 0.563 ± 0.029	0.718CysPro: 0.718 ± 0.036	0.257CysGln: 0.257 ± 0.017	0.516CysArg: 0.516 ± 0.026	0.824CysSer: 0.824 ± 0.03	0.657CysThr: 0.657 ± 0.025	0.722CysVal: 0.722 ± 0.033	0.083CysTrp: 0.083 ± 0.01	0.379CysTyr: 0.379 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	4.22AspAla: 4.22 ± 0.098	0.645AspCys: 0.645 ± 0.028	3.997AspAsp: 3.997 ± 0.085	5.381AspGlu: 5.381 ± 0.091	2.883AspPhe: 2.883 ± 0.057	4.282AspGly: 4.282 ± 0.099	0.909AspHis: 0.909 ± 0.037	6.198AspIle: 6.198 ± 0.088	3.505AspLys: 3.505 ± 0.068	5.38AspLeu: 5.38 ± 0.08	2.016AspMet: 2.016 ± 0.049	2.924AspAsn: 2.924 ± 0.067	2.329AspPro: 2.329 ± 0.054	1.096AspGln: 1.096 ± 0.03	2.335AspArg: 2.335 ± 0.059	4.494AspSer: 4.494 ± 0.098	3.302AspThr: 3.302 ± 0.07	5.031AspVal: 5.031 ± 0.088	0.538AspTrp: 0.538 ± 0.025	2.492AspTyr: 2.492 ± 0.065	0.0AspXaa: 0.0 ± 0.0
Glu	4.803GluAla: 4.803 ± 0.105	0.777GluCys: 0.777 ± 0.031	4.552GluAsp: 4.552 ± 0.079	6.53GluGlu: 6.53 ± 0.12	2.92GluPhe: 2.92 ± 0.063	4.44GluGly: 4.44 ± 0.074	1.38GluHis: 1.38 ± 0.033	6.517GluIle: 6.517 ± 0.093	5.866GluLys: 5.866 ± 0.1	7.368GluLeu: 7.368 ± 0.104	2.794GluMet: 2.794 ± 0.063	4.417GluAsn: 4.417 ± 0.081	2.267GluPro: 2.267 ± 0.057	2.162GluGln: 2.162 ± 0.055	2.961GluArg: 2.961 ± 0.069	4.625GluSer: 4.625 ± 0.079	3.95GluThr: 3.95 ± 0.075	4.933GluVal: 4.933 ± 0.079	0.71GluTrp: 0.71 ± 0.032	2.886GluTyr: 2.886 ± 0.059	0.0GluXaa: 0.0 ± 0.0
Phe	2.832PheAla: 2.832 ± 0.062	0.478PheCys: 0.478 ± 0.024	2.74PheAsp: 2.74 ± 0.056	2.865PheGlu: 2.865 ± 0.053	1.795PhePhe: 1.795 ± 0.063	2.906PheGly: 2.906 ± 0.056	0.651PheHis: 0.651 ± 0.023	3.159PheIle: 3.159 ± 0.07	2.23PheLys: 2.23 ± 0.051	3.573PheLeu: 3.573 ± 0.081	1.13PheMet: 1.13 ± 0.039	1.791PheAsn: 1.791 ± 0.049	1.343PhePro: 1.343 ± 0.038	0.928PheGln: 0.928 ± 0.036	1.531PheArg: 1.531 ± 0.042	3.335PheSer: 3.335 ± 0.07	2.587PheThr: 2.587 ± 0.068	2.99PheVal: 2.99 ± 0.064	0.386PheTrp: 0.386 ± 0.02	1.542PheTyr: 1.542 ± 0.045	0.001PheXaa: 0.001 ± 0.001
Gly	4.445GlyAla: 4.445 ± 0.09	0.986GlyCys: 0.986 ± 0.04	4.055GlyAsp: 4.055 ± 0.094	4.59GlyGlu: 4.59 ± 0.073	3.097GlyPhe: 3.097 ± 0.062	4.468GlyGly: 4.468 ± 0.083	1.246GlyHis: 1.246 ± 0.041	6.316GlyIle: 6.316 ± 0.089	4.897GlyLys: 4.897 ± 0.089	5.704GlyLeu: 5.704 ± 0.098	2.195GlyMet: 2.195 ± 0.048	3.37GlyAsn: 3.37 ± 0.083	1.726GlyPro: 1.726 ± 0.044	1.605GlyGln: 1.605 ± 0.042	2.421GlyArg: 2.421 ± 0.056	4.843GlySer: 4.843 ± 0.098	4.424GlyThr: 4.424 ± 0.078	4.919GlyVal: 4.919 ± 0.08	0.684GlyTrp: 0.684 ± 0.029	2.715GlyTyr: 2.715 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	1.211HisAla: 1.211 ± 0.036	0.28HisCys: 0.28 ± 0.019	1.145HisAsp: 1.145 ± 0.036	1.338HisGlu: 1.338 ± 0.044	0.76HisPhe: 0.76 ± 0.027	1.297HisGly: 1.297 ± 0.04	0.404HisHis: 0.404 ± 0.026	1.486HisIle: 1.486 ± 0.043	0.939HisLys: 0.939 ± 0.036	1.559HisLeu: 1.559 ± 0.043	0.507HisMet: 0.507 ± 0.025	0.766HisAsn: 0.766 ± 0.032	0.861HisPro: 0.861 ± 0.03	0.422HisGln: 0.422 ± 0.022	0.747HisArg: 0.747 ± 0.03	1.144HisSer: 1.144 ± 0.032	0.866HisThr: 0.866 ± 0.035	1.278HisVal: 1.278 ± 0.04	0.168HisTrp: 0.168 ± 0.015	0.685HisTyr: 0.685 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.994IleAla: 5.994 ± 0.09	0.955IleCys: 0.955 ± 0.037	5.49IleAsp: 5.49 ± 0.084	6.306IleGlu: 6.306 ± 0.093	3.327IlePhe: 3.327 ± 0.082	5.839IleGly: 5.839 ± 0.09	1.468IleHis: 1.468 ± 0.048	6.527IleIle: 6.527 ± 0.109	4.708IleLys: 4.708 ± 0.087	7.428IleLeu: 7.428 ± 0.111	2.116IleMet: 2.116 ± 0.047	3.636IleAsn: 3.636 ± 0.074	3.441IlePro: 3.441 ± 0.061	1.906IleGln: 1.906 ± 0.046	3.197IleArg: 3.197 ± 0.069	6.402IleSer: 6.402 ± 0.074	4.852IleThr: 4.852 ± 0.075	5.88IleVal: 5.88 ± 0.089	0.604IleTrp: 0.604 ± 0.027	2.568IleTyr: 2.568 ± 0.067	0.0IleXaa: 0.0 ± 0.0
Lys	4.156LysAla: 4.156 ± 0.089	0.75LysCys: 0.75 ± 0.034	3.998LysAsp: 3.998 ± 0.078	5.472LysGlu: 5.472 ± 0.106	1.986LysPhe: 1.986 ± 0.046	3.787LysGly: 3.787 ± 0.08	1.187LysHis: 1.187 ± 0.038	5.016LysIle: 5.016 ± 0.094	5.044LysLys: 5.044 ± 0.107	5.241LysLeu: 5.241 ± 0.08	2.02LysMet: 2.02 ± 0.047	3.223LysAsn: 3.223 ± 0.067	2.055LysPro: 2.055 ± 0.057	1.817LysGln: 1.817 ± 0.052	2.623LysArg: 2.623 ± 0.067	3.768LysSer: 3.768 ± 0.064	3.406LysThr: 3.406 ± 0.067	4.185LysVal: 4.185 ± 0.073	0.602LysTrp: 0.602 ± 0.024	2.284LysTyr: 2.284 ± 0.053	0.0LysXaa: 0.0 ± 0.0
Leu	6.422LeuAla: 6.422 ± 0.103	0.995LeuCys: 0.995 ± 0.036	5.645LeuAsp: 5.645 ± 0.088	6.771LeuGlu: 6.771 ± 0.105	3.681LeuPhe: 3.681 ± 0.091	5.631LeuGly: 5.631 ± 0.097	1.556LeuHis: 1.556 ± 0.042	6.99LeuIle: 6.99 ± 0.096	6.004LeuLys: 6.004 ± 0.1	8.309LeuLeu: 8.309 ± 0.146	2.517LeuMet: 2.517 ± 0.054	4.174LeuAsn: 4.174 ± 0.076	3.307LeuPro: 3.307 ± 0.065	2.252LeuGln: 2.252 ± 0.052	3.364LeuArg: 3.364 ± 0.065	6.592LeuSer: 6.592 ± 0.091	4.518LeuThr: 4.518 ± 0.079	6.027LeuVal: 6.027 ± 0.084	0.67LeuTrp: 0.67 ± 0.029	2.653LeuTyr: 2.653 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	2.186MetAla: 2.186 ± 0.05	0.347MetCys: 0.347 ± 0.023	1.994MetAsp: 1.994 ± 0.046	2.337MetGlu: 2.337 ± 0.052	1.026MetPhe: 1.026 ± 0.036	2.097MetGly: 2.097 ± 0.049	0.573MetHis: 0.573 ± 0.023	2.052MetIle: 2.052 ± 0.046	2.125MetLys: 2.125 ± 0.048	2.689MetLeu: 2.689 ± 0.053	0.925MetMet: 0.925 ± 0.032	1.501MetAsn: 1.501 ± 0.042	1.127MetPro: 1.127 ± 0.043	0.986MetGln: 0.986 ± 0.037	1.192MetArg: 1.192 ± 0.039	2.027MetSer: 2.027 ± 0.048	1.615MetThr: 1.615 ± 0.042	2.006MetVal: 2.006 ± 0.051	0.228MetTrp: 0.228 ± 0.015	0.863MetTyr: 0.863 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	3.071AsnAla: 3.071 ± 0.068	0.547AsnCys: 0.547 ± 0.027	2.804AsnAsp: 2.804 ± 0.066	3.468AsnGlu: 3.468 ± 0.072	1.672AsnPhe: 1.672 ± 0.048	3.23AsnGly: 3.23 ± 0.08	0.715AsnHis: 0.715 ± 0.031	4.327AsnIle: 4.327 ± 0.078	2.687AsnLys: 2.687 ± 0.062	3.899AsnLeu: 3.899 ± 0.066	1.458AsnMet: 1.458 ± 0.041	2.5AsnAsn: 2.5 ± 0.081	2.18AsnPro: 2.18 ± 0.057	1.1AsnGln: 1.1 ± 0.039	1.671AsnArg: 1.671 ± 0.046	3.492AsnSer: 3.492 ± 0.087	2.572AsnThr: 2.572 ± 0.073	3.529AsnVal: 3.529 ± 0.08	0.45AsnTrp: 0.45 ± 0.025	1.722AsnTyr: 1.722 ± 0.044	0.0AsnXaa: 0.0 ± 0.0
Pro	2.416ProAla: 2.416 ± 0.058	0.416ProCys: 0.416 ± 0.024	2.861ProAsp: 2.861 ± 0.072	3.797ProGlu: 3.797 ± 0.074	1.606ProPhe: 1.606 ± 0.05	2.501ProGly: 2.501 ± 0.057	0.69ProHis: 0.69 ± 0.034	2.461ProIle: 2.461 ± 0.05	1.635ProLys: 1.635 ± 0.043	3.126ProLeu: 3.126 ± 0.066	0.873ProMet: 0.873 ± 0.028	1.133ProAsn: 1.133 ± 0.039	1.039ProPro: 1.039 ± 0.047	1.009ProGln: 1.009 ± 0.031	1.103ProArg: 1.103 ± 0.032	2.239ProSer: 2.239 ± 0.058	1.748ProThr: 1.748 ± 0.045	3.41ProVal: 3.41 ± 0.059	0.316ProTrp: 0.316 ± 0.021	1.271ProTyr: 1.271 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	1.663GlnAla: 1.663 ± 0.048	0.283GlnCys: 0.283 ± 0.018	1.454GlnAsp: 1.454 ± 0.041	2.08GlnGlu: 2.08 ± 0.054	0.925GlnPhe: 0.925 ± 0.031	1.475GlnGly: 1.475 ± 0.046	0.442GlnHis: 0.442 ± 0.022	2.02GlnIle: 2.02 ± 0.048	1.901GlnLys: 1.901 ± 0.042	2.185GlnLeu: 2.185 ± 0.05	0.929GlnMet: 0.929 ± 0.03	1.31GlnAsn: 1.31 ± 0.041	0.724GlnPro: 0.724 ± 0.03	0.863GlnGln: 0.863 ± 0.043	1.125GlnArg: 1.125 ± 0.036	1.557GlnSer: 1.557 ± 0.047	1.336GlnThr: 1.336 ± 0.043	1.629GlnVal: 1.629 ± 0.045	0.258GlnTrp: 0.258 ± 0.016	0.983GlnTyr: 0.983 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.52ArgAla: 2.52 ± 0.065	0.44ArgCys: 0.44 ± 0.021	2.408ArgAsp: 2.408 ± 0.064	3.017ArgGlu: 3.017 ± 0.067	1.553ArgPhe: 1.553 ± 0.042	2.287ArgGly: 2.287 ± 0.052	0.717ArgHis: 0.717 ± 0.031	3.29ArgIle: 3.29 ± 0.065	3.152ArgLys: 3.152 ± 0.064	3.15ArgLeu: 3.15 ± 0.068	1.274ArgMet: 1.274 ± 0.041	1.996ArgAsn: 1.996 ± 0.05	1.247ArgPro: 1.247 ± 0.035	1.052ArgGln: 1.052 ± 0.036	1.684ArgArg: 1.684 ± 0.049	2.406ArgSer: 2.406 ± 0.055	2.043ArgThr: 2.043 ± 0.049	2.483ArgVal: 2.483 ± 0.055	0.347ArgTrp: 0.347 ± 0.021	1.475ArgTyr: 1.475 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	4.292SerAla: 4.292 ± 0.095	0.76SerCys: 0.76 ± 0.03	4.422SerAsp: 4.422 ± 0.091	5.18SerGlu: 5.18 ± 0.083	3.078SerPhe: 3.078 ± 0.063	5.766SerGly: 5.766 ± 0.105	1.282SerHis: 1.282 ± 0.033	5.778SerIle: 5.778 ± 0.082	4.082SerLys: 4.082 ± 0.083	6.098SerLeu: 6.098 ± 0.091	2.074SerMet: 2.074 ± 0.045	3.175SerAsn: 3.175 ± 0.075	2.481SerPro: 2.481 ± 0.05	1.837SerGln: 1.837 ± 0.047	2.834SerArg: 2.834 ± 0.063	6.059SerSer: 6.059 ± 0.148	3.878SerThr: 3.878 ± 0.095	4.943SerVal: 4.943 ± 0.094	0.63SerTrp: 0.63 ± 0.033	2.599SerTyr: 2.599 ± 0.076	0.0SerXaa: 0.0 ± 0.0
Thr	3.717ThrAla: 3.717 ± 0.061	0.591ThrCys: 0.591 ± 0.026	3.652ThrAsp: 3.652 ± 0.069	3.954ThrGlu: 3.954 ± 0.075	2.267ThrPhe: 2.267 ± 0.059	4.671ThrGly: 4.671 ± 0.078	1.058ThrHis: 1.058 ± 0.032	4.855ThrIle: 4.855 ± 0.091	2.725ThrLys: 2.725 ± 0.06	4.856ThrLeu: 4.856 ± 0.083	1.325ThrMet: 1.325 ± 0.038	2.267ThrAsn: 2.267 ± 0.056	2.312ThrPro: 2.312 ± 0.06	1.253ThrGln: 1.253 ± 0.04	2.028ThrArg: 2.028 ± 0.044	3.818ThrSer: 3.818 ± 0.09	3.161ThrThr: 3.161 ± 0.071	4.257ThrVal: 4.257 ± 0.105	0.482ThrTrp: 0.482 ± 0.029	2.041ThrTyr: 2.041 ± 0.066	0.0ThrXaa: 0.0 ± 0.0
Val	4.993ValAla: 4.993 ± 0.093	0.895ValCys: 0.895 ± 0.034	4.646ValAsp: 4.646 ± 0.077	5.146ValGlu: 5.146 ± 0.078	3.108ValPhe: 3.108 ± 0.064	4.464ValGly: 4.464 ± 0.08	1.302ValHis: 1.302 ± 0.039	5.756ValIle: 5.756 ± 0.08	4.137ValLys: 4.137 ± 0.071	6.542ValLeu: 6.542 ± 0.106	2.051ValMet: 2.051 ± 0.048	3.303ValAsn: 3.303 ± 0.091	2.854ValPro: 2.854 ± 0.059	1.757ValGln: 1.757 ± 0.05	2.746ValArg: 2.746 ± 0.064	5.508ValSer: 5.508 ± 0.105	4.331ValThr: 4.331 ± 0.083	5.36ValVal: 5.36 ± 0.094	0.619ValTrp: 0.619 ± 0.025	2.323ValTyr: 2.323 ± 0.059	0.001ValXaa: 0.001 ± 0.001
Trp	0.423TrpAla: 0.423 ± 0.023	0.101TrpCys: 0.101 ± 0.011	0.641TrpAsp: 0.641 ± 0.032	0.589TrpGlu: 0.589 ± 0.032	0.383TrpPhe: 0.383 ± 0.023	0.554TrpGly: 0.554 ± 0.027	0.161TrpHis: 0.161 ± 0.013	0.784TrpIle: 0.784 ± 0.03	0.62TrpLys: 0.62 ± 0.025	0.775TrpLeu: 0.775 ± 0.032	0.313TrpMet: 0.313 ± 0.019	0.542TrpAsn: 0.542 ± 0.024	0.19TrpPro: 0.19 ± 0.015	0.243TrpGln: 0.243 ± 0.016	0.278TrpArg: 0.278 ± 0.019	0.547TrpSer: 0.547 ± 0.026	0.557TrpThr: 0.557 ± 0.037	0.594TrpVal: 0.594 ± 0.028	0.121TrpTrp: 0.121 ± 0.011	0.374TrpTyr: 0.374 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.187TyrAla: 2.187 ± 0.053	0.455TyrCys: 0.455 ± 0.024	2.478TyrAsp: 2.478 ± 0.074	2.472TyrGlu: 2.472 ± 0.055	1.57TyrPhe: 1.57 ± 0.049	2.497TyrGly: 2.497 ± 0.057	0.693TyrHis: 0.693 ± 0.029	2.494TyrIle: 2.494 ± 0.055	1.669TyrLys: 1.669 ± 0.05	3.135TyrLeu: 3.135 ± 0.066	0.987TyrMet: 0.987 ± 0.036	1.769TyrAsn: 1.769 ± 0.053	1.457TyrPro: 1.457 ± 0.045	0.992TyrGln: 0.992 ± 0.032	1.478TyrArg: 1.478 ± 0.041	2.888TyrSer: 2.888 ± 0.074	1.97TyrThr: 1.97 ± 0.055	2.441TyrVal: 2.441 ± 0.055	0.399TyrTrp: 0.399 ± 0.025	1.572TyrTyr: 1.572 ± 0.058	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 2912 proteins (910742 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---