Amino acid dipepetide frequency for Thielaviopsis punctulata

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.878AlaAla: 12.878 ± 0.137	0.984AlaCys: 0.984 ± 0.02	5.011AlaAsp: 5.011 ± 0.044	5.819AlaGlu: 5.819 ± 0.063	3.121AlaPhe: 3.121 ± 0.037	6.419AlaGly: 6.419 ± 0.064	2.014AlaHis: 2.014 ± 0.03	4.172AlaIle: 4.172 ± 0.04	4.521AlaLys: 4.521 ± 0.062	8.336AlaLeu: 8.336 ± 0.064	2.451AlaMet: 2.451 ± 0.03	3.172AlaAsn: 3.172 ± 0.036	5.823AlaPro: 5.823 ± 0.074	3.915AlaGln: 3.915 ± 0.068	5.505AlaArg: 5.505 ± 0.056	8.263AlaSer: 8.263 ± 0.068	6.069AlaThr: 6.069 ± 0.053	6.336AlaVal: 6.336 ± 0.057	1.089AlaTrp: 1.089 ± 0.019	2.181AlaTyr: 2.181 ± 0.031	0.0AlaXaa: 0.0 ± 0.0
Cys	0.917CysAla: 0.917 ± 0.02	0.188CysCys: 0.188 ± 0.008	0.605CysAsp: 0.605 ± 0.014	0.552CysGlu: 0.552 ± 0.015	0.489CysPhe: 0.489 ± 0.015	0.856CysGly: 0.856 ± 0.02	0.285CysHis: 0.285 ± 0.011	0.635CysIle: 0.635 ± 0.015	0.5CysLys: 0.5 ± 0.015	1.082CysLeu: 1.082 ± 0.024	0.28CysMet: 0.28 ± 0.01	0.399CysAsn: 0.399 ± 0.013	0.571CysPro: 0.571 ± 0.018	0.356CysGln: 0.356 ± 0.012	0.609CysArg: 0.609 ± 0.016	0.809CysSer: 0.809 ± 0.019	0.631CysThr: 0.631 ± 0.016	0.733CysVal: 0.733 ± 0.015	0.161CysTrp: 0.161 ± 0.007	0.311CysTyr: 0.311 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	5.381AspAla: 5.381 ± 0.048	0.581AspCys: 0.581 ± 0.016	4.636AspAsp: 4.636 ± 0.068	4.544AspGlu: 4.544 ± 0.057	2.222AspPhe: 2.222 ± 0.03	3.954AspGly: 3.954 ± 0.04	1.145AspHis: 1.145 ± 0.024	2.991AspIle: 2.991 ± 0.036	2.512AspLys: 2.512 ± 0.033	4.851AspLeu: 4.851 ± 0.047	1.511AspMet: 1.511 ± 0.025	1.932AspAsn: 1.932 ± 0.029	3.06AspPro: 3.06 ± 0.035	1.646AspGln: 1.646 ± 0.023	2.93AspArg: 2.93 ± 0.058	4.278AspSer: 4.278 ± 0.047	2.765AspThr: 2.765 ± 0.034	3.847AspVal: 3.847 ± 0.037	0.74AspTrp: 0.74 ± 0.017	1.534AspTyr: 1.534 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	5.966GluAla: 5.966 ± 0.065	0.575GluCys: 0.575 ± 0.015	4.009GluAsp: 4.009 ± 0.054	5.468GluGlu: 5.468 ± 0.085	1.993GluPhe: 1.993 ± 0.028	3.251GluGly: 3.251 ± 0.038	1.229GluHis: 1.229 ± 0.021	2.914GluIle: 2.914 ± 0.037	3.801GluLys: 3.801 ± 0.051	4.907GluLeu: 4.907 ± 0.048	1.688GluMet: 1.688 ± 0.024	2.246GluAsn: 2.246 ± 0.029	2.61GluPro: 2.61 ± 0.039	2.286GluGln: 2.286 ± 0.034	3.813GluArg: 3.813 ± 0.048	4.121GluSer: 4.121 ± 0.045	3.469GluThr: 3.469 ± 0.045	3.493GluVal: 3.493 ± 0.038	0.866GluTrp: 0.866 ± 0.019	1.68GluTyr: 1.68 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	3.089PheAla: 3.089 ± 0.038	0.52PheCys: 0.52 ± 0.013	2.214PheAsp: 2.214 ± 0.03	2.039PheGlu: 2.039 ± 0.029	1.615PhePhe: 1.615 ± 0.03	2.778PheGly: 2.778 ± 0.041	0.845PheHis: 0.845 ± 0.017	1.653PheIle: 1.653 ± 0.028	1.535PheLys: 1.535 ± 0.026	3.255PheLeu: 3.255 ± 0.046	0.866PheMet: 0.866 ± 0.018	1.457PheAsn: 1.457 ± 0.024	1.794PhePro: 1.794 ± 0.026	1.216PheGln: 1.216 ± 0.021	1.896PheArg: 1.896 ± 0.029	3.111PheSer: 3.111 ± 0.037	2.101PheThr: 2.101 ± 0.029	2.454PheVal: 2.454 ± 0.032	0.562PheTrp: 0.562 ± 0.015	1.05PheTyr: 1.05 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	5.695GlyAla: 5.695 ± 0.058	0.746GlyCys: 0.746 ± 0.02	3.368GlyAsp: 3.368 ± 0.037	3.385GlyGlu: 3.385 ± 0.038	2.704GlyPhe: 2.704 ± 0.034	5.62GlyGly: 5.62 ± 0.08	1.612GlyHis: 1.612 ± 0.029	3.268GlyIle: 3.268 ± 0.038	3.303GlyLys: 3.303 ± 0.038	5.789GlyLeu: 5.789 ± 0.05	1.766GlyMet: 1.766 ± 0.031	2.374GlyAsn: 2.374 ± 0.035	3.272GlyPro: 3.272 ± 0.045	2.268GlyGln: 2.268 ± 0.028	4.004GlyArg: 4.004 ± 0.042	5.903GlySer: 5.903 ± 0.064	3.706GlyThr: 3.706 ± 0.039	4.447GlyVal: 4.447 ± 0.044	1.024GlyTrp: 1.024 ± 0.021	1.932GlyTyr: 1.932 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	1.931HisAla: 1.931 ± 0.029	0.27HisCys: 0.27 ± 0.011	1.296HisAsp: 1.296 ± 0.024	1.294HisGlu: 1.294 ± 0.021	0.855HisPhe: 0.855 ± 0.017	1.661HisGly: 1.661 ± 0.03	0.811HisHis: 0.811 ± 0.024	1.205HisIle: 1.205 ± 0.023	0.992HisLys: 0.992 ± 0.02	2.002HisLeu: 2.002 ± 0.027	0.616HisMet: 0.616 ± 0.015	0.882HisAsn: 0.882 ± 0.02	1.425HisPro: 1.425 ± 0.03	0.965HisGln: 0.965 ± 0.025	1.404HisArg: 1.404 ± 0.028	1.907HisSer: 1.907 ± 0.035	1.218HisThr: 1.218 ± 0.02	1.487HisVal: 1.487 ± 0.024	0.284HisTrp: 0.284 ± 0.01	0.663HisTyr: 0.663 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	4.063IleAla: 4.063 ± 0.043	0.646IleCys: 0.646 ± 0.016	2.928IleAsp: 2.928 ± 0.035	2.768IleGlu: 2.768 ± 0.034	1.776IlePhe: 1.776 ± 0.029	2.954IleGly: 2.954 ± 0.036	1.057IleHis: 1.057 ± 0.02	2.273IleIle: 2.273 ± 0.035	2.326IleLys: 2.326 ± 0.034	4.096IleLeu: 4.096 ± 0.042	1.202IleMet: 1.202 ± 0.022	1.823IleAsn: 1.823 ± 0.027	2.858IlePro: 2.858 ± 0.035	1.689IleGln: 1.689 ± 0.028	2.571IleArg: 2.571 ± 0.035	3.87IleSer: 3.87 ± 0.044	2.682IleThr: 2.682 ± 0.036	3.164IleVal: 3.164 ± 0.041	0.582IleTrp: 0.582 ± 0.016	1.258IleTyr: 1.258 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	4.787LysAla: 4.787 ± 0.062	0.456LysCys: 0.456 ± 0.013	2.692LysAsp: 2.692 ± 0.034	3.243LysGlu: 3.243 ± 0.048	1.507LysPhe: 1.507 ± 0.024	2.653LysGly: 2.653 ± 0.038	1.107LysHis: 1.107 ± 0.024	2.297LysIle: 2.297 ± 0.03	3.694LysLys: 3.694 ± 0.067	4.093LysLeu: 4.093 ± 0.044	1.184LysMet: 1.184 ± 0.023	1.813LysAsn: 1.813 ± 0.025	2.874LysPro: 2.874 ± 0.039	1.818LysGln: 1.818 ± 0.031	3.334LysArg: 3.334 ± 0.043	3.506LysSer: 3.506 ± 0.04	3.156LysThr: 3.156 ± 0.036	2.827LysVal: 2.827 ± 0.04	0.615LysTrp: 0.615 ± 0.014	1.351LysTyr: 1.351 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	8.492LeuAla: 8.492 ± 0.065	1.122LeuCys: 1.122 ± 0.022	5.047LeuAsp: 5.047 ± 0.05	5.142LeuGlu: 5.142 ± 0.057	3.155LeuPhe: 3.155 ± 0.041	5.578LeuGly: 5.578 ± 0.049	2.029LeuHis: 2.029 ± 0.029	3.63LeuIle: 3.63 ± 0.045	4.112LeuLys: 4.112 ± 0.043	7.783LeuLeu: 7.783 ± 0.069	1.974LeuMet: 1.974 ± 0.029	3.048LeuAsn: 3.048 ± 0.037	5.058LeuPro: 5.058 ± 0.047	3.556LeuGln: 3.556 ± 0.045	5.619LeuArg: 5.619 ± 0.057	7.128LeuSer: 7.128 ± 0.062	4.647LeuThr: 4.647 ± 0.046	5.604LeuVal: 5.604 ± 0.054	1.1LeuTrp: 1.1 ± 0.024	2.21LeuTyr: 2.21 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.781MetAla: 2.781 ± 0.032	0.267MetCys: 0.267 ± 0.009	1.453MetAsp: 1.453 ± 0.022	1.381MetGlu: 1.381 ± 0.023	0.884MetPhe: 0.884 ± 0.019	1.715MetGly: 1.715 ± 0.029	0.582MetHis: 0.582 ± 0.013	1.015MetIle: 1.015 ± 0.021	1.082MetLys: 1.082 ± 0.018	2.125MetLeu: 2.125 ± 0.03	0.712MetMet: 0.712 ± 0.019	0.861MetAsn: 0.861 ± 0.019	1.549MetPro: 1.549 ± 0.027	1.037MetGln: 1.037 ± 0.021	1.459MetArg: 1.459 ± 0.023	2.216MetSer: 2.216 ± 0.028	1.489MetThr: 1.489 ± 0.023	1.508MetVal: 1.508 ± 0.023	0.283MetTrp: 0.283 ± 0.01	0.657MetTyr: 0.657 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.199AsnAla: 3.199 ± 0.036	0.39AsnCys: 0.39 ± 0.012	2.027AsnAsp: 2.027 ± 0.03	1.955AsnGlu: 1.955 ± 0.031	1.341AsnPhe: 1.341 ± 0.023	2.753AsnGly: 2.753 ± 0.041	0.835AsnHis: 0.835 ± 0.017	1.944AsnIle: 1.944 ± 0.027	1.708AsnLys: 1.708 ± 0.023	3.008AsnLeu: 3.008 ± 0.039	1.059AsnMet: 1.059 ± 0.023	1.764AsnAsn: 1.764 ± 0.037	2.302AsnPro: 2.302 ± 0.029	1.241AsnGln: 1.241 ± 0.025	1.81AsnArg: 1.81 ± 0.027	2.953AsnSer: 2.953 ± 0.041	2.17AsnThr: 2.17 ± 0.031	2.348AsnVal: 2.348 ± 0.028	0.479AsnTrp: 0.479 ± 0.014	1.028AsnTyr: 1.028 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	6.32ProAla: 6.32 ± 0.072	0.438ProCys: 0.438 ± 0.014	3.036ProAsp: 3.036 ± 0.037	3.697ProGlu: 3.697 ± 0.042	1.904ProPhe: 1.904 ± 0.03	3.739ProGly: 3.739 ± 0.043	1.316ProHis: 1.316 ± 0.028	2.403ProIle: 2.403 ± 0.031	2.577ProLys: 2.577 ± 0.032	4.555ProLeu: 4.555 ± 0.041	1.304ProMet: 1.304 ± 0.026	2.033ProAsn: 2.033 ± 0.031	5.026ProPro: 5.026 ± 0.097	2.37ProGln: 2.37 ± 0.048	3.216ProArg: 3.216 ± 0.041	5.728ProSer: 5.728 ± 0.072	3.912ProThr: 3.912 ± 0.051	3.973ProVal: 3.973 ± 0.04	0.607ProTrp: 0.607 ± 0.014	1.37ProTyr: 1.37 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.755GlnAla: 3.755 ± 0.064	0.396GlnCys: 0.396 ± 0.013	1.855GlnAsp: 1.855 ± 0.024	2.123GlnGlu: 2.123 ± 0.029	1.238GlnPhe: 1.238 ± 0.024	1.984GlnGly: 1.984 ± 0.032	1.051GlnHis: 1.051 ± 0.024	1.784GlnIle: 1.784 ± 0.028	1.934GlnLys: 1.934 ± 0.027	3.289GlnLeu: 3.289 ± 0.037	1.038GlnMet: 1.038 ± 0.024	1.507GlnAsn: 1.507 ± 0.026	2.444GlnPro: 2.444 ± 0.051	3.208GlnGln: 3.208 ± 0.127	2.586GlnArg: 2.586 ± 0.036	2.884GlnSer: 2.884 ± 0.04	2.29GlnThr: 2.29 ± 0.03	2.166GlnVal: 2.166 ± 0.026	0.508GlnTrp: 0.508 ± 0.013	1.068GlnTyr: 1.068 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	5.155ArgAla: 5.155 ± 0.051	0.612ArgCys: 0.612 ± 0.016	3.404ArgAsp: 3.404 ± 0.054	3.833ArgGlu: 3.833 ± 0.049	2.117ArgPhe: 2.117 ± 0.029	3.616ArgGly: 3.616 ± 0.052	1.522ArgHis: 1.522 ± 0.026	2.845ArgIle: 2.845 ± 0.035	3.349ArgLys: 3.349 ± 0.036	5.306ArgLeu: 5.306 ± 0.056	1.491ArgMet: 1.491 ± 0.024	2.226ArgAsn: 2.226 ± 0.027	3.284ArgPro: 3.284 ± 0.04	2.454ArgGln: 2.454 ± 0.034	4.968ArgArg: 4.968 ± 0.062	4.687ArgSer: 4.687 ± 0.058	3.132ArgThr: 3.132 ± 0.035	3.523ArgVal: 3.523 ± 0.041	0.808ArgTrp: 0.808 ± 0.015	1.527ArgTyr: 1.527 ± 0.025	0.0ArgXaa: 0.0 ± 0.0
Ser	8.163SerAla: 8.163 ± 0.072	0.752SerCys: 0.752 ± 0.018	4.26SerAsp: 4.26 ± 0.043	3.995SerGlu: 3.995 ± 0.037	3.0SerPhe: 3.0 ± 0.03	5.8SerGly: 5.8 ± 0.057	1.986SerHis: 1.986 ± 0.037	3.798SerIle: 3.798 ± 0.043	3.667SerLys: 3.667 ± 0.044	7.066SerLeu: 7.066 ± 0.053	2.018SerMet: 2.018 ± 0.03	2.903SerAsn: 2.903 ± 0.038	5.42SerPro: 5.42 ± 0.069	3.121SerGln: 3.121 ± 0.049	4.975SerArg: 4.975 ± 0.057	9.472SerSer: 9.472 ± 0.124	5.641SerThr: 5.641 ± 0.067	4.99SerVal: 4.99 ± 0.045	0.966SerTrp: 0.966 ± 0.018	1.938SerTyr: 1.938 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	6.072ThrAla: 6.072 ± 0.048	0.654ThrCys: 0.654 ± 0.017	2.892ThrAsp: 2.892 ± 0.03	3.115ThrGlu: 3.115 ± 0.043	2.015ThrPhe: 2.015 ± 0.029	4.169ThrGly: 4.169 ± 0.046	1.315ThrHis: 1.315 ± 0.022	2.897ThrIle: 2.897 ± 0.036	2.616ThrLys: 2.616 ± 0.035	5.181ThrLeu: 5.181 ± 0.048	1.286ThrMet: 1.286 ± 0.023	2.033ThrAsn: 2.033 ± 0.03	4.451ThrPro: 4.451 ± 0.047	2.073ThrGln: 2.073 ± 0.033	3.143ThrArg: 3.143 ± 0.034	5.161ThrSer: 5.161 ± 0.055	4.442ThrThr: 4.442 ± 0.068	3.853ThrVal: 3.853 ± 0.055	0.733ThrTrp: 0.733 ± 0.019	1.476ThrTyr: 1.476 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	6.113ValAla: 6.113 ± 0.051	0.835ValCys: 0.835 ± 0.016	3.795ValAsp: 3.795 ± 0.042	3.767ValGlu: 3.767 ± 0.043	2.576ValPhe: 2.576 ± 0.032	3.97ValGly: 3.97 ± 0.044	1.464ValHis: 1.464 ± 0.022	2.904ValIle: 2.904 ± 0.037	2.94ValLys: 2.94 ± 0.04	5.738ValLeu: 5.738 ± 0.057	1.526ValMet: 1.526 ± 0.023	2.187ValAsn: 2.187 ± 0.03	3.92ValPro: 3.92 ± 0.045	2.424ValGln: 2.424 ± 0.034	3.689ValArg: 3.689 ± 0.038	5.082ValSer: 5.082 ± 0.046	3.645ValThr: 3.645 ± 0.05	4.699ValVal: 4.699 ± 0.05	0.841ValTrp: 0.841 ± 0.02	1.817ValTyr: 1.817 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.102TrpAla: 1.102 ± 0.02	0.167TrpCys: 0.167 ± 0.008	0.837TrpAsp: 0.837 ± 0.019	0.763TrpGlu: 0.763 ± 0.018	0.467TrpPhe: 0.467 ± 0.013	0.794TrpGly: 0.794 ± 0.021	0.295TrpHis: 0.295 ± 0.01	0.624TrpIle: 0.624 ± 0.013	0.738TrpLys: 0.738 ± 0.016	1.147TrpLeu: 1.147 ± 0.023	0.385TrpMet: 0.385 ± 0.013	0.531TrpAsn: 0.531 ± 0.016	0.511TrpPro: 0.511 ± 0.015	0.491TrpGln: 0.491 ± 0.014	0.819TrpArg: 0.819 ± 0.017	0.916TrpSer: 0.916 ± 0.018	0.839TrpThr: 0.839 ± 0.019	0.822TrpVal: 0.822 ± 0.019	0.25TrpTrp: 0.25 ± 0.011	0.376TrpTyr: 0.376 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.218TyrAla: 2.218 ± 0.03	0.369TyrCys: 0.369 ± 0.013	1.695TyrAsp: 1.695 ± 0.027	1.5TyrGlu: 1.5 ± 0.024	1.071TyrPhe: 1.071 ± 0.02	1.924TyrGly: 1.924 ± 0.032	0.67TyrHis: 0.67 ± 0.016	1.337TyrIle: 1.337 ± 0.023	1.099TyrLys: 1.099 ± 0.02	2.424TyrLeu: 2.424 ± 0.032	0.695TyrMet: 0.695 ± 0.015	1.122TyrAsn: 1.122 ± 0.022	1.276TyrPro: 1.276 ± 0.022	0.975TyrGln: 0.975 ± 0.017	1.508TyrArg: 1.508 ± 0.026	1.938TyrSer: 1.938 ± 0.03	1.572TyrThr: 1.572 ± 0.027	1.658TyrVal: 1.658 ± 0.025	0.375TyrTrp: 0.375 ± 0.012	0.872TyrTyr: 0.872 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.005XaaXaa: 0.005 ± 0.003

Statistics based on 5254 proteins (2870050 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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