Amino acid dipepetide frequency for Yangia sp. CCB-MM3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.182AlaAla: 17.182 ± 0.151
1.187AlaCys: 1.187 ± 0.032
6.214AlaAsp: 6.214 ± 0.063
9.501AlaGlu: 9.501 ± 0.094
4.224AlaPhe: 4.224 ± 0.056
10.759AlaGly: 10.759 ± 0.093
2.324AlaHis: 2.324 ± 0.044
5.36AlaIle: 5.36 ± 0.061
3.721AlaLys: 3.721 ± 0.051
15.291AlaLeu: 15.291 ± 0.128
3.831AlaMet: 3.831 ± 0.05
2.341AlaAsn: 2.341 ± 0.043
6.337AlaPro: 6.337 ± 0.081
5.062AlaGln: 5.062 ± 0.067
8.916AlaArg: 8.916 ± 0.114
5.951AlaSer: 5.951 ± 0.066
5.591AlaThr: 5.591 ± 0.062
8.132AlaVal: 8.132 ± 0.083
1.443AlaTrp: 1.443 ± 0.032
2.512AlaTyr: 2.512 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
1.217CysAla: 1.217 ± 0.034
0.117CysCys: 0.117 ± 0.009
0.613CysAsp: 0.613 ± 0.02
0.498CysGlu: 0.498 ± 0.019
0.331CysPhe: 0.331 ± 0.015
0.974CysGly: 0.974 ± 0.027
0.254CysHis: 0.254 ± 0.015
0.409CysIle: 0.409 ± 0.016
0.18CysLys: 0.18 ± 0.013
0.877CysLeu: 0.877 ± 0.025
0.181CysMet: 0.181 ± 0.012
0.203CysAsn: 0.203 ± 0.011
0.494CysPro: 0.494 ± 0.019
0.215CysGln: 0.215 ± 0.013
0.575CysArg: 0.575 ± 0.021
0.475CysSer: 0.475 ± 0.016
0.46CysThr: 0.46 ± 0.016
0.6CysVal: 0.6 ± 0.022
0.12CysTrp: 0.12 ± 0.009
0.218CysTyr: 0.218 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
7.035AspAla: 7.035 ± 0.075
0.491AspCys: 0.491 ± 0.019
3.058AspAsp: 3.058 ± 0.06
3.782AspGlu: 3.782 ± 0.053
2.255AspPhe: 2.255 ± 0.039
5.407AspGly: 5.407 ± 0.102
1.225AspHis: 1.225 ± 0.027
2.737AspIle: 2.737 ± 0.046
1.508AspLys: 1.508 ± 0.039
6.471AspLeu: 6.471 ± 0.062
1.571AspMet: 1.571 ± 0.028
1.127AspAsn: 1.127 ± 0.035
3.764AspPro: 3.764 ± 0.055
1.566AspGln: 1.566 ± 0.031
3.743AspArg: 3.743 ± 0.052
2.161AspSer: 2.161 ± 0.037
2.787AspThr: 2.787 ± 0.051
4.021AspVal: 4.021 ± 0.053
1.168AspTrp: 1.168 ± 0.026
1.543AspTyr: 1.543 ± 0.032
0.0AspXaa: 0.0 ± 0.0
Glu
9.271GluAla: 9.271 ± 0.099
0.364GluCys: 0.364 ± 0.017
3.614GluAsp: 3.614 ± 0.056
4.121GluGlu: 4.121 ± 0.057
1.93GluPhe: 1.93 ± 0.035
5.584GluGly: 5.584 ± 0.062
1.202GluHis: 1.202 ± 0.029
3.766GluIle: 3.766 ± 0.043
2.152GluLys: 2.152 ± 0.043
5.653GluLeu: 5.653 ± 0.068
2.06GluMet: 2.06 ± 0.035
1.624GluAsn: 1.624 ± 0.036
2.816GluPro: 2.816 ± 0.048
2.073GluGln: 2.073 ± 0.042
4.401GluArg: 4.401 ± 0.063
2.412GluSer: 2.412 ± 0.04
4.075GluThr: 4.075 ± 0.052
4.699GluVal: 4.699 ± 0.049
0.688GluTrp: 0.688 ± 0.018
1.087GluTyr: 1.087 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
4.468PheAla: 4.468 ± 0.062
0.4PheCys: 0.4 ± 0.015
2.807PheAsp: 2.807 ± 0.05
2.353PheGlu: 2.353 ± 0.041
1.407PhePhe: 1.407 ± 0.033
3.824PheGly: 3.824 ± 0.055
0.738PheHis: 0.738 ± 0.024
1.615PheIle: 1.615 ± 0.037
0.821PheLys: 0.821 ± 0.024
3.348PheLeu: 3.348 ± 0.048
0.869PheMet: 0.869 ± 0.028
0.976PheAsn: 0.976 ± 0.029
1.57PhePro: 1.57 ± 0.035
0.946PheGln: 0.946 ± 0.025
2.136PheArg: 2.136 ± 0.038
2.174PheSer: 2.174 ± 0.044
2.147PheThr: 2.147 ± 0.038
2.641PheVal: 2.641 ± 0.043
0.553PheTrp: 0.553 ± 0.022
0.909PheTyr: 0.909 ± 0.022
0.0PheXaa: 0.0 ± 0.0
Gly
10.589GlyAla: 10.589 ± 0.104
0.926GlyCys: 0.926 ± 0.026
4.671GlyAsp: 4.671 ± 0.067
5.123GlyGlu: 5.123 ± 0.059
3.664GlyPhe: 3.664 ± 0.053
7.724GlyGly: 7.724 ± 0.102
1.903GlyHis: 1.903 ± 0.037
4.411GlyIle: 4.411 ± 0.06
3.008GlyLys: 3.008 ± 0.053
9.687GlyLeu: 9.687 ± 0.089
2.749GlyMet: 2.749 ± 0.045
2.106GlyAsn: 2.106 ± 0.047
3.785GlyPro: 3.785 ± 0.049
3.078GlyGln: 3.078 ± 0.047
5.692GlyArg: 5.692 ± 0.071
4.691GlySer: 4.691 ± 0.074
4.922GlyThr: 4.922 ± 0.069
6.446GlyVal: 6.446 ± 0.07
1.559GlyTrp: 1.559 ± 0.034
2.402GlyTyr: 2.402 ± 0.038
0.0GlyXaa: 0.0 ± 0.0
His
2.298HisAla: 2.298 ± 0.046
0.249HisCys: 0.249 ± 0.014
1.244HisAsp: 1.244 ± 0.032
1.153HisGlu: 1.153 ± 0.026
0.804HisPhe: 0.804 ± 0.023
1.983HisGly: 1.983 ± 0.039
0.525HisHis: 0.525 ± 0.02
0.834HisIle: 0.834 ± 0.024
0.487HisLys: 0.487 ± 0.019
2.131HisLeu: 2.131 ± 0.041
0.558HisMet: 0.558 ± 0.019
0.415HisAsn: 0.415 ± 0.016
1.383HisPro: 1.383 ± 0.034
0.523HisGln: 0.523 ± 0.019
1.263HisArg: 1.263 ± 0.029
0.881HisSer: 0.881 ± 0.029
0.755HisThr: 0.755 ± 0.02
1.545HisVal: 1.545 ± 0.031
0.36HisTrp: 0.36 ± 0.015
0.516HisTyr: 0.516 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
6.849IleAla: 6.849 ± 0.078
0.609IleCys: 0.609 ± 0.021
3.355IleAsp: 3.355 ± 0.049
3.496IleGlu: 3.496 ± 0.044
1.82IlePhe: 1.82 ± 0.039
4.675IleGly: 4.675 ± 0.06
0.861IleHis: 0.861 ± 0.026
1.988IleIle: 1.988 ± 0.043
1.174IleLys: 1.174 ± 0.026
4.467IleLeu: 4.467 ± 0.066
0.998IleMet: 0.998 ± 0.034
1.214IleAsn: 1.214 ± 0.032
2.309IlePro: 2.309 ± 0.043
1.015IleGln: 1.015 ± 0.026
2.965IleArg: 2.965 ± 0.05
2.935IleSer: 2.935 ± 0.048
2.853IleThr: 2.853 ± 0.045
3.48IleVal: 3.48 ± 0.057
0.69IleTrp: 0.69 ± 0.021
1.061IleTyr: 1.061 ± 0.026
0.0IleXaa: 0.0 ± 0.0
Lys
3.731LysAla: 3.731 ± 0.054
0.177LysCys: 0.177 ± 0.012
1.632LysAsp: 1.632 ± 0.036
1.492LysGlu: 1.492 ± 0.036
0.839LysPhe: 0.839 ± 0.026
2.63LysGly: 2.63 ± 0.045
0.555LysHis: 0.555 ± 0.019
1.529LysIle: 1.529 ± 0.031
1.089LysLys: 1.089 ± 0.029
3.08LysLeu: 3.08 ± 0.043
0.823LysMet: 0.823 ± 0.024
0.633LysAsn: 0.633 ± 0.022
1.726LysPro: 1.726 ± 0.036
0.825LysGln: 0.825 ± 0.022
2.074LysArg: 2.074 ± 0.038
1.614LysSer: 1.614 ± 0.032
1.76LysThr: 1.76 ± 0.036
2.265LysVal: 2.265 ± 0.041
0.343LysTrp: 0.343 ± 0.013
0.596LysTyr: 0.596 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
13.664LeuAla: 13.664 ± 0.125
1.103LeuCys: 1.103 ± 0.027
6.008LeuAsp: 6.008 ± 0.062
5.853LeuGlu: 5.853 ± 0.072
3.561LeuPhe: 3.561 ± 0.057
8.991LeuGly: 8.991 ± 0.089
1.952LeuHis: 1.952 ± 0.035
5.103LeuIle: 5.103 ± 0.078
3.074LeuLys: 3.074 ± 0.051
10.089LeuLeu: 10.089 ± 0.116
2.667LeuMet: 2.667 ± 0.051
2.416LeuAsn: 2.416 ± 0.041
6.225LeuPro: 6.225 ± 0.072
3.072LeuGln: 3.072 ± 0.05
7.64LeuArg: 7.64 ± 0.084
7.015LeuSer: 7.015 ± 0.067
5.875LeuThr: 5.875 ± 0.068
7.066LeuVal: 7.066 ± 0.079
1.347LeuTrp: 1.347 ± 0.036
2.071LeuTyr: 2.071 ± 0.036
0.0LeuXaa: 0.0 ± 0.0
Met
3.475MetAla: 3.475 ± 0.053
0.179MetCys: 0.179 ± 0.011
1.393MetAsp: 1.393 ± 0.034
1.371MetGlu: 1.371 ± 0.03
0.777MetPhe: 0.777 ± 0.023
2.281MetGly: 2.281 ± 0.04
0.445MetHis: 0.445 ± 0.018
1.598MetIle: 1.598 ± 0.035
1.04MetLys: 1.04 ± 0.027
2.763MetLeu: 2.763 ± 0.045
0.772MetMet: 0.772 ± 0.025
0.783MetAsn: 0.783 ± 0.023
1.55MetPro: 1.55 ± 0.032
1.002MetGln: 1.002 ± 0.025
1.903MetArg: 1.903 ± 0.039
1.871MetSer: 1.871 ± 0.033
2.003MetThr: 2.003 ± 0.038
1.908MetVal: 1.908 ± 0.033
0.233MetTrp: 0.233 ± 0.012
0.335MetTyr: 0.335 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
2.919AsnAla: 2.919 ± 0.047
0.236AsnCys: 0.236 ± 0.012
1.294AsnAsp: 1.294 ± 0.034
1.126AsnGlu: 1.126 ± 0.025
0.925AsnPhe: 0.925 ± 0.027
2.194AsnGly: 2.194 ± 0.05
0.482AsnHis: 0.482 ± 0.019
1.266AsnIle: 1.266 ± 0.03
0.557AsnLys: 0.557 ± 0.019
2.349AsnLeu: 2.349 ± 0.037
0.645AsnMet: 0.645 ± 0.021
0.594AsnAsn: 0.594 ± 0.026
1.652AsnPro: 1.652 ± 0.036
0.568AsnGln: 0.568 ± 0.022
1.493AsnArg: 1.493 ± 0.034
1.13AsnSer: 1.13 ± 0.03
1.175AsnThr: 1.175 ± 0.033
1.705AsnVal: 1.705 ± 0.038
0.399AsnTrp: 0.399 ± 0.017
0.624AsnTyr: 0.624 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
5.98ProAla: 5.98 ± 0.069
0.369ProCys: 0.369 ± 0.016
3.617ProAsp: 3.617 ± 0.05
4.953ProGlu: 4.953 ± 0.065
1.971ProPhe: 1.971 ± 0.036
4.786ProGly: 4.786 ± 0.065
1.091ProHis: 1.091 ± 0.026
2.097ProIle: 2.097 ± 0.042
1.641ProLys: 1.641 ± 0.038
5.072ProLeu: 5.072 ± 0.061
1.356ProMet: 1.356 ± 0.031
1.213ProAsn: 1.213 ± 0.031
2.293ProPro: 2.293 ± 0.049
1.92ProGln: 1.92 ± 0.041
3.037ProArg: 3.037 ± 0.046
2.641ProSer: 2.641 ± 0.051
2.274ProThr: 2.274 ± 0.039
4.227ProVal: 4.227 ± 0.05
0.681ProTrp: 0.681 ± 0.022
1.147ProTyr: 1.147 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
3.961GlnAla: 3.961 ± 0.056
0.209GlnCys: 0.209 ± 0.012
1.624GlnAsp: 1.624 ± 0.032
1.647GlnGlu: 1.647 ± 0.033
1.025GlnPhe: 1.025 ± 0.025
2.723GlnGly: 2.723 ± 0.047
0.621GlnHis: 0.621 ± 0.023
1.983GlnIle: 1.983 ± 0.043
1.037GlnLys: 1.037 ± 0.027
3.016GlnLeu: 3.016 ± 0.049
1.078GlnMet: 1.078 ± 0.024
0.798GlnAsn: 0.798 ± 0.023
1.649GlnPro: 1.649 ± 0.03
1.202GlnGln: 1.202 ± 0.034
2.27GlnArg: 2.27 ± 0.043
1.848GlnSer: 1.848 ± 0.034
1.723GlnThr: 1.723 ± 0.033
2.426GlnVal: 2.426 ± 0.039
0.376GlnTrp: 0.376 ± 0.016
0.606GlnTyr: 0.606 ± 0.021
0.0GlnXaa: 0.0 ± 0.0
Arg
8.348ArgAla: 8.348 ± 0.104
0.528ArgCys: 0.528 ± 0.021
4.018ArgAsp: 4.018 ± 0.056
4.166ArgGlu: 4.166 ± 0.057
2.674ArgPhe: 2.674 ± 0.041
4.935ArgGly: 4.935 ± 0.056
1.513ArgHis: 1.513 ± 0.036
3.577ArgIle: 3.577 ± 0.051
2.158ArgLys: 2.158 ± 0.038
7.316ArgLeu: 7.316 ± 0.077
1.93ArgMet: 1.93 ± 0.039
1.642ArgAsn: 1.642 ± 0.039
3.304ArgPro: 3.304 ± 0.047
2.19ArgGln: 2.19 ± 0.038
5.157ArgArg: 5.157 ± 0.082
3.382ArgSer: 3.382 ± 0.045
2.75ArgThr: 2.75 ± 0.051
4.53ArgVal: 4.53 ± 0.055
0.933ArgTrp: 0.933 ± 0.027
1.515ArgTyr: 1.515 ± 0.028
0.0ArgXaa: 0.0 ± 0.0
Ser
6.37SerAla: 6.37 ± 0.065
0.422SerCys: 0.422 ± 0.02
3.207SerAsp: 3.207 ± 0.05
3.14SerGlu: 3.14 ± 0.044
2.404SerPhe: 2.404 ± 0.044
5.764SerGly: 5.764 ± 0.07
1.095SerHis: 1.095 ± 0.03
2.388SerIle: 2.388 ± 0.045
1.456SerLys: 1.456 ± 0.03
5.224SerLeu: 5.224 ± 0.065
1.361SerMet: 1.361 ± 0.027
1.293SerAsn: 1.293 ± 0.033
2.534SerPro: 2.534 ± 0.043
1.594SerGln: 1.594 ± 0.031
3.27SerArg: 3.27 ± 0.05
2.832SerSer: 2.832 ± 0.056
2.588SerThr: 2.588 ± 0.042
3.846SerVal: 3.846 ± 0.053
0.769SerTrp: 0.769 ± 0.021
1.473SerTyr: 1.473 ± 0.029
0.0SerXaa: 0.0 ± 0.0
Thr
6.021ThrAla: 6.021 ± 0.077
0.45ThrCys: 0.45 ± 0.018
2.93ThrAsp: 2.93 ± 0.056
3.33ThrGlu: 3.33 ± 0.053
1.899ThrPhe: 1.899 ± 0.038
5.398ThrGly: 5.398 ± 0.082
1.077ThrHis: 1.077 ± 0.024
2.463ThrIle: 2.463 ± 0.044
1.328ThrLys: 1.328 ± 0.029
6.105ThrLeu: 6.105 ± 0.07
1.19ThrMet: 1.19 ± 0.03
1.137ThrAsn: 1.137 ± 0.029
3.484ThrPro: 3.484 ± 0.051
1.557ThrGln: 1.557 ± 0.03
3.44ThrArg: 3.44 ± 0.054
2.658ThrSer: 2.658 ± 0.042
2.623ThrThr: 2.623 ± 0.046
4.106ThrVal: 4.106 ± 0.061
0.676ThrTrp: 0.676 ± 0.019
1.202ThrTyr: 1.202 ± 0.028
0.0ThrXaa: 0.0 ± 0.0
Val
8.573ValAla: 8.573 ± 0.08
0.638ValCys: 0.638 ± 0.018
3.751ValAsp: 3.751 ± 0.058
4.395ValGlu: 4.395 ± 0.055
2.788ValPhe: 2.788 ± 0.045
5.303ValGly: 5.303 ± 0.064
1.226ValHis: 1.226 ± 0.03
4.148ValIle: 4.148 ± 0.054
2.019ValLys: 2.019 ± 0.038
7.854ValLeu: 7.854 ± 0.089
2.147ValMet: 2.147 ± 0.038
1.843ValAsn: 1.843 ± 0.036
3.739ValPro: 3.739 ± 0.057
2.12ValGln: 2.12 ± 0.037
3.912ValArg: 3.912 ± 0.055
4.423ValSer: 4.423 ± 0.061
4.78ValThr: 4.78 ± 0.074
5.327ValVal: 5.327 ± 0.066
0.956ValTrp: 0.956 ± 0.025
1.482ValTyr: 1.482 ± 0.031
0.0ValXaa: 0.0 ± 0.0
Trp
1.315TrpAla: 1.315 ± 0.03
0.127TrpCys: 0.127 ± 0.009
0.782TrpAsp: 0.782 ± 0.027
0.697TrpGlu: 0.697 ± 0.022
0.537TrpPhe: 0.537 ± 0.019
1.065TrpGly: 1.065 ± 0.028
0.338TrpHis: 0.338 ± 0.016
0.677TrpIle: 0.677 ± 0.021
0.437TrpLys: 0.437 ± 0.016
1.686TrpLeu: 1.686 ± 0.039
0.399TrpMet: 0.399 ± 0.015
0.405TrpAsn: 0.405 ± 0.015
0.68TrpPro: 0.68 ± 0.022
0.634TrpGln: 0.634 ± 0.021
1.147TrpArg: 1.147 ± 0.028
0.818TrpSer: 0.818 ± 0.022
0.755TrpThr: 0.755 ± 0.023
0.879TrpVal: 0.879 ± 0.022
0.21TrpTrp: 0.21 ± 0.013
0.293TrpTyr: 0.293 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.613TyrAla: 2.613 ± 0.043
0.231TyrCys: 0.231 ± 0.012
1.587TyrAsp: 1.587 ± 0.037
1.394TyrGlu: 1.394 ± 0.034
0.87TyrPhe: 0.87 ± 0.02
2.137TyrGly: 2.137 ± 0.042
0.48TyrHis: 0.48 ± 0.019
0.866TyrIle: 0.866 ± 0.026
0.528TyrLys: 0.528 ± 0.019
2.316TyrLeu: 2.316 ± 0.04
0.497TyrMet: 0.497 ± 0.019
0.57TyrAsn: 0.57 ± 0.021
1.072TyrPro: 1.072 ± 0.03
0.658TyrGln: 0.658 ± 0.021
1.535TyrArg: 1.535 ± 0.036
1.114TyrSer: 1.114 ± 0.029
1.174TyrThr: 1.174 ± 0.031
1.575TyrVal: 1.575 ± 0.034
0.374TyrTrp: 0.374 ± 0.018
0.562TyrTyr: 0.562 ± 0.025
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4896 proteins (1570501 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski