Amino acid dipepetide frequency for Alistipes sp. An31A

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.719AlaAla: 11.719 ± 0.219	1.305AlaCys: 1.305 ± 0.045	5.356AlaAsp: 5.356 ± 0.093	7.211AlaGlu: 7.211 ± 0.113	3.238AlaPhe: 3.238 ± 0.077	7.686AlaGly: 7.686 ± 0.123	1.53AlaHis: 1.53 ± 0.054	4.368AlaIle: 4.368 ± 0.083	3.222AlaLys: 3.222 ± 0.068	9.646AlaLeu: 9.646 ± 0.154	2.365AlaMet: 2.365 ± 0.061	2.602AlaAsn: 2.602 ± 0.068	3.952AlaPro: 3.952 ± 0.098	3.187AlaGln: 3.187 ± 0.077	6.655AlaArg: 6.655 ± 0.114	5.402AlaSer: 5.402 ± 0.1	4.832AlaThr: 4.832 ± 0.095	6.646AlaVal: 6.646 ± 0.105	1.108AlaTrp: 1.108 ± 0.038	2.891AlaTyr: 2.891 ± 0.063	0.0AlaXaa: 0.0 ± 0.0
Cys	1.112CysAla: 1.112 ± 0.042	0.258CysCys: 0.258 ± 0.019	0.821CysAsp: 0.821 ± 0.033	0.724CysGlu: 0.724 ± 0.033	0.553CysPhe: 0.553 ± 0.028	1.303CysGly: 1.303 ± 0.05	0.283CysHis: 0.283 ± 0.018	0.768CysIle: 0.768 ± 0.031	0.413CysLys: 0.413 ± 0.022	0.919CysLeu: 0.919 ± 0.041	0.294CysMet: 0.294 ± 0.02	0.461CysAsn: 0.461 ± 0.025	0.65CysPro: 0.65 ± 0.033	0.262CysGln: 0.262 ± 0.018	1.126CysArg: 1.126 ± 0.039	0.888CysSer: 0.888 ± 0.035	0.774CysThr: 0.774 ± 0.044	0.776CysVal: 0.776 ± 0.032	0.133CysTrp: 0.133 ± 0.014	0.533CysTyr: 0.533 ± 0.031	0.0CysXaa: 0.0 ± 0.0
Asp	5.303AspAla: 5.303 ± 0.104	0.676AspCys: 0.676 ± 0.031	2.906AspAsp: 2.906 ± 0.078	4.099AspGlu: 4.099 ± 0.076	2.752AspPhe: 2.752 ± 0.067	4.484AspGly: 4.484 ± 0.094	0.906AspHis: 0.906 ± 0.032	3.315AspIle: 3.315 ± 0.072	2.248AspLys: 2.248 ± 0.061	4.333AspLeu: 4.333 ± 0.074	1.291AspMet: 1.291 ± 0.039	2.015AspAsn: 2.015 ± 0.056	2.374AspPro: 2.374 ± 0.058	1.101AspGln: 1.101 ± 0.042	3.643AspArg: 3.643 ± 0.078	2.969AspSer: 2.969 ± 0.079	2.781AspThr: 2.781 ± 0.061	3.585AspVal: 3.585 ± 0.079	0.766AspTrp: 0.766 ± 0.036	2.642AspTyr: 2.642 ± 0.066	0.0AspXaa: 0.0 ± 0.0
Glu	6.883GluAla: 6.883 ± 0.122	0.743GluCys: 0.743 ± 0.032	2.508GluAsp: 2.508 ± 0.067	5.838GluGlu: 5.838 ± 0.115	2.589GluPhe: 2.589 ± 0.064	5.309GluGly: 5.309 ± 0.094	1.515GluHis: 1.515 ± 0.044	3.595GluIle: 3.595 ± 0.073	3.283GluLys: 3.283 ± 0.076	7.286GluLeu: 7.286 ± 0.11	1.929GluMet: 1.929 ± 0.05	2.488GluAsn: 2.488 ± 0.067	2.757GluPro: 2.757 ± 0.081	3.3GluGln: 3.3 ± 0.065	5.828GluArg: 5.828 ± 0.126	3.141GluSer: 3.141 ± 0.071	3.064GluThr: 3.064 ± 0.067	5.183GluVal: 5.183 ± 0.088	0.895GluTrp: 0.895 ± 0.04	2.42GluTyr: 2.42 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	3.808PheAla: 3.808 ± 0.082	0.563PheCys: 0.563 ± 0.03	3.044PheAsp: 3.044 ± 0.069	2.661PheGlu: 2.661 ± 0.059	1.807PhePhe: 1.807 ± 0.051	3.303PheGly: 3.303 ± 0.078	0.781PheHis: 0.781 ± 0.031	2.281PheIle: 2.281 ± 0.067	1.377PheLys: 1.377 ± 0.046	3.389PheLeu: 3.389 ± 0.069	0.978PheMet: 0.978 ± 0.038	1.615PheAsn: 1.615 ± 0.054	1.594PhePro: 1.594 ± 0.048	0.917PheGln: 0.917 ± 0.035	2.871PheArg: 2.871 ± 0.071	2.567PheSer: 2.567 ± 0.064	2.675PheThr: 2.675 ± 0.065	2.852PheVal: 2.852 ± 0.064	0.516PheTrp: 0.516 ± 0.027	1.62PheTyr: 1.62 ± 0.052	0.0PheXaa: 0.0 ± 0.0
Gly	6.607GlyAla: 6.607 ± 0.102	1.197GlyCys: 1.197 ± 0.046	3.956GlyAsp: 3.956 ± 0.084	5.357GlyGlu: 5.357 ± 0.103	3.143GlyPhe: 3.143 ± 0.07	5.969GlyGly: 5.969 ± 0.113	1.473GlyHis: 1.473 ± 0.046	4.64GlyIle: 4.64 ± 0.092	3.415GlyLys: 3.415 ± 0.065	6.331GlyLeu: 6.331 ± 0.092	2.061GlyMet: 2.061 ± 0.061	2.627GlyAsn: 2.627 ± 0.064	1.703GlyPro: 1.703 ± 0.047	2.134GlyGln: 2.134 ± 0.056	5.467GlyArg: 5.467 ± 0.112	4.606GlySer: 4.606 ± 0.085	4.312GlyThr: 4.312 ± 0.089	5.597GlyVal: 5.597 ± 0.096	1.13GlyTrp: 1.13 ± 0.047	3.371GlyTyr: 3.371 ± 0.075	0.0GlyXaa: 0.0 ± 0.0
His	1.568HisAla: 1.568 ± 0.049	0.309HisCys: 0.309 ± 0.02	1.052HisAsp: 1.052 ± 0.041	1.112HisGlu: 1.112 ± 0.037	0.894HisPhe: 0.894 ± 0.035	1.359HisGly: 1.359 ± 0.046	0.459HisHis: 0.459 ± 0.032	1.314HisIle: 1.314 ± 0.043	0.722HisLys: 0.722 ± 0.031	1.852HisLeu: 1.852 ± 0.054	0.386HisMet: 0.386 ± 0.021	0.765HisAsn: 0.765 ± 0.034	1.178HisPro: 1.178 ± 0.044	0.457HisGln: 0.457 ± 0.025	1.39HisArg: 1.39 ± 0.046	0.969HisSer: 0.969 ± 0.034	1.159HisThr: 1.159 ± 0.038	1.062HisVal: 1.062 ± 0.039	0.195HisTrp: 0.195 ± 0.017	0.857HisTyr: 0.857 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.303IleAla: 5.303 ± 0.097	0.781IleCys: 0.781 ± 0.036	3.745IleAsp: 3.745 ± 0.071	3.933IleGlu: 3.933 ± 0.081	2.189IlePhe: 2.189 ± 0.058	3.992IleGly: 3.992 ± 0.081	1.092IleHis: 1.092 ± 0.042	2.881IleIle: 2.881 ± 0.084	1.917IleLys: 1.917 ± 0.064	4.556IleLeu: 4.556 ± 0.095	1.004IleMet: 1.004 ± 0.044	1.909IleAsn: 1.909 ± 0.058	2.727IlePro: 2.727 ± 0.06	1.314IleGln: 1.314 ± 0.048	3.94IleArg: 3.94 ± 0.087	3.05IleSer: 3.05 ± 0.065	3.158IleThr: 3.158 ± 0.08	4.03IleVal: 4.03 ± 0.079	0.481IleTrp: 0.481 ± 0.028	2.061IleTyr: 2.061 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	3.602LysAla: 3.602 ± 0.075	0.397LysCys: 0.397 ± 0.021	1.745LysAsp: 1.745 ± 0.057	2.999LysGlu: 2.999 ± 0.073	1.419LysPhe: 1.419 ± 0.044	2.988LysGly: 2.988 ± 0.063	0.78LysHis: 0.78 ± 0.029	2.508LysIle: 2.508 ± 0.071	2.146LysLys: 2.146 ± 0.071	3.557LysLeu: 3.557 ± 0.087	1.369LysMet: 1.369 ± 0.045	1.67LysAsn: 1.67 ± 0.054	1.601LysPro: 1.601 ± 0.047	1.505LysGln: 1.505 ± 0.05	2.836LysArg: 2.836 ± 0.058	2.383LysSer: 2.383 ± 0.071	2.118LysThr: 2.118 ± 0.058	2.843LysVal: 2.843 ± 0.063	0.474LysTrp: 0.474 ± 0.026	1.689LysTyr: 1.689 ± 0.05	0.0LysXaa: 0.0 ± 0.0
Leu	9.089LeuAla: 9.089 ± 0.137	1.53LeuCys: 1.53 ± 0.048	5.258LeuAsp: 5.258 ± 0.089	5.811LeuGlu: 5.811 ± 0.101	4.67LeuPhe: 4.67 ± 0.103	6.598LeuGly: 6.598 ± 0.098	2.102LeuHis: 2.102 ± 0.053	4.271LeuIle: 4.271 ± 0.084	3.936LeuLys: 3.936 ± 0.083	10.923LeuLeu: 10.923 ± 0.211	2.319LeuMet: 2.319 ± 0.062	3.169LeuAsn: 3.169 ± 0.074	4.569LeuPro: 4.569 ± 0.091	2.979LeuGln: 2.979 ± 0.063	7.586LeuArg: 7.586 ± 0.14	6.259LeuSer: 6.259 ± 0.108	5.677LeuThr: 5.677 ± 0.104	6.066LeuVal: 6.066 ± 0.114	1.133LeuTrp: 1.133 ± 0.041	3.487LeuTyr: 3.487 ± 0.073	0.0LeuXaa: 0.0 ± 0.0
Met	2.447MetAla: 2.447 ± 0.061	0.228MetCys: 0.228 ± 0.017	1.085MetAsp: 1.085 ± 0.043	1.763MetGlu: 1.763 ± 0.055	0.853MetPhe: 0.853 ± 0.034	1.76MetGly: 1.76 ± 0.052	0.411MetHis: 0.411 ± 0.022	1.081MetIle: 1.081 ± 0.039	1.798MetLys: 1.798 ± 0.054	2.763MetLeu: 2.763 ± 0.073	0.728MetMet: 0.728 ± 0.034	1.088MetAsn: 1.088 ± 0.037	1.251MetPro: 1.251 ± 0.04	0.983MetGln: 0.983 ± 0.036	1.744MetArg: 1.744 ± 0.053	1.449MetSer: 1.449 ± 0.043	1.586MetThr: 1.586 ± 0.043	1.568MetVal: 1.568 ± 0.055	0.264MetTrp: 0.264 ± 0.023	0.588MetTyr: 0.588 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	2.999AsnAla: 2.999 ± 0.074	0.372AsnCys: 0.372 ± 0.025	1.929AsnAsp: 1.929 ± 0.054	2.021AsnGlu: 2.021 ± 0.058	1.574AsnPhe: 1.574 ± 0.049	2.858AsnGly: 2.858 ± 0.072	0.648AsnHis: 0.648 ± 0.035	2.436AsnIle: 2.436 ± 0.066	1.332AsnLys: 1.332 ± 0.052	3.359AsnLeu: 3.359 ± 0.076	0.888AsnMet: 0.888 ± 0.037	1.446AsnAsn: 1.446 ± 0.053	2.146AsnPro: 2.146 ± 0.059	0.924AsnGln: 0.924 ± 0.04	2.47AsnArg: 2.47 ± 0.059	1.879AsnSer: 1.879 ± 0.049	1.914AsnThr: 1.914 ± 0.052	2.241AsnVal: 2.241 ± 0.053	0.405AsnTrp: 0.405 ± 0.024	1.576AsnTyr: 1.576 ± 0.05	0.0AsnXaa: 0.0 ± 0.0
Pro	4.639ProAla: 4.639 ± 0.115	0.461ProCys: 0.461 ± 0.028	2.984ProAsp: 2.984 ± 0.062	4.003ProGlu: 4.003 ± 0.081	1.809ProPhe: 1.809 ± 0.057	2.874ProGly: 2.874 ± 0.069	0.799ProHis: 0.799 ± 0.035	1.726ProIle: 1.726 ± 0.049	1.546ProLys: 1.546 ± 0.049	4.025ProLeu: 4.025 ± 0.08	0.98ProMet: 0.98 ± 0.036	1.204ProAsn: 1.204 ± 0.037	1.037ProPro: 1.037 ± 0.046	1.544ProGln: 1.544 ± 0.053	2.446ProArg: 2.446 ± 0.066	2.536ProSer: 2.536 ± 0.068	2.167ProThr: 2.167 ± 0.058	3.382ProVal: 3.382 ± 0.069	0.471ProTrp: 0.471 ± 0.029	1.593ProTyr: 1.593 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	2.683GlnAla: 2.683 ± 0.062	0.277GlnCys: 0.277 ± 0.02	1.023GlnAsp: 1.023 ± 0.037	1.905GlnGlu: 1.905 ± 0.056	1.126GlnPhe: 1.126 ± 0.041	2.063GlnGly: 2.063 ± 0.061	0.622GlnHis: 0.622 ± 0.029	1.802GlnIle: 1.802 ± 0.054	1.443GlnLys: 1.443 ± 0.052	3.395GlnLeu: 3.395 ± 0.079	0.996GlnMet: 0.996 ± 0.042	1.252GlnAsn: 1.252 ± 0.052	1.361GlnPro: 1.361 ± 0.037	1.578GlnGln: 1.578 ± 0.051	2.292GlnArg: 2.292 ± 0.064	1.876GlnSer: 1.876 ± 0.05	1.953GlnThr: 1.953 ± 0.05	1.975GlnVal: 1.975 ± 0.047	0.4GlnTrp: 0.4 ± 0.023	1.18GlnTyr: 1.18 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	5.382ArgAla: 5.382 ± 0.095	0.879ArgCys: 0.879 ± 0.035	3.356ArgAsp: 3.356 ± 0.079	5.264ArgGlu: 5.264 ± 0.102	3.16ArgPhe: 3.16 ± 0.062	4.135ArgGly: 4.135 ± 0.078	1.572ArgHis: 1.572 ± 0.049	4.714ArgIle: 4.714 ± 0.089	2.903ArgLys: 2.903 ± 0.056	7.453ArgLeu: 7.453 ± 0.134	2.323ArgMet: 2.323 ± 0.063	2.762ArgAsn: 2.762 ± 0.063	2.838ArgPro: 2.838 ± 0.071	2.557ArgGln: 2.557 ± 0.066	6.053ArgArg: 6.053 ± 0.134	3.883ArgSer: 3.883 ± 0.089	4.088ArgThr: 4.088 ± 0.087	4.121ArgVal: 4.121 ± 0.089	0.974ArgTrp: 0.974 ± 0.04	3.147ArgTyr: 3.147 ± 0.078	0.0ArgXaa: 0.0 ± 0.0
Ser	5.048SerAla: 5.048 ± 0.084	0.791SerCys: 0.791 ± 0.032	3.211SerAsp: 3.211 ± 0.073	3.787SerGlu: 3.787 ± 0.074	2.777SerPhe: 2.777 ± 0.069	4.897SerGly: 4.897 ± 0.096	1.016SerHis: 1.016 ± 0.038	3.038SerIle: 3.038 ± 0.065	2.171SerLys: 2.171 ± 0.058	5.887SerLeu: 5.887 ± 0.105	1.387SerMet: 1.387 ± 0.042	1.939SerAsn: 1.939 ± 0.056	2.462SerPro: 2.462 ± 0.063	1.645SerGln: 1.645 ± 0.054	3.437SerArg: 3.437 ± 0.071	3.45SerSer: 3.45 ± 0.084	3.013SerThr: 3.013 ± 0.066	4.236SerVal: 4.236 ± 0.075	0.78SerTrp: 0.78 ± 0.034	2.462SerTyr: 2.462 ± 0.072	0.0SerXaa: 0.0 ± 0.0
Thr	5.353ThrAla: 5.353 ± 0.105	0.534ThrCys: 0.534 ± 0.031	3.044ThrAsp: 3.044 ± 0.064	3.472ThrGlu: 3.472 ± 0.082	2.292ThrPhe: 2.292 ± 0.062	4.625ThrGly: 4.625 ± 0.091	0.976ThrHis: 0.976 ± 0.042	2.922ThrIle: 2.922 ± 0.071	1.825ThrLys: 1.825 ± 0.062	6.607ThrLeu: 6.607 ± 0.111	1.224ThrMet: 1.224 ± 0.041	1.695ThrAsn: 1.695 ± 0.055	3.33ThrPro: 3.33 ± 0.08	1.574ThrGln: 1.574 ± 0.044	3.142ThrArg: 3.142 ± 0.072	3.106ThrSer: 3.106 ± 0.063	3.561ThrThr: 3.561 ± 0.076	4.409ThrVal: 4.409 ± 0.08	0.596ThrTrp: 0.596 ± 0.03	1.887ThrTyr: 1.887 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	7.016ValAla: 7.016 ± 0.105	0.986ValCys: 0.986 ± 0.035	4.017ValAsp: 4.017 ± 0.084	5.406ValGlu: 5.406 ± 0.092	2.203ValPhe: 2.203 ± 0.059	4.971ValGly: 4.971 ± 0.083	1.127ValHis: 1.127 ± 0.041	3.807ValIle: 3.807 ± 0.075	3.024ValLys: 3.024 ± 0.065	6.149ValLeu: 6.149 ± 0.109	1.754ValMet: 1.754 ± 0.052	2.498ValAsn: 2.498 ± 0.071	2.749ValPro: 2.749 ± 0.069	1.835ValGln: 1.835 ± 0.053	4.902ValArg: 4.902 ± 0.1	4.177ValSer: 4.177 ± 0.093	4.26ValThr: 4.26 ± 0.076	5.95ValVal: 5.95 ± 0.111	0.839ValTrp: 0.839 ± 0.039	2.135ValTyr: 2.135 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.875TrpAla: 0.875 ± 0.036	0.249TrpCys: 0.249 ± 0.018	0.526TrpAsp: 0.526 ± 0.028	0.78TrpGlu: 0.78 ± 0.037	0.538TrpPhe: 0.538 ± 0.031	0.975TrpGly: 0.975 ± 0.038	0.282TrpHis: 0.282 ± 0.022	0.527TrpIle: 0.527 ± 0.027	0.529TrpLys: 0.529 ± 0.03	1.399TrpLeu: 1.399 ± 0.051	0.346TrpMet: 0.346 ± 0.022	0.552TrpAsn: 0.552 ± 0.035	0.299TrpPro: 0.299 ± 0.021	0.493TrpGln: 0.493 ± 0.029	0.894TrpArg: 0.894 ± 0.042	0.862TrpSer: 0.862 ± 0.04	0.63TrpThr: 0.63 ± 0.03	0.77TrpVal: 0.77 ± 0.039	0.236TrpTrp: 0.236 ± 0.019	0.47TrpTyr: 0.47 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.484TyrAla: 3.484 ± 0.068	0.516TyrCys: 0.516 ± 0.029	2.623TyrAsp: 2.623 ± 0.061	2.406TyrGlu: 2.406 ± 0.062	1.637TyrPhe: 1.637 ± 0.053	2.948TyrGly: 2.948 ± 0.076	0.685TyrHis: 0.685 ± 0.031	2.071TyrIle: 2.071 ± 0.057	1.376TyrLys: 1.376 ± 0.044	3.605TyrLeu: 3.605 ± 0.08	0.813TyrMet: 0.813 ± 0.036	1.663TyrAsn: 1.663 ± 0.051	1.646TyrPro: 1.646 ± 0.049	0.91TyrGln: 0.91 ± 0.038	2.844TyrArg: 2.844 ± 0.069	1.982TyrSer: 1.982 ± 0.053	2.451TyrThr: 2.451 ± 0.075	2.512TyrVal: 2.512 ± 0.064	0.437TyrTrp: 0.437 ± 0.028	1.684TyrTyr: 1.684 ± 0.059	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2054 proteins (728213 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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