Amino acid dipepetide frequency for Delphinapterus leucas (Beluga whale)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.341AlaAla: 7.341 ± 0.038	1.389AlaCys: 1.389 ± 0.009	3.003AlaAsp: 3.003 ± 0.01	5.118AlaGlu: 5.118 ± 0.023	2.501AlaPhe: 2.501 ± 0.01	4.946AlaGly: 4.946 ± 0.022	1.579AlaHis: 1.579 ± 0.008	2.571AlaIle: 2.571 ± 0.011	3.37AlaLys: 3.37 ± 0.014	7.342AlaLeu: 7.342 ± 0.024	1.427AlaMet: 1.427 ± 0.008	1.951AlaAsn: 1.951 ± 0.01	4.579AlaPro: 4.579 ± 0.026	3.474AlaGln: 3.474 ± 0.015	3.933AlaArg: 3.933 ± 0.018	6.133AlaSer: 6.133 ± 0.022	3.584AlaThr: 3.584 ± 0.014	4.755AlaVal: 4.755 ± 0.017	0.799AlaTrp: 0.799 ± 0.007	1.448AlaTyr: 1.448 ± 0.008	0.006AlaXaa: 0.006 ± 0.0
Cys	1.223CysAla: 1.223 ± 0.009	0.56CysCys: 0.56 ± 0.005	0.995CysAsp: 0.995 ± 0.009	1.253CysGlu: 1.253 ± 0.01	0.777CysPhe: 0.777 ± 0.006	1.654CysGly: 1.654 ± 0.014	0.644CysHis: 0.644 ± 0.006	0.872CysIle: 0.872 ± 0.006	1.067CysLys: 1.067 ± 0.009	2.074CysLeu: 2.074 ± 0.011	0.386CysMet: 0.386 ± 0.004	0.743CysAsn: 0.743 ± 0.007	1.355CysPro: 1.355 ± 0.012	1.031CysGln: 1.031 ± 0.008	1.261CysArg: 1.261 ± 0.009	1.938CysSer: 1.938 ± 0.013	1.037CysThr: 1.037 ± 0.008	1.254CysVal: 1.254 ± 0.009	0.268CysTrp: 0.268 ± 0.003	0.52CysTyr: 0.52 ± 0.004	0.002CysXaa: 0.002 ± 0.0
Asp	2.959AspAla: 2.959 ± 0.011	1.014AspCys: 1.014 ± 0.009	2.704AspAsp: 2.704 ± 0.016	3.536AspGlu: 3.536 ± 0.015	2.076AspPhe: 2.076 ± 0.009	3.38AspGly: 3.38 ± 0.016	1.161AspHis: 1.161 ± 0.008	2.461AspIle: 2.461 ± 0.011	2.478AspLys: 2.478 ± 0.014	5.069AspLeu: 5.069 ± 0.016	1.082AspMet: 1.082 ± 0.007	1.566AspAsn: 1.566 ± 0.009	2.991AspPro: 2.991 ± 0.013	1.886AspGln: 1.886 ± 0.009	2.499AspArg: 2.499 ± 0.011	4.319AspSer: 4.319 ± 0.016	2.466AspThr: 2.466 ± 0.011	3.103AspVal: 3.103 ± 0.014	0.624AspTrp: 0.624 ± 0.005	1.414AspTyr: 1.414 ± 0.007	0.004AspXaa: 0.004 ± 0.0
Glu	5.486GluAla: 5.486 ± 0.023	1.391GluCys: 1.391 ± 0.014	4.556GluAsp: 4.556 ± 0.016	8.193GluGlu: 8.193 ± 0.042	1.995GluPhe: 1.995 ± 0.01	4.423GluGly: 4.423 ± 0.017	1.533GluHis: 1.533 ± 0.008	3.095GluIle: 3.095 ± 0.016	5.545GluLys: 5.545 ± 0.032	6.744GluLeu: 6.744 ± 0.032	1.685GluMet: 1.685 ± 0.009	3.111GluAsn: 3.111 ± 0.015	3.465GluPro: 3.465 ± 0.016	3.352GluGln: 3.352 ± 0.02	4.339GluArg: 4.339 ± 0.021	4.648GluSer: 4.648 ± 0.017	3.493GluThr: 3.493 ± 0.013	4.272GluVal: 4.272 ± 0.015	0.677GluTrp: 0.677 ± 0.005	1.524GluTyr: 1.524 ± 0.008	0.005GluXaa: 0.005 ± 0.0
Phe	1.887PheAla: 1.887 ± 0.009	0.847PheCys: 0.847 ± 0.006	1.589PheAsp: 1.589 ± 0.009	1.954PheGlu: 1.954 ± 0.009	1.402PhePhe: 1.402 ± 0.01	2.069PheGly: 2.069 ± 0.011	1.013PheHis: 1.013 ± 0.006	1.643PheIle: 1.643 ± 0.01	1.652PheLys: 1.652 ± 0.009	3.758PheLeu: 3.758 ± 0.015	0.713PheMet: 0.713 ± 0.005	1.23PheAsn: 1.23 ± 0.008	1.96PhePro: 1.96 ± 0.01	1.791PheGln: 1.791 ± 0.008	1.904PheArg: 1.904 ± 0.01	3.305PheSer: 3.305 ± 0.015	1.898PheThr: 1.898 ± 0.01	1.988PheVal: 1.988 ± 0.009	0.455PheTrp: 0.455 ± 0.004	1.057PheTyr: 1.057 ± 0.007	0.004PheXaa: 0.004 ± 0.0
Gly	4.745GlyAla: 4.745 ± 0.022	1.251GlyCys: 1.251 ± 0.009	3.197GlyAsp: 3.197 ± 0.014	4.253GlyGlu: 4.253 ± 0.022	2.295GlyPhe: 2.295 ± 0.013	5.263GlyGly: 5.263 ± 0.029	1.746GlyHis: 1.746 ± 0.009	2.525GlyIle: 2.525 ± 0.011	3.702GlyLys: 3.702 ± 0.018	5.889GlyLeu: 5.889 ± 0.02	1.268GlyMet: 1.268 ± 0.009	2.267GlyAsn: 2.267 ± 0.012	4.628GlyPro: 4.628 ± 0.033	2.879GlyGln: 2.879 ± 0.013	4.017GlyArg: 4.017 ± 0.018	6.082GlySer: 6.082 ± 0.026	3.568GlyThr: 3.568 ± 0.016	3.495GlyVal: 3.495 ± 0.015	0.778GlyTrp: 0.778 ± 0.007	1.624GlyTyr: 1.624 ± 0.009	0.007GlyXaa: 0.007 ± 0.001
His	1.361HisAla: 1.361 ± 0.007	0.694HisCys: 0.694 ± 0.006	0.898HisAsp: 0.898 ± 0.005	1.35HisGlu: 1.35 ± 0.008	1.011HisPhe: 1.011 ± 0.005	1.554HisGly: 1.554 ± 0.009	0.907HisHis: 0.907 ± 0.007	1.187HisIle: 1.187 ± 0.006	1.27HisLys: 1.27 ± 0.007	2.931HisLeu: 2.931 ± 0.012	0.563HisMet: 0.563 ± 0.005	0.806HisAsn: 0.806 ± 0.005	1.699HisPro: 1.699 ± 0.011	1.401HisGln: 1.401 ± 0.01	1.641HisArg: 1.641 ± 0.008	2.337HisSer: 2.337 ± 0.012	1.513HisThr: 1.513 ± 0.011	1.555HisVal: 1.555 ± 0.008	0.345HisTrp: 0.345 ± 0.004	0.776HisTyr: 0.776 ± 0.006	0.002HisXaa: 0.002 ± 0.0
Ile	2.424IleAla: 2.424 ± 0.011	0.939IleCys: 0.939 ± 0.006	1.945IleAsp: 1.945 ± 0.011	2.52IleGlu: 2.52 ± 0.013	1.669IlePhe: 1.669 ± 0.009	2.031IleGly: 2.031 ± 0.01	1.289IleHis: 1.289 ± 0.009	2.092IleIle: 2.092 ± 0.012	2.48IleLys: 2.48 ± 0.014	4.181IleLeu: 4.181 ± 0.018	0.892IleMet: 0.892 ± 0.007	1.69IleAsn: 1.69 ± 0.009	2.518IlePro: 2.518 ± 0.011	2.249IleGln: 2.249 ± 0.011	2.282IleArg: 2.282 ± 0.008	3.577IleSer: 3.577 ± 0.015	2.428IleThr: 2.428 ± 0.012	2.276IleVal: 2.276 ± 0.012	0.468IleTrp: 0.468 ± 0.004	1.241IleTyr: 1.241 ± 0.007	0.003IleXaa: 0.003 ± 0.0
Lys	3.97LysAla: 3.97 ± 0.018	1.067LysCys: 1.067 ± 0.009	3.141LysAsp: 3.141 ± 0.017	5.234LysGlu: 5.234 ± 0.028	1.631LysPhe: 1.631 ± 0.007	3.213LysGly: 3.213 ± 0.015	1.376LysHis: 1.376 ± 0.008	2.583LysIle: 2.583 ± 0.014	4.543LysLys: 4.543 ± 0.023	5.157LysLeu: 5.157 ± 0.023	1.377LysMet: 1.377 ± 0.008	2.276LysAsn: 2.276 ± 0.012	3.164LysPro: 3.164 ± 0.016	2.699LysGln: 2.699 ± 0.013	3.316LysArg: 3.316 ± 0.014	3.982LysSer: 3.982 ± 0.018	3.069LysThr: 3.069 ± 0.014	3.41LysVal: 3.41 ± 0.015	0.588LysTrp: 0.588 ± 0.006	1.446LysTyr: 1.446 ± 0.008	0.004LysXaa: 0.004 ± 0.0
Leu	6.842LeuAla: 6.842 ± 0.024	2.128LeuCys: 2.128 ± 0.011	4.825LeuAsp: 4.825 ± 0.016	7.515LeuGlu: 7.515 ± 0.035	3.096LeuPhe: 3.096 ± 0.015	5.914LeuGly: 5.914 ± 0.022	2.772LeuHis: 2.772 ± 0.012	3.628LeuIle: 3.628 ± 0.017	5.808LeuLys: 5.808 ± 0.023	10.649LeuLeu: 10.649 ± 0.04	1.933LeuMet: 1.933 ± 0.011	3.396LeuAsn: 3.396 ± 0.013	6.188LeuPro: 6.188 ± 0.022	6.087LeuGln: 6.087 ± 0.027	6.072LeuArg: 6.072 ± 0.023	8.042LeuSer: 8.042 ± 0.021	4.939LeuThr: 4.939 ± 0.015	5.328LeuVal: 5.328 ± 0.019	1.087LeuTrp: 1.087 ± 0.007	2.376LeuTyr: 2.376 ± 0.011	0.009LeuXaa: 0.009 ± 0.001
Met	1.813MetAla: 1.813 ± 0.008	0.373MetCys: 0.373 ± 0.004	1.214MetAsp: 1.214 ± 0.007	1.868MetGlu: 1.868 ± 0.009	0.666MetPhe: 0.666 ± 0.005	1.222MetGly: 1.222 ± 0.008	0.459MetHis: 0.459 ± 0.004	0.761MetIle: 0.761 ± 0.005	1.381MetLys: 1.381 ± 0.008	1.888MetLeu: 1.888 ± 0.01	0.526MetMet: 0.526 ± 0.005	0.845MetAsn: 0.845 ± 0.007	1.086MetPro: 1.086 ± 0.008	0.933MetGln: 0.933 ± 0.006	1.037MetArg: 1.037 ± 0.007	1.507MetSer: 1.507 ± 0.007	1.08MetThr: 1.08 ± 0.006	1.329MetVal: 1.329 ± 0.007	0.225MetTrp: 0.225 ± 0.003	0.511MetTyr: 0.511 ± 0.004	0.002MetXaa: 0.002 ± 0.0
Asn	1.967AsnAla: 1.967 ± 0.01	0.76AsnCys: 0.76 ± 0.006	1.472AsnAsp: 1.472 ± 0.01	2.136AsnGlu: 2.136 ± 0.011	1.346AsnPhe: 1.346 ± 0.008	2.381AsnGly: 2.381 ± 0.014	0.905AsnHis: 0.905 ± 0.006	1.94AsnIle: 1.94 ± 0.011	2.086AsnLys: 2.086 ± 0.012	3.598AsnLeu: 3.598 ± 0.013	0.828AsnMet: 0.828 ± 0.006	1.398AsnAsn: 1.398 ± 0.008	2.076AsnPro: 2.076 ± 0.011	1.649AsnGln: 1.649 ± 0.009	1.766AsnArg: 1.766 ± 0.008	3.1AsnSer: 3.1 ± 0.014	1.883AsnThr: 1.883 ± 0.009	2.111AsnVal: 2.111 ± 0.011	0.413AsnTrp: 0.413 ± 0.004	1.004AsnTyr: 1.004 ± 0.007	0.003AsnXaa: 0.003 ± 0.0
Pro	5.436ProAla: 5.436 ± 0.031	1.13ProCys: 1.13 ± 0.011	2.841ProAsp: 2.841 ± 0.014	4.718ProGlu: 4.718 ± 0.018	1.883ProPhe: 1.883 ± 0.011	5.66ProGly: 5.66 ± 0.042	1.48ProHis: 1.48 ± 0.01	1.805ProIle: 1.805 ± 0.008	2.803ProLys: 2.803 ± 0.014	5.43ProLeu: 5.43 ± 0.022	1.034ProMet: 1.034 ± 0.007	1.758ProAsn: 1.758 ± 0.011	6.721ProPro: 6.721 ± 0.042	3.024ProGln: 3.024 ± 0.017	3.676ProArg: 3.676 ± 0.02	6.198ProSer: 6.198 ± 0.026	3.191ProThr: 3.191 ± 0.015	3.956ProVal: 3.956 ± 0.017	0.693ProTrp: 0.693 ± 0.005	1.475ProTyr: 1.475 ± 0.011	0.007ProXaa: 0.007 ± 0.0
Gln	3.751GlnAla: 3.751 ± 0.017	0.903GlnCys: 0.903 ± 0.007	2.427GlnAsp: 2.427 ± 0.011	4.15GlnGlu: 4.15 ± 0.022	1.349GlnPhe: 1.349 ± 0.008	2.993GlnGly: 2.993 ± 0.014	1.361GlnHis: 1.361 ± 0.007	1.952GlnIle: 1.952 ± 0.01	3.036GlnLys: 3.036 ± 0.016	4.952GlnLeu: 4.952 ± 0.023	1.117GlnMet: 1.117 ± 0.008	1.825GlnAsn: 1.825 ± 0.009	3.017GlnPro: 3.017 ± 0.018	3.325GlnGln: 3.325 ± 0.024	3.192GlnArg: 3.192 ± 0.016	3.333GlnSer: 3.333 ± 0.016	2.375GlnThr: 2.375 ± 0.01	2.886GlnVal: 2.886 ± 0.011	0.537GlnTrp: 0.537 ± 0.005	1.13GlnTyr: 1.13 ± 0.007	0.004GlnXaa: 0.004 ± 0.0
Arg	4.107ArgAla: 4.107 ± 0.02	1.203ArgCys: 1.203 ± 0.011	2.842ArgAsp: 2.842 ± 0.011	4.269ArgGlu: 4.269 ± 0.017	1.784ArgPhe: 1.784 ± 0.009	3.852ArgGly: 3.852 ± 0.021	1.554ArgHis: 1.554 ± 0.009	2.348ArgIle: 2.348 ± 0.01	3.696ArgLys: 3.696 ± 0.013	5.626ArgLeu: 5.626 ± 0.022	1.174ArgMet: 1.174 ± 0.008	2.04ArgAsn: 2.04 ± 0.009	3.54ArgPro: 3.54 ± 0.019	2.824ArgGln: 2.824 ± 0.014	4.666ArgArg: 4.666 ± 0.025	4.613ArgSer: 4.613 ± 0.024	2.924ArgThr: 2.924 ± 0.013	3.197ArgVal: 3.197 ± 0.013	0.699ArgTrp: 0.699 ± 0.006	1.37ArgTyr: 1.37 ± 0.007	0.005ArgXaa: 0.005 ± 0.0
Ser	5.689SerAla: 5.689 ± 0.021	1.78SerCys: 1.78 ± 0.012	3.971SerAsp: 3.971 ± 0.016	5.482SerGlu: 5.482 ± 0.02	2.923SerPhe: 2.923 ± 0.012	5.828SerGly: 5.828 ± 0.021	2.155SerHis: 2.155 ± 0.01	3.088SerIle: 3.088 ± 0.012	4.159SerLys: 4.159 ± 0.016	8.424SerLeu: 8.424 ± 0.022	1.558SerMet: 1.558 ± 0.008	2.59SerAsn: 2.59 ± 0.011	6.634SerPro: 6.634 ± 0.036	4.096SerGln: 4.096 ± 0.016	4.791SerArg: 4.791 ± 0.022	10.011SerSer: 10.011 ± 0.045	4.563SerThr: 4.563 ± 0.013	4.968SerVal: 4.968 ± 0.018	1.064SerTrp: 1.064 ± 0.007	1.987SerTyr: 1.987 ± 0.011	0.006SerXaa: 0.006 ± 0.001
Thr	3.852ThrAla: 3.852 ± 0.015	1.231ThrCys: 1.231 ± 0.01	2.429ThrAsp: 2.429 ± 0.009	3.604ThrGlu: 3.604 ± 0.014	1.979ThrPhe: 1.979 ± 0.009	3.523ThrGly: 3.523 ± 0.014	1.268ThrHis: 1.268 ± 0.008	2.174ThrIle: 2.174 ± 0.01	2.632ThrLys: 2.632 ± 0.012	5.231ThrLeu: 5.231 ± 0.017	1.065ThrMet: 1.065 ± 0.006	1.639ThrAsn: 1.639 ± 0.01	3.74ThrPro: 3.74 ± 0.019	2.336ThrGln: 2.336 ± 0.011	2.531ThrArg: 2.531 ± 0.011	4.723ThrSer: 4.723 ± 0.018	2.922ThrThr: 2.922 ± 0.017	3.769ThrVal: 3.769 ± 0.016	0.675ThrTrp: 0.675 ± 0.006	1.338ThrTyr: 1.338 ± 0.008	0.005ThrXaa: 0.005 ± 0.0
Val	4.291ValAla: 4.291 ± 0.016	1.391ValCys: 1.391 ± 0.01	2.929ValAsp: 2.929 ± 0.012	3.91ValGlu: 3.91 ± 0.016	2.241ValPhe: 2.241 ± 0.01	3.302ValGly: 3.302 ± 0.014	1.582ValHis: 1.582 ± 0.009	2.7ValIle: 2.7 ± 0.012	3.398ValLys: 3.398 ± 0.017	6.017ValLeu: 6.017 ± 0.021	1.251ValMet: 1.251 ± 0.008	2.208ValAsn: 2.208 ± 0.01	3.774ValPro: 3.774 ± 0.016	2.817ValGln: 2.817 ± 0.013	3.097ValArg: 3.097 ± 0.012	4.937ValSer: 4.937 ± 0.018	3.711ValThr: 3.711 ± 0.018	3.836ValVal: 3.836 ± 0.016	0.678ValTrp: 0.678 ± 0.005	1.519ValTyr: 1.519 ± 0.01	0.004ValXaa: 0.004 ± 0.0
Trp	0.792TrpAla: 0.792 ± 0.006	0.238TrpCys: 0.238 ± 0.003	0.616TrpAsp: 0.616 ± 0.005	0.813TrpGlu: 0.813 ± 0.006	0.407TrpPhe: 0.407 ± 0.004	0.717TrpGly: 0.717 ± 0.007	0.309TrpHis: 0.309 ± 0.003	0.501TrpIle: 0.501 ± 0.005	0.752TrpLys: 0.752 ± 0.007	1.188TrpLeu: 1.188 ± 0.009	0.306TrpMet: 0.306 ± 0.003	0.504TrpAsn: 0.504 ± 0.005	0.547TrpPro: 0.547 ± 0.006	0.527TrpGln: 0.527 ± 0.005	0.742TrpArg: 0.742 ± 0.006	0.843TrpSer: 0.843 ± 0.007	0.648TrpThr: 0.648 ± 0.005	0.642TrpVal: 0.642 ± 0.004	0.18TrpTrp: 0.18 ± 0.003	0.31TrpTyr: 0.31 ± 0.004	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.307TyrAla: 1.307 ± 0.008	0.627TyrCys: 0.627 ± 0.005	1.192TyrAsp: 1.192 ± 0.007	1.653TyrGlu: 1.653 ± 0.009	1.083TyrPhe: 1.083 ± 0.008	1.546TyrGly: 1.546 ± 0.01	0.708TyrHis: 0.708 ± 0.005	1.264TyrIle: 1.264 ± 0.008	1.386TyrLys: 1.386 ± 0.009	2.475TyrLeu: 2.475 ± 0.012	0.542TyrMet: 0.542 ± 0.005	0.977TyrAsn: 0.977 ± 0.006	1.232TyrPro: 1.232 ± 0.008	1.229TyrGln: 1.229 ± 0.006	1.563TyrArg: 1.563 ± 0.009	2.13TyrSer: 2.13 ± 0.012	1.365TyrThr: 1.365 ± 0.009	1.46TyrVal: 1.46 ± 0.008	0.33TyrTrp: 0.33 ± 0.004	0.861TyrTyr: 0.861 ± 0.007	0.002TyrXaa: 0.002 ± 0.0
Xaa	0.007XaaAla: 0.007 ± 0.001	0.002XaaCys: 0.002 ± 0.0	0.004XaaAsp: 0.004 ± 0.0	0.006XaaGlu: 0.006 ± 0.001	0.004XaaPhe: 0.004 ± 0.0	0.007XaaGly: 0.007 ± 0.001	0.002XaaHis: 0.002 ± 0.0	0.003XaaIle: 0.003 ± 0.0	0.005XaaLys: 0.005 ± 0.0	0.009XaaLeu: 0.009 ± 0.001	0.001XaaMet: 0.001 ± 0.0	0.003XaaAsn: 0.003 ± 0.0	0.006XaaPro: 0.006 ± 0.0	0.004XaaGln: 0.004 ± 0.0	0.005XaaArg: 0.005 ± 0.0	0.005XaaSer: 0.005 ± 0.0	0.004XaaThr: 0.004 ± 0.0	0.005XaaVal: 0.005 ± 0.0	0.001XaaTrp: 0.001 ± 0.0	0.002XaaTyr: 0.002 ± 0.0	0.002XaaXaa: 0.002 ± 0.001

Statistics based on 40783 proteins (29353646 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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