Amino acid dipepetide frequency for Candidatus Rickettsiella viridis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.246AlaAla: 7.246 ± 0.157
1.116AlaCys: 1.116 ± 0.06
3.821AlaAsp: 3.821 ± 0.101
4.854AlaGlu: 4.854 ± 0.115
3.188AlaPhe: 3.188 ± 0.097
4.917AlaGly: 4.917 ± 0.125
1.729AlaHis: 1.729 ± 0.065
6.347AlaIle: 6.347 ± 0.133
5.485AlaLys: 5.485 ± 0.128
10.141AlaLeu: 10.141 ± 0.163
1.872AlaMet: 1.872 ± 0.081
3.524AlaAsn: 3.524 ± 0.105
2.467AlaPro: 2.467 ± 0.073
3.651AlaGln: 3.651 ± 0.095
3.567AlaArg: 3.567 ± 0.104
4.924AlaSer: 4.924 ± 0.11
4.2AlaThr: 4.2 ± 0.152
4.827AlaVal: 4.827 ± 0.115
0.894AlaTrp: 0.894 ± 0.044
2.582AlaTyr: 2.582 ± 0.088
0.0AlaXaa: 0.0 ± 0.0
Cys
0.767CysAla: 0.767 ± 0.045
0.154CysCys: 0.154 ± 0.019
0.49CysAsp: 0.49 ± 0.037
0.629CysGlu: 0.629 ± 0.041
0.615CysPhe: 0.615 ± 0.041
0.783CysGly: 0.783 ± 0.042
0.297CysHis: 0.297 ± 0.024
0.803CysIle: 0.803 ± 0.043
0.608CysLys: 0.608 ± 0.044
1.457CysLeu: 1.457 ± 0.073
0.245CysMet: 0.245 ± 0.026
0.334CysAsn: 0.334 ± 0.029
0.536CysPro: 0.536 ± 0.035
0.511CysGln: 0.511 ± 0.036
0.499CysArg: 0.499 ± 0.037
0.694CysSer: 0.694 ± 0.038
0.474CysThr: 0.474 ± 0.033
0.667CysVal: 0.667 ± 0.043
0.118CysTrp: 0.118 ± 0.016
0.431CysTyr: 0.431 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
3.445AspAla: 3.445 ± 0.1
0.617AspCys: 0.617 ± 0.042
2.015AspAsp: 2.015 ± 0.071
2.789AspGlu: 2.789 ± 0.089
2.331AspPhe: 2.331 ± 0.082
2.365AspGly: 2.365 ± 0.092
0.994AspHis: 0.994 ± 0.05
3.747AspIle: 3.747 ± 0.1
3.669AspLys: 3.669 ± 0.106
5.278AspLeu: 5.278 ± 0.114
0.908AspMet: 0.908 ± 0.041
1.992AspAsn: 1.992 ± 0.071
2.165AspPro: 2.165 ± 0.075
1.811AspGln: 1.811 ± 0.072
2.158AspArg: 2.158 ± 0.071
2.941AspSer: 2.941 ± 0.091
2.262AspThr: 2.262 ± 0.075
2.523AspVal: 2.523 ± 0.079
0.617AspTrp: 0.617 ± 0.041
2.024AspTyr: 2.024 ± 0.061
0.0AspXaa: 0.0 ± 0.0
Glu
4.706GluAla: 4.706 ± 0.114
0.526GluCys: 0.526 ± 0.039
2.34GluAsp: 2.34 ± 0.074
3.914GluGlu: 3.914 ± 0.115
2.197GluPhe: 2.197 ± 0.071
3.048GluGly: 3.048 ± 0.084
1.203GluHis: 1.203 ± 0.051
4.434GluIle: 4.434 ± 0.113
5.51GluLys: 5.51 ± 0.152
6.213GluLeu: 6.213 ± 0.133
1.2GluMet: 1.2 ± 0.053
3.272GluAsn: 3.272 ± 0.106
1.652GluPro: 1.652 ± 0.063
3.379GluGln: 3.379 ± 0.101
2.85GluArg: 2.85 ± 0.096
3.213GluSer: 3.213 ± 0.102
3.179GluThr: 3.179 ± 0.099
3.354GluVal: 3.354 ± 0.113
0.579GluTrp: 0.579 ± 0.038
1.448GluTyr: 1.448 ± 0.06
0.0GluXaa: 0.0 ± 0.0
Phe
3.088PheAla: 3.088 ± 0.086
0.542PheCys: 0.542 ± 0.035
2.167PheAsp: 2.167 ± 0.067
2.011PheGlu: 2.011 ± 0.08
2.494PhePhe: 2.494 ± 0.09
2.29PheGly: 2.29 ± 0.075
0.951PheHis: 0.951 ± 0.048
3.538PheIle: 3.538 ± 0.102
2.641PheLys: 2.641 ± 0.096
5.038PheLeu: 5.038 ± 0.131
0.871PheMet: 0.871 ± 0.04
2.315PheAsn: 2.315 ± 0.09
1.82PhePro: 1.82 ± 0.075
1.57PheGln: 1.57 ± 0.065
1.552PheArg: 1.552 ± 0.066
4.13PheSer: 4.13 ± 0.107
2.281PheThr: 2.281 ± 0.074
2.276PheVal: 2.276 ± 0.069
0.495PheTrp: 0.495 ± 0.037
1.704PheTyr: 1.704 ± 0.076
0.0PheXaa: 0.0 ± 0.0
Gly
4.268GlyAla: 4.268 ± 0.126
0.874GlyCys: 0.874 ± 0.049
2.689GlyAsp: 2.689 ± 0.097
3.195GlyGlu: 3.195 ± 0.095
2.941GlyPhe: 2.941 ± 0.083
3.926GlyGly: 3.926 ± 0.137
1.461GlyHis: 1.461 ± 0.065
4.74GlyIle: 4.74 ± 0.127
3.883GlyLys: 3.883 ± 0.116
7.114GlyLeu: 7.114 ± 0.149
1.359GlyMet: 1.359 ± 0.057
2.392GlyAsn: 2.392 ± 0.123
1.695GlyPro: 1.695 ± 0.068
2.573GlyGln: 2.573 ± 0.086
2.834GlyArg: 2.834 ± 0.091
3.595GlySer: 3.595 ± 0.102
2.966GlyThr: 2.966 ± 0.15
3.846GlyVal: 3.846 ± 0.098
0.76GlyTrp: 0.76 ± 0.05
2.113GlyTyr: 2.113 ± 0.073
0.0GlyXaa: 0.0 ± 0.0
His
1.883HisAla: 1.883 ± 0.068
0.413HisCys: 0.413 ± 0.028
0.969HisAsp: 0.969 ± 0.05
1.18HisGlu: 1.18 ± 0.053
1.244HisPhe: 1.244 ± 0.053
1.341HisGly: 1.341 ± 0.066
0.685HisHis: 0.685 ± 0.044
1.586HisIle: 1.586 ± 0.058
1.135HisLys: 1.135 ± 0.05
2.825HisLeu: 2.825 ± 0.091
0.458HisMet: 0.458 ± 0.035
0.865HisAsn: 0.865 ± 0.05
1.196HisPro: 1.196 ± 0.053
1.028HisGln: 1.028 ± 0.047
1.225HisArg: 1.225 ± 0.058
1.552HisSer: 1.552 ± 0.056
1.141HisThr: 1.141 ± 0.054
1.223HisVal: 1.223 ± 0.057
0.39HisTrp: 0.39 ± 0.028
1.2HisTyr: 1.2 ± 0.057
0.0HisXaa: 0.0 ± 0.0
Ile
6.66IleAla: 6.66 ± 0.136
0.762IleCys: 0.762 ± 0.047
3.978IleAsp: 3.978 ± 0.099
4.484IleGlu: 4.484 ± 0.118
2.846IlePhe: 2.846 ± 0.09
4.693IleGly: 4.693 ± 0.126
1.809IleHis: 1.809 ± 0.07
5.024IleIle: 5.024 ± 0.14
5.011IleLys: 5.011 ± 0.108
7.064IleLeu: 7.064 ± 0.139
1.175IleMet: 1.175 ± 0.054
3.837IleAsn: 3.837 ± 0.103
3.295IlePro: 3.295 ± 0.1
3.343IleGln: 3.343 ± 0.088
3.016IleArg: 3.016 ± 0.084
4.697IleSer: 4.697 ± 0.112
4.141IleThr: 4.141 ± 0.131
4.019IleVal: 4.019 ± 0.099
0.579IleTrp: 0.579 ± 0.035
2.244IleTyr: 2.244 ± 0.072
0.0IleXaa: 0.0 ± 0.0
Lys
4.893LysAla: 4.893 ± 0.115
0.497LysCys: 0.497 ± 0.042
2.975LysAsp: 2.975 ± 0.104
4.647LysGlu: 4.647 ± 0.162
1.995LysPhe: 1.995 ± 0.068
3.331LysGly: 3.331 ± 0.095
1.498LysHis: 1.498 ± 0.058
4.843LysIle: 4.843 ± 0.123
5.893LysLys: 5.893 ± 0.149
6.767LysLeu: 6.767 ± 0.141
1.33LysMet: 1.33 ± 0.064
4.094LysAsn: 4.094 ± 0.124
2.839LysPro: 2.839 ± 0.079
4.08LysGln: 4.08 ± 0.119
3.12LysArg: 3.12 ± 0.085
3.601LysSer: 3.601 ± 0.088
3.933LysThr: 3.933 ± 0.093
3.288LysVal: 3.288 ± 0.103
0.517LysTrp: 0.517 ± 0.033
1.55LysTyr: 1.55 ± 0.066
0.0LysXaa: 0.0 ± 0.0
Leu
10.373LeuAla: 10.373 ± 0.176
1.155LeuCys: 1.155 ± 0.052
5.514LeuAsp: 5.514 ± 0.125
6.608LeuGlu: 6.608 ± 0.142
5.396LeuPhe: 5.396 ± 0.135
6.924LeuGly: 6.924 ± 0.138
2.564LeuHis: 2.564 ± 0.072
8.285LeuIle: 8.285 ± 0.158
7.704LeuLys: 7.704 ± 0.152
13.659LeuLeu: 13.659 ± 0.25
2.19LeuMet: 2.19 ± 0.076
5.789LeuAsn: 5.789 ± 0.141
5.378LeuPro: 5.378 ± 0.117
5.421LeuGln: 5.421 ± 0.126
5.188LeuArg: 5.188 ± 0.114
9.052LeuSer: 9.052 ± 0.162
6.195LeuThr: 6.195 ± 0.119
6.016LeuVal: 6.016 ± 0.137
1.103LeuTrp: 1.103 ± 0.058
3.098LeuTyr: 3.098 ± 0.09
0.0LeuXaa: 0.0 ± 0.0
Met
1.974MetAla: 1.974 ± 0.079
0.132MetCys: 0.132 ± 0.014
0.974MetAsp: 0.974 ± 0.046
0.983MetGlu: 0.983 ± 0.046
0.565MetPhe: 0.565 ± 0.037
1.387MetGly: 1.387 ± 0.059
0.411MetHis: 0.411 ± 0.031
1.182MetIle: 1.182 ± 0.05
1.101MetLys: 1.101 ± 0.05
2.408MetLeu: 2.408 ± 0.088
0.474MetMet: 0.474 ± 0.037
0.853MetAsn: 0.853 ± 0.05
1.08MetPro: 1.08 ± 0.048
1.08MetGln: 1.08 ± 0.048
1.033MetArg: 1.033 ± 0.047
1.262MetSer: 1.262 ± 0.058
1.157MetThr: 1.157 ± 0.06
1.126MetVal: 1.126 ± 0.055
0.125MetTrp: 0.125 ± 0.018
0.379MetTyr: 0.379 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
3.57AsnAla: 3.57 ± 0.094
0.488AsnCys: 0.488 ± 0.031
2.097AsnAsp: 2.097 ± 0.068
2.272AsnGlu: 2.272 ± 0.074
1.972AsnPhe: 1.972 ± 0.072
2.192AsnGly: 2.192 ± 0.078
1.146AsnHis: 1.146 ± 0.053
3.138AsnIle: 3.138 ± 0.106
3.551AsnLys: 3.551 ± 0.114
4.956AsnLeu: 4.956 ± 0.114
0.749AsnMet: 0.749 ± 0.043
2.621AsnAsn: 2.621 ± 0.125
2.678AsnPro: 2.678 ± 0.078
2.278AsnGln: 2.278 ± 0.082
2.154AsnArg: 2.154 ± 0.077
2.866AsnSer: 2.866 ± 0.078
2.97AsnThr: 2.97 ± 0.084
2.294AsnVal: 2.294 ± 0.113
0.502AsnTrp: 0.502 ± 0.032
1.745AsnTyr: 1.745 ± 0.088
0.0AsnXaa: 0.0 ± 0.0
Pro
2.848ProAla: 2.848 ± 0.092
0.445ProCys: 0.445 ± 0.031
2.104ProAsp: 2.104 ± 0.072
2.911ProGlu: 2.911 ± 0.106
1.938ProPhe: 1.938 ± 0.064
2.523ProGly: 2.523 ± 0.087
0.976ProHis: 0.976 ± 0.048
3.161ProIle: 3.161 ± 0.088
2.158ProLys: 2.158 ± 0.073
5.076ProLeu: 5.076 ± 0.111
0.787ProMet: 0.787 ± 0.043
1.902ProAsn: 1.902 ± 0.065
1.505ProPro: 1.505 ± 0.062
1.734ProGln: 1.734 ± 0.072
1.545ProArg: 1.545 ± 0.062
2.882ProSer: 2.882 ± 0.076
2.222ProThr: 2.222 ± 0.069
2.675ProVal: 2.675 ± 0.087
0.474ProTrp: 0.474 ± 0.036
1.441ProTyr: 1.441 ± 0.059
0.0ProXaa: 0.0 ± 0.0
Gln
4.824GlnAla: 4.824 ± 0.139
0.443GlnCys: 0.443 ± 0.034
1.781GlnAsp: 1.781 ± 0.066
2.837GlnGlu: 2.837 ± 0.094
1.992GlnPhe: 1.992 ± 0.071
3.193GlnGly: 3.193 ± 0.1
1.427GlnHis: 1.427 ± 0.066
3.082GlnIle: 3.082 ± 0.085
2.827GlnLys: 2.827 ± 0.087
6.377GlnLeu: 6.377 ± 0.139
0.826GlnMet: 0.826 ± 0.038
1.697GlnAsn: 1.697 ± 0.068
1.647GlnPro: 1.647 ± 0.07
3.654GlnGln: 3.654 ± 0.127
2.744GlnArg: 2.744 ± 0.097
2.932GlnSer: 2.932 ± 0.082
2.759GlnThr: 2.759 ± 0.096
2.63GlnVal: 2.63 ± 0.085
0.631GlnTrp: 0.631 ± 0.039
1.212GlnTyr: 1.212 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
3.27ArgAla: 3.27 ± 0.084
0.515ArgCys: 0.515 ± 0.03
2.126ArgAsp: 2.126 ± 0.084
2.812ArgGlu: 2.812 ± 0.084
2.324ArgPhe: 2.324 ± 0.075
2.476ArgGly: 2.476 ± 0.08
1.248ArgHis: 1.248 ± 0.048
3.29ArgIle: 3.29 ± 0.101
2.492ArgLys: 2.492 ± 0.062
6.122ArgLeu: 6.122 ± 0.134
0.876ArgMet: 0.876 ± 0.048
1.813ArgAsn: 1.813 ± 0.066
1.579ArgPro: 1.579 ± 0.07
2.46ArgGln: 2.46 ± 0.087
2.485ArgArg: 2.485 ± 0.084
2.496ArgSer: 2.496 ± 0.073
1.945ArgThr: 1.945 ± 0.067
2.762ArgVal: 2.762 ± 0.089
0.608ArgTrp: 0.608 ± 0.04
1.861ArgTyr: 1.861 ± 0.071
0.0ArgXaa: 0.0 ± 0.0
Ser
5.124SerAla: 5.124 ± 0.108
0.658SerCys: 0.658 ± 0.037
3.147SerAsp: 3.147 ± 0.094
3.744SerGlu: 3.744 ± 0.09
3.145SerPhe: 3.145 ± 0.089
4.116SerGly: 4.116 ± 0.125
1.461SerHis: 1.461 ± 0.063
4.677SerIle: 4.677 ± 0.121
3.42SerLys: 3.42 ± 0.098
8.183SerLeu: 8.183 ± 0.133
1.425SerMet: 1.425 ± 0.06
2.843SerAsn: 2.843 ± 0.1
2.669SerPro: 2.669 ± 0.077
3.079SerGln: 3.079 ± 0.094
2.582SerArg: 2.582 ± 0.078
4.477SerSer: 4.477 ± 0.109
3.506SerThr: 3.506 ± 0.089
3.772SerVal: 3.772 ± 0.092
0.683SerTrp: 0.683 ± 0.036
2.199SerTyr: 2.199 ± 0.076
0.0SerXaa: 0.0 ± 0.0
Thr
4.632ThrAla: 4.632 ± 0.164
0.524ThrCys: 0.524 ± 0.038
2.446ThrAsp: 2.446 ± 0.083
3.116ThrGlu: 3.116 ± 0.09
1.931ThrPhe: 1.931 ± 0.073
3.601ThrGly: 3.601 ± 0.128
1.452ThrHis: 1.452 ± 0.06
3.787ThrIle: 3.787 ± 0.094
2.753ThrLys: 2.753 ± 0.079
6.828ThrLeu: 6.828 ± 0.143
0.976ThrMet: 0.976 ± 0.049
2.033ThrAsn: 2.033 ± 0.077
2.943ThrPro: 2.943 ± 0.1
2.898ThrGln: 2.898 ± 0.091
2.308ThrArg: 2.308 ± 0.076
3.073ThrSer: 3.073 ± 0.099
3.102ThrThr: 3.102 ± 0.179
3.411ThrVal: 3.411 ± 0.108
0.488ThrTrp: 0.488 ± 0.033
1.398ThrTyr: 1.398 ± 0.065
0.0ThrXaa: 0.0 ± 0.0
Val
4.704ValAla: 4.704 ± 0.107
0.674ValCys: 0.674 ± 0.039
3.034ValAsp: 3.034 ± 0.095
3.204ValGlu: 3.204 ± 0.091
2.451ValPhe: 2.451 ± 0.077
3.74ValGly: 3.74 ± 0.137
1.033ValHis: 1.033 ± 0.051
4.436ValIle: 4.436 ± 0.114
3.515ValLys: 3.515 ± 0.087
6.417ValLeu: 6.417 ± 0.134
1.234ValMet: 1.234 ± 0.055
2.514ValAsn: 2.514 ± 0.083
2.228ValPro: 2.228 ± 0.085
2.024ValGln: 2.024 ± 0.06
2.367ValArg: 2.367 ± 0.086
3.835ValSer: 3.835 ± 0.122
3.136ValThr: 3.136 ± 0.115
3.699ValVal: 3.699 ± 0.095
0.599ValTrp: 0.599 ± 0.039
1.745ValTyr: 1.745 ± 0.064
0.0ValXaa: 0.0 ± 0.0
Trp
0.66TrpAla: 0.66 ± 0.039
0.127TrpCys: 0.127 ± 0.017
0.486TrpAsp: 0.486 ± 0.032
0.558TrpGlu: 0.558 ± 0.04
0.472TrpPhe: 0.472 ± 0.03
0.576TrpGly: 0.576 ± 0.039
0.315TrpHis: 0.315 ± 0.027
0.856TrpIle: 0.856 ± 0.046
0.572TrpLys: 0.572 ± 0.042
1.468TrpLeu: 1.468 ± 0.066
0.227TrpMet: 0.227 ± 0.022
0.467TrpAsn: 0.467 ± 0.042
0.467TrpPro: 0.467 ± 0.037
0.794TrpGln: 0.794 ± 0.052
0.59TrpArg: 0.59 ± 0.043
0.533TrpSer: 0.533 ± 0.036
0.413TrpThr: 0.413 ± 0.026
0.738TrpVal: 0.738 ± 0.037
0.125TrpTrp: 0.125 ± 0.016
0.284TrpTyr: 0.284 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.419TyrAla: 2.419 ± 0.081
0.449TyrCys: 0.449 ± 0.032
1.498TyrAsp: 1.498 ± 0.072
1.47TyrGlu: 1.47 ± 0.063
1.738TyrPhe: 1.738 ± 0.065
1.804TyrGly: 1.804 ± 0.074
0.88TyrHis: 0.88 ± 0.045
1.72TyrIle: 1.72 ± 0.065
1.763TyrLys: 1.763 ± 0.066
4.221TyrLeu: 4.221 ± 0.1
0.497TyrMet: 0.497 ± 0.034
1.08TyrAsn: 1.08 ± 0.062
1.468TyrPro: 1.468 ± 0.059
2.147TyrGln: 2.147 ± 0.084
1.743TyrArg: 1.743 ± 0.068
2.156TyrSer: 2.156 ± 0.079
1.716TyrThr: 1.716 ± 0.067
1.446TyrVal: 1.446 ± 0.062
0.443TyrTrp: 0.443 ± 0.032
1.248TyrTyr: 1.248 ± 0.055
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1355 proteins (440673 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski