Amino acid dipepetide frequency for Gammaproteobacteria bacterium LSUCC0112

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.962AlaAla: 10.962 ± 0.16	1.059AlaCys: 1.059 ± 0.037	6.048AlaAsp: 6.048 ± 0.082	5.783AlaGlu: 5.783 ± 0.079	3.644AlaPhe: 3.644 ± 0.061	8.352AlaGly: 8.352 ± 0.112	1.96AlaHis: 1.96 ± 0.05	5.677AlaIle: 5.677 ± 0.081	2.549AlaLys: 2.549 ± 0.053	11.363AlaLeu: 11.363 ± 0.139	2.915AlaMet: 2.915 ± 0.051	3.446AlaAsn: 3.446 ± 0.071	3.818AlaPro: 3.818 ± 0.076	4.595AlaGln: 4.595 ± 0.079	5.836AlaArg: 5.836 ± 0.095	6.283AlaSer: 6.283 ± 0.079	5.074AlaThr: 5.074 ± 0.12	7.15AlaVal: 7.15 ± 0.11	1.277AlaTrp: 1.277 ± 0.04	2.36AlaTyr: 2.36 ± 0.054	0.002AlaXaa: 0.002 ± 0.001
Cys	0.878CysAla: 0.878 ± 0.03	0.151CysCys: 0.151 ± 0.016	0.493CysAsp: 0.493 ± 0.023	0.505CysGlu: 0.505 ± 0.023	0.402CysPhe: 0.402 ± 0.021	0.8CysGly: 0.8 ± 0.028	0.331CysHis: 0.331 ± 0.018	0.51CysIle: 0.51 ± 0.023	0.285CysLys: 0.285 ± 0.017	1.064CysLeu: 1.064 ± 0.03	0.206CysMet: 0.206 ± 0.015	0.287CysAsn: 0.287 ± 0.018	0.442CysPro: 0.442 ± 0.023	0.383CysGln: 0.383 ± 0.018	0.565CysArg: 0.565 ± 0.025	0.611CysSer: 0.611 ± 0.028	0.466CysThr: 0.466 ± 0.022	0.64CysVal: 0.64 ± 0.028	0.129CysTrp: 0.129 ± 0.011	0.252CysTyr: 0.252 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.865AspAla: 5.865 ± 0.075	0.543AspCys: 0.543 ± 0.021	3.168AspAsp: 3.168 ± 0.079	3.408AspGlu: 3.408 ± 0.061	2.438AspPhe: 2.438 ± 0.053	4.255AspGly: 4.255 ± 0.075	1.151AspHis: 1.151 ± 0.036	3.798AspIle: 3.798 ± 0.056	1.969AspLys: 1.969 ± 0.049	5.409AspLeu: 5.409 ± 0.072	1.503AspMet: 1.503 ± 0.041	2.243AspAsn: 2.243 ± 0.056	2.692AspPro: 2.692 ± 0.053	2.372AspGln: 2.372 ± 0.046	3.088AspArg: 3.088 ± 0.056	3.277AspSer: 3.277 ± 0.061	3.083AspThr: 3.083 ± 0.063	4.345AspVal: 4.345 ± 0.07	0.899AspTrp: 0.899 ± 0.023	1.874AspTyr: 1.874 ± 0.041	0.001AspXaa: 0.001 ± 0.001
Glu	4.876GluAla: 4.876 ± 0.087	0.338GluCys: 0.338 ± 0.016	2.417GluAsp: 2.417 ± 0.05	2.864GluGlu: 2.864 ± 0.065	2.227GluPhe: 2.227 ± 0.041	3.446GluGly: 3.446 ± 0.071	1.466GluHis: 1.466 ± 0.038	3.285GluIle: 3.285 ± 0.059	2.175GluLys: 2.175 ± 0.057	6.31GluLeu: 6.31 ± 0.093	1.445GluMet: 1.445 ± 0.038	2.034GluAsn: 2.034 ± 0.045	2.156GluPro: 2.156 ± 0.055	3.422GluGln: 3.422 ± 0.073	3.861GluArg: 3.861 ± 0.073	3.288GluSer: 3.288 ± 0.066	2.958GluThr: 2.958 ± 0.06	3.602GluVal: 3.602 ± 0.066	0.711GluTrp: 0.711 ± 0.025	1.389GluTyr: 1.389 ± 0.037	0.002GluXaa: 0.002 ± 0.001
Phe	3.726PheAla: 3.726 ± 0.061	0.444PheCys: 0.444 ± 0.022	2.656PheAsp: 2.656 ± 0.048	2.241PheGlu: 2.241 ± 0.048	1.61PhePhe: 1.61 ± 0.051	3.162PheGly: 3.162 ± 0.056	0.718PheHis: 0.718 ± 0.023	2.065PheIle: 2.065 ± 0.05	1.264PheLys: 1.264 ± 0.031	3.562PheLeu: 3.562 ± 0.069	1.072PheMet: 1.072 ± 0.033	1.694PheAsn: 1.694 ± 0.045	1.528PhePro: 1.528 ± 0.041	1.237PheGln: 1.237 ± 0.037	1.981PheArg: 1.981 ± 0.047	3.009PheSer: 3.009 ± 0.054	2.303PheThr: 2.303 ± 0.064	2.979PheVal: 2.979 ± 0.061	0.513PheTrp: 0.513 ± 0.022	1.297PheTyr: 1.297 ± 0.041	0.007PheXaa: 0.007 ± 0.003
Gly	6.621GlyAla: 6.621 ± 0.101	0.767GlyCys: 0.767 ± 0.032	4.142GlyAsp: 4.142 ± 0.066	3.965GlyGlu: 3.965 ± 0.062	3.437GlyPhe: 3.437 ± 0.063	5.696GlyGly: 5.696 ± 0.129	1.619GlyHis: 1.619 ± 0.046	4.72GlyIle: 4.72 ± 0.066	2.983GlyLys: 2.983 ± 0.065	7.702GlyLeu: 7.702 ± 0.097	2.24GlyMet: 2.24 ± 0.05	2.938GlyAsn: 2.938 ± 0.064	2.315GlyPro: 2.315 ± 0.051	3.089GlyGln: 3.089 ± 0.061	4.336GlyArg: 4.336 ± 0.071	4.98GlySer: 4.98 ± 0.085	4.393GlyThr: 4.393 ± 0.127	5.603GlyVal: 5.603 ± 0.072	1.112GlyTrp: 1.112 ± 0.03	2.222GlyTyr: 2.222 ± 0.044	0.002GlyXaa: 0.002 ± 0.001
His	2.0HisAla: 2.0 ± 0.048	0.302HisCys: 0.302 ± 0.018	1.095HisAsp: 1.095 ± 0.03	1.16HisGlu: 1.16 ± 0.037	0.92HisPhe: 0.92 ± 0.03	1.678HisGly: 1.678 ± 0.048	0.647HisHis: 0.647 ± 0.027	1.227HisIle: 1.227 ± 0.039	0.776HisLys: 0.776 ± 0.029	2.2HisLeu: 2.2 ± 0.049	0.525HisMet: 0.525 ± 0.021	0.791HisAsn: 0.791 ± 0.029	1.213HisPro: 1.213 ± 0.032	1.056HisGln: 1.056 ± 0.036	1.275HisArg: 1.275 ± 0.035	1.254HisSer: 1.254 ± 0.031	1.198HisThr: 1.198 ± 0.034	1.472HisVal: 1.472 ± 0.037	0.383HisTrp: 0.383 ± 0.022	0.723HisTyr: 0.723 ± 0.026	0.001HisXaa: 0.001 ± 0.001
Ile	6.135IleAla: 6.135 ± 0.076	0.597IleCys: 0.597 ± 0.024	3.81IleAsp: 3.81 ± 0.065	3.504IleGlu: 3.504 ± 0.064	1.902IlePhe: 1.902 ± 0.047	4.254IleGly: 4.254 ± 0.069	1.183IleHis: 1.183 ± 0.036	2.838IleIle: 2.838 ± 0.054	2.282IleLys: 2.282 ± 0.053	4.734IleLeu: 4.734 ± 0.073	1.199IleMet: 1.199 ± 0.033	2.819IleAsn: 2.819 ± 0.053	2.712IlePro: 2.712 ± 0.053	1.984IleGln: 1.984 ± 0.048	3.321IleArg: 3.321 ± 0.059	4.111IleSer: 4.111 ± 0.075	3.394IleThr: 3.394 ± 0.059	4.102IleVal: 4.102 ± 0.065	0.614IleTrp: 0.614 ± 0.027	1.41IleTyr: 1.41 ± 0.04	0.01IleXaa: 0.01 ± 0.003
Lys	3.226LysAla: 3.226 ± 0.069	0.19LysCys: 0.19 ± 0.015	1.741LysAsp: 1.741 ± 0.048	1.584LysGlu: 1.584 ± 0.048	0.948LysPhe: 0.948 ± 0.031	2.056LysGly: 2.056 ± 0.05	0.857LysHis: 0.857 ± 0.03	1.822LysIle: 1.822 ± 0.045	1.503LysLys: 1.503 ± 0.044	3.384LysLeu: 3.384 ± 0.07	0.768LysMet: 0.768 ± 0.031	1.21LysAsn: 1.21 ± 0.036	1.802LysPro: 1.802 ± 0.053	1.617LysGln: 1.617 ± 0.04	2.102LysArg: 2.102 ± 0.05	2.025LysSer: 2.025 ± 0.042	2.099LysThr: 2.099 ± 0.051	2.341LysVal: 2.341 ± 0.049	0.318LysTrp: 0.318 ± 0.017	0.713LysTyr: 0.713 ± 0.026	0.002LysXaa: 0.002 ± 0.001
Leu	11.304LeuAla: 11.304 ± 0.126	0.997LeuCys: 0.997 ± 0.03	6.013LeuAsp: 6.013 ± 0.077	5.466LeuGlu: 5.466 ± 0.079	3.905LeuPhe: 3.905 ± 0.078	7.473LeuGly: 7.473 ± 0.09	2.137LeuHis: 2.137 ± 0.05	6.169LeuIle: 6.169 ± 0.087	3.386LeuLys: 3.386 ± 0.065	11.376LeuLeu: 11.376 ± 0.151	2.955LeuMet: 2.955 ± 0.058	4.007LeuAsn: 4.007 ± 0.064	5.472LeuPro: 5.472 ± 0.089	4.821LeuGln: 4.821 ± 0.083	6.305LeuArg: 6.305 ± 0.086	7.779LeuSer: 7.779 ± 0.106	5.993LeuThr: 5.993 ± 0.072	7.146LeuVal: 7.146 ± 0.086	1.152LeuTrp: 1.152 ± 0.037	2.442LeuTyr: 2.442 ± 0.049	0.006LeuXaa: 0.006 ± 0.003
Met	2.773MetAla: 2.773 ± 0.054	0.201MetCys: 0.201 ± 0.012	1.305MetAsp: 1.305 ± 0.037	1.211MetGlu: 1.211 ± 0.035	0.893MetPhe: 0.893 ± 0.025	1.779MetGly: 1.779 ± 0.048	0.505MetHis: 0.505 ± 0.02	1.589MetIle: 1.589 ± 0.038	0.952MetLys: 0.952 ± 0.028	2.992MetLeu: 2.992 ± 0.056	0.784MetMet: 0.784 ± 0.028	1.044MetAsn: 1.044 ± 0.033	1.48MetPro: 1.48 ± 0.037	1.252MetGln: 1.252 ± 0.031	1.524MetArg: 1.524 ± 0.037	2.028MetSer: 2.028 ± 0.046	1.777MetThr: 1.777 ± 0.04	1.718MetVal: 1.718 ± 0.041	0.204MetTrp: 0.204 ± 0.013	0.481MetTyr: 0.481 ± 0.021	0.001MetXaa: 0.001 ± 0.001
Asn	3.718AsnAla: 3.718 ± 0.062	0.376AsnCys: 0.376 ± 0.022	2.065AsnAsp: 2.065 ± 0.065	1.886AsnGlu: 1.886 ± 0.042	1.372AsnPhe: 1.372 ± 0.04	2.864AsnGly: 2.864 ± 0.063	0.753AsnHis: 0.753 ± 0.026	2.174AsnIle: 2.174 ± 0.043	1.33AsnLys: 1.33 ± 0.036	3.672AsnLeu: 3.672 ± 0.061	0.917AsnMet: 0.917 ± 0.025	1.741AsnAsn: 1.741 ± 0.051	2.239AsnPro: 2.239 ± 0.05	1.638AsnGln: 1.638 ± 0.042	2.291AsnArg: 2.291 ± 0.046	2.207AsnSer: 2.207 ± 0.053	2.371AsnThr: 2.371 ± 0.055	2.459AsnVal: 2.459 ± 0.049	0.588AsnTrp: 0.588 ± 0.023	1.064AsnTyr: 1.064 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	5.366ProAla: 5.366 ± 0.09	0.341ProCys: 0.341 ± 0.02	3.567ProAsp: 3.567 ± 0.063	3.129ProGlu: 3.129 ± 0.056	1.755ProPhe: 1.755 ± 0.044	3.995ProGly: 3.995 ± 0.067	0.905ProHis: 0.905 ± 0.029	2.055ProIle: 2.055 ± 0.056	1.018ProLys: 1.018 ± 0.036	4.414ProLeu: 4.414 ± 0.071	1.223ProMet: 1.223 ± 0.035	1.318ProAsn: 1.318 ± 0.037	1.759ProPro: 1.759 ± 0.053	1.679ProGln: 1.679 ± 0.036	2.087ProArg: 2.087 ± 0.053	2.569ProSer: 2.569 ± 0.054	2.217ProThr: 2.217 ± 0.046	4.237ProVal: 4.237 ± 0.068	0.654ProTrp: 0.654 ± 0.027	1.047ProTyr: 1.047 ± 0.029	0.001ProXaa: 0.001 ± 0.001
Gln	4.659GlnAla: 4.659 ± 0.083	0.347GlnCys: 0.347 ± 0.017	2.064GlnAsp: 2.064 ± 0.043	2.085GlnGlu: 2.085 ± 0.057	1.634GlnPhe: 1.634 ± 0.041	3.005GlnGly: 3.005 ± 0.059	1.259GlnHis: 1.259 ± 0.037	2.532GlnIle: 2.532 ± 0.058	1.326GlnLys: 1.326 ± 0.043	5.182GlnLeu: 5.182 ± 0.09	1.142GlnMet: 1.142 ± 0.035	1.431GlnAsn: 1.431 ± 0.041	2.081GlnPro: 2.081 ± 0.044	3.142GlnGln: 3.142 ± 0.098	3.207GlnArg: 3.207 ± 0.071	2.805GlnSer: 2.805 ± 0.059	2.461GlnThr: 2.461 ± 0.049	3.005GlnVal: 3.005 ± 0.057	0.674GlnTrp: 0.674 ± 0.029	1.115GlnTyr: 1.115 ± 0.034	0.001GlnXaa: 0.001 ± 0.001
Arg	5.313ArgAla: 5.313 ± 0.089	0.529ArgCys: 0.529 ± 0.024	3.474ArgAsp: 3.474 ± 0.062	3.609ArgGlu: 3.609 ± 0.071	2.716ArgPhe: 2.716 ± 0.048	3.634ArgGly: 3.634 ± 0.072	1.533ArgHis: 1.533 ± 0.042	3.561ArgIle: 3.561 ± 0.062	1.896ArgLys: 1.896 ± 0.046	6.715ArgLeu: 6.715 ± 0.091	1.572ArgMet: 1.572 ± 0.037	2.123ArgAsn: 2.123 ± 0.05	2.444ArgPro: 2.444 ± 0.052	3.052ArgGln: 3.052 ± 0.055	3.684ArgArg: 3.684 ± 0.074	3.567ArgSer: 3.567 ± 0.067	2.846ArgThr: 2.846 ± 0.051	4.291ArgVal: 4.291 ± 0.071	0.952ArgTrp: 0.952 ± 0.032	2.0ArgTyr: 2.0 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.817SerAla: 6.817 ± 0.093	0.588SerCys: 0.588 ± 0.025	3.736SerAsp: 3.736 ± 0.067	3.267SerGlu: 3.267 ± 0.061	2.561SerPhe: 2.561 ± 0.051	5.732SerGly: 5.732 ± 0.095	1.328SerHis: 1.328 ± 0.033	3.512SerIle: 3.512 ± 0.064	1.886SerLys: 1.886 ± 0.046	7.038SerLeu: 7.038 ± 0.101	1.629SerMet: 1.629 ± 0.037	2.453SerAsn: 2.453 ± 0.061	2.908SerPro: 2.908 ± 0.06	2.553SerGln: 2.553 ± 0.048	3.817SerArg: 3.817 ± 0.069	4.298SerSer: 4.298 ± 0.09	3.602SerThr: 3.602 ± 0.068	4.959SerVal: 4.959 ± 0.072	0.882SerTrp: 0.882 ± 0.034	1.705SerTyr: 1.705 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	5.624ThrAla: 5.624 ± 0.119	0.411ThrCys: 0.411 ± 0.021	3.196ThrAsp: 3.196 ± 0.071	2.805ThrGlu: 2.805 ± 0.054	1.939ThrPhe: 1.939 ± 0.054	5.339ThrGly: 5.339 ± 0.109	1.229ThrHis: 1.229 ± 0.032	3.008ThrIle: 3.008 ± 0.086	1.208ThrLys: 1.208 ± 0.04	6.685ThrLeu: 6.685 ± 0.085	1.21ThrMet: 1.21 ± 0.035	1.776ThrAsn: 1.776 ± 0.055	3.084ThrPro: 3.084 ± 0.054	2.25ThrGln: 2.25 ± 0.051	3.369ThrArg: 3.369 ± 0.052	3.313ThrSer: 3.313 ± 0.074	3.021ThrThr: 3.021 ± 0.072	4.242ThrVal: 4.242 ± 0.106	0.673ThrTrp: 0.673 ± 0.029	1.336ThrTyr: 1.336 ± 0.04	0.006ThrXaa: 0.006 ± 0.002
Val	6.79ValAla: 6.79 ± 0.093	0.796ValCys: 0.796 ± 0.027	4.262ValAsp: 4.262 ± 0.07	3.796ValGlu: 3.796 ± 0.063	3.062ValPhe: 3.062 ± 0.061	4.547ValGly: 4.547 ± 0.072	1.35ValHis: 1.35 ± 0.036	4.443ValIle: 4.443 ± 0.07	2.328ValLys: 2.328 ± 0.052	7.947ValLeu: 7.947 ± 0.099	2.208ValMet: 2.208 ± 0.052	2.917ValAsn: 2.917 ± 0.057	3.311ValPro: 3.311 ± 0.058	2.623ValGln: 2.623 ± 0.056	4.026ValArg: 4.026 ± 0.069	5.348ValSer: 5.348 ± 0.083	4.398ValThr: 4.398 ± 0.1	5.48ValVal: 5.48 ± 0.082	0.86ValTrp: 0.86 ± 0.03	1.884ValTyr: 1.884 ± 0.05	0.006ValXaa: 0.006 ± 0.002
Trp	1.005TrpAla: 1.005 ± 0.031	0.129TrpCys: 0.129 ± 0.011	0.624TrpAsp: 0.624 ± 0.027	0.551TrpGlu: 0.551 ± 0.02	0.558TrpPhe: 0.558 ± 0.022	0.8TrpGly: 0.8 ± 0.024	0.357TrpHis: 0.357 ± 0.02	0.739TrpIle: 0.739 ± 0.029	0.342TrpLys: 0.342 ± 0.022	1.723TrpLeu: 1.723 ± 0.045	0.423TrpMet: 0.423 ± 0.023	0.466TrpAsn: 0.466 ± 0.02	0.597TrpPro: 0.597 ± 0.028	0.965TrpGln: 0.965 ± 0.032	0.966TrpArg: 0.966 ± 0.034	0.856TrpSer: 0.856 ± 0.033	0.652TrpThr: 0.652 ± 0.027	0.867TrpVal: 0.867 ± 0.036	0.223TrpTrp: 0.223 ± 0.017	0.394TrpTyr: 0.394 ± 0.022	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.497TyrAla: 2.497 ± 0.048	0.293TyrCys: 0.293 ± 0.015	1.502TyrAsp: 1.502 ± 0.037	1.45TyrGlu: 1.45 ± 0.038	1.142TyrPhe: 1.142 ± 0.036	2.011TyrGly: 2.011 ± 0.049	0.61TyrHis: 0.61 ± 0.025	1.189TyrIle: 1.189 ± 0.034	0.85TyrLys: 0.85 ± 0.032	2.822TyrLeu: 2.822 ± 0.056	0.556TyrMet: 0.556 ± 0.021	0.987TyrAsn: 0.987 ± 0.038	1.277TyrPro: 1.277 ± 0.038	1.423TyrGln: 1.423 ± 0.039	1.865TyrArg: 1.865 ± 0.043	1.661TyrSer: 1.661 ± 0.041	1.413TyrThr: 1.413 ± 0.04	1.739TyrVal: 1.739 ± 0.041	0.422TyrTrp: 0.422 ± 0.021	0.831TyrTyr: 0.831 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.001XaaCys: 0.001 ± 0.001	0.002XaaAsp: 0.002 ± 0.001	0.005XaaGlu: 0.005 ± 0.002	0.003XaaPhe: 0.003 ± 0.001	0.004XaaGly: 0.004 ± 0.002	0.0XaaHis: 0.0 ± 0.0	0.003XaaIle: 0.003 ± 0.002	0.001XaaLys: 0.001 ± 0.001	0.008XaaLeu: 0.008 ± 0.003	0.001XaaMet: 0.001 ± 0.001	0.001XaaAsn: 0.001 ± 0.001	0.004XaaPro: 0.004 ± 0.002	0.003XaaGln: 0.003 ± 0.002	0.002XaaArg: 0.002 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.005XaaThr: 0.005 ± 0.003	0.004XaaVal: 0.004 ± 0.002	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3053 proteins (1073988 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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