Amino acid dipepetide frequency for Cardinium endosymbiont of Dermatophagoides farinae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.21AlaAla: 6.21 ± 0.195
1.252AlaCys: 1.252 ± 0.06
3.15AlaAsp: 3.15 ± 0.089
3.159AlaGlu: 3.159 ± 0.122
3.344AlaPhe: 3.344 ± 0.104
3.776AlaGly: 3.776 ± 0.129
2.059AlaHis: 2.059 ± 0.083
6.606AlaIle: 6.606 ± 0.167
4.837AlaLys: 4.837 ± 0.124
8.478AlaLeu: 8.478 ± 0.198
1.941AlaMet: 1.941 ± 0.078
2.679AlaAsn: 2.679 ± 0.095
2.24AlaPro: 2.24 ± 0.093
3.132AlaGln: 3.132 ± 0.114
2.534AlaArg: 2.534 ± 0.089
4.686AlaSer: 4.686 ± 0.124
4.112AlaThr: 4.112 ± 0.136
4.018AlaVal: 4.018 ± 0.126
0.611AlaTrp: 0.611 ± 0.044
3.129AlaTyr: 3.129 ± 0.112
0.0AlaXaa: 0.0 ± 0.0
Cys
0.834CysAla: 0.834 ± 0.056
0.296CysCys: 0.296 ± 0.042
0.671CysAsp: 0.671 ± 0.049
0.523CysGlu: 0.523 ± 0.042
0.904CysPhe: 0.904 ± 0.05
0.825CysGly: 0.825 ± 0.056
0.393CysHis: 0.393 ± 0.035
1.342CysIle: 1.342 ± 0.066
1.079CysLys: 1.079 ± 0.063
1.512CysLeu: 1.512 ± 0.073
0.423CysMet: 0.423 ± 0.03
0.695CysAsn: 0.695 ± 0.049
0.52CysPro: 0.52 ± 0.041
0.423CysGln: 0.423 ± 0.032
0.544CysArg: 0.544 ± 0.045
1.267CysSer: 1.267 ± 0.068
0.768CysThr: 0.768 ± 0.058
0.707CysVal: 0.707 ± 0.048
0.169CysTrp: 0.169 ± 0.021
0.75CysTyr: 0.75 ± 0.049
0.0CysXaa: 0.0 ± 0.0
Asp
3.359AspAla: 3.359 ± 0.116
0.786AspCys: 0.786 ± 0.051
2.144AspAsp: 2.144 ± 0.072
2.558AspGlu: 2.558 ± 0.098
2.322AspPhe: 2.322 ± 0.092
2.679AspGly: 2.679 ± 0.107
1.303AspHis: 1.303 ± 0.062
3.855AspIle: 3.855 ± 0.105
4.381AspLys: 4.381 ± 0.151
5.264AspLeu: 5.264 ± 0.143
1.031AspMet: 1.031 ± 0.059
2.008AspAsn: 2.008 ± 0.087
2.388AspPro: 2.388 ± 0.084
2.434AspGln: 2.434 ± 0.095
2.159AspArg: 2.159 ± 0.079
2.878AspSer: 2.878 ± 0.102
2.528AspThr: 2.528 ± 0.087
2.446AspVal: 2.446 ± 0.08
0.565AspTrp: 0.565 ± 0.041
2.401AspTyr: 2.401 ± 0.08
0.0AspXaa: 0.0 ± 0.0
Glu
4.65GluAla: 4.65 ± 0.152
0.523GluCys: 0.523 ± 0.041
2.854GluAsp: 2.854 ± 0.109
4.069GluGlu: 4.069 ± 0.134
1.639GluPhe: 1.639 ± 0.082
3.072GluGly: 3.072 ± 0.1
1.237GluHis: 1.237 ± 0.06
3.927GluIle: 3.927 ± 0.107
5.563GluLys: 5.563 ± 0.155
5.085GluLeu: 5.085 ± 0.136
1.412GluMet: 1.412 ± 0.067
2.407GluAsn: 2.407 ± 0.098
1.657GluPro: 1.657 ± 0.079
2.67GluGln: 2.67 ± 0.089
2.854GluArg: 2.854 ± 0.1
3.081GluSer: 3.081 ± 0.103
2.863GluThr: 2.863 ± 0.095
3.746GluVal: 3.746 ± 0.121
0.517GluTrp: 0.517 ± 0.034
1.551GluTyr: 1.551 ± 0.075
0.0GluXaa: 0.0 ± 0.0
Phe
2.636PheAla: 2.636 ± 0.086
0.717PheCys: 0.717 ± 0.046
2.201PheAsp: 2.201 ± 0.087
2.156PheGlu: 2.156 ± 0.083
2.648PhePhe: 2.648 ± 0.112
2.364PheGly: 2.364 ± 0.087
1.137PheHis: 1.137 ± 0.058
3.752PheIle: 3.752 ± 0.107
3.22PheLys: 3.22 ± 0.095
5.167PheLeu: 5.167 ± 0.145
1.152PheMet: 1.152 ± 0.052
2.119PheAsn: 2.119 ± 0.078
1.651PhePro: 1.651 ± 0.07
1.82PheGln: 1.82 ± 0.073
1.542PheArg: 1.542 ± 0.07
3.704PheSer: 3.704 ± 0.117
2.24PheThr: 2.24 ± 0.088
2.373PheVal: 2.373 ± 0.094
0.553PheTrp: 0.553 ± 0.042
1.92PheTyr: 1.92 ± 0.076
0.0PheXaa: 0.0 ± 0.0
Gly
3.822GlyAla: 3.822 ± 0.142
0.974GlyCys: 0.974 ± 0.061
2.289GlyAsp: 2.289 ± 0.091
2.376GlyGlu: 2.376 ± 0.083
2.597GlyPhe: 2.597 ± 0.09
3.389GlyGly: 3.389 ± 0.124
1.53GlyHis: 1.53 ± 0.073
4.946GlyIle: 4.946 ± 0.122
5.085GlyLys: 5.085 ± 0.124
6.177GlyLeu: 6.177 ± 0.145
1.645GlyMet: 1.645 ± 0.062
2.927GlyAsn: 2.927 ± 0.091
1.394GlyPro: 1.394 ± 0.065
1.772GlyGln: 1.772 ± 0.075
2.594GlyArg: 2.594 ± 0.083
3.749GlySer: 3.749 ± 0.117
2.884GlyThr: 2.884 ± 0.109
3.165GlyVal: 3.165 ± 0.104
0.559GlyTrp: 0.559 ± 0.044
3.132GlyTyr: 3.132 ± 0.114
0.0GlyXaa: 0.0 ± 0.0
His
1.723HisAla: 1.723 ± 0.077
0.314HisCys: 0.314 ± 0.033
0.934HisAsp: 0.934 ± 0.056
1.064HisGlu: 1.064 ± 0.054
1.306HisPhe: 1.306 ± 0.066
1.451HisGly: 1.451 ± 0.061
0.877HisHis: 0.877 ± 0.057
2.265HisIle: 2.265 ± 0.102
1.651HisLys: 1.651 ± 0.073
3.156HisLeu: 3.156 ± 0.107
0.565HisMet: 0.565 ± 0.043
1.164HisAsn: 1.164 ± 0.062
1.27HisPro: 1.27 ± 0.057
1.361HisGln: 1.361 ± 0.06
1.025HisArg: 1.025 ± 0.06
1.418HisSer: 1.418 ± 0.064
1.748HisThr: 1.748 ± 0.074
1.197HisVal: 1.197 ± 0.07
0.342HisTrp: 0.342 ± 0.034
1.406HisTyr: 1.406 ± 0.066
0.0HisXaa: 0.0 ± 0.0
Ile
6.833IleAla: 6.833 ± 0.168
1.252IleCys: 1.252 ± 0.067
4.916IleAsp: 4.916 ± 0.133
4.883IleGlu: 4.883 ± 0.111
3.117IlePhe: 3.117 ± 0.118
4.983IleGly: 4.983 ± 0.144
1.935IleHis: 1.935 ± 0.074
5.07IleIle: 5.07 ± 0.145
5.998IleLys: 5.998 ± 0.159
7.301IleLeu: 7.301 ± 0.167
1.391IleMet: 1.391 ± 0.067
3.531IleAsn: 3.531 ± 0.114
3.205IlePro: 3.205 ± 0.115
3.664IleGln: 3.664 ± 0.101
3.277IleArg: 3.277 ± 0.105
4.989IleSer: 4.989 ± 0.131
4.435IleThr: 4.435 ± 0.116
4.547IleVal: 4.547 ± 0.134
0.798IleTrp: 0.798 ± 0.049
2.697IleTyr: 2.697 ± 0.095
0.0IleXaa: 0.0 ± 0.0
Lys
5.085LysAla: 5.085 ± 0.138
0.747LysCys: 0.747 ± 0.058
4.553LysAsp: 4.553 ± 0.13
6.062LysGlu: 6.062 ± 0.17
2.425LysPhe: 2.425 ± 0.084
4.354LysGly: 4.354 ± 0.127
1.741LysHis: 1.741 ± 0.079
5.554LysIle: 5.554 ± 0.155
7.25LysLys: 7.25 ± 0.175
7.208LysLeu: 7.208 ± 0.172
1.56LysMet: 1.56 ± 0.068
4.29LysAsn: 4.29 ± 0.156
2.395LysPro: 2.395 ± 0.091
3.713LysGln: 3.713 ± 0.118
3.477LysArg: 3.477 ± 0.101
5.091LysSer: 5.091 ± 0.142
3.758LysThr: 3.758 ± 0.117
4.596LysVal: 4.596 ± 0.13
0.789LysTrp: 0.789 ± 0.049
2.658LysTyr: 2.658 ± 0.094
0.0LysXaa: 0.0 ± 0.0
Leu
7.631LeuAla: 7.631 ± 0.176
1.59LeuCys: 1.59 ± 0.073
5.605LeuAsp: 5.605 ± 0.13
6.434LeuGlu: 6.434 ± 0.153
5.294LeuPhe: 5.294 ± 0.143
5.463LeuGly: 5.463 ± 0.124
3.096LeuHis: 3.096 ± 0.12
7.047LeuIle: 7.047 ± 0.154
7.38LeuLys: 7.38 ± 0.168
12.952LeuLeu: 12.952 ± 0.314
2.437LeuMet: 2.437 ± 0.09
4.967LeuAsn: 4.967 ± 0.123
4.68LeuPro: 4.68 ± 0.12
4.26LeuGln: 4.26 ± 0.113
3.755LeuArg: 3.755 ± 0.123
7.985LeuSer: 7.985 ± 0.181
5.883LeuThr: 5.883 ± 0.154
5.95LeuVal: 5.95 ± 0.149
0.946LeuTrp: 0.946 ± 0.058
3.952LeuTyr: 3.952 ± 0.128
0.0LeuXaa: 0.0 ± 0.0
Met
2.011MetAla: 2.011 ± 0.091
0.218MetCys: 0.218 ± 0.028
1.131MetAsp: 1.131 ± 0.063
1.382MetGlu: 1.382 ± 0.068
0.735MetPhe: 0.735 ± 0.054
1.348MetGly: 1.348 ± 0.062
0.759MetHis: 0.759 ± 0.045
1.735MetIle: 1.735 ± 0.06
1.379MetLys: 1.379 ± 0.056
2.887MetLeu: 2.887 ± 0.119
0.49MetMet: 0.49 ± 0.042
0.853MetAsn: 0.853 ± 0.047
0.94MetPro: 0.94 ± 0.049
1.137MetGln: 1.137 ± 0.061
1.11MetArg: 1.11 ± 0.052
1.276MetSer: 1.276 ± 0.062
0.792MetThr: 0.792 ± 0.048
1.965MetVal: 1.965 ± 0.085
0.154MetTrp: 0.154 ± 0.021
0.723MetTyr: 0.723 ± 0.045
0.0MetXaa: 0.0 ± 0.0
Asn
2.821AsnAla: 2.821 ± 0.103
0.644AsnCys: 0.644 ± 0.046
2.159AsnAsp: 2.159 ± 0.083
2.413AsnGlu: 2.413 ± 0.111
1.878AsnPhe: 1.878 ± 0.079
3.051AsnGly: 3.051 ± 0.104
1.318AsnHis: 1.318 ± 0.062
3.822AsnIle: 3.822 ± 0.118
3.952AsnLys: 3.952 ± 0.139
4.632AsnLeu: 4.632 ± 0.108
0.958AsnMet: 0.958 ± 0.059
2.733AsnAsn: 2.733 ± 0.118
2.355AsnPro: 2.355 ± 0.087
2.388AsnGln: 2.388 ± 0.091
2.425AsnArg: 2.425 ± 0.083
2.679AsnSer: 2.679 ± 0.095
2.452AsnThr: 2.452 ± 0.093
2.271AsnVal: 2.271 ± 0.092
0.526AsnTrp: 0.526 ± 0.041
1.491AsnTyr: 1.491 ± 0.069
0.0AsnXaa: 0.0 ± 0.0
Pro
2.219ProAla: 2.219 ± 0.109
0.547ProCys: 0.547 ± 0.041
1.847ProAsp: 1.847 ± 0.066
1.977ProGlu: 1.977 ± 0.085
2.044ProPhe: 2.044 ± 0.084
1.896ProGly: 1.896 ± 0.076
0.868ProHis: 0.868 ± 0.052
3.846ProIle: 3.846 ± 0.112
2.476ProLys: 2.476 ± 0.095
4.29ProLeu: 4.29 ± 0.148
0.804ProMet: 0.804 ± 0.053
1.986ProAsn: 1.986 ± 0.086
1.221ProPro: 1.221 ± 0.068
0.967ProGln: 0.967 ± 0.055
1.152ProArg: 1.152 ± 0.058
2.905ProSer: 2.905 ± 0.096
2.322ProThr: 2.322 ± 0.083
2.222ProVal: 2.222 ± 0.079
0.447ProTrp: 0.447 ± 0.04
1.636ProTyr: 1.636 ± 0.083
0.0ProXaa: 0.0 ± 0.0
Gln
3.501GlnAla: 3.501 ± 0.113
0.454GlnCys: 0.454 ± 0.039
1.983GlnAsp: 1.983 ± 0.081
3.407GlnGlu: 3.407 ± 0.127
1.633GlnPhe: 1.633 ± 0.073
2.168GlnGly: 2.168 ± 0.076
1.128GlnHis: 1.128 ± 0.059
2.733GlnIle: 2.733 ± 0.093
3.577GlnLys: 3.577 ± 0.109
4.499GlnLeu: 4.499 ± 0.138
0.804GlnMet: 0.804 ± 0.051
1.844GlnAsn: 1.844 ± 0.08
1.575GlnPro: 1.575 ± 0.068
2.159GlnGln: 2.159 ± 0.088
1.744GlnArg: 1.744 ± 0.076
2.476GlnSer: 2.476 ± 0.095
1.911GlnThr: 1.911 ± 0.076
2.452GlnVal: 2.452 ± 0.094
0.354GlnTrp: 0.354 ± 0.035
1.581GlnTyr: 1.581 ± 0.078
0.0GlnXaa: 0.0 ± 0.0
Arg
2.446ArgAla: 2.446 ± 0.09
0.541ArgCys: 0.541 ± 0.034
1.796ArgAsp: 1.796 ± 0.086
2.056ArgGlu: 2.056 ± 0.095
2.228ArgPhe: 2.228 ± 0.092
1.974ArgGly: 1.974 ± 0.092
1.016ArgHis: 1.016 ± 0.057
3.114ArgIle: 3.114 ± 0.093
3.356ArgLys: 3.356 ± 0.101
4.674ArgLeu: 4.674 ± 0.135
1.119ArgMet: 1.119 ± 0.053
1.965ArgAsn: 1.965 ± 0.078
1.56ArgPro: 1.56 ± 0.07
1.59ArgGln: 1.59 ± 0.071
1.717ArgArg: 1.717 ± 0.082
2.921ArgSer: 2.921 ± 0.093
1.914ArgThr: 1.914 ± 0.077
2.201ArgVal: 2.201 ± 0.083
0.493ArgTrp: 0.493 ± 0.039
1.95ArgTyr: 1.95 ± 0.078
0.0ArgXaa: 0.0 ± 0.0
Ser
3.924SerAla: 3.924 ± 0.123
1.336SerCys: 1.336 ± 0.061
3.286SerAsp: 3.286 ± 0.111
3.075SerGlu: 3.075 ± 0.104
3.831SerPhe: 3.831 ± 0.112
4.221SerGly: 4.221 ± 0.119
1.433SerHis: 1.433 ± 0.065
6.026SerIle: 6.026 ± 0.137
4.801SerLys: 4.801 ± 0.137
7.038SerLeu: 7.038 ± 0.155
1.59SerMet: 1.59 ± 0.077
3.595SerAsn: 3.595 ± 0.114
2.065SerPro: 2.065 ± 0.092
1.986SerGln: 1.986 ± 0.078
2.54SerArg: 2.54 ± 0.087
5.031SerSer: 5.031 ± 0.158
3.268SerThr: 3.268 ± 0.101
3.32SerVal: 3.32 ± 0.093
0.608SerTrp: 0.608 ± 0.046
2.806SerTyr: 2.806 ± 0.102
0.0SerXaa: 0.0 ± 0.0
Thr
4.085ThrAla: 4.085 ± 0.118
0.753ThrCys: 0.753 ± 0.056
2.41ThrAsp: 2.41 ± 0.095
2.528ThrGlu: 2.528 ± 0.082
2.455ThrPhe: 2.455 ± 0.095
3.416ThrGly: 3.416 ± 0.108
1.46ThrHis: 1.46 ± 0.075
5.149ThrIle: 5.149 ± 0.135
3.746ThrLys: 3.746 ± 0.114
5.784ThrLeu: 5.784 ± 0.122
1.034ThrMet: 1.034 ± 0.055
2.141ThrAsn: 2.141 ± 0.081
2.742ThrPro: 2.742 ± 0.108
1.917ThrGln: 1.917 ± 0.078
1.905ThrArg: 1.905 ± 0.074
3.084ThrSer: 3.084 ± 0.105
3.407ThrThr: 3.407 ± 0.107
2.951ThrVal: 2.951 ± 0.105
0.457ThrTrp: 0.457 ± 0.043
2.077ThrTyr: 2.077 ± 0.086
0.0ThrXaa: 0.0 ± 0.0
Val
4.928ValAla: 4.928 ± 0.142
0.892ValCys: 0.892 ± 0.052
3.159ValAsp: 3.159 ± 0.094
3.005ValGlu: 3.005 ± 0.109
2.219ValPhe: 2.219 ± 0.093
3.48ValGly: 3.48 ± 0.115
1.324ValHis: 1.324 ± 0.071
4.003ValIle: 4.003 ± 0.129
3.867ValLys: 3.867 ± 0.11
5.696ValLeu: 5.696 ± 0.134
1.427ValMet: 1.427 ± 0.073
2.449ValAsn: 2.449 ± 0.1
1.926ValPro: 1.926 ± 0.065
2.485ValGln: 2.485 ± 0.098
2.192ValArg: 2.192 ± 0.094
3.568ValSer: 3.568 ± 0.131
3.283ValThr: 3.283 ± 0.12
4.048ValVal: 4.048 ± 0.135
0.454ValTrp: 0.454 ± 0.037
2.283ValTyr: 2.283 ± 0.087
0.0ValXaa: 0.0 ± 0.0
Trp
0.593TrpAla: 0.593 ± 0.051
0.178TrpCys: 0.178 ± 0.021
0.508TrpAsp: 0.508 ± 0.039
0.52TrpGlu: 0.52 ± 0.036
0.414TrpPhe: 0.414 ± 0.034
0.505TrpGly: 0.505 ± 0.045
0.351TrpHis: 0.351 ± 0.033
0.795TrpIle: 0.795 ± 0.058
0.723TrpLys: 0.723 ± 0.048
1.291TrpLeu: 1.291 ± 0.065
0.296TrpMet: 0.296 ± 0.032
0.405TrpAsn: 0.405 ± 0.035
0.299TrpPro: 0.299 ± 0.03
0.408TrpGln: 0.408 ± 0.038
0.32TrpArg: 0.32 ± 0.031
0.71TrpSer: 0.71 ± 0.047
0.402TrpThr: 0.402 ± 0.033
0.756TrpVal: 0.756 ± 0.05
0.121TrpTrp: 0.121 ± 0.02
0.484TrpTyr: 0.484 ± 0.038
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.642TyrAla: 2.642 ± 0.092
0.635TyrCys: 0.635 ± 0.041
1.89TyrAsp: 1.89 ± 0.085
1.729TyrGlu: 1.729 ± 0.076
2.041TyrPhe: 2.041 ± 0.087
2.591TyrGly: 2.591 ± 0.081
1.273TyrHis: 1.273 ± 0.074
3.235TyrIle: 3.235 ± 0.097
2.984TyrLys: 2.984 ± 0.106
4.218TyrLeu: 4.218 ± 0.121
0.94TyrMet: 0.94 ± 0.053
2.21TyrAsn: 2.21 ± 0.08
1.59TyrPro: 1.59 ± 0.072
1.696TyrGln: 1.696 ± 0.073
1.766TyrArg: 1.766 ± 0.075
2.283TyrSer: 2.283 ± 0.077
2.528TyrThr: 2.528 ± 0.09
1.757TyrVal: 1.757 ± 0.073
0.617TyrTrp: 0.617 ± 0.043
1.838TyrTyr: 1.838 ± 0.089
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1187 proteins (330757 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski