Amino acid dipepetide frequency for Phytophthora fragariae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.628AlaAla: 11.628 ± 0.053	1.371AlaCys: 1.371 ± 0.014	4.964AlaAsp: 4.964 ± 0.024	5.914AlaGlu: 5.914 ± 0.032	3.215AlaPhe: 3.215 ± 0.018	5.58AlaGly: 5.58 ± 0.031	1.893AlaHis: 1.893 ± 0.014	3.541AlaIle: 3.541 ± 0.02	4.657AlaLys: 4.657 ± 0.023	8.794AlaLeu: 8.794 ± 0.035	2.396AlaMet: 2.396 ± 0.014	2.958AlaAsn: 2.958 ± 0.019	4.941AlaPro: 4.941 ± 0.032	3.73AlaGln: 3.73 ± 0.02	5.892AlaArg: 5.892 ± 0.03	8.29AlaSer: 8.29 ± 0.035	6.21AlaThr: 6.21 ± 0.031	6.9AlaVal: 6.9 ± 0.029	0.974AlaTrp: 0.974 ± 0.009	1.931AlaTyr: 1.931 ± 0.016	0.0AlaXaa: 0.0 ± 0.0
Cys	1.377CysAla: 1.377 ± 0.013	0.46CysCys: 0.46 ± 0.008	0.883CysAsp: 0.883 ± 0.012	0.888CysGlu: 0.888 ± 0.01	0.677CysPhe: 0.677 ± 0.009	1.225CysGly: 1.225 ± 0.012	0.382CysHis: 0.382 ± 0.007	0.74CysIle: 0.74 ± 0.009	0.703CysLys: 0.703 ± 0.008	1.41CysLeu: 1.41 ± 0.013	0.425CysMet: 0.425 ± 0.006	0.524CysAsn: 0.524 ± 0.007	0.816CysPro: 0.816 ± 0.016	0.537CysGln: 0.537 ± 0.009	1.056CysArg: 1.056 ± 0.012	1.46CysSer: 1.46 ± 0.015	0.969CysThr: 0.969 ± 0.011	1.315CysVal: 1.315 ± 0.014	0.258CysTrp: 0.258 ± 0.005	0.452CysTyr: 0.452 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	5.911AspAla: 5.911 ± 0.027	0.841AspCys: 0.841 ± 0.012	4.794AspAsp: 4.794 ± 0.034	5.068AspGlu: 5.068 ± 0.026	2.125AspPhe: 2.125 ± 0.014	4.108AspGly: 4.108 ± 0.025	1.151AspHis: 1.151 ± 0.011	2.282AspIle: 2.282 ± 0.017	2.411AspLys: 2.411 ± 0.016	4.716AspLeu: 4.716 ± 0.024	1.319AspMet: 1.319 ± 0.012	1.765AspAsn: 1.765 ± 0.014	2.67AspPro: 2.67 ± 0.019	1.893AspGln: 1.893 ± 0.014	2.989AspArg: 2.989 ± 0.018	4.234AspSer: 4.234 ± 0.024	2.884AspThr: 2.884 ± 0.017	4.429AspVal: 4.429 ± 0.019	0.692AspTrp: 0.692 ± 0.008	1.424AspTyr: 1.424 ± 0.013	0.0AspXaa: 0.0 ± 0.0
Glu	6.28GluAla: 6.28 ± 0.031	0.898GluCys: 0.898 ± 0.01	4.485GluAsp: 4.485 ± 0.03	6.08GluGlu: 6.08 ± 0.048	2.159GluPhe: 2.159 ± 0.017	3.447GluGly: 3.447 ± 0.019	1.447GluHis: 1.447 ± 0.013	2.595GluIle: 2.595 ± 0.016	3.543GluLys: 3.543 ± 0.027	6.61GluLeu: 6.61 ± 0.033	1.732GluMet: 1.732 ± 0.013	2.192GluAsn: 2.192 ± 0.018	2.485GluPro: 2.485 ± 0.018	2.998GluGln: 2.998 ± 0.022	4.428GluArg: 4.428 ± 0.027	4.417GluSer: 4.417 ± 0.023	3.556GluThr: 3.556 ± 0.024	4.367GluVal: 4.367 ± 0.022	0.844GluTrp: 0.844 ± 0.009	1.653GluTyr: 1.653 ± 0.014	0.0GluXaa: 0.0 ± 0.0
Phe	3.136PheAla: 3.136 ± 0.018	0.715PheCys: 0.715 ± 0.009	2.152PheAsp: 2.152 ± 0.015	2.117PheGlu: 2.117 ± 0.014	1.45PhePhe: 1.45 ± 0.014	2.508PheGly: 2.508 ± 0.018	0.875PheHis: 0.875 ± 0.009	1.365PheIle: 1.365 ± 0.012	1.416PheLys: 1.416 ± 0.011	3.248PheLeu: 3.248 ± 0.02	0.888PheMet: 0.888 ± 0.01	1.196PheAsn: 1.196 ± 0.01	1.538PhePro: 1.538 ± 0.012	1.401PheGln: 1.401 ± 0.012	2.121PheArg: 2.121 ± 0.016	2.688PheSer: 2.688 ± 0.02	1.924PheThr: 1.924 ± 0.014	2.868PheVal: 2.868 ± 0.018	0.471PheTrp: 0.471 ± 0.006	1.045PheTyr: 1.045 ± 0.01	0.0PheXaa: 0.0 ± 0.0
Gly	5.512GlyAla: 5.512 ± 0.028	1.095GlyCys: 1.095 ± 0.01	3.945GlyAsp: 3.945 ± 0.02	3.698GlyGlu: 3.698 ± 0.02	2.241GlyPhe: 2.241 ± 0.016	5.194GlyGly: 5.194 ± 0.047	1.509GlyHis: 1.509 ± 0.015	2.466GlyIle: 2.466 ± 0.018	3.036GlyLys: 3.036 ± 0.02	4.923GlyLeu: 4.923 ± 0.025	1.49GlyMet: 1.49 ± 0.014	2.172GlyAsn: 2.172 ± 0.017	2.312GlyPro: 2.312 ± 0.018	2.059GlyGln: 2.059 ± 0.015	3.822GlyArg: 3.822 ± 0.024	5.605GlySer: 5.605 ± 0.036	3.308GlyThr: 3.308 ± 0.024	4.611GlyVal: 4.611 ± 0.025	0.794GlyTrp: 0.794 ± 0.009	1.754GlyTyr: 1.754 ± 0.017	0.0GlyXaa: 0.0 ± 0.0
His	2.083HisAla: 2.083 ± 0.014	0.443HisCys: 0.443 ± 0.005	1.268HisAsp: 1.268 ± 0.011	1.534HisGlu: 1.534 ± 0.015	0.965HisPhe: 0.965 ± 0.008	1.567HisGly: 1.567 ± 0.015	0.708HisHis: 0.708 ± 0.009	0.857HisIle: 0.857 ± 0.008	0.928HisLys: 0.928 ± 0.01	2.224HisLeu: 2.224 ± 0.016	0.498HisMet: 0.498 ± 0.006	0.669HisAsn: 0.669 ± 0.008	1.246HisPro: 1.246 ± 0.01	0.98HisGln: 0.98 ± 0.011	1.629HisArg: 1.629 ± 0.011	1.666HisSer: 1.666 ± 0.011	1.064HisThr: 1.064 ± 0.01	1.811HisVal: 1.811 ± 0.015	0.318HisTrp: 0.318 ± 0.006	0.614HisTyr: 0.614 ± 0.008	0.0HisXaa: 0.0 ± 0.0
Ile	3.561IleAla: 3.561 ± 0.019	0.722IleCys: 0.722 ± 0.009	2.387IleAsp: 2.387 ± 0.017	2.363IleGlu: 2.363 ± 0.018	1.394IlePhe: 1.394 ± 0.012	2.212IleGly: 2.212 ± 0.018	0.842IleHis: 0.842 ± 0.008	1.411IleIle: 1.411 ± 0.012	1.75IleLys: 1.75 ± 0.014	3.181IleLeu: 3.181 ± 0.017	0.856IleMet: 0.856 ± 0.009	1.281IleAsn: 1.281 ± 0.012	2.022IlePro: 2.022 ± 0.014	1.491IleGln: 1.491 ± 0.014	2.358IleArg: 2.358 ± 0.015	2.89IleSer: 2.89 ± 0.018	2.027IleThr: 2.027 ± 0.017	2.911IleVal: 2.911 ± 0.017	0.433IleTrp: 0.433 ± 0.006	0.996IleTyr: 0.996 ± 0.011	0.0IleXaa: 0.0 ± 0.0
Lys	4.226LysAla: 4.226 ± 0.023	0.747LysCys: 0.747 ± 0.008	2.381LysAsp: 2.381 ± 0.016	3.235LysGlu: 3.235 ± 0.023	1.557LysPhe: 1.557 ± 0.012	2.286LysGly: 2.286 ± 0.017	1.182LysHis: 1.182 ± 0.011	1.826LysIle: 1.826 ± 0.014	3.898LysLys: 3.898 ± 0.033	4.854LysLeu: 4.854 ± 0.024	1.331LysMet: 1.331 ± 0.012	1.734LysAsn: 1.734 ± 0.014	2.363LysPro: 2.363 ± 0.019	2.211LysGln: 2.211 ± 0.018	3.876LysArg: 3.876 ± 0.023	3.417LysSer: 3.417 ± 0.021	3.094LysThr: 3.094 ± 0.018	2.929LysVal: 2.929 ± 0.015	0.699LysTrp: 0.699 ± 0.008	1.343LysTyr: 1.343 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	8.299LeuAla: 8.299 ± 0.03	1.534LeuCys: 1.534 ± 0.015	5.011LeuAsp: 5.011 ± 0.022	6.197LeuGlu: 6.197 ± 0.034	3.141LeuPhe: 3.141 ± 0.02	5.099LeuGly: 5.099 ± 0.024	2.466LeuHis: 2.466 ± 0.014	2.919LeuIle: 2.919 ± 0.018	4.523LeuLys: 4.523 ± 0.023	9.746LeuLeu: 9.746 ± 0.047	2.12LeuMet: 2.12 ± 0.015	2.891LeuAsn: 2.891 ± 0.017	4.823LeuPro: 4.823 ± 0.023	4.628LeuGln: 4.628 ± 0.026	6.786LeuArg: 6.786 ± 0.032	7.039LeuSer: 7.039 ± 0.03	4.831LeuThr: 4.831 ± 0.021	6.549LeuVal: 6.549 ± 0.028	1.04LeuTrp: 1.04 ± 0.011	2.154LeuTyr: 2.154 ± 0.013	0.0LeuXaa: 0.0 ± 0.0
Met	2.3MetAla: 2.3 ± 0.017	0.368MetCys: 0.368 ± 0.006	1.381MetAsp: 1.381 ± 0.011	1.773MetGlu: 1.773 ± 0.013	0.723MetPhe: 0.723 ± 0.009	1.332MetGly: 1.332 ± 0.01	0.558MetHis: 0.558 ± 0.007	0.858MetIle: 0.858 ± 0.01	1.372MetLys: 1.372 ± 0.011	2.412MetLeu: 2.412 ± 0.016	0.718MetMet: 0.718 ± 0.009	0.835MetAsn: 0.835 ± 0.011	1.157MetPro: 1.157 ± 0.01	1.135MetGln: 1.135 ± 0.009	1.601MetArg: 1.601 ± 0.012	1.819MetSer: 1.819 ± 0.013	1.494MetThr: 1.494 ± 0.011	1.547MetVal: 1.547 ± 0.012	0.299MetTrp: 0.299 ± 0.005	0.578MetTyr: 0.578 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	3.404AsnAla: 3.404 ± 0.022	0.568AsnCys: 0.568 ± 0.008	1.856AsnAsp: 1.856 ± 0.012	2.11AsnGlu: 2.11 ± 0.017	1.179AsnPhe: 1.179 ± 0.011	2.554AsnGly: 2.554 ± 0.02	0.658AsnHis: 0.658 ± 0.007	1.303AsnIle: 1.303 ± 0.012	1.473AsnLys: 1.473 ± 0.012	2.659AsnLeu: 2.659 ± 0.017	0.809AsnMet: 0.809 ± 0.009	1.221AsnAsn: 1.221 ± 0.013	1.692AsnPro: 1.692 ± 0.014	1.218AsnGln: 1.218 ± 0.013	1.851AsnArg: 1.851 ± 0.014	2.476AsnSer: 2.476 ± 0.016	1.777AsnThr: 1.777 ± 0.014	2.386AsnVal: 2.386 ± 0.016	0.411AsnTrp: 0.411 ± 0.006	0.894AsnTyr: 0.894 ± 0.01	0.0AsnXaa: 0.0 ± 0.0
Pro	5.053ProAla: 5.053 ± 0.035	0.632ProCys: 0.632 ± 0.011	2.605ProAsp: 2.605 ± 0.016	3.119ProGlu: 3.119 ± 0.019	1.635ProPhe: 1.635 ± 0.013	2.772ProGly: 2.772 ± 0.018	1.101ProHis: 1.101 ± 0.011	1.638ProIle: 1.638 ± 0.012	2.233ProLys: 2.233 ± 0.018	4.082ProLeu: 4.082 ± 0.02	1.157ProMet: 1.157 ± 0.01	1.551ProAsn: 1.551 ± 0.013	3.876ProPro: 3.876 ± 0.035	1.898ProGln: 1.898 ± 0.016	3.357ProArg: 3.357 ± 0.022	4.85ProSer: 4.85 ± 0.025	3.714ProThr: 3.714 ± 0.023	3.653ProVal: 3.653 ± 0.018	0.543ProTrp: 0.543 ± 0.008	0.973ProTyr: 0.973 ± 0.009	0.0ProXaa: 0.0 ± 0.0
Gln	3.595GlnAla: 3.595 ± 0.021	0.599GlnCys: 0.599 ± 0.009	2.061GlnAsp: 2.061 ± 0.015	2.778GlnGlu: 2.778 ± 0.02	1.336GlnPhe: 1.336 ± 0.011	1.967GlnGly: 1.967 ± 0.016	1.167GlnHis: 1.167 ± 0.012	1.502GlnIle: 1.502 ± 0.012	1.947GlnLys: 1.947 ± 0.014	4.432GlnLeu: 4.432 ± 0.023	1.023GlnMet: 1.023 ± 0.009	1.215GlnAsn: 1.215 ± 0.011	1.935GlnPro: 1.935 ± 0.018	3.131GlnGln: 3.131 ± 0.031	3.416GlnArg: 3.416 ± 0.023	2.803GlnSer: 2.803 ± 0.016	2.301GlnThr: 2.301 ± 0.015	2.728GlnVal: 2.728 ± 0.017	0.619GlnTrp: 0.619 ± 0.008	0.999GlnTyr: 0.999 ± 0.009	0.0GlnXaa: 0.0 ± 0.0
Arg	5.834ArgAla: 5.834 ± 0.029	1.139ArgCys: 1.139 ± 0.012	3.458ArgAsp: 3.458 ± 0.02	4.286ArgGlu: 4.286 ± 0.027	2.363ArgPhe: 2.363 ± 0.013	3.841ArgGly: 3.841 ± 0.023	1.77ArgHis: 1.77 ± 0.014	2.423ArgIle: 2.423 ± 0.015	3.517ArgLys: 3.517 ± 0.02	6.212ArgLeu: 6.212 ± 0.029	1.606ArgMet: 1.606 ± 0.012	2.038ArgAsn: 2.038 ± 0.015	3.027ArgPro: 3.027 ± 0.02	3.102ArgGln: 3.102 ± 0.021	6.242ArgArg: 6.242 ± 0.039	5.366ArgSer: 5.366 ± 0.031	3.395ArgThr: 3.395 ± 0.017	4.688ArgVal: 4.688 ± 0.023	0.945ArgTrp: 0.945 ± 0.01	1.656ArgTyr: 1.656 ± 0.013	0.0ArgXaa: 0.0 ± 0.0
Ser	7.743SerAla: 7.743 ± 0.031	1.326SerCys: 1.326 ± 0.013	4.751SerAsp: 4.751 ± 0.027	4.469SerGlu: 4.469 ± 0.024	2.808SerPhe: 2.808 ± 0.02	5.63SerGly: 5.63 ± 0.037	1.548SerHis: 1.548 ± 0.012	2.986SerIle: 2.986 ± 0.021	3.732SerLys: 3.732 ± 0.023	6.594SerLeu: 6.594 ± 0.027	1.859SerMet: 1.859 ± 0.014	2.63SerAsn: 2.63 ± 0.019	4.587SerPro: 4.587 ± 0.029	2.598SerGln: 2.598 ± 0.016	5.047SerArg: 5.047 ± 0.028	9.912SerSer: 9.912 ± 0.056	5.832SerThr: 5.832 ± 0.034	5.537SerVal: 5.537 ± 0.029	1.006SerTrp: 1.006 ± 0.01	1.771SerTyr: 1.771 ± 0.015	0.0SerXaa: 0.0 ± 0.0
Thr	5.713ThrAla: 5.713 ± 0.03	0.968ThrCys: 0.968 ± 0.012	2.847ThrAsp: 2.847 ± 0.02	3.362ThrGlu: 3.362 ± 0.023	1.999ThrPhe: 1.999 ± 0.014	3.674ThrGly: 3.674 ± 0.023	1.202ThrHis: 1.202 ± 0.011	2.285ThrIle: 2.285 ± 0.019	2.922ThrLys: 2.922 ± 0.018	5.212ThrLeu: 5.212 ± 0.025	1.366ThrMet: 1.366 ± 0.012	1.919ThrAsn: 1.919 ± 0.014	4.003ThrPro: 4.003 ± 0.03	2.202ThrGln: 2.202 ± 0.015	3.642ThrArg: 3.642 ± 0.017	5.437ThrSer: 5.437 ± 0.032	4.516ThrThr: 4.516 ± 0.037	3.876ThrVal: 3.876 ± 0.023	0.686ThrTrp: 0.686 ± 0.009	1.291ThrTyr: 1.291 ± 0.012	0.0ThrXaa: 0.0 ± 0.0
Val	7.052ValAla: 7.052 ± 0.029	1.357ValCys: 1.357 ± 0.012	4.392ValAsp: 4.392 ± 0.02	4.907ValGlu: 4.907 ± 0.028	2.636ValPhe: 2.636 ± 0.018	4.16ValGly: 4.16 ± 0.025	1.686ValHis: 1.686 ± 0.014	2.641ValIle: 2.641 ± 0.017	3.391ValLys: 3.391 ± 0.02	6.878ValLeu: 6.878 ± 0.03	1.687ValMet: 1.687 ± 0.014	2.331ValAsn: 2.331 ± 0.015	3.446ValPro: 3.446 ± 0.017	2.875ValGln: 2.875 ± 0.015	4.25ValArg: 4.25 ± 0.023	5.278ValSer: 5.278 ± 0.026	4.168ValThr: 4.168 ± 0.024	6.025ValVal: 6.025 ± 0.031	0.837ValTrp: 0.837 ± 0.01	1.82ValTyr: 1.82 ± 0.014	0.0ValXaa: 0.0 ± 0.0
Trp	0.854TrpAla: 0.854 ± 0.01	0.234TrpCys: 0.234 ± 0.004	0.639TrpAsp: 0.639 ± 0.008	0.721TrpGlu: 0.721 ± 0.009	0.471TrpPhe: 0.471 ± 0.006	0.709TrpGly: 0.709 ± 0.01	0.291TrpHis: 0.291 ± 0.006	0.551TrpIle: 0.551 ± 0.007	0.744TrpLys: 0.744 ± 0.01	1.307TrpLeu: 1.307 ± 0.014	0.384TrpMet: 0.384 ± 0.007	0.515TrpAsn: 0.515 ± 0.008	0.469TrpPro: 0.469 ± 0.007	0.488TrpGln: 0.488 ± 0.006	0.954TrpArg: 0.954 ± 0.011	0.955TrpSer: 0.955 ± 0.01	0.776TrpThr: 0.776 ± 0.008	0.829TrpVal: 0.829 ± 0.008	0.215TrpTrp: 0.215 ± 0.005	0.338TrpTyr: 0.338 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.217TyrAla: 2.217 ± 0.015	0.54TyrCys: 0.54 ± 0.009	1.444TyrAsp: 1.444 ± 0.013	1.596TyrGlu: 1.596 ± 0.012	1.051TyrPhe: 1.051 ± 0.011	1.682TyrGly: 1.682 ± 0.015	0.634TyrHis: 0.634 ± 0.009	0.902TyrIle: 0.902 ± 0.01	0.993TyrLys: 0.993 ± 0.011	2.299TyrLeu: 2.299 ± 0.017	0.598TyrMet: 0.598 ± 0.008	0.862TyrAsn: 0.862 ± 0.01	1.035TyrPro: 1.035 ± 0.012	0.98TyrGln: 0.98 ± 0.01	1.592TyrArg: 1.592 ± 0.011	1.759TyrSer: 1.759 ± 0.013	1.282TyrThr: 1.282 ± 0.013	1.857TyrVal: 1.857 ± 0.015	0.362TyrTrp: 0.362 ± 0.007	0.822TyrTyr: 0.822 ± 0.01	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.008XaaXaa: 0.008 ± 0.007

Statistics based on 34421 proteins (11269359 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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