Amino acid dipepetide frequency for Alteromonas phage XX1924

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.378AlaAla: 7.378 ± 1.172
1.174AlaCys: 1.174 ± 0.335
4.528AlaAsp: 4.528 ± 0.584
5.45AlaGlu: 5.45 ± 0.655
3.018AlaPhe: 3.018 ± 0.58
8.468AlaGly: 8.468 ± 0.987
1.258AlaHis: 1.258 ± 0.364
5.114AlaIle: 5.114 ± 0.707
5.785AlaLys: 5.785 ± 0.855
8.217AlaLeu: 8.217 ± 0.996
1.761AlaMet: 1.761 ± 0.39
4.36AlaAsn: 4.36 ± 0.761
3.438AlaPro: 3.438 ± 0.859
3.857AlaGln: 3.857 ± 0.677
3.186AlaArg: 3.186 ± 0.628
4.779AlaSer: 4.779 ± 0.641
3.941AlaThr: 3.941 ± 0.508
5.114AlaVal: 5.114 ± 0.777
1.258AlaTrp: 1.258 ± 0.319
2.431AlaTyr: 2.431 ± 0.352
0.0AlaXaa: 0.0 ± 0.0
Cys
1.258CysAla: 1.258 ± 0.344
0.0CysCys: 0.0 ± 0.0
1.174CysAsp: 1.174 ± 0.416
0.671CysGlu: 0.671 ± 0.217
0.671CysPhe: 0.671 ± 0.217
0.755CysGly: 0.755 ± 0.211
0.671CysHis: 0.671 ± 0.223
0.587CysIle: 0.587 ± 0.182
1.174CysLys: 1.174 ± 0.258
1.174CysLeu: 1.174 ± 0.299
0.335CysMet: 0.335 ± 0.221
0.755CysAsn: 0.755 ± 0.235
0.587CysPro: 0.587 ± 0.191
0.755CysGln: 0.755 ± 0.238
0.838CysArg: 0.838 ± 0.237
0.755CysSer: 0.755 ± 0.254
0.419CysThr: 0.419 ± 0.16
0.419CysVal: 0.419 ± 0.182
0.419CysTrp: 0.419 ± 0.198
0.168CysTyr: 0.168 ± 0.123
0.0CysXaa: 0.0 ± 0.0
Asp
5.114AspAla: 5.114 ± 0.774
1.006AspCys: 1.006 ± 0.305
4.36AspAsp: 4.36 ± 0.877
4.863AspGlu: 4.863 ± 0.706
2.851AspPhe: 2.851 ± 0.583
5.618AspGly: 5.618 ± 0.657
1.09AspHis: 1.09 ± 0.285
2.767AspIle: 2.767 ± 0.472
3.773AspLys: 3.773 ± 0.585
4.779AspLeu: 4.779 ± 0.595
2.096AspMet: 2.096 ± 0.469
2.683AspAsn: 2.683 ± 0.441
1.593AspPro: 1.593 ± 0.429
1.09AspGln: 1.09 ± 0.325
2.096AspArg: 2.096 ± 0.424
4.779AspSer: 4.779 ± 0.638
2.851AspThr: 2.851 ± 0.497
4.024AspVal: 4.024 ± 0.527
0.838AspTrp: 0.838 ± 0.282
2.264AspTyr: 2.264 ± 0.478
0.0AspXaa: 0.0 ± 0.0
Glu
4.276GluAla: 4.276 ± 0.571
0.838GluCys: 0.838 ± 0.259
3.018GluAsp: 3.018 ± 0.453
4.108GluGlu: 4.108 ± 0.684
2.767GluPhe: 2.767 ± 0.52
3.773GluGly: 3.773 ± 0.679
1.677GluHis: 1.677 ± 0.352
4.528GluIle: 4.528 ± 0.579
5.869GluLys: 5.869 ± 0.76
5.785GluLeu: 5.785 ± 0.801
2.264GluMet: 2.264 ± 0.431
2.431GluAsn: 2.431 ± 0.432
1.928GluPro: 1.928 ± 0.351
3.857GluGln: 3.857 ± 0.776
3.689GluArg: 3.689 ± 0.679
5.198GluSer: 5.198 ± 0.783
3.27GluThr: 3.27 ± 0.474
3.857GluVal: 3.857 ± 0.562
1.761GluTrp: 1.761 ± 0.397
3.521GluTyr: 3.521 ± 0.591
0.0GluXaa: 0.0 ± 0.0
Phe
2.599PheAla: 2.599 ± 0.401
0.671PheCys: 0.671 ± 0.238
3.438PheAsp: 3.438 ± 0.46
2.515PheGlu: 2.515 ± 0.659
1.425PhePhe: 1.425 ± 0.346
3.018PheGly: 3.018 ± 0.531
0.419PheHis: 0.419 ± 0.172
2.515PheIle: 2.515 ± 0.433
2.264PheLys: 2.264 ± 0.445
3.102PheLeu: 3.102 ± 0.535
1.174PheMet: 1.174 ± 0.338
2.683PheAsn: 2.683 ± 0.505
0.503PhePro: 0.503 ± 0.19
0.419PheGln: 0.419 ± 0.198
1.593PheArg: 1.593 ± 0.431
2.515PheSer: 2.515 ± 0.487
3.186PheThr: 3.186 ± 0.576
2.012PheVal: 2.012 ± 0.444
0.671PheTrp: 0.671 ± 0.215
1.761PheTyr: 1.761 ± 0.353
0.0PheXaa: 0.0 ± 0.0
Gly
6.204GlyAla: 6.204 ± 0.964
1.006GlyCys: 1.006 ± 0.332
4.947GlyAsp: 4.947 ± 0.61
4.947GlyGlu: 4.947 ± 0.684
3.605GlyPhe: 3.605 ± 0.475
4.947GlyGly: 4.947 ± 0.805
1.341GlyHis: 1.341 ± 0.297
4.024GlyIle: 4.024 ± 0.674
5.282GlyLys: 5.282 ± 0.798
6.037GlyLeu: 6.037 ± 0.7
1.677GlyMet: 1.677 ± 0.425
3.773GlyAsn: 3.773 ± 0.505
0.838GlyPro: 0.838 ± 0.262
2.767GlyGln: 2.767 ± 0.498
4.192GlyArg: 4.192 ± 0.617
4.276GlySer: 4.276 ± 0.711
3.521GlyThr: 3.521 ± 0.553
4.947GlyVal: 4.947 ± 0.683
0.838GlyTrp: 0.838 ± 0.236
3.018GlyTyr: 3.018 ± 0.555
0.0GlyXaa: 0.0 ± 0.0
His
0.755HisAla: 0.755 ± 0.248
0.671HisCys: 0.671 ± 0.272
0.755HisAsp: 0.755 ± 0.22
1.006HisGlu: 1.006 ± 0.304
0.755HisPhe: 0.755 ± 0.232
1.258HisGly: 1.258 ± 0.401
0.587HisHis: 0.587 ± 0.22
2.096HisIle: 2.096 ± 0.399
1.258HisLys: 1.258 ± 0.275
1.509HisLeu: 1.509 ± 0.434
0.252HisMet: 0.252 ± 0.161
0.922HisAsn: 0.922 ± 0.273
0.922HisPro: 0.922 ± 0.25
1.006HisGln: 1.006 ± 0.361
1.006HisArg: 1.006 ± 0.298
1.509HisSer: 1.509 ± 0.338
0.922HisThr: 0.922 ± 0.238
1.425HisVal: 1.425 ± 0.345
0.419HisTrp: 0.419 ± 0.163
0.503HisTyr: 0.503 ± 0.196
0.0HisXaa: 0.0 ± 0.0
Ile
4.779IleAla: 4.779 ± 0.593
0.755IleCys: 0.755 ± 0.217
4.276IleAsp: 4.276 ± 0.564
6.037IleGlu: 6.037 ± 0.764
1.593IlePhe: 1.593 ± 0.322
4.444IleGly: 4.444 ± 0.604
1.258IleHis: 1.258 ± 0.3
3.438IleIle: 3.438 ± 0.63
4.779IleLys: 4.779 ± 0.595
3.354IleLeu: 3.354 ± 0.525
0.922IleMet: 0.922 ± 0.249
4.192IleAsn: 4.192 ± 0.6
2.599IlePro: 2.599 ± 0.562
2.096IleGln: 2.096 ± 0.406
2.935IleArg: 2.935 ± 0.41
4.863IleSer: 4.863 ± 0.616
4.024IleThr: 4.024 ± 0.66
4.36IleVal: 4.36 ± 0.524
0.671IleTrp: 0.671 ± 0.205
2.18IleTyr: 2.18 ± 0.416
0.0IleXaa: 0.0 ± 0.0
Lys
6.959LysAla: 6.959 ± 0.819
0.671LysCys: 0.671 ± 0.219
3.857LysAsp: 3.857 ± 0.609
4.444LysGlu: 4.444 ± 0.754
2.18LysPhe: 2.18 ± 0.425
3.605LysGly: 3.605 ± 0.513
1.509LysHis: 1.509 ± 0.331
3.27LysIle: 3.27 ± 0.438
4.276LysLys: 4.276 ± 0.623
5.953LysLeu: 5.953 ± 0.657
2.767LysMet: 2.767 ± 0.556
2.431LysAsn: 2.431 ± 0.422
3.186LysPro: 3.186 ± 0.62
3.354LysGln: 3.354 ± 0.551
3.941LysArg: 3.941 ± 0.572
4.947LysSer: 4.947 ± 0.714
4.611LysThr: 4.611 ± 0.731
4.108LysVal: 4.108 ± 0.629
1.174LysTrp: 1.174 ± 0.308
1.593LysTyr: 1.593 ± 0.397
0.0LysXaa: 0.0 ± 0.0
Leu
6.959LeuAla: 6.959 ± 0.874
1.006LeuCys: 1.006 ± 0.31
5.785LeuAsp: 5.785 ± 0.664
4.779LeuGlu: 4.779 ± 0.664
3.438LeuPhe: 3.438 ± 0.623
5.198LeuGly: 5.198 ± 0.856
1.258LeuHis: 1.258 ± 0.275
5.198LeuIle: 5.198 ± 0.668
4.444LeuLys: 4.444 ± 0.528
4.695LeuLeu: 4.695 ± 0.66
2.18LeuMet: 2.18 ± 0.462
3.27LeuAsn: 3.27 ± 0.442
3.521LeuPro: 3.521 ± 0.619
2.935LeuGln: 2.935 ± 0.44
4.192LeuArg: 4.192 ± 0.637
6.288LeuSer: 6.288 ± 0.65
5.114LeuThr: 5.114 ± 0.648
4.444LeuVal: 4.444 ± 0.496
0.503LeuTrp: 0.503 ± 0.213
2.348LeuTyr: 2.348 ± 0.501
0.0LeuXaa: 0.0 ± 0.0
Met
2.348MetAla: 2.348 ± 0.439
0.335MetCys: 0.335 ± 0.158
1.09MetAsp: 1.09 ± 0.259
1.677MetGlu: 1.677 ± 0.343
0.922MetPhe: 0.922 ± 0.252
1.341MetGly: 1.341 ± 0.319
0.838MetHis: 0.838 ± 0.268
1.845MetIle: 1.845 ± 0.386
2.515MetLys: 2.515 ± 0.465
2.012MetLeu: 2.012 ± 0.397
0.671MetMet: 0.671 ± 0.277
1.006MetAsn: 1.006 ± 0.253
0.922MetPro: 0.922 ± 0.31
1.761MetGln: 1.761 ± 0.482
1.341MetArg: 1.341 ± 0.392
2.515MetSer: 2.515 ± 0.454
1.677MetThr: 1.677 ± 0.346
1.341MetVal: 1.341 ± 0.314
0.503MetTrp: 0.503 ± 0.184
0.755MetTyr: 0.755 ± 0.239
0.0MetXaa: 0.0 ± 0.0
Asn
4.192AsnAla: 4.192 ± 0.525
1.006AsnCys: 1.006 ± 0.321
2.935AsnAsp: 2.935 ± 0.471
3.521AsnGlu: 3.521 ± 0.578
1.509AsnPhe: 1.509 ± 0.447
4.192AsnGly: 4.192 ± 0.765
1.174AsnHis: 1.174 ± 0.343
2.935AsnIle: 2.935 ± 0.665
3.354AsnLys: 3.354 ± 0.474
2.935AsnLeu: 2.935 ± 0.54
1.341AsnMet: 1.341 ± 0.337
2.18AsnAsn: 2.18 ± 0.484
2.18AsnPro: 2.18 ± 0.362
2.096AsnGln: 2.096 ± 0.346
2.515AsnArg: 2.515 ± 0.524
2.431AsnSer: 2.431 ± 0.641
2.348AsnThr: 2.348 ± 0.432
3.018AsnVal: 3.018 ± 0.453
0.587AsnTrp: 0.587 ± 0.217
1.509AsnTyr: 1.509 ± 0.334
0.0AsnXaa: 0.0 ± 0.0
Pro
3.521ProAla: 3.521 ± 0.697
0.755ProCys: 0.755 ± 0.26
2.515ProAsp: 2.515 ± 0.511
2.683ProGlu: 2.683 ± 0.576
1.341ProPhe: 1.341 ± 0.386
1.341ProGly: 1.341 ± 0.408
0.671ProHis: 0.671 ± 0.216
2.599ProIle: 2.599 ± 0.405
2.012ProLys: 2.012 ± 0.393
1.677ProLeu: 1.677 ± 0.354
1.174ProMet: 1.174 ± 0.283
1.928ProAsn: 1.928 ± 0.276
1.425ProPro: 1.425 ± 0.274
1.174ProGln: 1.174 ± 0.31
1.09ProArg: 1.09 ± 0.239
3.018ProSer: 3.018 ± 0.877
2.599ProThr: 2.599 ± 0.555
2.012ProVal: 2.012 ± 0.357
0.335ProTrp: 0.335 ± 0.169
0.838ProTyr: 0.838 ± 0.262
0.0ProXaa: 0.0 ± 0.0
Gln
4.192GlnAla: 4.192 ± 0.665
0.671GlnCys: 0.671 ± 0.219
2.096GlnAsp: 2.096 ± 0.33
1.928GlnGlu: 1.928 ± 0.45
1.174GlnPhe: 1.174 ± 0.32
2.264GlnGly: 2.264 ± 0.381
1.006GlnHis: 1.006 ± 0.282
2.18GlnIle: 2.18 ± 0.356
2.767GlnLys: 2.767 ± 0.448
4.36GlnLeu: 4.36 ± 0.647
1.341GlnMet: 1.341 ± 0.304
2.012GlnAsn: 2.012 ± 0.42
1.258GlnPro: 1.258 ± 0.315
1.677GlnGln: 1.677 ± 0.424
2.431GlnArg: 2.431 ± 0.54
3.27GlnSer: 3.27 ± 0.6
2.096GlnThr: 2.096 ± 0.392
1.761GlnVal: 1.761 ± 0.464
0.419GlnTrp: 0.419 ± 0.175
0.755GlnTyr: 0.755 ± 0.264
0.0GlnXaa: 0.0 ± 0.0
Arg
3.354ArgAla: 3.354 ± 0.558
0.419ArgCys: 0.419 ± 0.192
2.599ArgAsp: 2.599 ± 0.446
3.102ArgGlu: 3.102 ± 0.442
1.928ArgPhe: 1.928 ± 0.407
3.354ArgGly: 3.354 ± 0.451
0.503ArgHis: 0.503 ± 0.197
4.36ArgIle: 4.36 ± 0.699
3.773ArgLys: 3.773 ± 0.617
4.192ArgLeu: 4.192 ± 0.673
1.509ArgMet: 1.509 ± 0.346
2.012ArgAsn: 2.012 ± 0.508
1.593ArgPro: 1.593 ± 0.32
2.599ArgGln: 2.599 ± 0.503
2.683ArgArg: 2.683 ± 0.453
2.515ArgSer: 2.515 ± 0.563
2.431ArgThr: 2.431 ± 0.443
3.438ArgVal: 3.438 ± 0.508
0.922ArgTrp: 0.922 ± 0.281
1.928ArgTyr: 1.928 ± 0.403
0.0ArgXaa: 0.0 ± 0.0
Ser
6.875SerAla: 6.875 ± 0.932
0.755SerCys: 0.755 ± 0.237
3.521SerAsp: 3.521 ± 0.656
5.45SerGlu: 5.45 ± 0.585
2.767SerPhe: 2.767 ± 0.49
6.372SerGly: 6.372 ± 0.689
1.09SerHis: 1.09 ± 0.253
5.534SerIle: 5.534 ± 0.552
4.779SerLys: 4.779 ± 0.72
5.031SerLeu: 5.031 ± 0.765
2.012SerMet: 2.012 ± 0.429
3.354SerAsn: 3.354 ± 0.66
2.515SerPro: 2.515 ± 0.446
2.515SerGln: 2.515 ± 0.369
1.928SerArg: 1.928 ± 0.346
5.618SerSer: 5.618 ± 0.821
3.102SerThr: 3.102 ± 0.589
4.695SerVal: 4.695 ± 0.647
0.587SerTrp: 0.587 ± 0.211
1.928SerTyr: 1.928 ± 0.564
0.0SerXaa: 0.0 ± 0.0
Thr
5.114ThrAla: 5.114 ± 1.079
0.587ThrCys: 0.587 ± 0.225
2.851ThrAsp: 2.851 ± 0.438
3.773ThrGlu: 3.773 ± 0.607
1.509ThrPhe: 1.509 ± 0.41
5.031ThrGly: 5.031 ± 0.608
1.341ThrHis: 1.341 ± 0.37
4.192ThrIle: 4.192 ± 0.609
3.018ThrLys: 3.018 ± 0.547
4.276ThrLeu: 4.276 ± 0.589
0.838ThrMet: 0.838 ± 0.299
2.683ThrAsn: 2.683 ± 0.513
2.431ThrPro: 2.431 ± 0.717
2.348ThrGln: 2.348 ± 0.544
2.264ThrArg: 2.264 ± 0.551
3.438ThrSer: 3.438 ± 0.614
2.851ThrThr: 2.851 ± 0.539
2.851ThrVal: 2.851 ± 0.48
1.09ThrTrp: 1.09 ± 0.284
2.012ThrTyr: 2.012 ± 0.317
0.0ThrXaa: 0.0 ± 0.0
Val
4.444ValAla: 4.444 ± 0.518
0.922ValCys: 0.922 ± 0.267
3.773ValAsp: 3.773 ± 0.556
4.36ValGlu: 4.36 ± 0.561
2.935ValPhe: 2.935 ± 0.5
4.444ValGly: 4.444 ± 0.658
1.174ValHis: 1.174 ± 0.309
3.438ValIle: 3.438 ± 0.46
4.36ValLys: 4.36 ± 0.539
3.857ValLeu: 3.857 ± 0.438
1.593ValMet: 1.593 ± 0.471
3.354ValAsn: 3.354 ± 0.744
1.761ValPro: 1.761 ± 0.401
1.677ValGln: 1.677 ± 0.364
3.438ValArg: 3.438 ± 0.489
3.941ValSer: 3.941 ± 0.686
3.521ValThr: 3.521 ± 0.507
3.102ValVal: 3.102 ± 0.583
1.174ValTrp: 1.174 ± 0.36
2.599ValTyr: 2.599 ± 0.555
0.0ValXaa: 0.0 ± 0.0
Trp
1.174TrpAla: 1.174 ± 0.383
0.0TrpCys: 0.0 ± 0.0
0.671TrpAsp: 0.671 ± 0.238
0.922TrpGlu: 0.922 ± 0.268
0.922TrpPhe: 0.922 ± 0.264
0.587TrpGly: 0.587 ± 0.28
0.252TrpHis: 0.252 ± 0.14
0.838TrpIle: 0.838 ± 0.262
1.09TrpLys: 1.09 ± 0.296
2.012TrpLeu: 2.012 ± 0.374
0.335TrpMet: 0.335 ± 0.163
0.335TrpAsn: 0.335 ± 0.151
0.419TrpPro: 0.419 ± 0.17
0.587TrpGln: 0.587 ± 0.213
1.425TrpArg: 1.425 ± 0.322
1.341TrpSer: 1.341 ± 0.308
0.419TrpThr: 0.419 ± 0.204
0.587TrpVal: 0.587 ± 0.314
0.335TrpTrp: 0.335 ± 0.174
0.587TrpTyr: 0.587 ± 0.202
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.018TyrAla: 3.018 ± 0.366
0.419TyrCys: 0.419 ± 0.198
2.348TyrAsp: 2.348 ± 0.352
2.18TyrGlu: 2.18 ± 0.427
1.174TyrPhe: 1.174 ± 0.289
2.18TyrGly: 2.18 ± 0.409
0.419TyrHis: 0.419 ± 0.18
2.096TyrIle: 2.096 ± 0.52
2.264TyrLys: 2.264 ± 0.453
2.599TyrLeu: 2.599 ± 0.403
1.09TyrMet: 1.09 ± 0.395
1.593TyrAsn: 1.593 ± 0.251
1.09TyrPro: 1.09 ± 0.327
1.09TyrGln: 1.09 ± 0.251
2.431TyrArg: 2.431 ± 0.403
2.431TyrSer: 2.431 ± 0.498
1.593TyrThr: 1.593 ± 0.303
2.348TyrVal: 2.348 ± 0.434
0.335TyrTrp: 0.335 ± 0.168
1.509TyrTyr: 1.509 ± 0.351
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 64 proteins (11928 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski