Amino acid dipepetide frequency for Mycoplasma suis (strain Illinois)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.157AlaAla: 2.157 ± 0.121
0.455AlaCys: 0.455 ± 0.044
1.297AlaAsp: 1.297 ± 0.083
2.853AlaGlu: 2.853 ± 0.103
1.702AlaPhe: 1.702 ± 0.092
2.948AlaGly: 2.948 ± 0.119
0.51AlaHis: 0.51 ± 0.051
3.13AlaIle: 3.13 ± 0.115
3.294AlaLys: 3.294 ± 0.133
4.131AlaLeu: 4.131 ± 0.148
0.569AlaMet: 0.569 ± 0.049
1.638AlaAsn: 1.638 ± 0.099
0.905AlaPro: 0.905 ± 0.069
1.251AlaGln: 1.251 ± 0.085
1.433AlaArg: 1.433 ± 0.086
3.13AlaSer: 3.13 ± 0.126
1.774AlaThr: 1.774 ± 0.086
1.902AlaVal: 1.902 ± 0.104
0.359AlaTrp: 0.359 ± 0.042
1.028AlaTyr: 1.028 ± 0.071
0.0AlaXaa: 0.0 ± 0.0
Cys
0.382CysAla: 0.382 ± 0.046
0.382CysCys: 0.382 ± 0.097
0.714CysAsp: 0.714 ± 0.06
1.483CysGlu: 1.483 ± 0.087
0.764CysPhe: 0.764 ± 0.068
0.673CysGly: 0.673 ± 0.057
0.25CysHis: 0.25 ± 0.036
0.573CysIle: 0.573 ± 0.049
1.461CysLys: 1.461 ± 0.091
1.147CysLeu: 1.147 ± 0.079
0.109CysMet: 0.109 ± 0.023
0.678CysAsn: 0.678 ± 0.052
0.337CysPro: 0.337 ± 0.042
0.728CysGln: 0.728 ± 0.058
0.441CysArg: 0.441 ± 0.044
1.283CysSer: 1.283 ± 0.08
0.56CysThr: 0.56 ± 0.056
0.614CysVal: 0.614 ± 0.05
0.173CysTrp: 0.173 ± 0.029
0.409CysTyr: 0.409 ± 0.046
0.0CysXaa: 0.0 ± 0.0
Asp
1.16AspAla: 1.16 ± 0.078
0.682AspCys: 0.682 ± 0.056
1.852AspAsp: 1.852 ± 0.104
3.331AspGlu: 3.331 ± 0.134
2.744AspPhe: 2.744 ± 0.122
2.484AspGly: 2.484 ± 0.104
0.664AspHis: 0.664 ± 0.055
2.994AspIle: 2.994 ± 0.114
4.068AspLys: 4.068 ± 0.142
4.814AspLeu: 4.814 ± 0.155
0.664AspMet: 0.664 ± 0.049
2.785AspAsn: 2.785 ± 0.114
1.424AspPro: 1.424 ± 0.082
1.943AspGln: 1.943 ± 0.098
1.588AspArg: 1.588 ± 0.089
5.255AspSer: 5.255 ± 0.171
1.474AspThr: 1.474 ± 0.083
1.865AspVal: 1.865 ± 0.099
1.006AspTrp: 1.006 ± 0.067
1.852AspTyr: 1.852 ± 0.08
0.0AspXaa: 0.0 ± 0.0
Glu
2.853GluAla: 2.853 ± 0.121
1.165GluCys: 1.165 ± 0.083
4.609GluAsp: 4.609 ± 0.16
11.165GluGlu: 11.165 ± 0.358
3.29GluPhe: 3.29 ± 0.109
5.21GluGly: 5.21 ± 0.169
1.183GluHis: 1.183 ± 0.07
7.43GluIle: 7.43 ± 0.213
11.898GluLys: 11.898 ± 0.347
7.48GluLeu: 7.48 ± 0.197
1.383GluMet: 1.383 ± 0.076
6.647GluAsn: 6.647 ± 0.216
1.342GluPro: 1.342 ± 0.08
3.517GluGln: 3.517 ± 0.168
3.713GluArg: 3.713 ± 0.144
6.479GluSer: 6.479 ± 0.202
3.594GluThr: 3.594 ± 0.132
5.019GluVal: 5.019 ± 0.159
1.506GluTrp: 1.506 ± 0.075
2.416GluTyr: 2.416 ± 0.117
0.0GluXaa: 0.0 ± 0.0
Phe
2.066PheAla: 2.066 ± 0.09
0.801PheCys: 0.801 ± 0.06
2.075PheAsp: 2.075 ± 0.096
3.917PheGlu: 3.917 ± 0.164
3.522PhePhe: 3.522 ± 0.173
3.126PheGly: 3.126 ± 0.136
0.655PheHis: 0.655 ± 0.06
2.985PheIle: 2.985 ± 0.138
4.295PheLys: 4.295 ± 0.155
6.306PheLeu: 6.306 ± 0.204
0.751PheMet: 0.751 ± 0.064
2.571PheAsn: 2.571 ± 0.105
1.934PhePro: 1.934 ± 0.114
1.765PheGln: 1.765 ± 0.09
1.825PheArg: 1.825 ± 0.11
6.434PheSer: 6.434 ± 0.193
2.088PheThr: 2.088 ± 0.108
2.266PheVal: 2.266 ± 0.116
1.106PheTrp: 1.106 ± 0.073
1.852PheTyr: 1.852 ± 0.097
0.0PheXaa: 0.0 ± 0.0
Gly
2.766GlyAla: 2.766 ± 0.119
0.687GlyCys: 0.687 ± 0.063
2.907GlyAsp: 2.907 ± 0.113
5.287GlyGlu: 5.287 ± 0.18
2.566GlyPhe: 2.566 ± 0.119
6.138GlyGly: 6.138 ± 0.236
0.696GlyHis: 0.696 ± 0.054
4.491GlyIle: 4.491 ± 0.148
5.851GlyLys: 5.851 ± 0.165
4.855GlyLeu: 4.855 ± 0.17
0.773GlyMet: 0.773 ± 0.056
3.767GlyAsn: 3.767 ± 0.13
0.878GlyPro: 0.878 ± 0.065
2.02GlyGln: 2.02 ± 0.115
2.207GlyArg: 2.207 ± 0.116
4.777GlySer: 4.777 ± 0.172
2.935GlyThr: 2.935 ± 0.101
3.604GlyVal: 3.604 ± 0.126
1.156GlyTrp: 1.156 ± 0.079
1.815GlyTyr: 1.815 ± 0.072
0.0GlyXaa: 0.0 ± 0.0
His
0.378HisAla: 0.378 ± 0.041
0.187HisCys: 0.187 ± 0.03
0.482HisAsp: 0.482 ± 0.042
0.764HisGlu: 0.764 ± 0.058
0.887HisPhe: 0.887 ± 0.07
0.514HisGly: 0.514 ± 0.051
0.232HisHis: 0.232 ± 0.031
0.883HisIle: 0.883 ± 0.066
1.197HisLys: 1.197 ± 0.068
1.479HisLeu: 1.479 ± 0.087
0.2HisMet: 0.2 ± 0.03
0.878HisAsn: 0.878 ± 0.064
0.409HisPro: 0.409 ± 0.04
0.5HisGln: 0.5 ± 0.051
0.428HisArg: 0.428 ± 0.045
1.529HisSer: 1.529 ± 0.082
0.555HisThr: 0.555 ± 0.054
0.464HisVal: 0.464 ± 0.051
0.227HisTrp: 0.227 ± 0.035
0.619HisTyr: 0.619 ± 0.066
0.0HisXaa: 0.0 ± 0.0
Ile
3.053IleAla: 3.053 ± 0.132
1.046IleCys: 1.046 ± 0.07
3.44IleAsp: 3.44 ± 0.139
5.351IleGlu: 5.351 ± 0.159
4.204IlePhe: 4.204 ± 0.152
3.735IleGly: 3.735 ± 0.145
0.887IleHis: 0.887 ± 0.062
4.75IleIle: 4.75 ± 0.171
6.916IleLys: 6.916 ± 0.188
6.165IleLeu: 6.165 ± 0.181
1.056IleMet: 1.056 ± 0.073
3.954IleAsn: 3.954 ± 0.144
2.835IlePro: 2.835 ± 0.123
2.471IleGln: 2.471 ± 0.109
2.461IleArg: 2.461 ± 0.103
7.83IleSer: 7.83 ± 0.214
3.358IleThr: 3.358 ± 0.143
3.745IleVal: 3.745 ± 0.132
0.942IleTrp: 0.942 ± 0.069
2.548IleTyr: 2.548 ± 0.111
0.0IleXaa: 0.0 ± 0.0
Lys
3.171LysAla: 3.171 ± 0.128
1.16LysCys: 1.16 ± 0.09
5.719LysAsp: 5.719 ± 0.18
11.666LysGlu: 11.666 ± 0.295
4.263LysPhe: 4.263 ± 0.155
4.987LysGly: 4.987 ± 0.145
1.046LysHis: 1.046 ± 0.073
7.621LysIle: 7.621 ± 0.222
11.407LysLys: 11.407 ± 0.285
9.441LysLeu: 9.441 ± 0.24
1.665LysMet: 1.665 ± 0.082
7.63LysAsn: 7.63 ± 0.202
2.166LysPro: 2.166 ± 0.103
3.385LysGln: 3.385 ± 0.121
3.849LysArg: 3.849 ± 0.129
7.034LysSer: 7.034 ± 0.206
4.864LysThr: 4.864 ± 0.156
5.806LysVal: 5.806 ± 0.174
1.884LysTrp: 1.884 ± 0.098
3.535LysTyr: 3.535 ± 0.129
0.0LysXaa: 0.0 ± 0.0
Leu
3.795LeuAla: 3.795 ± 0.145
0.828LeuCys: 0.828 ± 0.064
4.018LeuAsp: 4.018 ± 0.126
8.467LeuGlu: 8.467 ± 0.202
5.519LeuPhe: 5.519 ± 0.21
6.242LeuGly: 6.242 ± 0.191
1.201LeuHis: 1.201 ± 0.07
6.916LeuIle: 6.916 ± 0.184
10.351LeuLys: 10.351 ± 0.245
9.746LeuLeu: 9.746 ± 0.244
1.588LeuMet: 1.588 ± 0.096
5.351LeuAsn: 5.351 ± 0.179
3.13LeuPro: 3.13 ± 0.141
2.835LeuGln: 2.835 ± 0.106
3.558LeuArg: 3.558 ± 0.14
10.005LeuSer: 10.005 ± 0.221
5.064LeuThr: 5.064 ± 0.157
5.237LeuVal: 5.237 ± 0.175
1.188LeuTrp: 1.188 ± 0.09
2.179LeuTyr: 2.179 ± 0.12
0.0LeuXaa: 0.0 ± 0.0
Met
0.778MetAla: 0.778 ± 0.066
0.182MetCys: 0.182 ± 0.026
0.646MetAsp: 0.646 ± 0.057
1.056MetGlu: 1.056 ± 0.07
0.887MetPhe: 0.887 ± 0.058
1.119MetGly: 1.119 ± 0.075
0.209MetHis: 0.209 ± 0.027
1.174MetIle: 1.174 ± 0.075
1.652MetLys: 1.652 ± 0.084
1.347MetLeu: 1.347 ± 0.073
0.209MetMet: 0.209 ± 0.035
0.919MetAsn: 0.919 ± 0.064
0.478MetPro: 0.478 ± 0.043
0.405MetGln: 0.405 ± 0.041
0.646MetArg: 0.646 ± 0.059
1.488MetSer: 1.488 ± 0.079
0.755MetThr: 0.755 ± 0.062
0.801MetVal: 0.801 ± 0.07
0.309MetTrp: 0.309 ± 0.037
0.296MetTyr: 0.296 ± 0.039
0.0MetXaa: 0.0 ± 0.0
Asn
1.215AsnAla: 1.215 ± 0.083
0.864AsnCys: 0.864 ± 0.061
2.261AsnAsp: 2.261 ± 0.101
4.127AsnGlu: 4.127 ± 0.137
3.594AsnPhe: 3.594 ± 0.151
3.267AsnGly: 3.267 ± 0.17
0.896AsnHis: 0.896 ± 0.063
4.204AsnIle: 4.204 ± 0.147
6.256AsnLys: 6.256 ± 0.173
6.415AsnLeu: 6.415 ± 0.195
1.024AsnMet: 1.024 ± 0.063
4.263AsnAsn: 4.263 ± 0.171
2.093AsnPro: 2.093 ± 0.108
2.634AsnGln: 2.634 ± 0.114
2.107AsnArg: 2.107 ± 0.081
6.77AsnSer: 6.77 ± 0.204
2.239AsnThr: 2.239 ± 0.1
2.393AsnVal: 2.393 ± 0.097
1.333AsnTrp: 1.333 ± 0.085
2.603AsnTyr: 2.603 ± 0.121
0.0AsnXaa: 0.0 ± 0.0
Pro
1.037ProAla: 1.037 ± 0.079
0.2ProCys: 0.2 ± 0.036
1.115ProAsp: 1.115 ± 0.077
3.299ProGlu: 3.299 ± 0.134
1.679ProPhe: 1.679 ± 0.097
0.71ProGly: 0.71 ± 0.071
0.391ProHis: 0.391 ± 0.042
2.084ProIle: 2.084 ± 0.1
3.117ProLys: 3.117 ± 0.107
2.794ProLeu: 2.794 ± 0.124
0.341ProMet: 0.341 ± 0.038
1.329ProAsn: 1.329 ± 0.081
0.978ProPro: 0.978 ± 0.073
1.151ProGln: 1.151 ± 0.079
0.878ProArg: 0.878 ± 0.063
2.639ProSer: 2.639 ± 0.113
1.265ProThr: 1.265 ± 0.08
1.552ProVal: 1.552 ± 0.085
0.3ProTrp: 0.3 ± 0.04
0.81ProTyr: 0.81 ± 0.066
0.0ProXaa: 0.0 ± 0.0
Gln
1.338GlnAla: 1.338 ± 0.071
0.328GlnCys: 0.328 ± 0.041
1.693GlnAsp: 1.693 ± 0.091
4.345GlnGlu: 4.345 ± 0.163
1.092GlnPhe: 1.092 ± 0.067
1.652GlnGly: 1.652 ± 0.092
0.409GlnHis: 0.409 ± 0.048
2.552GlnIle: 2.552 ± 0.089
4.322GlnLys: 4.322 ± 0.142
3.613GlnLeu: 3.613 ± 0.136
0.596GlnMet: 0.596 ± 0.054
2.448GlnAsn: 2.448 ± 0.108
1.065GlnPro: 1.065 ± 0.082
2.434GlnGln: 2.434 ± 0.179
1.374GlnArg: 1.374 ± 0.077
2.703GlnSer: 2.703 ± 0.138
1.738GlnThr: 1.738 ± 0.097
1.784GlnVal: 1.784 ± 0.087
0.651GlnTrp: 0.651 ± 0.058
0.878GlnTyr: 0.878 ± 0.061
0.0GlnXaa: 0.0 ± 0.0
Arg
1.497ArgAla: 1.497 ± 0.078
0.268ArgCys: 0.268 ± 0.033
1.92ArgAsp: 1.92 ± 0.087
4.691ArgGlu: 4.691 ± 0.161
1.492ArgPhe: 1.492 ± 0.077
2.466ArgGly: 2.466 ± 0.118
0.469ArgHis: 0.469 ± 0.042
2.566ArgIle: 2.566 ± 0.118
4.15ArgLys: 4.15 ± 0.138
2.744ArgLeu: 2.744 ± 0.113
0.814ArgMet: 0.814 ± 0.054
2.507ArgAsn: 2.507 ± 0.108
0.728ArgPro: 0.728 ± 0.062
1.156ArgGln: 1.156 ± 0.08
1.925ArgArg: 1.925 ± 0.093
2.361ArgSer: 2.361 ± 0.103
1.697ArgThr: 1.697 ± 0.078
2.002ArgVal: 2.002 ± 0.1
0.678ArgTrp: 0.678 ± 0.055
1.101ArgTyr: 1.101 ± 0.072
0.0ArgXaa: 0.0 ± 0.0
Ser
3.23SerAla: 3.23 ± 0.156
1.729SerCys: 1.729 ± 0.108
3.917SerAsp: 3.917 ± 0.17
8.631SerGlu: 8.631 ± 0.241
5.314SerPhe: 5.314 ± 0.168
5.883SerGly: 5.883 ± 0.189
1.256SerHis: 1.256 ± 0.082
5.942SerIle: 5.942 ± 0.154
8.722SerLys: 8.722 ± 0.223
9.919SerLeu: 9.919 ± 0.239
1.461SerMet: 1.461 ± 0.075
5.269SerAsn: 5.269 ± 0.161
2.876SerPro: 2.876 ± 0.115
3.958SerGln: 3.958 ± 0.148
3.34SerArg: 3.34 ± 0.127
12.594SerSer: 12.594 ± 0.384
3.881SerThr: 3.881 ± 0.136
4.095SerVal: 4.095 ± 0.146
1.674SerTrp: 1.674 ± 0.095
2.903SerTyr: 2.903 ± 0.126
0.0SerXaa: 0.0 ± 0.0
Thr
1.615ThrAla: 1.615 ± 0.094
0.851ThrCys: 0.851 ± 0.066
1.606ThrAsp: 1.606 ± 0.086
3.381ThrGlu: 3.381 ± 0.124
2.398ThrPhe: 2.398 ± 0.11
2.63ThrGly: 2.63 ± 0.108
0.605ThrHis: 0.605 ± 0.053
3.376ThrIle: 3.376 ± 0.145
4.131ThrLys: 4.131 ± 0.148
4.559ThrLeu: 4.559 ± 0.142
0.591ThrMet: 0.591 ± 0.048
2.539ThrAsn: 2.539 ± 0.135
1.638ThrPro: 1.638 ± 0.092
1.888ThrGln: 1.888 ± 0.088
1.574ThrArg: 1.574 ± 0.089
4.473ThrSer: 4.473 ± 0.185
2.612ThrThr: 2.612 ± 0.126
2.198ThrVal: 2.198 ± 0.096
0.692ThrTrp: 0.692 ± 0.063
1.324ThrTyr: 1.324 ± 0.086
0.0ThrXaa: 0.0 ± 0.0
Val
2.234ValAla: 2.234 ± 0.103
0.737ValCys: 0.737 ± 0.051
2.33ValAsp: 2.33 ± 0.113
4.259ValGlu: 4.259 ± 0.142
2.862ValPhe: 2.862 ± 0.122
3.453ValGly: 3.453 ± 0.136
0.705ValHis: 0.705 ± 0.051
3.604ValIle: 3.604 ± 0.132
4.486ValLys: 4.486 ± 0.149
4.641ValLeu: 4.641 ± 0.147
0.719ValMet: 0.719 ± 0.061
3.13ValAsn: 3.13 ± 0.118
1.438ValPro: 1.438 ± 0.089
1.583ValGln: 1.583 ± 0.078
1.911ValArg: 1.911 ± 0.093
5.137ValSer: 5.137 ± 0.174
2.457ValThr: 2.457 ± 0.106
3.149ValVal: 3.149 ± 0.145
0.783ValTrp: 0.783 ± 0.06
1.219ValTyr: 1.219 ± 0.073
0.0ValXaa: 0.0 ± 0.0
Trp
0.71TrpAla: 0.71 ± 0.059
0.173TrpCys: 0.173 ± 0.028
0.751TrpAsp: 0.751 ± 0.063
1.72TrpGlu: 1.72 ± 0.093
1.197TrpPhe: 1.197 ± 0.079
1.092TrpGly: 1.092 ± 0.079
0.127TrpHis: 0.127 ± 0.026
1.383TrpIle: 1.383 ± 0.076
1.765TrpLys: 1.765 ± 0.088
1.52TrpLeu: 1.52 ± 0.086
0.423TrpMet: 0.423 ± 0.046
1.174TrpAsn: 1.174 ± 0.067
0.191TrpPro: 0.191 ± 0.032
0.387TrpGln: 0.387 ± 0.042
0.596TrpArg: 0.596 ± 0.047
1.26TrpSer: 1.26 ± 0.083
0.892TrpThr: 0.892 ± 0.067
0.955TrpVal: 0.955 ± 0.068
0.35TrpTrp: 0.35 ± 0.038
0.369TrpTyr: 0.369 ± 0.041
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.033TyrAla: 1.033 ± 0.071
0.437TyrCys: 0.437 ± 0.047
1.297TyrAsp: 1.297 ± 0.085
2.107TyrGlu: 2.107 ± 0.1
2.361TyrPhe: 2.361 ± 0.106
1.847TyrGly: 1.847 ± 0.096
0.419TyrHis: 0.419 ± 0.041
2.088TyrIle: 2.088 ± 0.1
2.962TyrLys: 2.962 ± 0.107
4.109TyrLeu: 4.109 ± 0.149
0.414TyrMet: 0.414 ± 0.046
1.083TyrAsn: 1.083 ± 0.076
0.824TyrPro: 0.824 ± 0.057
1.001TyrGln: 1.001 ± 0.067
1.379TyrArg: 1.379 ± 0.066
3.412TyrSer: 3.412 ± 0.155
0.878TyrThr: 0.878 ± 0.061
1.388TyrVal: 1.388 ± 0.084
0.719TyrTrp: 0.719 ± 0.061
1.501TyrTyr: 1.501 ± 0.088
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 844 proteins (219786 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski