Amino acid dipepetide frequency for Mycolicibacterium fallax (Mycobacterium fallax)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	24.259AlaAla: 24.259 ± 0.264	0.91AlaCys: 0.91 ± 0.028	9.456AlaAsp: 9.456 ± 0.104	9.078AlaGlu: 9.078 ± 0.11	3.264AlaPhe: 3.264 ± 0.055	13.925AlaGly: 13.925 ± 0.13	2.506AlaHis: 2.506 ± 0.053	5.096AlaIle: 5.096 ± 0.064	2.939AlaLys: 2.939 ± 0.06	14.097AlaLeu: 14.097 ± 0.144	2.924AlaMet: 2.924 ± 0.05	2.497AlaAsn: 2.497 ± 0.044	7.363AlaPro: 7.363 ± 0.117	3.943AlaGln: 3.943 ± 0.065	9.357AlaArg: 9.357 ± 0.096	5.151AlaSer: 5.151 ± 0.066	7.462AlaThr: 7.462 ± 0.078	12.453AlaVal: 12.453 ± 0.105	1.607AlaTrp: 1.607 ± 0.037	2.132AlaTyr: 2.132 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	1.142CysAla: 1.142 ± 0.036	0.076CysCys: 0.076 ± 0.009	0.483CysAsp: 0.483 ± 0.02	0.394CysGlu: 0.394 ± 0.018	0.193CysPhe: 0.193 ± 0.012	0.921CysGly: 0.921 ± 0.03	0.163CysHis: 0.163 ± 0.012	0.249CysIle: 0.249 ± 0.014	0.116CysLys: 0.116 ± 0.009	0.624CysLeu: 0.624 ± 0.022	0.115CysMet: 0.115 ± 0.01	0.167CysAsn: 0.167 ± 0.014	0.525CysPro: 0.525 ± 0.026	0.222CysGln: 0.222 ± 0.013	0.574CysArg: 0.574 ± 0.021	0.447CysSer: 0.447 ± 0.016	0.46CysThr: 0.46 ± 0.019	0.57CysVal: 0.57 ± 0.021	0.121CysTrp: 0.121 ± 0.01	0.211CysTyr: 0.211 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	8.317AspAla: 8.317 ± 0.099	0.504AspCys: 0.504 ± 0.025	4.225AspAsp: 4.225 ± 0.095	3.775AspGlu: 3.775 ± 0.07	1.811AspPhe: 1.811 ± 0.043	6.472AspGly: 6.472 ± 0.068	1.248AspHis: 1.248 ± 0.03	2.52AspIle: 2.52 ± 0.053	1.188AspLys: 1.188 ± 0.038	6.066AspLeu: 6.066 ± 0.066	0.903AspMet: 0.903 ± 0.028	1.207AspAsn: 1.207 ± 0.034	5.074AspPro: 5.074 ± 0.073	1.696AspGln: 1.696 ± 0.038	4.991AspArg: 4.991 ± 0.068	2.511AspSer: 2.511 ± 0.051	3.361AspThr: 3.361 ± 0.053	4.686AspVal: 4.686 ± 0.071	1.126AspTrp: 1.126 ± 0.03	1.527AspTyr: 1.527 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	6.141GluAla: 6.141 ± 0.089	0.317GluCys: 0.317 ± 0.019	2.552GluAsp: 2.552 ± 0.053	2.376GluGlu: 2.376 ± 0.06	1.903GluPhe: 1.903 ± 0.04	3.072GluGly: 3.072 ± 0.057	1.59GluHis: 1.59 ± 0.033	2.555GluIle: 2.555 ± 0.051	1.201GluLys: 1.201 ± 0.042	7.185GluLeu: 7.185 ± 0.084	1.07GluMet: 1.07 ± 0.032	1.091GluAsn: 1.091 ± 0.028	3.204GluPro: 3.204 ± 0.052	2.281GluGln: 2.281 ± 0.047	4.201GluArg: 4.201 ± 0.067	2.455GluSer: 2.455 ± 0.046	2.561GluThr: 2.561 ± 0.051	4.499GluVal: 4.499 ± 0.071	0.601GluTrp: 0.601 ± 0.026	1.074GluTyr: 1.074 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.036PheAla: 4.036 ± 0.061	0.303PheCys: 0.303 ± 0.017	2.321PheAsp: 2.321 ± 0.048	1.425PheGlu: 1.425 ± 0.037	0.909PhePhe: 0.909 ± 0.032	3.455PheGly: 3.455 ± 0.058	0.592PheHis: 0.592 ± 0.026	1.019PheIle: 1.019 ± 0.034	0.482PheLys: 0.482 ± 0.021	2.526PheLeu: 2.526 ± 0.043	0.422PheMet: 0.422 ± 0.019	0.745PheAsn: 0.745 ± 0.026	1.378PhePro: 1.378 ± 0.035	0.647PheGln: 0.647 ± 0.023	1.628PheArg: 1.628 ± 0.045	1.535PheSer: 1.535 ± 0.035	2.035PheThr: 2.035 ± 0.047	2.306PheVal: 2.306 ± 0.042	0.432PheTrp: 0.432 ± 0.02	0.667PheTyr: 0.667 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	11.402GlyAla: 11.402 ± 0.114	0.807GlyCys: 0.807 ± 0.027	5.134GlyAsp: 5.134 ± 0.07	4.486GlyGlu: 4.486 ± 0.066	3.103GlyPhe: 3.103 ± 0.054	8.207GlyGly: 8.207 ± 0.117	2.059GlyHis: 2.059 ± 0.047	4.104GlyIle: 4.104 ± 0.052	2.185GlyLys: 2.185 ± 0.055	9.037GlyLeu: 9.037 ± 0.084	2.18GlyMet: 2.18 ± 0.047	1.91GlyAsn: 1.91 ± 0.038	5.123GlyPro: 5.123 ± 0.072	2.887GlyGln: 2.887 ± 0.061	6.723GlyArg: 6.723 ± 0.093	5.037GlySer: 5.037 ± 0.065	5.551GlyThr: 5.551 ± 0.071	7.512GlyVal: 7.512 ± 0.098	1.767GlyTrp: 1.767 ± 0.042	2.621GlyTyr: 2.621 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.277HisAla: 2.277 ± 0.048	0.205HisCys: 0.205 ± 0.012	1.28HisAsp: 1.28 ± 0.035	0.893HisGlu: 0.893 ± 0.031	0.632HisPhe: 0.632 ± 0.021	2.01HisGly: 2.01 ± 0.047	0.555HisHis: 0.555 ± 0.021	0.73HisIle: 0.73 ± 0.022	0.326HisLys: 0.326 ± 0.017	1.982HisLeu: 1.982 ± 0.042	0.285HisMet: 0.285 ± 0.016	0.49HisAsn: 0.49 ± 0.022	1.76HisPro: 1.76 ± 0.039	0.595HisGln: 0.595 ± 0.022	2.062HisArg: 2.062 ± 0.038	0.976HisSer: 0.976 ± 0.03	1.204HisThr: 1.204 ± 0.03	1.445HisVal: 1.445 ± 0.034	0.395HisTrp: 0.395 ± 0.019	0.522HisTyr: 0.522 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.501IleAla: 6.501 ± 0.082	0.376IleCys: 0.376 ± 0.018	3.349IleAsp: 3.349 ± 0.056	2.599IleGlu: 2.599 ± 0.06	1.027IlePhe: 1.027 ± 0.028	4.547IleGly: 4.547 ± 0.064	0.716IleHis: 0.716 ± 0.025	1.485IleIle: 1.485 ± 0.04	0.865IleLys: 0.865 ± 0.029	2.904IleLeu: 2.904 ± 0.052	0.588IleMet: 0.588 ± 0.019	1.101IleAsn: 1.101 ± 0.035	2.292IlePro: 2.292 ± 0.048	0.808IleGln: 0.808 ± 0.027	2.702IleArg: 2.702 ± 0.052	2.099IleSer: 2.099 ± 0.039	2.79IleThr: 2.79 ± 0.051	3.416IleVal: 3.416 ± 0.058	0.499IleTrp: 0.499 ± 0.021	0.809IleTyr: 0.809 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	2.52LysAla: 2.52 ± 0.057	0.13LysCys: 0.13 ± 0.01	1.046LysAsp: 1.046 ± 0.035	0.855LysGlu: 0.855 ± 0.038	0.599LysPhe: 0.599 ± 0.025	1.453LysGly: 1.453 ± 0.042	0.454LysHis: 0.454 ± 0.017	0.965LysIle: 0.965 ± 0.031	0.656LysLys: 0.656 ± 0.033	2.041LysLeu: 2.041 ± 0.049	0.499LysMet: 0.499 ± 0.021	0.498LysAsn: 0.498 ± 0.023	1.344LysPro: 1.344 ± 0.041	0.645LysGln: 0.645 ± 0.023	1.512LysArg: 1.512 ± 0.044	1.137LysSer: 1.137 ± 0.035	1.327LysThr: 1.327 ± 0.041	1.749LysVal: 1.749 ± 0.045	0.29LysTrp: 0.29 ± 0.016	0.444LysTyr: 0.444 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	15.602LeuAla: 15.602 ± 0.143	0.796LeuCys: 0.796 ± 0.025	6.654LeuAsp: 6.654 ± 0.078	4.21LeuGlu: 4.21 ± 0.075	2.503LeuPhe: 2.503 ± 0.048	9.173LeuGly: 9.173 ± 0.089	1.977LeuHis: 1.977 ± 0.042	4.289LeuIle: 4.289 ± 0.056	1.627LeuLys: 1.627 ± 0.043	10.288LeuLeu: 10.288 ± 0.117	1.772LeuMet: 1.772 ± 0.04	2.106LeuAsn: 2.106 ± 0.041	6.134LeuPro: 6.134 ± 0.08	2.383LeuGln: 2.383 ± 0.041	8.053LeuArg: 8.053 ± 0.079	5.511LeuSer: 5.511 ± 0.069	6.604LeuThr: 6.604 ± 0.085	8.201LeuVal: 8.201 ± 0.092	1.202LeuTrp: 1.202 ± 0.032	1.594LeuTyr: 1.594 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.635MetAla: 2.635 ± 0.048	0.187MetCys: 0.187 ± 0.013	0.902MetAsp: 0.902 ± 0.031	0.673MetGlu: 0.673 ± 0.023	0.659MetPhe: 0.659 ± 0.025	1.421MetGly: 1.421 ± 0.041	0.381MetHis: 0.381 ± 0.017	0.899MetIle: 0.899 ± 0.028	0.409MetLys: 0.409 ± 0.018	2.057MetLeu: 2.057 ± 0.038	0.426MetMet: 0.426 ± 0.019	0.484MetAsn: 0.484 ± 0.02	1.197MetPro: 1.197 ± 0.033	0.512MetGln: 0.512 ± 0.021	1.434MetArg: 1.434 ± 0.034	1.516MetSer: 1.516 ± 0.033	1.803MetThr: 1.803 ± 0.035	1.549MetVal: 1.549 ± 0.04	0.246MetTrp: 0.246 ± 0.015	0.349MetTyr: 0.349 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.649AsnAla: 2.649 ± 0.048	0.171AsnCys: 0.171 ± 0.013	1.186AsnAsp: 1.186 ± 0.034	0.901AsnGlu: 0.901 ± 0.028	0.66AsnPhe: 0.66 ± 0.025	1.924AsnGly: 1.924 ± 0.046	0.432AsnHis: 0.432 ± 0.019	0.911AsnIle: 0.911 ± 0.025	0.465AsnLys: 0.465 ± 0.022	2.093AsnLeu: 2.093 ± 0.043	0.399AsnMet: 0.399 ± 0.019	0.537AsnAsn: 0.537 ± 0.021	1.824AsnPro: 1.824 ± 0.043	0.586AsnGln: 0.586 ± 0.022	1.557AsnArg: 1.557 ± 0.037	1.056AsnSer: 1.056 ± 0.03	1.289AsnThr: 1.289 ± 0.033	1.624AsnVal: 1.624 ± 0.036	0.393AsnTrp: 0.393 ± 0.019	0.564AsnTyr: 0.564 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	9.027ProAla: 9.027 ± 0.129	0.276ProCys: 0.276 ± 0.018	4.537ProAsp: 4.537 ± 0.074	4.002ProGlu: 4.002 ± 0.068	1.509ProPhe: 1.509 ± 0.04	6.551ProGly: 6.551 ± 0.093	1.106ProHis: 1.106 ± 0.029	2.223ProIle: 2.223 ± 0.046	1.241ProLys: 1.241 ± 0.036	4.956ProLeu: 4.956 ± 0.073	1.243ProMet: 1.243 ± 0.032	1.293ProAsn: 1.293 ± 0.036	3.645ProPro: 3.645 ± 0.095	1.785ProGln: 1.785 ± 0.044	3.628ProArg: 3.628 ± 0.054	2.837ProSer: 2.837 ± 0.055	3.344ProThr: 3.344 ± 0.05	5.419ProVal: 5.419 ± 0.076	0.841ProTrp: 0.841 ± 0.03	1.12ProTyr: 1.12 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.579GlnAla: 3.579 ± 0.061	0.201GlnCys: 0.201 ± 0.014	1.223GlnAsp: 1.223 ± 0.034	0.988GlnGlu: 0.988 ± 0.03	0.867GlnPhe: 0.867 ± 0.024	1.858GlnGly: 1.858 ± 0.049	0.704GlnHis: 0.704 ± 0.025	1.526GlnIle: 1.526 ± 0.04	0.553GlnLys: 0.553 ± 0.021	3.509GlnLeu: 3.509 ± 0.056	0.64GlnMet: 0.64 ± 0.024	0.555GlnAsn: 0.555 ± 0.025	1.75GlnPro: 1.75 ± 0.054	1.329GlnGln: 1.329 ± 0.048	2.838GlnArg: 2.838 ± 0.053	1.261GlnSer: 1.261 ± 0.03	1.509GlnThr: 1.509 ± 0.04	2.471GlnVal: 2.471 ± 0.049	0.554GlnTrp: 0.554 ± 0.021	0.592GlnTyr: 0.592 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	9.274ArgAla: 9.274 ± 0.102	0.62ArgCys: 0.62 ± 0.025	4.441ArgAsp: 4.441 ± 0.059	3.834ArgGlu: 3.834 ± 0.067	2.415ArgPhe: 2.415 ± 0.044	5.539ArgGly: 5.539 ± 0.071	1.711ArgHis: 1.711 ± 0.037	3.589ArgIle: 3.589 ± 0.052	1.469ArgLys: 1.469 ± 0.038	7.691ArgLeu: 7.691 ± 0.09	1.84ArgMet: 1.84 ± 0.034	1.575ArgAsn: 1.575 ± 0.037	4.306ArgPro: 4.306 ± 0.068	2.215ArgGln: 2.215 ± 0.046	7.054ArgArg: 7.054 ± 0.095	3.759ArgSer: 3.759 ± 0.056	4.165ArgThr: 4.165 ± 0.059	5.693ArgVal: 5.693 ± 0.077	1.377ArgTrp: 1.377 ± 0.036	1.955ArgTyr: 1.955 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.637SerAla: 6.637 ± 0.089	0.404SerCys: 0.404 ± 0.019	2.789SerAsp: 2.789 ± 0.055	2.273SerGlu: 2.273 ± 0.049	1.486SerPhe: 1.486 ± 0.039	5.244SerGly: 5.244 ± 0.068	0.922SerHis: 0.922 ± 0.028	2.0SerIle: 2.0 ± 0.041	1.078SerLys: 1.078 ± 0.034	4.248SerLeu: 4.248 ± 0.064	1.23SerMet: 1.23 ± 0.031	1.066SerAsn: 1.066 ± 0.032	2.911SerPro: 2.911 ± 0.057	1.248SerGln: 1.248 ± 0.032	3.386SerArg: 3.386 ± 0.051	2.642SerSer: 2.642 ± 0.054	3.181SerThr: 3.181 ± 0.054	4.142SerVal: 4.142 ± 0.063	0.899SerTrp: 0.899 ± 0.028	1.317SerTyr: 1.317 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	8.619ThrAla: 8.619 ± 0.104	0.372ThrCys: 0.372 ± 0.018	3.943ThrAsp: 3.943 ± 0.06	3.386ThrGlu: 3.386 ± 0.055	1.662ThrPhe: 1.662 ± 0.036	6.273ThrGly: 6.273 ± 0.074	1.053ThrHis: 1.053 ± 0.033	2.181ThrIle: 2.181 ± 0.046	1.19ThrLys: 1.19 ± 0.035	5.694ThrLeu: 5.694 ± 0.068	1.13ThrMet: 1.13 ± 0.03	1.092ThrAsn: 1.092 ± 0.028	3.889ThrPro: 3.889 ± 0.065	1.339ThrGln: 1.339 ± 0.034	3.658ThrArg: 3.658 ± 0.057	2.781ThrSer: 2.781 ± 0.051	3.406ThrThr: 3.406 ± 0.072	6.104ThrVal: 6.104 ± 0.071	0.726ThrTrp: 0.726 ± 0.022	1.047ThrTyr: 1.047 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	11.74ValAla: 11.74 ± 0.123	0.732ValCys: 0.732 ± 0.029	5.471ValAsp: 5.471 ± 0.076	4.229ValGlu: 4.229 ± 0.067	2.505ValPhe: 2.505 ± 0.046	6.797ValGly: 6.797 ± 0.079	1.701ValHis: 1.701 ± 0.042	3.868ValIle: 3.868 ± 0.054	1.563ValLys: 1.563 ± 0.042	9.37ValLeu: 9.37 ± 0.09	1.489ValMet: 1.489 ± 0.032	1.934ValAsn: 1.934 ± 0.044	4.739ValPro: 4.739 ± 0.058	2.065ValGln: 2.065 ± 0.049	5.898ValArg: 5.898 ± 0.082	4.398ValSer: 4.398 ± 0.056	5.422ValThr: 5.422 ± 0.073	7.748ValVal: 7.748 ± 0.104	0.988ValTrp: 0.988 ± 0.03	1.539ValTyr: 1.539 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.63TrpAla: 1.63 ± 0.043	0.176TrpCys: 0.176 ± 0.013	0.841TrpAsp: 0.841 ± 0.027	0.593TrpGlu: 0.593 ± 0.022	0.479TrpPhe: 0.479 ± 0.023	0.999TrpGly: 0.999 ± 0.028	0.317TrpHis: 0.317 ± 0.016	0.626TrpIle: 0.626 ± 0.025	0.273TrpLys: 0.273 ± 0.016	1.776TrpLeu: 1.776 ± 0.048	0.32TrpMet: 0.32 ± 0.018	0.401TrpAsn: 0.401 ± 0.017	0.816TrpPro: 0.816 ± 0.026	0.618TrpGln: 0.618 ± 0.022	1.274TrpArg: 1.274 ± 0.031	0.89TrpSer: 0.89 ± 0.032	0.882TrpThr: 0.882 ± 0.029	1.151TrpVal: 1.151 ± 0.036	0.33TrpTrp: 0.33 ± 0.017	0.327TrpTyr: 0.327 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.432TyrAla: 2.432 ± 0.044	0.209TyrCys: 0.209 ± 0.014	1.374TyrAsp: 1.374 ± 0.04	0.957TyrGlu: 0.957 ± 0.03	0.676TyrPhe: 0.676 ± 0.024	1.993TyrGly: 1.993 ± 0.05	0.438TyrHis: 0.438 ± 0.018	0.64TyrIle: 0.64 ± 0.024	0.34TyrLys: 0.34 ± 0.016	2.535TyrLeu: 2.535 ± 0.044	0.261TyrMet: 0.261 ± 0.015	0.475TyrAsn: 0.475 ± 0.021	1.31TyrPro: 1.31 ± 0.039	0.704TyrGln: 0.704 ± 0.026	1.994TyrArg: 1.994 ± 0.039	1.104TyrSer: 1.104 ± 0.028	1.191TyrThr: 1.191 ± 0.034	1.457TyrVal: 1.457 ± 0.034	0.325TyrTrp: 0.325 ± 0.018	0.478TyrTyr: 0.478 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3787 proteins (1219274 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---