Amino acid dipepetide frequency for Lentibacillus salicampi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.08AlaAla: 6.08 ± 0.11
0.605AlaCys: 0.605 ± 0.024
4.253AlaAsp: 4.253 ± 0.067
5.082AlaGlu: 5.082 ± 0.072
3.518AlaPhe: 3.518 ± 0.059
5.835AlaGly: 5.835 ± 0.093
1.312AlaHis: 1.312 ± 0.04
5.758AlaIle: 5.758 ± 0.081
4.199AlaLys: 4.199 ± 0.068
6.838AlaLeu: 6.838 ± 0.094
2.176AlaMet: 2.176 ± 0.046
2.989AlaAsn: 2.989 ± 0.057
2.089AlaPro: 2.089 ± 0.054
2.217AlaGln: 2.217 ± 0.045
2.76AlaArg: 2.76 ± 0.058
4.3AlaSer: 4.3 ± 0.079
3.48AlaThr: 3.48 ± 0.062
5.773AlaVal: 5.773 ± 0.086
0.695AlaTrp: 0.695 ± 0.031
2.438AlaTyr: 2.438 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.403CysAla: 0.403 ± 0.023
0.08CysCys: 0.08 ± 0.012
0.394CysAsp: 0.394 ± 0.02
0.384CysGlu: 0.384 ± 0.02
0.256CysPhe: 0.256 ± 0.015
0.629CysGly: 0.629 ± 0.027
0.204CysHis: 0.204 ± 0.015
0.429CysIle: 0.429 ± 0.022
0.268CysLys: 0.268 ± 0.016
0.546CysLeu: 0.546 ± 0.024
0.16CysMet: 0.16 ± 0.012
0.222CysAsn: 0.222 ± 0.016
0.335CysPro: 0.335 ± 0.021
0.222CysGln: 0.222 ± 0.014
0.279CysArg: 0.279 ± 0.017
0.453CysSer: 0.453 ± 0.025
0.345CysThr: 0.345 ± 0.019
0.352CysVal: 0.352 ± 0.017
0.055CysTrp: 0.055 ± 0.008
0.226CysTyr: 0.226 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
4.007AspAla: 4.007 ± 0.07
0.329AspCys: 0.329 ± 0.016
3.804AspAsp: 3.804 ± 0.072
5.155AspGlu: 5.155 ± 0.078
2.546AspPhe: 2.546 ± 0.045
3.939AspGly: 3.939 ± 0.08
1.453AspHis: 1.453 ± 0.042
4.543AspIle: 4.543 ± 0.069
3.585AspLys: 3.585 ± 0.054
5.149AspLeu: 5.149 ± 0.067
1.842AspMet: 1.842 ± 0.041
2.446AspAsn: 2.446 ± 0.057
2.246AspPro: 2.246 ± 0.041
2.415AspGln: 2.415 ± 0.05
2.576AspArg: 2.576 ± 0.049
2.96AspSer: 2.96 ± 0.057
2.927AspThr: 2.927 ± 0.057
4.435AspVal: 4.435 ± 0.068
0.71AspTrp: 0.71 ± 0.028
2.562AspTyr: 2.562 ± 0.054
0.0AspXaa: 0.0 ± 0.0
Glu
5.724GluAla: 5.724 ± 0.083
0.34GluCys: 0.34 ± 0.019
4.123GluAsp: 4.123 ± 0.075
6.331GluGlu: 6.331 ± 0.105
2.379GluPhe: 2.379 ± 0.051
4.379GluGly: 4.379 ± 0.076
1.643GluHis: 1.643 ± 0.044
4.744GluIle: 4.744 ± 0.068
6.084GluLys: 6.084 ± 0.084
6.709GluLeu: 6.709 ± 0.095
2.325GluMet: 2.325 ± 0.054
3.993GluAsn: 3.993 ± 0.069
2.185GluPro: 2.185 ± 0.044
3.848GluGln: 3.848 ± 0.065
3.608GluArg: 3.608 ± 0.065
3.864GluSer: 3.864 ± 0.062
4.353GluThr: 4.353 ± 0.071
4.542GluVal: 4.542 ± 0.068
0.844GluTrp: 0.844 ± 0.031
2.005GluTyr: 2.005 ± 0.046
0.0GluXaa: 0.0 ± 0.0
Phe
3.077PheAla: 3.077 ± 0.065
0.274PheCys: 0.274 ± 0.016
2.545PheAsp: 2.545 ± 0.053
2.623PheGlu: 2.623 ± 0.045
2.215PhePhe: 2.215 ± 0.059
3.354PheGly: 3.354 ± 0.065
0.965PheHis: 0.965 ± 0.034
3.56PheIle: 3.56 ± 0.064
2.192PheLys: 2.192 ± 0.043
4.292PheLeu: 4.292 ± 0.083
1.34PheMet: 1.34 ± 0.038
1.878PheAsn: 1.878 ± 0.041
1.598PhePro: 1.598 ± 0.039
1.674PheGln: 1.674 ± 0.039
1.594PheArg: 1.594 ± 0.039
3.189PheSer: 3.189 ± 0.063
2.576PheThr: 2.576 ± 0.049
2.99PheVal: 2.99 ± 0.057
0.49PheTrp: 0.49 ± 0.024
1.666PheTyr: 1.666 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
4.944GlyAla: 4.944 ± 0.084
0.541GlyCys: 0.541 ± 0.027
3.712GlyAsp: 3.712 ± 0.062
4.697GlyGlu: 4.697 ± 0.079
3.477GlyPhe: 3.477 ± 0.063
5.018GlyGly: 5.018 ± 0.099
1.51GlyHis: 1.51 ± 0.04
5.699GlyIle: 5.699 ± 0.078
4.702GlyLys: 4.702 ± 0.072
6.483GlyLeu: 6.483 ± 0.079
2.276GlyMet: 2.276 ± 0.053
2.886GlyAsn: 2.886 ± 0.057
1.807GlyPro: 1.807 ± 0.044
2.167GlyGln: 2.167 ± 0.049
2.761GlyArg: 2.761 ± 0.064
4.249GlySer: 4.249 ± 0.063
4.201GlyThr: 4.201 ± 0.069
5.078GlyVal: 5.078 ± 0.079
0.868GlyTrp: 0.868 ± 0.027
2.815GlyTyr: 2.815 ± 0.052
0.0GlyXaa: 0.0 ± 0.0
His
1.439HisAla: 1.439 ± 0.039
0.181HisCys: 0.181 ± 0.013
1.381HisAsp: 1.381 ± 0.035
1.598HisGlu: 1.598 ± 0.047
1.058HisPhe: 1.058 ± 0.03
1.473HisGly: 1.473 ± 0.044
0.757HisHis: 0.757 ± 0.033
1.559HisIle: 1.559 ± 0.04
1.066HisLys: 1.066 ± 0.032
2.055HisLeu: 2.055 ± 0.048
0.601HisMet: 0.601 ± 0.027
0.896HisAsn: 0.896 ± 0.031
1.053HisPro: 1.053 ± 0.033
0.927HisGln: 0.927 ± 0.03
0.944HisArg: 0.944 ± 0.03
1.109HisSer: 1.109 ± 0.033
1.123HisThr: 1.123 ± 0.037
1.571HisVal: 1.571 ± 0.043
0.222HisTrp: 0.222 ± 0.015
1.041HisTyr: 1.041 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
5.859IleAla: 5.859 ± 0.091
0.53IleCys: 0.53 ± 0.026
4.618IleAsp: 4.618 ± 0.066
4.922IleGlu: 4.922 ± 0.082
3.092IlePhe: 3.092 ± 0.063
5.834IleGly: 5.834 ± 0.092
1.566IleHis: 1.566 ± 0.039
5.4IleIle: 5.4 ± 0.098
3.926IleLys: 3.926 ± 0.065
6.543IleLeu: 6.543 ± 0.095
1.892IleMet: 1.892 ± 0.044
3.319IleAsn: 3.319 ± 0.078
3.211IlePro: 3.211 ± 0.059
2.796IleGln: 2.796 ± 0.062
3.149IleArg: 3.149 ± 0.058
4.59IleSer: 4.59 ± 0.075
4.269IleThr: 4.269 ± 0.063
5.118IleVal: 5.118 ± 0.067
0.672IleTrp: 0.672 ± 0.028
2.38IleTyr: 2.38 ± 0.046
0.0IleXaa: 0.0 ± 0.0
Lys
4.34LysAla: 4.34 ± 0.07
0.26LysCys: 0.26 ± 0.016
3.64LysAsp: 3.64 ± 0.055
5.675LysGlu: 5.675 ± 0.091
1.627LysPhe: 1.627 ± 0.042
3.96LysGly: 3.96 ± 0.066
1.413LysHis: 1.413 ± 0.036
3.827LysIle: 3.827 ± 0.063
4.877LysLys: 4.877 ± 0.073
5.203LysLeu: 5.203 ± 0.069
2.044LysMet: 2.044 ± 0.042
3.161LysAsn: 3.161 ± 0.057
2.199LysPro: 2.199 ± 0.046
3.533LysGln: 3.533 ± 0.068
3.319LysArg: 3.319 ± 0.066
3.357LysSer: 3.357 ± 0.062
3.583LysThr: 3.583 ± 0.053
3.683LysVal: 3.683 ± 0.066
0.77LysTrp: 0.77 ± 0.026
1.883LysTyr: 1.883 ± 0.045
0.0LysXaa: 0.0 ± 0.0
Leu
7.018LeuAla: 7.018 ± 0.093
0.531LeuCys: 0.531 ± 0.023
5.201LeuAsp: 5.201 ± 0.079
6.393LeuGlu: 6.393 ± 0.097
4.666LeuPhe: 4.666 ± 0.098
6.162LeuGly: 6.162 ± 0.082
1.91LeuHis: 1.91 ± 0.054
6.758LeuIle: 6.758 ± 0.099
5.786LeuLys: 5.786 ± 0.087
9.463LeuLeu: 9.463 ± 0.138
2.653LeuMet: 2.653 ± 0.05
4.345LeuAsn: 4.345 ± 0.063
3.786LeuPro: 3.786 ± 0.062
3.464LeuGln: 3.464 ± 0.055
3.523LeuArg: 3.523 ± 0.066
6.231LeuSer: 6.231 ± 0.088
5.7LeuThr: 5.7 ± 0.08
5.75LeuVal: 5.75 ± 0.082
0.766LeuTrp: 0.766 ± 0.03
3.063LeuTyr: 3.063 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
2.38MetAla: 2.38 ± 0.046
0.14MetCys: 0.14 ± 0.013
1.838MetAsp: 1.838 ± 0.042
2.199MetGlu: 2.199 ± 0.05
1.081MetPhe: 1.081 ± 0.033
1.879MetGly: 1.879 ± 0.05
0.521MetHis: 0.521 ± 0.023
2.223MetIle: 2.223 ± 0.046
2.291MetLys: 2.291 ± 0.044
2.608MetLeu: 2.608 ± 0.055
0.885MetMet: 0.885 ± 0.028
1.651MetAsn: 1.651 ± 0.036
1.093MetPro: 1.093 ± 0.035
1.112MetGln: 1.112 ± 0.033
1.188MetArg: 1.188 ± 0.034
1.703MetSer: 1.703 ± 0.037
1.903MetThr: 1.903 ± 0.042
1.947MetVal: 1.947 ± 0.042
0.219MetTrp: 0.219 ± 0.014
0.784MetTyr: 0.784 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
2.991AsnAla: 2.991 ± 0.05
0.289AsnCys: 0.289 ± 0.018
2.819AsnAsp: 2.819 ± 0.062
3.51AsnGlu: 3.51 ± 0.061
1.639AsnPhe: 1.639 ± 0.035
3.479AsnGly: 3.479 ± 0.072
1.155AsnHis: 1.155 ± 0.04
3.245AsnIle: 3.245 ± 0.067
2.678AsnLys: 2.678 ± 0.056
3.689AsnLeu: 3.689 ± 0.064
1.37AsnMet: 1.37 ± 0.036
2.155AsnAsn: 2.155 ± 0.061
2.166AsnPro: 2.166 ± 0.051
2.233AsnGln: 2.233 ± 0.046
2.276AsnArg: 2.276 ± 0.044
2.148AsnSer: 2.148 ± 0.046
2.372AsnThr: 2.372 ± 0.05
3.07AsnVal: 3.07 ± 0.048
0.609AsnTrp: 0.609 ± 0.023
1.568AsnTyr: 1.568 ± 0.042
0.0AsnXaa: 0.0 ± 0.0
Pro
2.468ProAla: 2.468 ± 0.046
0.181ProCys: 0.181 ± 0.013
2.731ProAsp: 2.731 ± 0.056
3.322ProGlu: 3.322 ± 0.066
1.898ProPhe: 1.898 ± 0.044
2.528ProGly: 2.528 ± 0.054
0.767ProHis: 0.767 ± 0.026
2.522ProIle: 2.522 ± 0.051
1.986ProLys: 1.986 ± 0.052
3.374ProLeu: 3.374 ± 0.059
0.841ProMet: 0.841 ± 0.035
1.531ProAsn: 1.531 ± 0.043
1.005ProPro: 1.005 ± 0.033
1.025ProGln: 1.025 ± 0.032
1.096ProArg: 1.096 ± 0.034
2.128ProSer: 2.128 ± 0.041
1.791ProThr: 1.791 ± 0.04
3.122ProVal: 3.122 ± 0.055
0.341ProTrp: 0.341 ± 0.019
1.427ProTyr: 1.427 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
2.963GlnAla: 2.963 ± 0.06
0.182GlnCys: 0.182 ± 0.013
2.186GlnAsp: 2.186 ± 0.054
3.309GlnGlu: 3.309 ± 0.067
1.654GlnPhe: 1.654 ± 0.042
2.231GlnGly: 2.231 ± 0.044
0.926GlnHis: 0.926 ± 0.032
2.516GlnIle: 2.516 ± 0.045
2.768GlnLys: 2.768 ± 0.057
4.16GlnLeu: 4.16 ± 0.07
1.307GlnMet: 1.307 ± 0.031
1.845GlnAsn: 1.845 ± 0.045
1.246GlnPro: 1.246 ± 0.036
2.175GlnGln: 2.175 ± 0.062
1.606GlnArg: 1.606 ± 0.041
2.395GlnSer: 2.395 ± 0.048
2.33GlnThr: 2.33 ± 0.047
2.346GlnVal: 2.346 ± 0.046
0.411GlnTrp: 0.411 ± 0.02
1.365GlnTyr: 1.365 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
2.523ArgAla: 2.523 ± 0.056
0.285ArgCys: 0.285 ± 0.019
2.415ArgAsp: 2.415 ± 0.049
3.322ArgGlu: 3.322 ± 0.06
1.889ArgPhe: 1.889 ± 0.047
2.432ArgGly: 2.432 ± 0.054
1.012ArgHis: 1.012 ± 0.027
3.07ArgIle: 3.07 ± 0.059
3.176ArgLys: 3.176 ± 0.065
3.977ArgLeu: 3.977 ± 0.063
1.367ArgMet: 1.367 ± 0.035
2.041ArgAsn: 2.041 ± 0.041
1.348ArgPro: 1.348 ± 0.039
1.926ArgGln: 1.926 ± 0.048
2.075ArgArg: 2.075 ± 0.057
2.252ArgSer: 2.252 ± 0.05
2.248ArgThr: 2.248 ± 0.05
2.586ArgVal: 2.586 ± 0.052
0.433ArgTrp: 0.433 ± 0.021
1.573ArgTyr: 1.573 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
4.039SerAla: 4.039 ± 0.054
0.332SerCys: 0.332 ± 0.019
3.623SerAsp: 3.623 ± 0.059
4.092SerGlu: 4.092 ± 0.054
3.008SerPhe: 3.008 ± 0.059
4.738SerGly: 4.738 ± 0.069
1.22SerHis: 1.22 ± 0.037
4.647SerIle: 4.647 ± 0.066
3.132SerLys: 3.132 ± 0.052
5.572SerLeu: 5.572 ± 0.089
1.802SerMet: 1.802 ± 0.044
2.443SerAsn: 2.443 ± 0.052
2.123SerPro: 2.123 ± 0.05
2.047SerGln: 2.047 ± 0.048
2.422SerArg: 2.422 ± 0.045
3.574SerSer: 3.574 ± 0.074
3.053SerThr: 3.053 ± 0.061
4.243SerVal: 4.243 ± 0.065
0.626SerTrp: 0.626 ± 0.026
2.156SerTyr: 2.156 ± 0.043
0.0SerXaa: 0.0 ± 0.0
Thr
4.421ThrAla: 4.421 ± 0.069
0.352ThrCys: 0.352 ± 0.02
3.516ThrAsp: 3.516 ± 0.057
3.699ThrGlu: 3.699 ± 0.058
2.673ThrPhe: 2.673 ± 0.049
4.498ThrGly: 4.498 ± 0.06
1.076ThrHis: 1.076 ± 0.036
4.552ThrIle: 4.552 ± 0.073
3.02ThrLys: 3.02 ± 0.059
5.212ThrLeu: 5.212 ± 0.066
1.436ThrMet: 1.436 ± 0.033
2.47ThrAsn: 2.47 ± 0.051
2.266ThrPro: 2.266 ± 0.046
1.511ThrGln: 1.511 ± 0.039
1.992ThrArg: 1.992 ± 0.051
3.343ThrSer: 3.343 ± 0.057
2.99ThrThr: 2.99 ± 0.054
4.361ThrVal: 4.361 ± 0.074
0.58ThrTrp: 0.58 ± 0.023
2.09ThrTyr: 2.09 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
4.827ValAla: 4.827 ± 0.077
0.507ValCys: 0.507 ± 0.027
3.963ValAsp: 3.963 ± 0.063
4.529ValGlu: 4.529 ± 0.068
3.141ValPhe: 3.141 ± 0.064
4.399ValGly: 4.399 ± 0.068
1.433ValHis: 1.433 ± 0.04
5.472ValIle: 5.472 ± 0.074
4.06ValLys: 4.06 ± 0.071
6.718ValLeu: 6.718 ± 0.089
2.062ValMet: 2.062 ± 0.047
3.191ValAsn: 3.191 ± 0.062
2.63ValPro: 2.63 ± 0.052
2.466ValGln: 2.466 ± 0.047
2.687ValArg: 2.687 ± 0.052
4.548ValSer: 4.548 ± 0.067
4.39ValThr: 4.39 ± 0.076
4.892ValVal: 4.892 ± 0.079
0.633ValTrp: 0.633 ± 0.026
2.288ValTyr: 2.288 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
0.652TrpAla: 0.652 ± 0.027
0.064TrpCys: 0.064 ± 0.007
0.588TrpAsp: 0.588 ± 0.022
0.725TrpGlu: 0.725 ± 0.031
0.514TrpPhe: 0.514 ± 0.023
0.648TrpGly: 0.648 ± 0.026
0.225TrpHis: 0.225 ± 0.015
0.768TrpIle: 0.768 ± 0.029
0.706TrpLys: 0.706 ± 0.027
1.209TrpLeu: 1.209 ± 0.037
0.346TrpMet: 0.346 ± 0.018
0.519TrpAsn: 0.519 ± 0.023
0.279TrpPro: 0.279 ± 0.017
0.49TrpGln: 0.49 ± 0.021
0.435TrpArg: 0.435 ± 0.019
0.597TrpSer: 0.597 ± 0.028
0.511TrpThr: 0.511 ± 0.027
0.709TrpVal: 0.709 ± 0.029
0.153TrpTrp: 0.153 ± 0.014
0.37TrpTyr: 0.37 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.241TyrAla: 2.241 ± 0.05
0.239TyrCys: 0.239 ± 0.015
2.282TyrAsp: 2.282 ± 0.055
2.457TyrGlu: 2.457 ± 0.052
1.76TyrPhe: 1.76 ± 0.041
2.478TyrGly: 2.478 ± 0.045
0.986TyrHis: 0.986 ± 0.035
2.396TyrIle: 2.396 ± 0.049
1.85TyrLys: 1.85 ± 0.043
3.366TyrLeu: 3.366 ± 0.065
0.921TyrMet: 0.921 ± 0.03
1.481TyrAsn: 1.481 ± 0.042
1.419TyrPro: 1.419 ± 0.036
1.671TyrGln: 1.671 ± 0.037
1.661TyrArg: 1.661 ± 0.044
1.9TyrSer: 1.9 ± 0.041
1.911TyrThr: 1.911 ± 0.043
2.27TyrVal: 2.27 ± 0.052
0.409TyrTrp: 0.409 ± 0.02
1.412TyrTyr: 1.412 ± 0.039
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3721 proteins (1050092 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski