Amino acid dipepetide frequency for Cellulomonas gilvus (strain ATCC 13127 / NRRL B-14078) (Cellvibrio gilvus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	24.858AlaAla: 24.858 ± 0.248	0.934AlaCys: 0.934 ± 0.034	9.579AlaAsp: 9.579 ± 0.102	7.321AlaGlu: 7.321 ± 0.108	3.558AlaPhe: 3.558 ± 0.059	14.204AlaGly: 14.204 ± 0.144	3.117AlaHis: 3.117 ± 0.067	3.912AlaIle: 3.912 ± 0.069	2.029AlaLys: 2.029 ± 0.064	15.677AlaLeu: 15.677 ± 0.174	2.54AlaMet: 2.54 ± 0.056	1.777AlaAsn: 1.777 ± 0.046	8.576AlaPro: 8.576 ± 0.138	4.709AlaGln: 4.709 ± 0.074	11.941AlaArg: 11.941 ± 0.138	6.689AlaSer: 6.689 ± 0.084	9.008AlaThr: 9.008 ± 0.133	14.048AlaVal: 14.048 ± 0.155	2.458AlaTrp: 2.458 ± 0.056	2.433AlaTyr: 2.433 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.84CysAla: 0.84 ± 0.035	0.067CysCys: 0.067 ± 0.01	0.344CysAsp: 0.344 ± 0.019	0.299CysGlu: 0.299 ± 0.019	0.127CysPhe: 0.127 ± 0.01	0.65CysGly: 0.65 ± 0.026	0.142CysHis: 0.142 ± 0.012	0.12CysIle: 0.12 ± 0.011	0.051CysLys: 0.051 ± 0.006	0.479CysLeu: 0.479 ± 0.021	0.067CysMet: 0.067 ± 0.009	0.085CysAsn: 0.085 ± 0.009	0.387CysPro: 0.387 ± 0.018	0.13CysGln: 0.13 ± 0.011	0.419CysArg: 0.419 ± 0.023	0.331CysSer: 0.331 ± 0.017	0.42CysThr: 0.42 ± 0.02	0.517CysVal: 0.517 ± 0.023	0.085CysTrp: 0.085 ± 0.01	0.107CysTyr: 0.107 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	10.145AspAla: 10.145 ± 0.123	0.259AspCys: 0.259 ± 0.014	5.118AspAsp: 5.118 ± 0.081	5.17AspGlu: 5.17 ± 0.085	1.302AspPhe: 1.302 ± 0.041	6.907AspGly: 6.907 ± 0.09	1.269AspHis: 1.269 ± 0.033	1.3AspIle: 1.3 ± 0.037	0.799AspLys: 0.799 ± 0.031	6.862AspLeu: 6.862 ± 0.095	0.661AspMet: 0.661 ± 0.024	0.699AspAsn: 0.699 ± 0.029	4.612AspPro: 4.612 ± 0.062	1.629AspGln: 1.629 ± 0.042	4.534AspArg: 4.534 ± 0.075	1.965AspSer: 1.965 ± 0.047	2.58AspThr: 2.58 ± 0.058	7.205AspVal: 7.205 ± 0.095	0.879AspTrp: 0.879 ± 0.03	0.979AspTyr: 0.979 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	6.668GluAla: 6.668 ± 0.103	0.272GluCys: 0.272 ± 0.017	2.716GluAsp: 2.716 ± 0.057	2.099GluGlu: 2.099 ± 0.052	1.07GluPhe: 1.07 ± 0.033	3.568GluGly: 3.568 ± 0.062	1.788GluHis: 1.788 ± 0.046	1.989GluIle: 1.989 ± 0.049	0.846GluLys: 0.846 ± 0.038	6.334GluLeu: 6.334 ± 0.093	0.717GluMet: 0.717 ± 0.029	0.783GluAsn: 0.783 ± 0.032	3.55GluPro: 3.55 ± 0.07	2.384GluGln: 2.384 ± 0.057	5.264GluArg: 5.264 ± 0.08	2.157GluSer: 2.157 ± 0.051	2.451GluThr: 2.451 ± 0.047	4.902GluVal: 4.902 ± 0.071	0.587GluTrp: 0.587 ± 0.023	0.902GluTyr: 0.902 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	3.554PheAla: 3.554 ± 0.068	0.167PheCys: 0.167 ± 0.013	1.811PheAsp: 1.811 ± 0.042	1.346PheGlu: 1.346 ± 0.038	0.695PhePhe: 0.695 ± 0.028	2.581PheGly: 2.581 ± 0.054	0.464PheHis: 0.464 ± 0.021	0.549PheIle: 0.549 ± 0.026	0.348PheLys: 0.348 ± 0.019	2.171PheLeu: 2.171 ± 0.051	0.305PheMet: 0.305 ± 0.019	0.39PheAsn: 0.39 ± 0.021	1.126PhePro: 1.126 ± 0.035	0.589PheGln: 0.589 ± 0.024	1.542PheArg: 1.542 ± 0.038	1.272PheSer: 1.272 ± 0.042	1.751PheThr: 1.751 ± 0.056	2.642PheVal: 2.642 ± 0.056	0.398PheTrp: 0.398 ± 0.021	0.512PheTyr: 0.512 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	12.465GlyAla: 12.465 ± 0.135	0.596GlyCys: 0.596 ± 0.025	5.318GlyAsp: 5.318 ± 0.079	4.541GlyGlu: 4.541 ± 0.072	2.6GlyPhe: 2.6 ± 0.059	8.07GlyGly: 8.07 ± 0.11	1.951GlyHis: 1.951 ± 0.042	3.005GlyIle: 3.005 ± 0.06	1.794GlyLys: 1.794 ± 0.044	9.447GlyLeu: 9.447 ± 0.102	1.79GlyMet: 1.79 ± 0.042	1.304GlyAsn: 1.304 ± 0.044	5.135GlyPro: 5.135 ± 0.08	2.482GlyGln: 2.482 ± 0.046	7.308GlyArg: 7.308 ± 0.098	5.068GlySer: 5.068 ± 0.079	6.828GlyThr: 6.828 ± 0.11	8.876GlyVal: 8.876 ± 0.102	1.808GlyTrp: 1.808 ± 0.043	2.011GlyTyr: 2.011 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	3.161HisAla: 3.161 ± 0.063	0.111HisCys: 0.111 ± 0.009	1.501HisAsp: 1.501 ± 0.038	1.163HisGlu: 1.163 ± 0.036	0.409HisPhe: 0.409 ± 0.023	2.184HisGly: 2.184 ± 0.051	0.633HisHis: 0.633 ± 0.025	0.401HisIle: 0.401 ± 0.019	0.223HisLys: 0.223 ± 0.018	2.381HisLeu: 2.381 ± 0.056	0.232HisMet: 0.232 ± 0.016	0.278HisAsn: 0.278 ± 0.019	1.51HisPro: 1.51 ± 0.045	0.528HisGln: 0.528 ± 0.022	1.836HisArg: 1.836 ± 0.048	0.687HisSer: 0.687 ± 0.026	1.038HisThr: 1.038 ± 0.033	2.465HisVal: 2.465 ± 0.051	0.306HisTrp: 0.306 ± 0.016	0.372HisTyr: 0.372 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	4.499IleAla: 4.499 ± 0.093	0.176IleCys: 0.176 ± 0.013	2.32IleAsp: 2.32 ± 0.05	1.799IleGlu: 1.799 ± 0.044	0.606IlePhe: 0.606 ± 0.032	3.171IleGly: 3.171 ± 0.065	0.411IleHis: 0.411 ± 0.019	0.717IleIle: 0.717 ± 0.035	0.523IleLys: 0.523 ± 0.026	2.073IleLeu: 2.073 ± 0.058	0.364IleMet: 0.364 ± 0.02	0.531IleAsn: 0.531 ± 0.024	1.47IlePro: 1.47 ± 0.042	0.604IleGln: 0.604 ± 0.022	1.747IleArg: 1.747 ± 0.043	1.375IleSer: 1.375 ± 0.034	1.864IleThr: 1.864 ± 0.045	2.683IleVal: 2.683 ± 0.053	0.305IleTrp: 0.305 ± 0.018	0.426IleTyr: 0.426 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	1.964LysAla: 1.964 ± 0.052	0.065LysCys: 0.065 ± 0.009	0.88LysAsp: 0.88 ± 0.033	0.666LysGlu: 0.666 ± 0.027	0.321LysPhe: 0.321 ± 0.017	1.231LysGly: 1.231 ± 0.044	0.301LysHis: 0.301 ± 0.016	0.623LysIle: 0.623 ± 0.032	0.477LysLys: 0.477 ± 0.029	1.173LysLeu: 1.173 ± 0.039	0.221LysMet: 0.221 ± 0.015	0.335LysAsn: 0.335 ± 0.021	0.872LysPro: 0.872 ± 0.032	0.438LysGln: 0.438 ± 0.024	1.002LysArg: 1.002 ± 0.035	0.74LysSer: 0.74 ± 0.03	0.862LysThr: 0.862 ± 0.036	1.529LysVal: 1.529 ± 0.05	0.172LysTrp: 0.172 ± 0.013	0.303LysTyr: 0.303 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	16.594LeuAla: 16.594 ± 0.175	0.535LeuCys: 0.535 ± 0.022	7.22LeuAsp: 7.22 ± 0.083	5.119LeuGlu: 5.119 ± 0.075	2.094LeuPhe: 2.094 ± 0.052	9.376LeuGly: 9.376 ± 0.113	2.01LeuHis: 2.01 ± 0.044	2.277LeuIle: 2.277 ± 0.062	1.144LeuLys: 1.144 ± 0.042	10.539LeuLeu: 10.539 ± 0.167	1.35LeuMet: 1.35 ± 0.038	1.249LeuAsn: 1.249 ± 0.031	6.028LeuPro: 6.028 ± 0.079	2.318LeuGln: 2.318 ± 0.052	8.224LeuArg: 8.224 ± 0.11	4.451LeuSer: 4.451 ± 0.067	7.041LeuThr: 7.041 ± 0.091	11.917LeuVal: 11.917 ± 0.162	1.217LeuTrp: 1.217 ± 0.032	1.433LeuTyr: 1.433 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	1.914MetAla: 1.914 ± 0.046	0.089MetCys: 0.089 ± 0.009	0.723MetAsp: 0.723 ± 0.024	0.476MetGlu: 0.476 ± 0.022	0.38MetPhe: 0.38 ± 0.018	1.08MetGly: 1.08 ± 0.036	0.315MetHis: 0.315 ± 0.019	0.531MetIle: 0.531 ± 0.026	0.236MetLys: 0.236 ± 0.015	1.578MetLeu: 1.578 ± 0.044	0.2MetMet: 0.2 ± 0.014	0.296MetAsn: 0.296 ± 0.016	0.97MetPro: 0.97 ± 0.03	0.403MetGln: 0.403 ± 0.02	1.236MetArg: 1.236 ± 0.035	1.308MetSer: 1.308 ± 0.034	1.659MetThr: 1.659 ± 0.036	1.243MetVal: 1.243 ± 0.038	0.193MetTrp: 0.193 ± 0.011	0.222MetTyr: 0.222 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	1.887AsnAla: 1.887 ± 0.051	0.087AsnCys: 0.087 ± 0.01	0.846AsnAsp: 0.846 ± 0.036	0.604AsnGlu: 0.604 ± 0.028	0.402AsnPhe: 0.402 ± 0.024	1.469AsnGly: 1.469 ± 0.053	0.298AsnHis: 0.298 ± 0.017	0.467AsnIle: 0.467 ± 0.021	0.254AsnLys: 0.254 ± 0.016	1.44AsnLeu: 1.44 ± 0.038	0.21AsnMet: 0.21 ± 0.015	0.303AsnAsn: 0.303 ± 0.022	1.145AsnPro: 1.145 ± 0.035	0.41AsnGln: 0.41 ± 0.02	0.947AsnArg: 0.947 ± 0.032	0.593AsnSer: 0.593 ± 0.027	0.774AsnThr: 0.774 ± 0.036	1.358AsnVal: 1.358 ± 0.037	0.209AsnTrp: 0.209 ± 0.014	0.293AsnTyr: 0.293 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	9.871ProAla: 9.871 ± 0.128	0.263ProCys: 0.263 ± 0.016	4.834ProAsp: 4.834 ± 0.083	3.397ProGlu: 3.397 ± 0.066	1.461ProPhe: 1.461 ± 0.045	6.429ProGly: 6.429 ± 0.096	1.268ProHis: 1.268 ± 0.035	1.159ProIle: 1.159 ± 0.036	0.642ProLys: 0.642 ± 0.03	4.981ProLeu: 4.981 ± 0.091	0.832ProMet: 0.832 ± 0.028	0.705ProAsn: 0.705 ± 0.03	3.23ProPro: 3.23 ± 0.076	1.682ProGln: 1.682 ± 0.04	4.033ProArg: 4.033 ± 0.063	3.096ProSer: 3.096 ± 0.064	4.294ProThr: 4.294 ± 0.083	6.117ProVal: 6.117 ± 0.09	1.004ProTrp: 1.004 ± 0.032	1.001ProTyr: 1.001 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.95GlnAla: 3.95 ± 0.068	0.131GlnCys: 0.131 ± 0.011	1.701GlnAsp: 1.701 ± 0.047	1.325GlnGlu: 1.325 ± 0.034	0.644GlnPhe: 0.644 ± 0.029	2.189GlnGly: 2.189 ± 0.047	0.71GlnHis: 0.71 ± 0.025	1.034GlnIle: 1.034 ± 0.032	0.369GlnLys: 0.369 ± 0.02	2.688GlnLeu: 2.688 ± 0.06	0.49GlnMet: 0.49 ± 0.022	0.412GlnAsn: 0.412 ± 0.023	1.701GlnPro: 1.701 ± 0.048	1.041GlnGln: 1.041 ± 0.033	2.533GlnArg: 2.533 ± 0.049	1.14GlnSer: 1.14 ± 0.039	1.379GlnThr: 1.379 ± 0.038	3.271GlnVal: 3.271 ± 0.056	0.554GlnTrp: 0.554 ± 0.024	0.555GlnTyr: 0.555 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	11.306ArgAla: 11.306 ± 0.135	0.41ArgCys: 0.41 ± 0.022	4.554ArgAsp: 4.554 ± 0.072	4.147ArgGlu: 4.147 ± 0.067	1.986ArgPhe: 1.986 ± 0.04	6.052ArgGly: 6.052 ± 0.081	1.766ArgHis: 1.766 ± 0.039	2.675ArgIle: 2.675 ± 0.048	1.024ArgLys: 1.024 ± 0.037	8.274ArgLeu: 8.274 ± 0.128	1.488ArgMet: 1.488 ± 0.038	0.983ArgAsn: 0.983 ± 0.033	4.605ArgPro: 4.605 ± 0.087	1.988ArgGln: 1.988 ± 0.049	7.854ArgArg: 7.854 ± 0.136	4.043ArgSer: 4.043 ± 0.067	5.767ArgThr: 5.767 ± 0.074	7.319ArgVal: 7.319 ± 0.096	1.553ArgTrp: 1.553 ± 0.041	1.618ArgTyr: 1.618 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.864SerAla: 6.864 ± 0.092	0.311SerCys: 0.311 ± 0.018	2.873SerAsp: 2.873 ± 0.06	1.885SerGlu: 1.885 ± 0.039	1.389SerPhe: 1.389 ± 0.037	5.319SerGly: 5.319 ± 0.092	0.867SerHis: 0.867 ± 0.027	1.51SerIle: 1.51 ± 0.045	0.642SerLys: 0.642 ± 0.029	4.414SerLeu: 4.414 ± 0.07	0.935SerMet: 0.935 ± 0.025	0.727SerAsn: 0.727 ± 0.034	2.877SerPro: 2.877 ± 0.055	1.193SerGln: 1.193 ± 0.035	3.345SerArg: 3.345 ± 0.066	3.134SerSer: 3.134 ± 0.075	3.559SerThr: 3.559 ± 0.072	4.331SerVal: 4.331 ± 0.072	0.883SerTrp: 0.883 ± 0.031	1.086SerTyr: 1.086 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	9.256ThrAla: 9.256 ± 0.116	0.379ThrCys: 0.379 ± 0.02	3.73ThrAsp: 3.73 ± 0.07	2.603ThrGlu: 2.603 ± 0.054	1.877ThrPhe: 1.877 ± 0.05	6.527ThrGly: 6.527 ± 0.101	1.272ThrHis: 1.272 ± 0.041	1.989ThrIle: 1.989 ± 0.055	0.934ThrLys: 0.934 ± 0.033	6.331ThrLeu: 6.331 ± 0.084	0.88ThrMet: 0.88 ± 0.029	1.04ThrAsn: 1.04 ± 0.04	4.611ThrPro: 4.611 ± 0.085	1.683ThrGln: 1.683 ± 0.048	4.325ThrArg: 4.325 ± 0.065	3.777ThrSer: 3.777 ± 0.073	4.973ThrThr: 4.973 ± 0.103	6.786ThrVal: 6.786 ± 0.126	1.254ThrTrp: 1.254 ± 0.044	1.375ThrTyr: 1.375 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	15.196ValAla: 15.196 ± 0.164	0.541ValCys: 0.541 ± 0.025	6.672ValAsp: 6.672 ± 0.086	5.591ValGlu: 5.591 ± 0.078	2.243ValPhe: 2.243 ± 0.05	8.564ValGly: 8.564 ± 0.106	2.161ValHis: 2.161 ± 0.049	2.633ValIle: 2.633 ± 0.053	1.337ValLys: 1.337 ± 0.041	11.617ValLeu: 11.617 ± 0.151	1.331ValMet: 1.331 ± 0.043	1.423ValAsn: 1.423 ± 0.037	6.16ValPro: 6.16 ± 0.089	2.46ValGln: 2.46 ± 0.047	8.307ValArg: 8.307 ± 0.105	4.395ValSer: 4.395 ± 0.08	7.08ValThr: 7.08 ± 0.108	12.741ValVal: 12.741 ± 0.155	1.266ValTrp: 1.266 ± 0.037	1.405ValTyr: 1.405 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.902TrpAla: 1.902 ± 0.045	0.149TrpCys: 0.149 ± 0.013	0.895TrpAsp: 0.895 ± 0.03	0.6TrpGlu: 0.6 ± 0.024	0.522TrpPhe: 0.522 ± 0.025	1.116TrpGly: 1.116 ± 0.037	0.38TrpHis: 0.38 ± 0.019	0.43TrpIle: 0.43 ± 0.019	0.231TrpLys: 0.231 ± 0.017	1.755TrpLeu: 1.755 ± 0.043	0.255TrpMet: 0.255 ± 0.015	0.332TrpAsn: 0.332 ± 0.019	0.783TrpPro: 0.783 ± 0.029	0.598TrpGln: 0.598 ± 0.027	1.454TrpArg: 1.454 ± 0.038	1.084TrpSer: 1.084 ± 0.034	1.256TrpThr: 1.256 ± 0.038	1.351TrpVal: 1.351 ± 0.042	0.44TrpTrp: 0.44 ± 0.023	0.326TrpTyr: 0.326 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.472TyrAla: 2.472 ± 0.049	0.124TyrCys: 0.124 ± 0.012	1.237TyrAsp: 1.237 ± 0.037	0.895TyrGlu: 0.895 ± 0.035	0.527TyrPhe: 0.527 ± 0.021	1.71TyrGly: 1.71 ± 0.044	0.298TyrHis: 0.298 ± 0.017	0.344TyrIle: 0.344 ± 0.02	0.275TyrLys: 0.275 ± 0.018	1.926TyrLeu: 1.926 ± 0.044	0.184TyrMet: 0.184 ± 0.014	0.343TyrAsn: 0.343 ± 0.022	0.949TyrPro: 0.949 ± 0.035	0.55TyrGln: 0.55 ± 0.027	1.562TyrArg: 1.562 ± 0.04	0.838TyrSer: 0.838 ± 0.039	1.018TyrThr: 1.018 ± 0.034	1.821TyrVal: 1.821 ± 0.041	0.288TyrTrp: 0.288 ± 0.018	0.378TyrTyr: 0.378 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3153 proteins (1067109 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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