Amino acid dipepetide frequency for Edwardsiella ictaluri (strain 93-146)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.855AlaAla: 11.855 ± 0.152	1.454AlaCys: 1.454 ± 0.036	5.519AlaAsp: 5.519 ± 0.079	5.777AlaGlu: 5.777 ± 0.104	3.567AlaPhe: 3.567 ± 0.071	7.879AlaGly: 7.879 ± 0.115	2.165AlaHis: 2.165 ± 0.049	5.893AlaIle: 5.893 ± 0.092	2.987AlaLys: 2.987 ± 0.072	14.075AlaLeu: 14.075 ± 0.178	3.073AlaMet: 3.073 ± 0.056	2.886AlaAsn: 2.886 ± 0.065	4.19AlaPro: 4.19 ± 0.085	5.682AlaGln: 5.682 ± 0.102	6.888AlaArg: 6.888 ± 0.099	5.431AlaSer: 5.431 ± 0.08	4.671AlaThr: 4.671 ± 0.071	6.719AlaVal: 6.719 ± 0.09	1.436AlaTrp: 1.436 ± 0.039	2.452AlaTyr: 2.452 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	1.403CysAla: 1.403 ± 0.04	0.276CysCys: 0.276 ± 0.017	0.759CysAsp: 0.759 ± 0.026	0.594CysGlu: 0.594 ± 0.027	0.453CysPhe: 0.453 ± 0.018	1.348CysGly: 1.348 ± 0.038	0.442CysHis: 0.442 ± 0.027	0.635CysIle: 0.635 ± 0.027	0.302CysLys: 0.302 ± 0.017	1.226CysLeu: 1.226 ± 0.038	0.28CysMet: 0.28 ± 0.018	0.34CysAsn: 0.34 ± 0.02	0.625CysPro: 0.625 ± 0.025	0.645CysGln: 0.645 ± 0.042	0.895CysArg: 0.895 ± 0.029	0.802CysSer: 0.802 ± 0.028	0.572CysThr: 0.572 ± 0.023	0.905CysVal: 0.905 ± 0.032	0.23CysTrp: 0.23 ± 0.029	0.395CysTyr: 0.395 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	5.672AspAla: 5.672 ± 0.081	0.567AspCys: 0.567 ± 0.024	2.895AspAsp: 2.895 ± 0.063	3.178AspGlu: 3.178 ± 0.064	2.049AspPhe: 2.049 ± 0.041	4.294AspGly: 4.294 ± 0.071	1.026AspHis: 1.026 ± 0.029	3.284AspIle: 3.284 ± 0.06	1.973AspLys: 1.973 ± 0.047	4.891AspLeu: 4.891 ± 0.079	1.38AspMet: 1.38 ± 0.041	1.913AspAsn: 1.913 ± 0.051	2.418AspPro: 2.418 ± 0.054	1.583AspGln: 1.583 ± 0.045	3.245AspArg: 3.245 ± 0.063	2.948AspSer: 2.948 ± 0.06	2.628AspThr: 2.628 ± 0.05	3.429AspVal: 3.429 ± 0.07	0.806AspTrp: 0.806 ± 0.03	1.792AspTyr: 1.792 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	5.207GluAla: 5.207 ± 0.081	0.516GluCys: 0.516 ± 0.023	2.02GluAsp: 2.02 ± 0.048	2.672GluGlu: 2.672 ± 0.064	1.555GluPhe: 1.555 ± 0.041	3.334GluGly: 3.334 ± 0.055	1.255GluHis: 1.255 ± 0.038	3.044GluIle: 3.044 ± 0.058	2.387GluLys: 2.387 ± 0.055	5.077GluLeu: 5.077 ± 0.088	1.649GluMet: 1.649 ± 0.043	1.841GluAsn: 1.841 ± 0.043	1.807GluPro: 1.807 ± 0.047	3.335GluGln: 3.335 ± 0.072	4.092GluArg: 4.092 ± 0.084	2.743GluSer: 2.743 ± 0.057	2.517GluThr: 2.517 ± 0.053	3.422GluVal: 3.422 ± 0.06	0.694GluTrp: 0.694 ± 0.028	1.359GluTyr: 1.359 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.504PheAla: 3.504 ± 0.06	0.619PheCys: 0.619 ± 0.025	2.218PheAsp: 2.218 ± 0.055	1.506PheGlu: 1.506 ± 0.047	1.554PhePhe: 1.554 ± 0.05	2.924PheGly: 2.924 ± 0.057	0.826PheHis: 0.826 ± 0.029	2.532PheIle: 2.532 ± 0.053	1.029PheLys: 1.029 ± 0.03	3.144PheLeu: 3.144 ± 0.07	0.912PheMet: 0.912 ± 0.032	1.59PheAsn: 1.59 ± 0.042	1.442PhePro: 1.442 ± 0.04	1.042PheGln: 1.042 ± 0.027	1.856PheArg: 1.856 ± 0.04	2.979PheSer: 2.979 ± 0.066	2.099PheThr: 2.099 ± 0.041	2.25PheVal: 2.25 ± 0.043	0.554PheTrp: 0.554 ± 0.025	1.189PheTyr: 1.189 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	7.11GlyAla: 7.11 ± 0.097	1.22GlyCys: 1.22 ± 0.037	3.879GlyAsp: 3.879 ± 0.08	4.525GlyGlu: 4.525 ± 0.073	3.034GlyPhe: 3.034 ± 0.059	5.802GlyGly: 5.802 ± 0.113	1.836GlyHis: 1.836 ± 0.04	4.959GlyIle: 4.959 ± 0.071	3.304GlyLys: 3.304 ± 0.058	7.653GlyLeu: 7.653 ± 0.108	2.529GlyMet: 2.529 ± 0.051	2.516GlyAsn: 2.516 ± 0.062	2.041GlyPro: 2.041 ± 0.051	3.336GlyGln: 3.336 ± 0.071	4.573GlyArg: 4.573 ± 0.076	4.262GlySer: 4.262 ± 0.078	3.547GlyThr: 3.547 ± 0.069	5.899GlyVal: 5.899 ± 0.083	1.303GlyTrp: 1.303 ± 0.038	2.731GlyTyr: 2.731 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.203HisAla: 2.203 ± 0.051	0.454HisCys: 0.454 ± 0.031	1.308HisAsp: 1.308 ± 0.032	0.983HisGlu: 0.983 ± 0.03	1.07HisPhe: 1.07 ± 0.03	2.006HisGly: 2.006 ± 0.043	0.854HisHis: 0.854 ± 0.033	1.324HisIle: 1.324 ± 0.037	0.713HisLys: 0.713 ± 0.025	2.546HisLeu: 2.546 ± 0.057	0.549HisMet: 0.549 ± 0.02	0.781HisAsn: 0.781 ± 0.027	1.521HisPro: 1.521 ± 0.039	1.297HisGln: 1.297 ± 0.04	1.521HisArg: 1.521 ± 0.044	1.378HisSer: 1.378 ± 0.038	1.156HisThr: 1.156 ± 0.036	1.218HisVal: 1.218 ± 0.035	0.397HisTrp: 0.397 ± 0.023	0.884HisTyr: 0.884 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	6.51IleAla: 6.51 ± 0.1	0.756IleCys: 0.756 ± 0.026	3.583IleAsp: 3.583 ± 0.063	2.957IleGlu: 2.957 ± 0.059	1.849IlePhe: 1.849 ± 0.053	4.775IleGly: 4.775 ± 0.08	1.232IleHis: 1.232 ± 0.039	3.017IleIle: 3.017 ± 0.071	2.023IleLys: 2.023 ± 0.052	5.107IleLeu: 5.107 ± 0.085	1.23IleMet: 1.23 ± 0.039	2.317IleAsn: 2.317 ± 0.052	2.64IlePro: 2.64 ± 0.048	1.842IleGln: 1.842 ± 0.046	3.256IleArg: 3.256 ± 0.057	3.683IleSer: 3.683 ± 0.068	3.176IleThr: 3.176 ± 0.051	3.765IleVal: 3.765 ± 0.061	0.585IleTrp: 0.585 ± 0.026	1.591IleTyr: 1.591 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	3.291LysAla: 3.291 ± 0.068	0.268LysCys: 0.268 ± 0.019	1.472LysAsp: 1.472 ± 0.045	1.757LysGlu: 1.757 ± 0.053	0.871LysPhe: 0.871 ± 0.031	2.415LysGly: 2.415 ± 0.053	0.68LysHis: 0.68 ± 0.026	1.924LysIle: 1.924 ± 0.048	1.736LysLys: 1.736 ± 0.058	3.223LysLeu: 3.223 ± 0.065	0.991LysMet: 0.991 ± 0.029	1.47LysAsn: 1.47 ± 0.053	1.582LysPro: 1.582 ± 0.043	1.69LysGln: 1.69 ± 0.047	2.319LysArg: 2.319 ± 0.056	2.025LysSer: 2.025 ± 0.046	1.997LysThr: 1.997 ± 0.052	2.403LysVal: 2.403 ± 0.057	0.353LysTrp: 0.353 ± 0.02	0.954LysTyr: 0.954 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	12.767LeuAla: 12.767 ± 0.152	1.741LeuCys: 1.741 ± 0.047	5.753LeuAsp: 5.753 ± 0.085	5.12LeuGlu: 5.12 ± 0.075	4.321LeuPhe: 4.321 ± 0.08	7.946LeuGly: 7.946 ± 0.096	2.568LeuHis: 2.568 ± 0.049	5.83LeuIle: 5.83 ± 0.093	3.633LeuLys: 3.633 ± 0.074	13.735LeuLeu: 13.735 ± 0.207	3.115LeuMet: 3.115 ± 0.062	3.918LeuAsn: 3.918 ± 0.076	6.203LeuPro: 6.203 ± 0.093	5.096LeuGln: 5.096 ± 0.08	7.623LeuArg: 7.623 ± 0.099	7.788LeuSer: 7.788 ± 0.108	6.353LeuThr: 6.353 ± 0.094	6.857LeuVal: 6.857 ± 0.096	1.541LeuTrp: 1.541 ± 0.049	2.888LeuTyr: 2.888 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	3.194MetAla: 3.194 ± 0.057	0.236MetCys: 0.236 ± 0.013	1.218MetAsp: 1.218 ± 0.036	1.243MetGlu: 1.243 ± 0.038	0.84MetPhe: 0.84 ± 0.029	1.914MetGly: 1.914 ± 0.046	0.536MetHis: 0.536 ± 0.023	1.371MetIle: 1.371 ± 0.041	1.155MetLys: 1.155 ± 0.034	3.273MetLeu: 3.273 ± 0.06	0.89MetMet: 0.89 ± 0.033	0.928MetAsn: 0.928 ± 0.029	1.368MetPro: 1.368 ± 0.039	1.266MetGln: 1.266 ± 0.039	1.6MetArg: 1.6 ± 0.037	1.79MetSer: 1.79 ± 0.039	1.707MetThr: 1.707 ± 0.041	1.874MetVal: 1.874 ± 0.04	0.26MetTrp: 0.26 ± 0.016	0.535MetTyr: 0.535 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.373AsnAla: 3.373 ± 0.07	0.316AsnCys: 0.316 ± 0.021	1.739AsnAsp: 1.739 ± 0.047	1.449AsnGlu: 1.449 ± 0.041	1.038AsnPhe: 1.038 ± 0.039	2.872AsnGly: 2.872 ± 0.07	0.839AsnHis: 0.839 ± 0.031	2.048AsnIle: 2.048 ± 0.057	1.288AsnLys: 1.288 ± 0.042	3.304AsnLeu: 3.304 ± 0.06	0.882AsnMet: 0.882 ± 0.031	1.254AsnAsn: 1.254 ± 0.049	1.943AsnPro: 1.943 ± 0.036	1.507AsnGln: 1.507 ± 0.037	2.045AsnArg: 2.045 ± 0.051	1.805AsnSer: 1.805 ± 0.064	1.706AsnThr: 1.706 ± 0.051	2.121AsnVal: 2.121 ± 0.046	0.403AsnTrp: 0.403 ± 0.017	0.987AsnTyr: 0.987 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	4.801ProAla: 4.801 ± 0.071	0.507ProCys: 0.507 ± 0.022	2.797ProAsp: 2.797 ± 0.053	2.703ProGlu: 2.703 ± 0.063	1.755ProPhe: 1.755 ± 0.043	3.613ProGly: 3.613 ± 0.064	1.195ProHis: 1.195 ± 0.036	2.045ProIle: 2.045 ± 0.042	1.158ProLys: 1.158 ± 0.038	5.92ProLeu: 5.92 ± 0.095	1.122ProMet: 1.122 ± 0.037	1.17ProAsn: 1.17 ± 0.033	2.07ProPro: 2.07 ± 0.049	2.848ProGln: 2.848 ± 0.055	2.5ProArg: 2.5 ± 0.055	2.402ProSer: 2.402 ± 0.052	2.263ProThr: 2.263 ± 0.049	3.315ProVal: 3.315 ± 0.057	0.655ProTrp: 0.655 ± 0.028	1.375ProTyr: 1.375 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	6.0GlnAla: 6.0 ± 0.088	0.518GlnCys: 0.518 ± 0.031	2.049GlnAsp: 2.049 ± 0.049	2.305GlnGlu: 2.305 ± 0.055	1.368GlnPhe: 1.368 ± 0.038	3.698GlnGly: 3.698 ± 0.076	1.323GlnHis: 1.323 ± 0.035	2.493GlnIle: 2.493 ± 0.053	1.434GlnLys: 1.434 ± 0.036	5.311GlnLeu: 5.311 ± 0.074	1.307GlnMet: 1.307 ± 0.037	1.314GlnAsn: 1.314 ± 0.042	2.394GlnPro: 2.394 ± 0.056	3.607GlnGln: 3.607 ± 0.093	4.328GlnArg: 4.328 ± 0.082	2.388GlnSer: 2.388 ± 0.054	2.222GlnThr: 2.222 ± 0.045	3.267GlnVal: 3.267 ± 0.061	0.708GlnTrp: 0.708 ± 0.034	1.116GlnTyr: 1.116 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	5.925ArgAla: 5.925 ± 0.084	0.92ArgCys: 0.92 ± 0.035	3.586ArgAsp: 3.586 ± 0.07	3.784ArgGlu: 3.784 ± 0.069	2.739ArgPhe: 2.739 ± 0.051	4.081ArgGly: 4.081 ± 0.07	2.118ArgHis: 2.118 ± 0.045	3.766ArgIle: 3.766 ± 0.059	1.872ArgLys: 1.872 ± 0.051	8.13ArgLeu: 8.13 ± 0.099	1.703ArgMet: 1.703 ± 0.042	1.893ArgAsn: 1.893 ± 0.045	2.744ArgPro: 2.744 ± 0.051	4.038ArgGln: 4.038 ± 0.072	5.085ArgArg: 5.085 ± 0.095	3.21ArgSer: 3.21 ± 0.061	2.709ArgThr: 2.709 ± 0.054	4.247ArgVal: 4.247 ± 0.064	1.161ArgTrp: 1.161 ± 0.037	2.472ArgTyr: 2.472 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	6.448SerAla: 6.448 ± 0.08	0.701SerCys: 0.701 ± 0.027	3.124SerAsp: 3.124 ± 0.06	2.856SerGlu: 2.856 ± 0.055	1.973SerPhe: 1.973 ± 0.049	5.532SerGly: 5.532 ± 0.092	1.454SerHis: 1.454 ± 0.043	2.845SerIle: 2.845 ± 0.063	1.643SerLys: 1.643 ± 0.044	6.886SerLeu: 6.886 ± 0.122	1.396SerMet: 1.396 ± 0.035	1.827SerAsn: 1.827 ± 0.068	2.696SerPro: 2.696 ± 0.052	2.739SerGln: 2.739 ± 0.065	3.664SerArg: 3.664 ± 0.072	3.32SerSer: 3.32 ± 0.071	2.663SerThr: 2.663 ± 0.05	4.234SerVal: 4.234 ± 0.068	0.81SerTrp: 0.81 ± 0.027	1.572SerTyr: 1.572 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	4.825ThrAla: 4.825 ± 0.078	0.538ThrCys: 0.538 ± 0.025	2.393ThrAsp: 2.393 ± 0.054	2.185ThrGlu: 2.185 ± 0.046	1.793ThrPhe: 1.793 ± 0.047	3.798ThrGly: 3.798 ± 0.064	1.218ThrHis: 1.218 ± 0.036	2.539ThrIle: 2.539 ± 0.061	1.179ThrLys: 1.179 ± 0.035	8.402ThrLeu: 8.402 ± 0.113	1.058ThrMet: 1.058 ± 0.034	1.275ThrAsn: 1.275 ± 0.035	3.511ThrPro: 3.511 ± 0.06	2.251ThrGln: 2.251 ± 0.046	3.1ThrArg: 3.1 ± 0.054	2.437ThrSer: 2.437 ± 0.063	2.472ThrThr: 2.472 ± 0.063	3.419ThrVal: 3.419 ± 0.063	0.615ThrTrp: 0.615 ± 0.027	1.192ThrTyr: 1.192 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	7.003ValAla: 7.003 ± 0.083	0.906ValCys: 0.906 ± 0.033	3.577ValAsp: 3.577 ± 0.066	3.432ValGlu: 3.432 ± 0.063	2.257ValPhe: 2.257 ± 0.049	4.709ValGly: 4.709 ± 0.072	1.278ValHis: 1.278 ± 0.031	4.253ValIle: 4.253 ± 0.074	2.44ValLys: 2.44 ± 0.052	7.11ValLeu: 7.11 ± 0.105	2.127ValMet: 2.127 ± 0.048	2.429ValAsn: 2.429 ± 0.051	2.79ValPro: 2.79 ± 0.049	2.436ValGln: 2.436 ± 0.057	4.051ValArg: 4.051 ± 0.073	4.57ValSer: 4.57 ± 0.073	3.914ValThr: 3.914 ± 0.063	4.996ValVal: 4.996 ± 0.069	0.818ValTrp: 0.818 ± 0.03	1.772ValTyr: 1.772 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.942TrpAla: 0.942 ± 0.029	0.196TrpCys: 0.196 ± 0.016	0.526TrpAsp: 0.526 ± 0.026	0.484TrpGlu: 0.484 ± 0.021	0.543TrpPhe: 0.543 ± 0.023	0.87TrpGly: 0.87 ± 0.033	0.472TrpHis: 0.472 ± 0.033	0.68TrpIle: 0.68 ± 0.028	0.394TrpLys: 0.394 ± 0.021	2.407TrpLeu: 2.407 ± 0.067	0.393TrpMet: 0.393 ± 0.019	0.381TrpAsn: 0.381 ± 0.018	0.697TrpPro: 0.697 ± 0.025	1.232TrpGln: 1.232 ± 0.039	1.166TrpArg: 1.166 ± 0.041	0.73TrpSer: 0.73 ± 0.027	0.426TrpThr: 0.426 ± 0.02	0.902TrpVal: 0.902 ± 0.031	0.231TrpTrp: 0.231 ± 0.015	0.352TrpTyr: 0.352 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.567TyrAla: 2.567 ± 0.052	0.418TyrCys: 0.418 ± 0.019	1.555TyrAsp: 1.555 ± 0.041	1.015TyrGlu: 1.015 ± 0.032	1.14TyrPhe: 1.14 ± 0.035	2.248TyrGly: 2.248 ± 0.05	0.847TyrHis: 0.847 ± 0.029	1.409TyrIle: 1.409 ± 0.038	0.773TyrLys: 0.773 ± 0.029	3.378TyrLeu: 3.378 ± 0.066	0.613TyrMet: 0.613 ± 0.026	0.877TyrAsn: 0.877 ± 0.03	1.533TyrPro: 1.533 ± 0.04	1.679TyrGln: 1.679 ± 0.039	2.375TyrArg: 2.375 ± 0.054	1.693TyrSer: 1.693 ± 0.049	1.403TyrThr: 1.403 ± 0.035	1.625TyrVal: 1.625 ± 0.042	0.462TyrTrp: 0.462 ± 0.024	0.933TyrTyr: 0.933 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3686 proteins (1044215 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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