Amino acid dipepetide frequency for Actinospica robiniae DSM 44927

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
24.654AlaAla: 24.654 ± 1.243
1.414AlaCys: 1.414 ± 0.132
8.98AlaAsp: 8.98 ± 0.399
8.063AlaGlu: 8.063 ± 0.439
3.354AlaPhe: 3.354 ± 0.227
13.538AlaGly: 13.538 ± 0.503
2.753AlaHis: 2.753 ± 0.169
4.257AlaIle: 4.257 ± 0.281
2.467AlaLys: 2.467 ± 0.185
15.854AlaLeu: 15.854 ± 0.811
2.497AlaMet: 2.497 ± 0.193
2.542AlaAsn: 2.542 ± 0.274
6.092AlaPro: 6.092 ± 0.34
4.513AlaGln: 4.513 ± 0.248
9.732AlaArg: 9.732 ± 0.584
7.626AlaSer: 7.626 ± 0.447
8.198AlaThr: 8.198 ± 0.569
12.139AlaVal: 12.139 ± 0.653
2.301AlaTrp: 2.301 ± 0.221
2.813AlaTyr: 2.813 ± 0.233
0.0AlaXaa: 0.0 ± 0.0
Cys
1.67CysAla: 1.67 ± 0.162
0.181CysCys: 0.181 ± 0.051
0.692CysAsp: 0.692 ± 0.095
0.557CysGlu: 0.557 ± 0.09
0.256CysPhe: 0.256 ± 0.054
1.188CysGly: 1.188 ± 0.134
0.256CysHis: 0.256 ± 0.068
0.241CysIle: 0.241 ± 0.061
0.12CysLys: 0.12 ± 0.045
0.812CysLeu: 0.812 ± 0.124
0.12CysMet: 0.12 ± 0.041
0.286CysAsn: 0.286 ± 0.075
0.496CysPro: 0.496 ± 0.102
0.105CysGln: 0.105 ± 0.038
0.647CysArg: 0.647 ± 0.103
0.662CysSer: 0.662 ± 0.101
0.542CysThr: 0.542 ± 0.078
0.812CysVal: 0.812 ± 0.112
0.165CysTrp: 0.165 ± 0.049
0.316CysTyr: 0.316 ± 0.081
0.0CysXaa: 0.0 ± 0.0
Asp
7.596AspAla: 7.596 ± 0.371
0.391AspCys: 0.391 ± 0.076
3.339AspAsp: 3.339 ± 0.221
3.294AspGlu: 3.294 ± 0.229
1.594AspPhe: 1.594 ± 0.209
6.077AspGly: 6.077 ± 0.38
1.158AspHis: 1.158 ± 0.132
1.579AspIle: 1.579 ± 0.164
0.677AspLys: 0.677 ± 0.099
5.942AspLeu: 5.942 ± 0.305
0.707AspMet: 0.707 ± 0.108
1.128AspAsn: 1.128 ± 0.169
4.347AspPro: 4.347 ± 0.287
2.076AspGln: 2.076 ± 0.188
4.152AspArg: 4.152 ± 0.303
2.632AspSer: 2.632 ± 0.268
3.114AspThr: 3.114 ± 0.312
4.016AspVal: 4.016 ± 0.248
0.903AspTrp: 0.903 ± 0.133
1.414AspTyr: 1.414 ± 0.199
0.0AspXaa: 0.0 ± 0.0
Glu
6.453GluAla: 6.453 ± 0.428
0.481GluCys: 0.481 ± 0.075
2.482GluAsp: 2.482 ± 0.206
2.392GluGlu: 2.392 ± 0.227
1.158GluPhe: 1.158 ± 0.127
3.219GluGly: 3.219 ± 0.268
1.384GluHis: 1.384 ± 0.162
2.286GluIle: 2.286 ± 0.262
0.978GluLys: 0.978 ± 0.111
6.393GluLeu: 6.393 ± 0.39
0.767GluMet: 0.767 ± 0.11
1.173GluAsn: 1.173 ± 0.15
3.339GluPro: 3.339 ± 0.231
2.407GluGln: 2.407 ± 0.224
4.633GluArg: 4.633 ± 0.338
2.557GluSer: 2.557 ± 0.207
2.647GluThr: 2.647 ± 0.308
3.625GluVal: 3.625 ± 0.241
0.752GluTrp: 0.752 ± 0.111
1.143GluTyr: 1.143 ± 0.147
0.0GluXaa: 0.0 ± 0.0
Phe
4.001PheAla: 4.001 ± 0.272
0.271PheCys: 0.271 ± 0.066
1.835PheAsp: 1.835 ± 0.197
1.564PheGlu: 1.564 ± 0.149
0.948PhePhe: 0.948 ± 0.149
3.008PheGly: 3.008 ± 0.232
0.466PheHis: 0.466 ± 0.074
0.692PheIle: 0.692 ± 0.098
0.361PheLys: 0.361 ± 0.076
2.422PheLeu: 2.422 ± 0.231
0.421PheMet: 0.421 ± 0.096
0.647PheAsn: 0.647 ± 0.134
1.173PhePro: 1.173 ± 0.128
0.677PheGln: 0.677 ± 0.098
1.745PheArg: 1.745 ± 0.2
1.925PheSer: 1.925 ± 0.194
2.181PheThr: 2.181 ± 0.18
2.031PheVal: 2.031 ± 0.196
0.421PheTrp: 0.421 ± 0.077
0.572PheTyr: 0.572 ± 0.104
0.0PheXaa: 0.0 ± 0.0
Gly
11.056GlyAla: 11.056 ± 0.563
1.038GlyCys: 1.038 ± 0.124
4.934GlyAsp: 4.934 ± 0.378
4.392GlyGlu: 4.392 ± 0.308
2.738GlyPhe: 2.738 ± 0.209
7.777GlyGly: 7.777 ± 0.432
2.377GlyHis: 2.377 ± 0.167
3.67GlyIle: 3.67 ± 0.262
1.85GlyLys: 1.85 ± 0.163
9.085GlyLeu: 9.085 ± 0.413
1.835GlyMet: 1.835 ± 0.169
1.986GlyAsn: 1.986 ± 0.25
5.039GlyPro: 5.039 ± 0.301
3.4GlyGln: 3.4 ± 0.237
7.22GlyArg: 7.22 ± 0.432
6.965GlySer: 6.965 ± 0.408
6.859GlyThr: 6.859 ± 0.527
6.423GlyVal: 6.423 ± 0.313
1.82GlyTrp: 1.82 ± 0.191
3.054GlyTyr: 3.054 ± 0.256
0.0GlyXaa: 0.0 ± 0.0
His
2.933HisAla: 2.933 ± 0.218
0.256HisCys: 0.256 ± 0.055
1.158HisAsp: 1.158 ± 0.157
1.068HisGlu: 1.068 ± 0.136
0.662HisPhe: 0.662 ± 0.112
2.332HisGly: 2.332 ± 0.257
0.572HisHis: 0.572 ± 0.101
0.557HisIle: 0.557 ± 0.088
0.15HisLys: 0.15 ± 0.062
2.271HisLeu: 2.271 ± 0.193
0.316HisMet: 0.316 ± 0.053
0.376HisAsn: 0.376 ± 0.062
1.594HisPro: 1.594 ± 0.157
0.662HisGln: 0.662 ± 0.086
1.865HisArg: 1.865 ± 0.216
1.188HisSer: 1.188 ± 0.151
1.173HisThr: 1.173 ± 0.12
1.429HisVal: 1.429 ± 0.175
0.376HisTrp: 0.376 ± 0.07
0.617HisTyr: 0.617 ± 0.097
0.0HisXaa: 0.0 ± 0.0
Ile
4.859IleAla: 4.859 ± 0.275
0.391IleCys: 0.391 ± 0.076
2.377IleAsp: 2.377 ± 0.18
2.377IleGlu: 2.377 ± 0.217
0.782IlePhe: 0.782 ± 0.118
3.986IleGly: 3.986 ± 0.277
0.887IleHis: 0.887 ± 0.14
0.903IleIle: 0.903 ± 0.14
0.722IleLys: 0.722 ± 0.119
3.099IleLeu: 3.099 ± 0.222
0.496IleMet: 0.496 ± 0.095
0.692IleAsn: 0.692 ± 0.111
2.031IlePro: 2.031 ± 0.181
1.053IleGln: 1.053 ± 0.122
2.241IleArg: 2.241 ± 0.191
2.452IleSer: 2.452 ± 0.188
2.151IleThr: 2.151 ± 0.197
2.783IleVal: 2.783 ± 0.221
0.572IleTrp: 0.572 ± 0.098
0.857IleTyr: 0.857 ± 0.148
0.0IleXaa: 0.0 ± 0.0
Lys
2.527LysAla: 2.527 ± 0.21
0.12LysCys: 0.12 ± 0.042
0.722LysAsp: 0.722 ± 0.114
0.632LysGlu: 0.632 ± 0.102
0.391LysPhe: 0.391 ± 0.065
1.188LysGly: 1.188 ± 0.163
0.421LysHis: 0.421 ± 0.077
0.767LysIle: 0.767 ± 0.114
0.346LysLys: 0.346 ± 0.065
1.625LysLeu: 1.625 ± 0.156
0.286LysMet: 0.286 ± 0.066
0.286LysAsn: 0.286 ± 0.063
1.098LysPro: 1.098 ± 0.15
0.572LysGln: 0.572 ± 0.111
1.053LysArg: 1.053 ± 0.133
1.188LysSer: 1.188 ± 0.113
1.158LysThr: 1.158 ± 0.172
1.098LysVal: 1.098 ± 0.138
0.165LysTrp: 0.165 ± 0.049
0.376LysTyr: 0.376 ± 0.065
0.0LysXaa: 0.0 ± 0.0
Leu
15.599LeuAla: 15.599 ± 0.824
1.203LeuCys: 1.203 ± 0.11
6.107LeuAsp: 6.107 ± 0.318
4.738LeuGlu: 4.738 ± 0.297
2.587LeuPhe: 2.587 ± 0.247
9.191LeuGly: 9.191 ± 0.426
2.061LeuHis: 2.061 ± 0.209
4.317LeuIle: 4.317 ± 0.306
1.384LeuLys: 1.384 ± 0.15
10.033LeuLeu: 10.033 ± 0.632
1.61LeuMet: 1.61 ± 0.152
1.955LeuAsn: 1.955 ± 0.175
6.137LeuPro: 6.137 ± 0.277
2.226LeuGln: 2.226 ± 0.164
8.243LeuArg: 8.243 ± 0.493
5.776LeuSer: 5.776 ± 0.309
6.784LeuThr: 6.784 ± 0.344
7.972LeuVal: 7.972 ± 0.44
1.369LeuTrp: 1.369 ± 0.175
2.031LeuTyr: 2.031 ± 0.185
0.0LeuXaa: 0.0 ± 0.0
Met
2.211MetAla: 2.211 ± 0.205
0.196MetCys: 0.196 ± 0.059
0.602MetAsp: 0.602 ± 0.083
0.526MetGlu: 0.526 ± 0.089
0.511MetPhe: 0.511 ± 0.093
1.098MetGly: 1.098 ± 0.133
0.286MetHis: 0.286 ± 0.071
0.692MetIle: 0.692 ± 0.108
0.241MetLys: 0.241 ± 0.071
2.001MetLeu: 2.001 ± 0.197
0.256MetMet: 0.256 ± 0.046
0.451MetAsn: 0.451 ± 0.082
1.068MetPro: 1.068 ± 0.126
0.602MetGln: 0.602 ± 0.082
1.459MetArg: 1.459 ± 0.157
1.218MetSer: 1.218 ± 0.16
1.444MetThr: 1.444 ± 0.131
1.038MetVal: 1.038 ± 0.136
0.241MetTrp: 0.241 ± 0.067
0.271MetTyr: 0.271 ± 0.057
0.0MetXaa: 0.0 ± 0.0
Asn
2.798AsnAla: 2.798 ± 0.26
0.271AsnCys: 0.271 ± 0.079
0.978AsnAsp: 0.978 ± 0.138
1.113AsnGlu: 1.113 ± 0.14
0.587AsnPhe: 0.587 ± 0.088
2.723AsnGly: 2.723 ± 0.31
0.391AsnHis: 0.391 ± 0.079
0.617AsnIle: 0.617 ± 0.12
0.346AsnLys: 0.346 ± 0.072
2.166AsnLeu: 2.166 ± 0.21
0.391AsnMet: 0.391 ± 0.097
0.632AsnAsn: 0.632 ± 0.155
1.564AsnPro: 1.564 ± 0.223
0.617AsnGln: 0.617 ± 0.117
1.128AsnArg: 1.128 ± 0.127
1.068AsnSer: 1.068 ± 0.154
1.61AsnThr: 1.61 ± 0.271
1.369AsnVal: 1.369 ± 0.158
0.301AsnTrp: 0.301 ± 0.069
0.602AsnTyr: 0.602 ± 0.133
0.0AsnXaa: 0.0 ± 0.0
Pro
9.055ProAla: 9.055 ± 0.429
0.406ProCys: 0.406 ± 0.072
3.791ProAsp: 3.791 ± 0.239
3.911ProGlu: 3.911 ± 0.312
1.294ProPhe: 1.294 ± 0.167
6.498ProGly: 6.498 ± 0.345
1.128ProHis: 1.128 ± 0.149
1.67ProIle: 1.67 ± 0.153
0.526ProLys: 0.526 ± 0.086
5.009ProLeu: 5.009 ± 0.288
0.872ProMet: 0.872 ± 0.127
1.128ProAsn: 1.128 ± 0.155
3.039ProPro: 3.039 ± 0.284
1.76ProGln: 1.76 ± 0.192
3.249ProArg: 3.249 ± 0.288
3.49ProSer: 3.49 ± 0.277
4.137ProThr: 4.137 ± 0.363
4.768ProVal: 4.768 ± 0.346
0.857ProTrp: 0.857 ± 0.125
1.023ProTyr: 1.023 ± 0.133
0.0ProXaa: 0.0 ± 0.0
Gln
4.798GlnAla: 4.798 ± 0.285
0.331GlnCys: 0.331 ± 0.063
1.459GlnAsp: 1.459 ± 0.161
1.098GlnGlu: 1.098 ± 0.121
0.707GlnPhe: 0.707 ± 0.107
2.392GlnGly: 2.392 ± 0.201
0.481GlnHis: 0.481 ± 0.08
1.64GlnIle: 1.64 ± 0.135
0.436GlnLys: 0.436 ± 0.069
3.384GlnLeu: 3.384 ± 0.234
0.481GlnMet: 0.481 ± 0.075
0.933GlnAsn: 0.933 ± 0.143
1.594GlnPro: 1.594 ± 0.151
1.218GlnGln: 1.218 ± 0.141
2.647GlnArg: 2.647 ± 0.234
1.67GlnSer: 1.67 ± 0.187
1.594GlnThr: 1.594 ± 0.224
2.301GlnVal: 2.301 ± 0.223
0.557GlnTrp: 0.557 ± 0.088
0.933GlnTyr: 0.933 ± 0.168
0.0GlnXaa: 0.0 ± 0.0
Arg
9.702ArgAla: 9.702 ± 0.528
0.692ArgCys: 0.692 ± 0.116
3.791ArgAsp: 3.791 ± 0.305
3.776ArgGlu: 3.776 ± 0.308
2.347ArgPhe: 2.347 ± 0.23
5.114ArgGly: 5.114 ± 0.376
1.971ArgHis: 1.971 ± 0.239
3.144ArgIle: 3.144 ± 0.293
1.309ArgLys: 1.309 ± 0.161
8.138ArgLeu: 8.138 ± 0.514
1.625ArgMet: 1.625 ± 0.159
1.279ArgAsn: 1.279 ± 0.151
4.829ArgPro: 4.829 ± 0.356
1.82ArgGln: 1.82 ± 0.184
7.446ArgArg: 7.446 ± 0.543
4.001ArgSer: 4.001 ± 0.291
4.633ArgThr: 4.633 ± 0.291
5.52ArgVal: 5.52 ± 0.366
1.008ArgTrp: 1.008 ± 0.159
1.715ArgTyr: 1.715 ± 0.205
0.0ArgXaa: 0.0 ± 0.0
Ser
8.86SerAla: 8.86 ± 0.51
0.737SerCys: 0.737 ± 0.129
2.647SerAsp: 2.647 ± 0.266
2.557SerGlu: 2.557 ± 0.204
1.805SerPhe: 1.805 ± 0.19
6.949SerGly: 6.949 ± 0.444
1.083SerHis: 1.083 ± 0.129
2.196SerIle: 2.196 ± 0.178
0.978SerLys: 0.978 ± 0.147
5.099SerLeu: 5.099 ± 0.272
1.233SerMet: 1.233 ± 0.138
1.339SerAsn: 1.339 ± 0.169
3.761SerPro: 3.761 ± 0.304
1.519SerGln: 1.519 ± 0.153
3.776SerArg: 3.776 ± 0.239
4.813SerSer: 4.813 ± 0.601
4.287SerThr: 4.287 ± 0.447
4.633SerVal: 4.633 ± 0.33
1.158SerTrp: 1.158 ± 0.145
1.775SerTyr: 1.775 ± 0.278
0.0SerXaa: 0.0 ± 0.0
Thr
9.537ThrAla: 9.537 ± 0.644
0.496ThrCys: 0.496 ± 0.085
3.324ThrAsp: 3.324 ± 0.307
2.407ThrGlu: 2.407 ± 0.177
1.835ThrPhe: 1.835 ± 0.17
6.965ThrGly: 6.965 ± 0.447
1.203ThrHis: 1.203 ± 0.129
2.286ThrIle: 2.286 ± 0.231
1.309ThrLys: 1.309 ± 0.139
5.445ThrLeu: 5.445 ± 0.301
0.827ThrMet: 0.827 ± 0.108
1.444ThrAsn: 1.444 ± 0.298
4.227ThrPro: 4.227 ± 0.27
1.79ThrGln: 1.79 ± 0.211
3.55ThrArg: 3.55 ± 0.258
4.678ThrSer: 4.678 ± 0.574
4.708ThrThr: 4.708 ± 0.639
6.318ThrVal: 6.318 ± 0.326
1.233ThrTrp: 1.233 ± 0.149
1.579ThrTyr: 1.579 ± 0.353
0.0ThrXaa: 0.0 ± 0.0
Val
10.484ValAla: 10.484 ± 0.548
0.797ValCys: 0.797 ± 0.107
4.392ValAsp: 4.392 ± 0.265
4.197ValGlu: 4.197 ± 0.299
2.437ValPhe: 2.437 ± 0.233
6.949ValGly: 6.949 ± 0.389
1.745ValHis: 1.745 ± 0.162
2.813ValIle: 2.813 ± 0.185
1.098ValLys: 1.098 ± 0.117
8.634ValLeu: 8.634 ± 0.528
1.068ValMet: 1.068 ± 0.114
1.655ValAsn: 1.655 ± 0.189
3.956ValPro: 3.956 ± 0.267
2.121ValGln: 2.121 ± 0.166
5.641ValArg: 5.641 ± 0.418
4.573ValSer: 4.573 ± 0.31
4.964ValThr: 4.964 ± 0.372
6.709ValVal: 6.709 ± 0.416
1.459ValTrp: 1.459 ± 0.18
1.835ValTyr: 1.835 ± 0.185
0.0ValXaa: 0.0 ± 0.0
Trp
1.805TrpAla: 1.805 ± 0.158
0.226TrpCys: 0.226 ± 0.059
0.872TrpAsp: 0.872 ± 0.106
0.632TrpGlu: 0.632 ± 0.096
0.602TrpPhe: 0.602 ± 0.087
0.993TrpGly: 0.993 ± 0.126
0.587TrpHis: 0.587 ± 0.101
0.617TrpIle: 0.617 ± 0.1
0.271TrpLys: 0.271 ± 0.066
1.67TrpLeu: 1.67 ± 0.196
0.376TrpMet: 0.376 ± 0.076
0.511TrpAsn: 0.511 ± 0.099
1.008TrpPro: 1.008 ± 0.153
0.677TrpGln: 0.677 ± 0.09
1.309TrpArg: 1.309 ± 0.171
1.264TrpSer: 1.264 ± 0.167
1.384TrpThr: 1.384 ± 0.176
0.918TrpVal: 0.918 ± 0.108
0.391TrpTrp: 0.391 ± 0.086
0.406TrpTyr: 0.406 ± 0.082
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.189TyrAla: 3.189 ± 0.276
0.226TyrCys: 0.226 ± 0.061
1.655TyrAsp: 1.655 ± 0.389
0.978TyrGlu: 0.978 ± 0.125
0.767TyrPhe: 0.767 ± 0.115
2.332TyrGly: 2.332 ± 0.185
0.346TyrHis: 0.346 ± 0.068
0.767TyrIle: 0.767 ± 0.144
0.451TyrLys: 0.451 ± 0.077
2.241TyrLeu: 2.241 ± 0.178
0.211TyrMet: 0.211 ± 0.043
0.827TyrAsn: 0.827 ± 0.169
1.218TyrPro: 1.218 ± 0.153
0.842TyrGln: 0.842 ± 0.123
2.136TyrArg: 2.136 ± 0.205
1.459TyrSer: 1.459 ± 0.152
1.594TyrThr: 1.594 ± 0.337
1.625TyrVal: 1.625 ± 0.152
0.466TyrTrp: 0.466 ± 0.102
0.647TyrTyr: 0.647 ± 0.151
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 191 proteins (66481 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski