Amino acid dipepetide frequency for Photobacterium aquimaris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.679AlaAla: 8.679 ± 0.116
0.973AlaCys: 0.973 ± 0.03
4.935AlaAsp: 4.935 ± 0.075
5.091AlaGlu: 5.091 ± 0.077
3.26AlaPhe: 3.26 ± 0.057
5.867AlaGly: 5.867 ± 0.087
1.64AlaHis: 1.64 ± 0.04
6.858AlaIle: 6.858 ± 0.092
4.688AlaLys: 4.688 ± 0.081
9.507AlaLeu: 9.507 ± 0.107
2.868AlaMet: 2.868 ± 0.058
3.886AlaAsn: 3.886 ± 0.062
2.97AlaPro: 2.97 ± 0.057
4.079AlaGln: 4.079 ± 0.072
3.415AlaArg: 3.415 ± 0.062
4.886AlaSer: 4.886 ± 0.069
5.269AlaThr: 5.269 ± 0.079
6.033AlaVal: 6.033 ± 0.08
0.973AlaTrp: 0.973 ± 0.033
2.29AlaTyr: 2.29 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
0.865CysAla: 0.865 ± 0.028
0.217CysCys: 0.217 ± 0.015
0.746CysAsp: 0.746 ± 0.024
0.623CysGlu: 0.623 ± 0.023
0.484CysPhe: 0.484 ± 0.021
0.99CysGly: 0.99 ± 0.028
0.413CysHis: 0.413 ± 0.021
0.672CysIle: 0.672 ± 0.025
0.461CysLys: 0.461 ± 0.022
1.07CysLeu: 1.07 ± 0.03
0.251CysMet: 0.251 ± 0.016
0.461CysAsn: 0.461 ± 0.019
0.457CysPro: 0.457 ± 0.025
0.564CysGln: 0.564 ± 0.024
0.545CysArg: 0.545 ± 0.023
0.818CysSer: 0.818 ± 0.03
0.483CysThr: 0.483 ± 0.019
0.712CysVal: 0.712 ± 0.023
0.151CysTrp: 0.151 ± 0.012
0.453CysTyr: 0.453 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
4.319AspAla: 4.319 ± 0.074
0.632AspCys: 0.632 ± 0.026
3.307AspAsp: 3.307 ± 0.068
3.159AspGlu: 3.159 ± 0.059
2.44AspPhe: 2.44 ± 0.048
3.739AspGly: 3.739 ± 0.098
1.288AspHis: 1.288 ± 0.029
4.419AspIle: 4.419 ± 0.069
3.1AspLys: 3.1 ± 0.062
4.982AspLeu: 4.982 ± 0.081
1.45AspMet: 1.45 ± 0.038
2.989AspAsn: 2.989 ± 0.063
2.095AspPro: 2.095 ± 0.041
2.189AspGln: 2.189 ± 0.045
2.253AspArg: 2.253 ± 0.044
3.09AspSer: 3.09 ± 0.061
2.797AspThr: 2.797 ± 0.069
3.74AspVal: 3.74 ± 0.053
0.829AspTrp: 0.829 ± 0.029
2.18AspTyr: 2.18 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
4.479GluAla: 4.479 ± 0.08
0.507GluCys: 0.507 ± 0.021
2.326GluAsp: 2.326 ± 0.058
2.485GluGlu: 2.485 ± 0.068
2.044GluPhe: 2.044 ± 0.046
2.913GluGly: 2.913 ± 0.049
1.421GluHis: 1.421 ± 0.036
3.554GluIle: 3.554 ± 0.062
2.987GluLys: 2.987 ± 0.054
5.951GluLeu: 5.951 ± 0.091
1.56GluMet: 1.56 ± 0.036
2.396GluAsn: 2.396 ± 0.047
1.784GluPro: 1.784 ± 0.04
3.688GluGln: 3.688 ± 0.067
2.925GluArg: 2.925 ± 0.06
2.721GluSer: 2.721 ± 0.043
2.756GluThr: 2.756 ± 0.053
3.61GluVal: 3.61 ± 0.065
0.676GluTrp: 0.676 ± 0.026
1.594GluTyr: 1.594 ± 0.039
0.0GluXaa: 0.0 ± 0.0
Phe
3.586PheAla: 3.586 ± 0.066
0.541PheCys: 0.541 ± 0.021
2.644PheAsp: 2.644 ± 0.048
2.174PheGlu: 2.174 ± 0.037
1.748PhePhe: 1.748 ± 0.05
3.084PheGly: 3.084 ± 0.065
0.809PheHis: 0.809 ± 0.025
3.304PheIle: 3.304 ± 0.06
2.005PheLys: 2.005 ± 0.044
3.193PheLeu: 3.193 ± 0.056
1.062PheMet: 1.062 ± 0.031
2.304PheAsn: 2.304 ± 0.046
1.34PhePro: 1.34 ± 0.033
1.112PheGln: 1.112 ± 0.03
1.437PheArg: 1.437 ± 0.032
3.244PheSer: 3.244 ± 0.061
2.517PheThr: 2.517 ± 0.048
2.731PheVal: 2.731 ± 0.051
0.522PheTrp: 0.522 ± 0.022
1.37PheTyr: 1.37 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
4.959GlyAla: 4.959 ± 0.079
1.061GlyCys: 1.061 ± 0.03
3.668GlyAsp: 3.668 ± 0.079
3.651GlyGlu: 3.651 ± 0.057
3.243GlyPhe: 3.243 ± 0.057
4.612GlyGly: 4.612 ± 0.089
1.623GlyHis: 1.623 ± 0.034
5.003GlyIle: 5.003 ± 0.075
3.747GlyLys: 3.747 ± 0.063
6.886GlyLeu: 6.886 ± 0.085
2.046GlyMet: 2.046 ± 0.045
2.772GlyAsn: 2.772 ± 0.049
1.571GlyPro: 1.571 ± 0.043
2.803GlyGln: 2.803 ± 0.053
2.923GlyArg: 2.923 ± 0.054
3.855GlySer: 3.855 ± 0.068
3.394GlyThr: 3.394 ± 0.071
4.828GlyVal: 4.828 ± 0.063
1.044GlyTrp: 1.044 ± 0.029
2.588GlyTyr: 2.588 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
1.744HisAla: 1.744 ± 0.041
0.406HisCys: 0.406 ± 0.024
1.248HisAsp: 1.248 ± 0.029
0.955HisGlu: 0.955 ± 0.028
1.129HisPhe: 1.129 ± 0.031
1.615HisGly: 1.615 ± 0.037
0.909HisHis: 0.909 ± 0.039
1.578HisIle: 1.578 ± 0.038
1.056HisLys: 1.056 ± 0.032
2.235HisLeu: 2.235 ± 0.04
0.568HisMet: 0.568 ± 0.02
1.126HisAsn: 1.126 ± 0.03
1.165HisPro: 1.165 ± 0.035
1.593HisGln: 1.593 ± 0.036
1.082HisArg: 1.082 ± 0.03
1.526HisSer: 1.526 ± 0.042
1.172HisThr: 1.172 ± 0.033
1.263HisVal: 1.263 ± 0.035
0.372HisTrp: 0.372 ± 0.019
1.06HisTyr: 1.06 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
7.24IleAla: 7.24 ± 0.098
0.828IleCys: 0.828 ± 0.032
4.73IleAsp: 4.73 ± 0.069
4.497IleGlu: 4.497 ± 0.076
2.598IlePhe: 2.598 ± 0.055
5.129IleGly: 5.129 ± 0.076
1.341IleHis: 1.341 ± 0.035
5.06IleIle: 5.06 ± 0.083
3.889IleLys: 3.889 ± 0.068
5.662IleLeu: 5.662 ± 0.09
1.529IleMet: 1.529 ± 0.04
3.877IleAsn: 3.877 ± 0.065
2.799IlePro: 2.799 ± 0.045
2.273IleGln: 2.273 ± 0.04
2.712IleArg: 2.712 ± 0.043
4.929IleSer: 4.929 ± 0.068
4.741IleThr: 4.741 ± 0.079
4.479IleVal: 4.479 ± 0.066
0.624IleTrp: 0.624 ± 0.021
1.981IleTyr: 1.981 ± 0.04
0.0IleXaa: 0.0 ± 0.0
Lys
4.54LysAla: 4.54 ± 0.082
0.353LysCys: 0.353 ± 0.017
2.665LysAsp: 2.665 ± 0.05
2.565LysGlu: 2.565 ± 0.053
1.568LysPhe: 1.568 ± 0.038
3.024LysGly: 3.024 ± 0.055
1.255LysHis: 1.255 ± 0.035
3.376LysIle: 3.376 ± 0.058
3.08LysLys: 3.08 ± 0.064
5.213LysLeu: 5.213 ± 0.07
1.589LysMet: 1.589 ± 0.036
2.45LysAsn: 2.45 ± 0.049
2.345LysPro: 2.345 ± 0.049
3.069LysGln: 3.069 ± 0.058
2.449LysArg: 2.449 ± 0.045
2.799LysSer: 2.799 ± 0.057
3.106LysThr: 3.106 ± 0.053
3.513LysVal: 3.513 ± 0.058
0.567LysTrp: 0.567 ± 0.02
1.545LysTyr: 1.545 ± 0.039
0.0LysXaa: 0.0 ± 0.0
Leu
10.182LeuAla: 10.182 ± 0.113
1.131LeuCys: 1.131 ± 0.034
5.395LeuAsp: 5.395 ± 0.074
5.173LeuGlu: 5.173 ± 0.075
4.262LeuPhe: 4.262 ± 0.07
6.621LeuGly: 6.621 ± 0.074
2.167LeuHis: 2.167 ± 0.045
6.765LeuIle: 6.765 ± 0.102
4.852LeuLys: 4.852 ± 0.08
10.69LeuLeu: 10.69 ± 0.152
2.79LeuMet: 2.79 ± 0.05
4.723LeuAsn: 4.723 ± 0.06
4.818LeuPro: 4.818 ± 0.063
4.065LeuGln: 4.065 ± 0.069
4.309LeuArg: 4.309 ± 0.066
7.089LeuSer: 7.089 ± 0.078
6.832LeuThr: 6.832 ± 0.081
6.708LeuVal: 6.708 ± 0.093
1.134LeuTrp: 1.134 ± 0.039
2.652LeuTyr: 2.652 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
2.793MetAla: 2.793 ± 0.057
0.248MetCys: 0.248 ± 0.015
1.253MetAsp: 1.253 ± 0.038
1.165MetGlu: 1.165 ± 0.028
1.002MetPhe: 1.002 ± 0.032
1.811MetGly: 1.811 ± 0.04
0.508MetHis: 0.508 ± 0.021
1.808MetIle: 1.808 ± 0.037
1.451MetLys: 1.451 ± 0.034
2.784MetLeu: 2.784 ± 0.06
0.875MetMet: 0.875 ± 0.031
1.145MetAsn: 1.145 ± 0.03
1.33MetPro: 1.33 ± 0.033
1.147MetGln: 1.147 ± 0.031
1.194MetArg: 1.194 ± 0.033
1.852MetSer: 1.852 ± 0.039
1.898MetThr: 1.898 ± 0.044
2.006MetVal: 2.006 ± 0.041
0.241MetTrp: 0.241 ± 0.015
0.612MetTyr: 0.612 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.651AsnAla: 3.651 ± 0.063
0.483AsnCys: 0.483 ± 0.019
2.785AsnAsp: 2.785 ± 0.054
2.194AsnGlu: 2.194 ± 0.049
1.62AsnPhe: 1.62 ± 0.039
3.353AsnGly: 3.353 ± 0.084
1.226AsnHis: 1.226 ± 0.034
3.627AsnIle: 3.627 ± 0.054
2.815AsnLys: 2.815 ± 0.05
3.858AsnLeu: 3.858 ± 0.058
1.117AsnMet: 1.117 ± 0.03
3.028AsnAsn: 3.028 ± 0.07
2.165AsnPro: 2.165 ± 0.044
2.365AsnGln: 2.365 ± 0.052
1.931AsnArg: 1.931 ± 0.038
2.648AsnSer: 2.648 ± 0.052
2.701AsnThr: 2.701 ± 0.064
2.987AsnVal: 2.987 ± 0.051
0.585AsnTrp: 0.585 ± 0.023
1.668AsnTyr: 1.668 ± 0.043
0.0AsnXaa: 0.0 ± 0.0
Pro
3.293ProAla: 3.293 ± 0.05
0.343ProCys: 0.343 ± 0.017
2.022ProAsp: 2.022 ± 0.047
2.573ProGlu: 2.573 ± 0.053
1.787ProPhe: 1.787 ± 0.042
2.029ProGly: 2.029 ± 0.046
0.942ProHis: 0.942 ± 0.03
2.721ProIle: 2.721 ± 0.053
1.827ProLys: 1.827 ± 0.043
4.448ProLeu: 4.448 ± 0.066
1.095ProMet: 1.095 ± 0.032
1.782ProAsn: 1.782 ± 0.037
1.187ProPro: 1.187 ± 0.03
2.324ProGln: 2.324 ± 0.042
1.369ProArg: 1.369 ± 0.035
2.35ProSer: 2.35 ± 0.043
2.536ProThr: 2.536 ± 0.052
2.962ProVal: 2.962 ± 0.057
0.538ProTrp: 0.538 ± 0.022
1.32ProTyr: 1.32 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
4.578GlnAla: 4.578 ± 0.071
0.521GlnCys: 0.521 ± 0.025
2.018GlnAsp: 2.018 ± 0.045
1.838GlnGlu: 1.838 ± 0.046
1.767GlnPhe: 1.767 ± 0.035
2.971GlnGly: 2.971 ± 0.05
1.614GlnHis: 1.614 ± 0.037
2.647GlnIle: 2.647 ± 0.047
2.025GlnLys: 2.025 ± 0.044
6.149GlnLeu: 6.149 ± 0.108
1.188GlnMet: 1.188 ± 0.029
1.585GlnAsn: 1.585 ± 0.04
2.287GlnPro: 2.287 ± 0.05
5.05GlnGln: 5.05 ± 0.129
2.768GlnArg: 2.768 ± 0.053
2.477GlnSer: 2.477 ± 0.049
2.514GlnThr: 2.514 ± 0.049
2.997GlnVal: 2.997 ± 0.062
0.855GlnTrp: 0.855 ± 0.034
1.598GlnTyr: 1.598 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
3.164ArgAla: 3.164 ± 0.057
0.564ArgCys: 0.564 ± 0.026
2.355ArgAsp: 2.355 ± 0.047
2.512ArgGlu: 2.512 ± 0.052
2.078ArgPhe: 2.078 ± 0.043
2.478ArgGly: 2.478 ± 0.052
1.213ArgHis: 1.213 ± 0.034
3.055ArgIle: 3.055 ± 0.058
2.146ArgLys: 2.146 ± 0.048
4.89ArgLeu: 4.89 ± 0.072
1.146ArgMet: 1.146 ± 0.031
1.92ArgAsn: 1.92 ± 0.044
1.572ArgPro: 1.572 ± 0.04
2.451ArgGln: 2.451 ± 0.047
2.283ArgArg: 2.283 ± 0.054
2.401ArgSer: 2.401 ± 0.041
2.013ArgThr: 2.013 ± 0.041
2.816ArgVal: 2.816 ± 0.046
0.616ArgTrp: 0.616 ± 0.023
1.783ArgTyr: 1.783 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
5.087SerAla: 5.087 ± 0.079
0.716SerCys: 0.716 ± 0.026
3.272SerAsp: 3.272 ± 0.055
3.038SerGlu: 3.038 ± 0.048
2.741SerPhe: 2.741 ± 0.044
4.539SerGly: 4.539 ± 0.076
1.701SerHis: 1.701 ± 0.044
4.14SerIle: 4.14 ± 0.072
2.805SerLys: 2.805 ± 0.052
6.607SerLeu: 6.607 ± 0.076
1.604SerMet: 1.604 ± 0.041
2.681SerAsn: 2.681 ± 0.047
2.335SerPro: 2.335 ± 0.04
2.899SerGln: 2.899 ± 0.054
2.723SerArg: 2.723 ± 0.053
3.928SerSer: 3.928 ± 0.064
3.454SerThr: 3.454 ± 0.062
4.055SerVal: 4.055 ± 0.07
0.796SerTrp: 0.796 ± 0.026
2.092SerTyr: 2.092 ± 0.04
0.0SerXaa: 0.0 ± 0.0
Thr
5.417ThrAla: 5.417 ± 0.086
0.51ThrCys: 0.51 ± 0.024
3.35ThrAsp: 3.35 ± 0.068
3.065ThrGlu: 3.065 ± 0.052
2.163ThrPhe: 2.163 ± 0.042
4.127ThrGly: 4.127 ± 0.073
1.295ThrHis: 1.295 ± 0.035
4.197ThrIle: 4.197 ± 0.084
2.662ThrLys: 2.662 ± 0.051
6.492ThrLeu: 6.492 ± 0.086
1.316ThrMet: 1.316 ± 0.036
2.533ThrAsn: 2.533 ± 0.072
2.902ThrPro: 2.902 ± 0.051
2.589ThrGln: 2.589 ± 0.051
2.125ThrArg: 2.125 ± 0.046
3.361ThrSer: 3.361 ± 0.055
3.933ThrThr: 3.933 ± 0.091
4.355ThrVal: 4.355 ± 0.069
0.572ThrTrp: 0.572 ± 0.021
1.556ThrTyr: 1.556 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
6.427ValAla: 6.427 ± 0.096
0.784ValCys: 0.784 ± 0.03
3.985ValAsp: 3.985 ± 0.065
3.893ValGlu: 3.893 ± 0.08
2.742ValPhe: 2.742 ± 0.048
4.498ValGly: 4.498 ± 0.069
1.152ValHis: 1.152 ± 0.032
5.342ValIle: 5.342 ± 0.072
3.548ValLys: 3.548 ± 0.052
6.406ValLeu: 6.406 ± 0.082
2.074ValMet: 2.074 ± 0.042
3.205ValAsn: 3.205 ± 0.06
2.477ValPro: 2.477 ± 0.047
2.01ValGln: 2.01 ± 0.043
2.662ValArg: 2.662 ± 0.049
4.346ValSer: 4.346 ± 0.061
4.31ValThr: 4.31 ± 0.074
5.237ValVal: 5.237 ± 0.074
0.754ValTrp: 0.754 ± 0.025
1.812ValTyr: 1.812 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
0.814TrpAla: 0.814 ± 0.029
0.168TrpCys: 0.168 ± 0.011
0.555TrpAsp: 0.555 ± 0.028
0.456TrpGlu: 0.456 ± 0.021
0.615TrpPhe: 0.615 ± 0.023
0.741TrpGly: 0.741 ± 0.027
0.378TrpHis: 0.378 ± 0.016
0.768TrpIle: 0.768 ± 0.025
0.492TrpLys: 0.492 ± 0.021
1.879TrpLeu: 1.879 ± 0.046
0.327TrpMet: 0.327 ± 0.016
0.52TrpAsn: 0.52 ± 0.024
0.46TrpPro: 0.46 ± 0.02
1.097TrpGln: 1.097 ± 0.035
0.623TrpArg: 0.623 ± 0.024
0.704TrpSer: 0.704 ± 0.022
0.517TrpThr: 0.517 ± 0.023
0.837TrpVal: 0.837 ± 0.027
0.213TrpTrp: 0.213 ± 0.015
0.374TrpTyr: 0.374 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.351TyrAla: 2.351 ± 0.051
0.449TyrCys: 0.449 ± 0.021
1.736TyrAsp: 1.736 ± 0.041
1.272TyrGlu: 1.272 ± 0.034
1.437TyrPhe: 1.437 ± 0.031
2.135TyrGly: 2.135 ± 0.046
0.909TyrHis: 0.909 ± 0.029
2.024TyrIle: 2.024 ± 0.045
1.435TyrLys: 1.435 ± 0.037
3.454TyrLeu: 3.454 ± 0.057
0.667TyrMet: 0.667 ± 0.025
1.424TyrAsn: 1.424 ± 0.037
1.387TyrPro: 1.387 ± 0.032
2.082TyrGln: 2.082 ± 0.045
1.727TyrArg: 1.727 ± 0.036
2.194TyrSer: 2.194 ± 0.047
1.573TyrThr: 1.573 ± 0.036
1.793TyrVal: 1.793 ± 0.041
0.477TyrTrp: 0.477 ± 0.021
1.128TyrTyr: 1.128 ± 0.04
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3753 proteins (1203080 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski