Amino acid dipepetide frequency for Campylobacter iguaniorum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.566AlaAla: 4.566 ± 0.121
0.986AlaCys: 0.986 ± 0.049
3.062AlaAsp: 3.062 ± 0.077
2.596AlaGlu: 2.596 ± 0.082
3.511AlaPhe: 3.511 ± 0.09
4.776AlaGly: 4.776 ± 0.11
1.151AlaHis: 1.151 ± 0.047
6.565AlaIle: 6.565 ± 0.112
7.636AlaLys: 7.636 ± 0.127
7.72AlaLeu: 7.72 ± 0.143
2.087AlaMet: 2.087 ± 0.072
4.623AlaAsn: 4.623 ± 0.109
1.956AlaPro: 1.956 ± 0.059
1.946AlaGln: 1.946 ± 0.068
2.482AlaArg: 2.482 ± 0.065
4.888AlaSer: 4.888 ± 0.104
3.728AlaThr: 3.728 ± 0.091
4.286AlaVal: 4.286 ± 0.108
0.537AlaTrp: 0.537 ± 0.031
2.714AlaTyr: 2.714 ± 0.076
0.0AlaXaa: 0.0 ± 0.0
Cys
0.874CysAla: 0.874 ± 0.041
0.12CysCys: 0.12 ± 0.017
0.956CysAsp: 0.956 ± 0.042
0.981CysGlu: 0.981 ± 0.038
0.558CysPhe: 0.558 ± 0.029
1.056CysGly: 1.056 ± 0.05
0.284CysHis: 0.284 ± 0.037
0.823CysIle: 0.823 ± 0.039
0.936CysLys: 0.936 ± 0.047
0.962CysLeu: 0.962 ± 0.05
0.243CysMet: 0.243 ± 0.022
0.481CysAsn: 0.481 ± 0.033
0.423CysPro: 0.423 ± 0.031
0.26CysGln: 0.26 ± 0.022
0.255CysArg: 0.255 ± 0.023
0.794CysSer: 0.794 ± 0.043
0.427CysThr: 0.427 ± 0.03
0.904CysVal: 0.904 ± 0.049
0.054CysTrp: 0.054 ± 0.012
0.357CysTyr: 0.357 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
3.827AspAla: 3.827 ± 0.093
0.548AspCys: 0.548 ± 0.036
3.225AspAsp: 3.225 ± 0.092
5.963AspGlu: 5.963 ± 0.125
3.432AspPhe: 3.432 ± 0.1
3.664AspGly: 3.664 ± 0.092
0.648AspHis: 0.648 ± 0.038
5.573AspIle: 5.573 ± 0.125
5.21AspLys: 5.21 ± 0.108
4.866AspLeu: 4.866 ± 0.107
1.551AspMet: 1.551 ± 0.057
2.558AspAsn: 2.558 ± 0.079
1.604AspPro: 1.604 ± 0.063
1.082AspGln: 1.082 ± 0.048
1.905AspArg: 1.905 ± 0.063
3.213AspSer: 3.213 ± 0.085
2.573AspThr: 2.573 ± 0.07
3.103AspVal: 3.103 ± 0.083
0.331AspTrp: 0.331 ± 0.026
2.22AspTyr: 2.22 ± 0.067
0.0AspXaa: 0.0 ± 0.0
Glu
4.656GluAla: 4.656 ± 0.12
0.779GluCys: 0.779 ± 0.043
2.865GluAsp: 2.865 ± 0.083
3.603GluGlu: 3.603 ± 0.117
4.231GluPhe: 4.231 ± 0.108
2.568GluGly: 2.568 ± 0.075
1.052GluHis: 1.052 ± 0.041
6.678GluIle: 6.678 ± 0.142
4.845GluLys: 4.845 ± 0.113
7.671GluLeu: 7.671 ± 0.144
1.632GluMet: 1.632 ± 0.063
4.136GluAsn: 4.136 ± 0.08
1.853GluPro: 1.853 ± 0.056
2.074GluGln: 2.074 ± 0.064
1.948GluArg: 1.948 ± 0.069
3.168GluSer: 3.168 ± 0.071
2.287GluThr: 2.287 ± 0.07
3.859GluVal: 3.859 ± 0.098
0.473GluTrp: 0.473 ± 0.031
2.362GluTyr: 2.362 ± 0.071
0.0GluXaa: 0.0 ± 0.0
Phe
3.78PheAla: 3.78 ± 0.092
0.842PheCys: 0.842 ± 0.037
3.981PheAsp: 3.981 ± 0.095
3.644PheGlu: 3.644 ± 0.084
2.757PhePhe: 2.757 ± 0.084
4.58PheGly: 4.58 ± 0.122
0.619PheHis: 0.619 ± 0.036
4.965PheIle: 4.965 ± 0.135
4.267PheLys: 4.267 ± 0.104
5.251PheLeu: 5.251 ± 0.131
1.391PheMet: 1.391 ± 0.055
2.603PheAsn: 2.603 ± 0.074
1.104PhePro: 1.104 ± 0.053
0.893PheGln: 0.893 ± 0.045
1.555PheArg: 1.555 ± 0.054
4.273PheSer: 4.273 ± 0.095
2.261PheThr: 2.261 ± 0.068
3.53PheVal: 3.53 ± 0.099
0.53PheTrp: 0.53 ± 0.033
2.199PheTyr: 2.199 ± 0.067
0.0PheXaa: 0.0 ± 0.0
Gly
4.958GlyAla: 4.958 ± 0.107
0.795GlyCys: 0.795 ± 0.042
3.631GlyAsp: 3.631 ± 0.082
3.981GlyGlu: 3.981 ± 0.088
4.138GlyPhe: 4.138 ± 0.088
4.729GlyGly: 4.729 ± 0.133
0.998GlyHis: 0.998 ± 0.046
5.403GlyIle: 5.403 ± 0.101
4.83GlyLys: 4.83 ± 0.107
5.981GlyLeu: 5.981 ± 0.115
1.598GlyMet: 1.598 ± 0.068
2.833GlyAsn: 2.833 ± 0.092
0.788GlyPro: 0.788 ± 0.044
1.488GlyGln: 1.488 ± 0.062
1.984GlyArg: 1.984 ± 0.065
4.228GlySer: 4.228 ± 0.1
2.706GlyThr: 2.706 ± 0.073
5.373GlyVal: 5.373 ± 0.103
0.485GlyTrp: 0.485 ± 0.031
2.68GlyTyr: 2.68 ± 0.074
0.0GlyXaa: 0.0 ± 0.0
His
1.035HisAla: 1.035 ± 0.048
0.185HisCys: 0.185 ± 0.02
0.681HisAsp: 0.681 ± 0.035
0.84HisGlu: 0.84 ± 0.04
0.895HisPhe: 0.895 ± 0.048
1.012HisGly: 1.012 ± 0.051
0.339HisHis: 0.339 ± 0.034
1.379HisIle: 1.379 ± 0.053
1.202HisLys: 1.202 ± 0.044
1.364HisLeu: 1.364 ± 0.056
0.318HisMet: 0.318 ± 0.022
0.631HisAsn: 0.631 ± 0.039
0.717HisPro: 0.717 ± 0.041
0.447HisGln: 0.447 ± 0.03
0.444HisArg: 0.444 ± 0.03
0.992HisSer: 0.992 ± 0.045
0.756HisThr: 0.756 ± 0.036
0.616HisVal: 0.616 ± 0.032
0.118HisTrp: 0.118 ± 0.014
0.603HisTyr: 0.603 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
6.59IleAla: 6.59 ± 0.126
1.318IleCys: 1.318 ± 0.051
5.199IleAsp: 5.199 ± 0.111
5.066IleGlu: 5.066 ± 0.106
4.63IlePhe: 4.63 ± 0.125
5.319IleGly: 5.319 ± 0.102
0.966IleHis: 0.966 ± 0.045
7.016IleIle: 7.016 ± 0.133
8.085IleLys: 8.085 ± 0.149
8.113IleLeu: 8.113 ± 0.14
1.793IleMet: 1.793 ± 0.06
5.527IleAsn: 5.527 ± 0.119
2.332IlePro: 2.332 ± 0.077
1.872IleGln: 1.872 ± 0.057
2.476IleArg: 2.476 ± 0.072
6.874IleSer: 6.874 ± 0.13
4.179IleThr: 4.179 ± 0.098
4.999IleVal: 4.999 ± 0.102
0.604IleTrp: 0.604 ± 0.035
3.434IleTyr: 3.434 ± 0.095
0.0IleXaa: 0.0 ± 0.0
Lys
5.848LysAla: 5.848 ± 0.113
0.745LysCys: 0.745 ± 0.047
5.875LysAsp: 5.875 ± 0.111
6.956LysGlu: 6.956 ± 0.106
5.914LysPhe: 5.914 ± 0.119
3.868LysGly: 3.868 ± 0.098
1.132LysHis: 1.132 ± 0.051
7.832LysIle: 7.832 ± 0.147
7.05LysLys: 7.05 ± 0.126
7.155LysLeu: 7.155 ± 0.117
2.313LysMet: 2.313 ± 0.067
6.52LysAsn: 6.52 ± 0.128
2.525LysPro: 2.525 ± 0.066
2.476LysGln: 2.476 ± 0.068
2.813LysArg: 2.813 ± 0.069
5.813LysSer: 5.813 ± 0.113
4.222LysThr: 4.222 ± 0.103
4.535LysVal: 4.535 ± 0.097
0.543LysTrp: 0.543 ± 0.029
2.895LysTyr: 2.895 ± 0.069
0.0LysXaa: 0.0 ± 0.0
Leu
7.645LeuAla: 7.645 ± 0.124
1.175LeuCys: 1.175 ± 0.047
5.654LeuAsp: 5.654 ± 0.103
6.498LeuGlu: 6.498 ± 0.124
4.78LeuPhe: 4.78 ± 0.126
6.678LeuGly: 6.678 ± 0.127
1.359LeuHis: 1.359 ± 0.053
7.398LeuIle: 7.398 ± 0.141
9.299LeuLys: 9.299 ± 0.139
8.622LeuLeu: 8.622 ± 0.175
2.293LeuMet: 2.293 ± 0.075
6.715LeuAsn: 6.715 ± 0.137
3.133LeuPro: 3.133 ± 0.075
2.644LeuGln: 2.644 ± 0.069
3.153LeuArg: 3.153 ± 0.091
8.044LeuSer: 8.044 ± 0.131
3.911LeuThr: 3.911 ± 0.076
5.832LeuVal: 5.832 ± 0.111
0.625LeuTrp: 0.625 ± 0.035
3.223LeuTyr: 3.223 ± 0.088
0.0LeuXaa: 0.0 ± 0.0
Met
1.92MetAla: 1.92 ± 0.062
0.191MetCys: 0.191 ± 0.021
1.241MetAsp: 1.241 ± 0.043
1.166MetGlu: 1.166 ± 0.047
1.07MetPhe: 1.07 ± 0.05
1.568MetGly: 1.568 ± 0.055
0.35MetHis: 0.35 ± 0.025
2.156MetIle: 2.156 ± 0.064
2.154MetLys: 2.154 ± 0.06
2.601MetLeu: 2.601 ± 0.064
0.638MetMet: 0.638 ± 0.036
1.282MetAsn: 1.282 ± 0.053
1.005MetPro: 1.005 ± 0.045
1.181MetGln: 1.181 ± 0.05
0.868MetArg: 0.868 ± 0.042
1.997MetSer: 1.997 ± 0.063
0.917MetThr: 0.917 ± 0.041
1.46MetVal: 1.46 ± 0.05
0.148MetTrp: 0.148 ± 0.017
0.545MetTyr: 0.545 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
4.449AsnAla: 4.449 ± 0.102
0.5AsnCys: 0.5 ± 0.032
3.43AsnAsp: 3.43 ± 0.091
4.202AsnGlu: 4.202 ± 0.087
2.832AsnPhe: 2.832 ± 0.067
4.005AsnGly: 4.005 ± 0.091
0.865AsnHis: 0.865 ± 0.043
5.255AsnIle: 5.255 ± 0.125
4.136AsnLys: 4.136 ± 0.088
7.903AsnLeu: 7.903 ± 0.148
1.181AsnMet: 1.181 ± 0.05
2.366AsnAsn: 2.366 ± 0.077
2.242AsnPro: 2.242 ± 0.064
1.802AsnGln: 1.802 ± 0.07
1.634AsnArg: 1.634 ± 0.057
4.289AsnSer: 4.289 ± 0.104
2.519AsnThr: 2.519 ± 0.079
3.039AsnVal: 3.039 ± 0.086
0.356AsnTrp: 0.356 ± 0.023
2.109AsnTyr: 2.109 ± 0.062
0.0AsnXaa: 0.0 ± 0.0
Pro
1.842ProAla: 1.842 ± 0.055
0.316ProCys: 0.316 ± 0.022
1.465ProAsp: 1.465 ± 0.054
1.525ProGlu: 1.525 ± 0.056
1.707ProPhe: 1.707 ± 0.062
1.301ProGly: 1.301 ± 0.054
0.552ProHis: 0.552 ± 0.032
2.205ProIle: 2.205 ± 0.062
2.918ProLys: 2.918 ± 0.076
2.802ProLeu: 2.802 ± 0.08
0.642ProMet: 0.642 ± 0.036
2.304ProAsn: 2.304 ± 0.064
0.721ProPro: 0.721 ± 0.045
0.786ProGln: 0.786 ± 0.039
0.891ProArg: 0.891 ± 0.048
1.95ProSer: 1.95 ± 0.058
1.555ProThr: 1.555 ± 0.062
2.004ProVal: 2.004 ± 0.066
0.223ProTrp: 0.223 ± 0.021
1.233ProTyr: 1.233 ± 0.051
0.0ProXaa: 0.0 ± 0.0
Gln
1.782GlnAla: 1.782 ± 0.063
0.213GlnCys: 0.213 ± 0.021
1.284GlnAsp: 1.284 ± 0.055
1.394GlnGlu: 1.394 ± 0.061
0.983GlnPhe: 0.983 ± 0.045
1.319GlnGly: 1.319 ± 0.051
0.256GlnHis: 0.256 ± 0.021
3.232GlnIle: 3.232 ± 0.078
3.084GlnLys: 3.084 ± 0.08
1.731GlnLeu: 1.731 ± 0.06
0.702GlnMet: 0.702 ± 0.035
3.079GlnAsn: 3.079 ± 0.078
0.644GlnPro: 0.644 ± 0.037
0.453GlnGln: 0.453 ± 0.034
0.971GlnArg: 0.971 ± 0.051
1.913GlnSer: 1.913 ± 0.073
1.815GlnThr: 1.815 ± 0.069
1.42GlnVal: 1.42 ± 0.05
0.167GlnTrp: 0.167 ± 0.016
0.642GlnTyr: 0.642 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
2.498ArgAla: 2.498 ± 0.067
0.313ArgCys: 0.313 ± 0.026
1.933ArgAsp: 1.933 ± 0.068
1.928ArgGlu: 1.928 ± 0.063
1.817ArgPhe: 1.817 ± 0.064
1.864ArgGly: 1.864 ± 0.082
0.513ArgHis: 0.513 ± 0.035
2.465ArgIle: 2.465 ± 0.064
2.192ArgLys: 2.192 ± 0.064
3.314ArgLeu: 3.314 ± 0.084
0.722ArgMet: 0.722 ± 0.038
1.593ArgAsn: 1.593 ± 0.053
0.818ArgPro: 0.818 ± 0.038
1.056ArgGln: 1.056 ± 0.045
1.207ArgArg: 1.207 ± 0.05
1.924ArgSer: 1.924 ± 0.065
1.301ArgThr: 1.301 ± 0.053
2.339ArgVal: 2.339 ± 0.067
0.251ArgTrp: 0.251 ± 0.022
1.374ArgTyr: 1.374 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
4.288SerAla: 4.288 ± 0.086
0.752SerCys: 0.752 ± 0.044
4.22SerAsp: 4.22 ± 0.105
3.795SerGlu: 3.795 ± 0.093
3.986SerPhe: 3.986 ± 0.089
5.001SerGly: 5.001 ± 0.128
1.099SerHis: 1.099 ± 0.043
5.523SerIle: 5.523 ± 0.12
6.264SerLys: 6.264 ± 0.111
7.411SerLeu: 7.411 ± 0.13
1.671SerMet: 1.671 ± 0.051
3.898SerAsn: 3.898 ± 0.089
1.843SerPro: 1.843 ± 0.06
2.289SerGln: 2.289 ± 0.067
2.09SerArg: 2.09 ± 0.074
5.577SerSer: 5.577 ± 0.112
2.847SerThr: 2.847 ± 0.076
4.712SerVal: 4.712 ± 0.099
0.541SerTrp: 0.541 ± 0.04
2.581SerTyr: 2.581 ± 0.066
0.0SerXaa: 0.0 ± 0.0
Thr
2.837ThrAla: 2.837 ± 0.074
0.421ThrCys: 0.421 ± 0.033
2.182ThrAsp: 2.182 ± 0.076
1.645ThrGlu: 1.645 ± 0.066
2.017ThrPhe: 2.017 ± 0.063
2.998ThrGly: 2.998 ± 0.089
0.868ThrHis: 0.868 ± 0.048
3.803ThrIle: 3.803 ± 0.1
4.381ThrLys: 4.381 ± 0.092
4.733ThrLeu: 4.733 ± 0.093
0.99ThrMet: 0.99 ± 0.045
2.813ThrAsn: 2.813 ± 0.081
2.096ThrPro: 2.096 ± 0.064
1.574ThrGln: 1.574 ± 0.054
1.46ThrArg: 1.46 ± 0.056
3.249ThrSer: 3.249 ± 0.088
2.624ThrThr: 2.624 ± 0.094
2.364ThrVal: 2.364 ± 0.077
0.268ThrTrp: 0.268 ± 0.024
1.701ThrTyr: 1.701 ± 0.055
0.0ThrXaa: 0.0 ± 0.0
Val
5.173ValAla: 5.173 ± 0.106
1.007ValCys: 1.007 ± 0.042
3.365ValAsp: 3.365 ± 0.08
3.554ValGlu: 3.554 ± 0.106
3.241ValPhe: 3.241 ± 0.086
4.355ValGly: 4.355 ± 0.082
0.81ValHis: 0.81 ± 0.041
4.817ValIle: 4.817 ± 0.118
4.819ValLys: 4.819 ± 0.095
6.288ValLeu: 6.288 ± 0.135
1.585ValMet: 1.585 ± 0.049
3.017ValAsn: 3.017 ± 0.076
1.817ValPro: 1.817 ± 0.061
1.383ValGln: 1.383 ± 0.051
1.916ValArg: 1.916 ± 0.066
4.362ValSer: 4.362 ± 0.092
2.493ValThr: 2.493 ± 0.075
4.705ValVal: 4.705 ± 0.108
0.459ValTrp: 0.459 ± 0.027
2.04ValTyr: 2.04 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
0.582TrpAla: 0.582 ± 0.032
0.114TrpCys: 0.114 ± 0.012
0.44TrpAsp: 0.44 ± 0.029
0.328TrpGlu: 0.328 ± 0.025
0.357TrpPhe: 0.357 ± 0.025
0.548TrpGly: 0.548 ± 0.034
0.142TrpHis: 0.142 ± 0.018
0.608TrpIle: 0.608 ± 0.034
0.339TrpLys: 0.339 ± 0.025
0.827TrpLeu: 0.827 ± 0.04
0.236TrpMet: 0.236 ± 0.021
0.324TrpAsn: 0.324 ± 0.026
0.112TrpPro: 0.112 ± 0.015
0.329TrpGln: 0.329 ± 0.026
0.249TrpArg: 0.249 ± 0.022
0.43TrpSer: 0.43 ± 0.037
0.24TrpThr: 0.24 ± 0.024
0.462TrpVal: 0.462 ± 0.032
0.103TrpTrp: 0.103 ± 0.015
0.273TrpTyr: 0.273 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.665TyrAla: 2.665 ± 0.068
0.427TyrCys: 0.427 ± 0.034
2.409TyrAsp: 2.409 ± 0.059
3.077TyrGlu: 3.077 ± 0.08
2.167TyrPhe: 2.167 ± 0.07
2.397TyrGly: 2.397 ± 0.065
0.571TyrHis: 0.571 ± 0.032
2.693TyrIle: 2.693 ± 0.065
3.384TyrLys: 3.384 ± 0.08
3.363TyrLeu: 3.363 ± 0.076
0.87TyrMet: 0.87 ± 0.047
1.813TyrAsn: 1.813 ± 0.062
1.209TyrPro: 1.209 ± 0.043
1.05TyrGln: 1.05 ± 0.045
1.119TyrArg: 1.119 ± 0.045
2.41TyrSer: 2.41 ± 0.08
1.664TyrThr: 1.664 ± 0.068
1.666TyrVal: 1.666 ± 0.059
0.23TyrTrp: 0.23 ± 0.022
1.426TyrTyr: 1.426 ± 0.053
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1757 proteins (534331 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski