Amino acid dipepetide frequency for Couchioplanes caeruleus subsp. caeruleus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.597AlaAla: 23.597 ± 0.174	1.072AlaCys: 1.072 ± 0.026	8.673AlaAsp: 8.673 ± 0.078	8.505AlaGlu: 8.505 ± 0.073	3.479AlaPhe: 3.479 ± 0.041	14.427AlaGly: 14.427 ± 0.104	2.662AlaHis: 2.662 ± 0.036	4.216AlaIle: 4.216 ± 0.041	2.566AlaLys: 2.566 ± 0.048	14.268AlaLeu: 14.268 ± 0.114	2.757AlaMet: 2.757 ± 0.035	2.103AlaAsn: 2.103 ± 0.031	6.878AlaPro: 6.878 ± 0.082	3.89AlaGln: 3.89 ± 0.05	10.347AlaArg: 10.347 ± 0.085	6.003AlaSer: 6.003 ± 0.058	7.957AlaThr: 7.957 ± 0.076	12.967AlaVal: 12.967 ± 0.112	2.024AlaTrp: 2.024 ± 0.034	2.853AlaTyr: 2.853 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.051CysAla: 1.051 ± 0.025	0.084CysCys: 0.084 ± 0.007	0.496CysAsp: 0.496 ± 0.015	0.338CysGlu: 0.338 ± 0.013	0.197CysPhe: 0.197 ± 0.011	0.912CysGly: 0.912 ± 0.021	0.201CysHis: 0.201 ± 0.009	0.182CysIle: 0.182 ± 0.01	0.118CysLys: 0.118 ± 0.007	0.746CysLeu: 0.746 ± 0.02	0.129CysMet: 0.129 ± 0.008	0.136CysAsn: 0.136 ± 0.009	0.513CysPro: 0.513 ± 0.016	0.192CysGln: 0.192 ± 0.01	0.662CysArg: 0.662 ± 0.02	0.424CysSer: 0.424 ± 0.015	0.478CysThr: 0.478 ± 0.015	0.601CysVal: 0.601 ± 0.018	0.126CysTrp: 0.126 ± 0.009	0.175CysTyr: 0.175 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.832AspAla: 7.832 ± 0.072	0.399AspCys: 0.399 ± 0.014	4.049AspAsp: 4.049 ± 0.047	3.86AspGlu: 3.86 ± 0.054	1.555AspPhe: 1.555 ± 0.03	6.324AspGly: 6.324 ± 0.059	1.321AspHis: 1.321 ± 0.026	1.874AspIle: 1.874 ± 0.031	1.112AspLys: 1.112 ± 0.029	6.737AspLeu: 6.737 ± 0.063	0.817AspMet: 0.817 ± 0.019	0.998AspAsn: 0.998 ± 0.024	4.608AspPro: 4.608 ± 0.048	1.608AspGln: 1.608 ± 0.031	5.183AspArg: 5.183 ± 0.053	2.357AspSer: 2.357 ± 0.038	2.949AspThr: 2.949 ± 0.043	5.089AspVal: 5.089 ± 0.05	0.973AspTrp: 0.973 ± 0.025	1.124AspTyr: 1.124 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	6.841GluAla: 6.841 ± 0.067	0.342GluCys: 0.342 ± 0.012	2.337GluAsp: 2.337 ± 0.038	2.613GluGlu: 2.613 ± 0.044	1.458GluPhe: 1.458 ± 0.026	3.38GluGly: 3.38 ± 0.037	1.401GluHis: 1.401 ± 0.027	2.41GluIle: 2.41 ± 0.033	1.191GluLys: 1.191 ± 0.03	6.393GluLeu: 6.393 ± 0.065	0.951GluMet: 0.951 ± 0.025	0.907GluAsn: 0.907 ± 0.02	3.246GluPro: 3.246 ± 0.047	2.186GluGln: 2.186 ± 0.035	5.005GluArg: 5.005 ± 0.064	2.247GluSer: 2.247 ± 0.037	2.697GluThr: 2.697 ± 0.034	4.482GluVal: 4.482 ± 0.053	0.715GluTrp: 0.715 ± 0.018	1.051GluTyr: 1.051 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	3.929PheAla: 3.929 ± 0.046	0.281PheCys: 0.281 ± 0.012	2.005PheAsp: 2.005 ± 0.032	1.29PheGlu: 1.29 ± 0.025	0.814PhePhe: 0.814 ± 0.022	2.927PheGly: 2.927 ± 0.036	0.604PheHis: 0.604 ± 0.016	0.743PheIle: 0.743 ± 0.019	0.441PheLys: 0.441 ± 0.016	2.558PheLeu: 2.558 ± 0.037	0.354PheMet: 0.354 ± 0.013	0.518PheAsn: 0.518 ± 0.016	1.326PhePro: 1.326 ± 0.028	0.656PheGln: 0.656 ± 0.019	1.87PheArg: 1.87 ± 0.028	1.445PheSer: 1.445 ± 0.026	1.917PheThr: 1.917 ± 0.035	2.392PheVal: 2.392 ± 0.036	0.43PheTrp: 0.43 ± 0.014	0.579PheTyr: 0.579 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	11.038GlyAla: 11.038 ± 0.1	0.807GlyCys: 0.807 ± 0.022	5.533GlyAsp: 5.533 ± 0.053	4.652GlyGlu: 4.652 ± 0.053	2.886GlyPhe: 2.886 ± 0.04	8.441GlyGly: 8.441 ± 0.09	2.23GlyHis: 2.23 ± 0.031	3.469GlyIle: 3.469 ± 0.042	2.158GlyLys: 2.158 ± 0.04	9.264GlyLeu: 9.264 ± 0.064	1.988GlyMet: 1.988 ± 0.031	1.785GlyAsn: 1.785 ± 0.036	4.9GlyPro: 4.9 ± 0.059	2.525GlyGln: 2.525 ± 0.038	7.762GlyArg: 7.762 ± 0.065	4.722GlySer: 4.722 ± 0.053	6.002GlyThr: 6.002 ± 0.074	7.859GlyVal: 7.859 ± 0.084	1.821GlyTrp: 1.821 ± 0.034	2.333GlyTyr: 2.333 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.719HisAla: 2.719 ± 0.041	0.189HisCys: 0.189 ± 0.009	1.391HisAsp: 1.391 ± 0.026	1.126HisGlu: 1.126 ± 0.027	0.578HisPhe: 0.578 ± 0.017	2.226HisGly: 2.226 ± 0.037	0.696HisHis: 0.696 ± 0.02	0.603HisIle: 0.603 ± 0.018	0.307HisLys: 0.307 ± 0.013	2.501HisLeu: 2.501 ± 0.035	0.32HisMet: 0.32 ± 0.012	0.371HisAsn: 0.371 ± 0.013	1.677HisPro: 1.677 ± 0.031	0.659HisGln: 0.659 ± 0.019	2.156HisArg: 2.156 ± 0.033	0.94HisSer: 0.94 ± 0.021	1.178HisThr: 1.178 ± 0.025	1.803HisVal: 1.803 ± 0.031	0.339HisTrp: 0.339 ± 0.013	0.452HisTyr: 0.452 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	5.372IleAla: 5.372 ± 0.054	0.306IleCys: 0.306 ± 0.012	2.56IleAsp: 2.56 ± 0.032	2.057IleGlu: 2.057 ± 0.037	0.889IlePhe: 0.889 ± 0.021	3.68IleGly: 3.68 ± 0.05	0.63IleHis: 0.63 ± 0.018	1.035IleIle: 1.035 ± 0.024	0.746IleLys: 0.746 ± 0.019	2.716IleLeu: 2.716 ± 0.04	0.492IleMet: 0.492 ± 0.018	0.767IleAsn: 0.767 ± 0.022	1.727IlePro: 1.727 ± 0.03	0.725IleGln: 0.725 ± 0.019	2.547IleArg: 2.547 ± 0.038	1.811IleSer: 1.811 ± 0.028	2.321IleThr: 2.321 ± 0.033	3.218IleVal: 3.218 ± 0.045	0.424IleTrp: 0.424 ± 0.014	0.566IleTyr: 0.566 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	2.481LysAla: 2.481 ± 0.047	0.113LysCys: 0.113 ± 0.008	1.015LysAsp: 1.015 ± 0.025	0.876LysGlu: 0.876 ± 0.025	0.454LysPhe: 0.454 ± 0.015	1.41LysGly: 1.41 ± 0.03	0.381LysHis: 0.381 ± 0.013	0.883LysIle: 0.883 ± 0.024	0.578LysLys: 0.578 ± 0.025	1.995LysLeu: 1.995 ± 0.038	0.355LysMet: 0.355 ± 0.012	0.421LysAsn: 0.421 ± 0.016	1.255LysPro: 1.255 ± 0.025	0.607LysGln: 0.607 ± 0.022	1.402LysArg: 1.402 ± 0.028	0.973LysSer: 0.973 ± 0.024	1.161LysThr: 1.161 ± 0.027	1.737LysVal: 1.737 ± 0.034	0.262LysTrp: 0.262 ± 0.011	0.387LysTyr: 0.387 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	15.807LeuAla: 15.807 ± 0.108	0.833LeuCys: 0.833 ± 0.022	6.681LeuAsp: 6.681 ± 0.058	4.277LeuGlu: 4.277 ± 0.053	2.604LeuPhe: 2.604 ± 0.04	9.21LeuGly: 9.21 ± 0.072	2.412LeuHis: 2.412 ± 0.038	3.677LeuIle: 3.677 ± 0.049	1.626LeuLys: 1.626 ± 0.035	11.145LeuLeu: 11.145 ± 0.108	1.633LeuMet: 1.633 ± 0.027	1.667LeuAsn: 1.667 ± 0.028	6.326LeuPro: 6.326 ± 0.062	2.265LeuGln: 2.265 ± 0.035	9.071LeuArg: 9.071 ± 0.074	5.407LeuSer: 5.407 ± 0.054	6.89LeuThr: 6.89 ± 0.065	9.155LeuVal: 9.155 ± 0.067	1.276LeuTrp: 1.276 ± 0.03	1.752LeuTyr: 1.752 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.324MetAla: 2.324 ± 0.032	0.122MetCys: 0.122 ± 0.007	0.869MetAsp: 0.869 ± 0.02	0.645MetGlu: 0.645 ± 0.017	0.519MetPhe: 0.519 ± 0.014	1.195MetGly: 1.195 ± 0.026	0.365MetHis: 0.365 ± 0.012	0.773MetIle: 0.773 ± 0.019	0.372MetLys: 0.372 ± 0.014	1.938MetLeu: 1.938 ± 0.031	0.343MetMet: 0.343 ± 0.016	0.382MetAsn: 0.382 ± 0.014	1.201MetPro: 1.201 ± 0.025	0.487MetGln: 0.487 ± 0.015	1.516MetArg: 1.516 ± 0.025	1.263MetSer: 1.263 ± 0.023	1.65MetThr: 1.65 ± 0.031	1.458MetVal: 1.458 ± 0.026	0.208MetTrp: 0.208 ± 0.011	0.301MetTyr: 0.301 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.252AsnAla: 2.252 ± 0.034	0.16AsnCys: 0.16 ± 0.008	1.023AsnAsp: 1.023 ± 0.023	0.782AsnGlu: 0.782 ± 0.019	0.47AsnPhe: 0.47 ± 0.015	1.879AsnGly: 1.879 ± 0.038	0.367AsnHis: 0.367 ± 0.013	0.611AsnIle: 0.611 ± 0.017	0.341AsnLys: 0.341 ± 0.014	1.825AsnLeu: 1.825 ± 0.032	0.287AsnMet: 0.287 ± 0.013	0.45AsnAsn: 0.45 ± 0.015	1.413AsnPro: 1.413 ± 0.03	0.504AsnGln: 0.504 ± 0.017	1.411AsnArg: 1.411 ± 0.025	0.84AsnSer: 0.84 ± 0.021	1.027AsnThr: 1.027 ± 0.025	1.416AsnVal: 1.416 ± 0.028	0.313AsnTrp: 0.313 ± 0.013	0.388AsnTyr: 0.388 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	9.355ProAla: 9.355 ± 0.091	0.31ProCys: 0.31 ± 0.012	4.391ProAsp: 4.391 ± 0.045	3.736ProGlu: 3.736 ± 0.049	1.451ProPhe: 1.451 ± 0.025	6.331ProGly: 6.331 ± 0.065	1.268ProHis: 1.268 ± 0.022	1.66ProIle: 1.66 ± 0.031	0.972ProLys: 0.972 ± 0.022	5.089ProLeu: 5.089 ± 0.056	1.021ProMet: 1.021 ± 0.02	0.913ProAsn: 0.913 ± 0.021	3.872ProPro: 3.872 ± 0.057	1.625ProGln: 1.625 ± 0.032	3.973ProArg: 3.973 ± 0.047	3.075ProSer: 3.075 ± 0.049	3.291ProThr: 3.291 ± 0.044	5.445ProVal: 5.445 ± 0.056	0.91ProTrp: 0.91 ± 0.02	1.233ProTyr: 1.233 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.971GlnAla: 3.971 ± 0.06	0.172GlnCys: 0.172 ± 0.009	1.224GlnAsp: 1.224 ± 0.025	1.251GlnGlu: 1.251 ± 0.024	0.771GlnPhe: 0.771 ± 0.022	1.925GlnGly: 1.925 ± 0.037	0.667GlnHis: 0.667 ± 0.018	1.148GlnIle: 1.148 ± 0.024	0.529GlnLys: 0.529 ± 0.02	3.007GlnLeu: 3.007 ± 0.044	0.54GlnMet: 0.54 ± 0.017	0.512GlnAsn: 0.512 ± 0.018	1.718GlnPro: 1.718 ± 0.035	1.229GlnGln: 1.229 ± 0.03	2.689GlnArg: 2.689 ± 0.038	1.239GlnSer: 1.239 ± 0.027	1.414GlnThr: 1.414 ± 0.027	2.61GlnVal: 2.61 ± 0.034	0.474GlnTrp: 0.474 ± 0.015	0.564GlnTyr: 0.564 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	9.993ArgAla: 9.993 ± 0.078	0.645ArgCys: 0.645 ± 0.017	4.679ArgAsp: 4.679 ± 0.049	4.352ArgGlu: 4.352 ± 0.052	2.384ArgPhe: 2.384 ± 0.036	5.78ArgGly: 5.78 ± 0.048	2.231ArgHis: 2.231 ± 0.038	3.33ArgIle: 3.33 ± 0.037	1.51ArgLys: 1.51 ± 0.032	9.3ArgLeu: 9.3 ± 0.086	1.91ArgMet: 1.91 ± 0.031	1.467ArgAsn: 1.467 ± 0.027	5.067ArgPro: 5.067 ± 0.063	2.575ArgGln: 2.575 ± 0.036	8.425ArgArg: 8.425 ± 0.082	4.084ArgSer: 4.084 ± 0.044	5.056ArgThr: 5.056 ± 0.054	6.097ArgVal: 6.097 ± 0.056	1.58ArgTrp: 1.58 ± 0.032	1.971ArgTyr: 1.971 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	6.799SerAla: 6.799 ± 0.067	0.383SerCys: 0.383 ± 0.013	2.587SerAsp: 2.587 ± 0.036	2.135SerGlu: 2.135 ± 0.037	1.45SerPhe: 1.45 ± 0.026	5.558SerGly: 5.558 ± 0.059	0.953SerHis: 0.953 ± 0.02	1.674SerIle: 1.674 ± 0.033	0.821SerLys: 0.821 ± 0.022	4.702SerLeu: 4.702 ± 0.044	1.051SerMet: 1.051 ± 0.019	0.85SerAsn: 0.85 ± 0.02	3.08SerPro: 3.08 ± 0.042	1.215SerGln: 1.215 ± 0.026	3.815SerArg: 3.815 ± 0.041	2.736SerSer: 2.736 ± 0.044	2.973SerThr: 2.973 ± 0.04	4.143SerVal: 4.143 ± 0.043	0.894SerTrp: 0.894 ± 0.019	1.112SerTyr: 1.112 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	8.923ThrAla: 8.923 ± 0.08	0.464ThrCys: 0.464 ± 0.016	3.649ThrAsp: 3.649 ± 0.042	2.907ThrGlu: 2.907 ± 0.036	1.722ThrPhe: 1.722 ± 0.026	6.604ThrGly: 6.604 ± 0.07	1.094ThrHis: 1.094 ± 0.026	2.126ThrIle: 2.126 ± 0.034	1.093ThrLys: 1.093 ± 0.028	5.676ThrLeu: 5.676 ± 0.057	1.086ThrMet: 1.086 ± 0.022	1.032ThrAsn: 1.032 ± 0.025	3.88ThrPro: 3.88 ± 0.052	1.304ThrGln: 1.304 ± 0.022	4.041ThrArg: 4.041 ± 0.045	3.036ThrSer: 3.036 ± 0.04	3.918ThrThr: 3.918 ± 0.057	6.254ThrVal: 6.254 ± 0.061	0.92ThrTrp: 0.92 ± 0.022	1.309ThrTyr: 1.309 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	12.398ValAla: 12.398 ± 0.091	0.763ValCys: 0.763 ± 0.018	5.47ValAsp: 5.47 ± 0.051	4.679ValGlu: 4.679 ± 0.058	2.271ValPhe: 2.271 ± 0.033	6.85ValGly: 6.85 ± 0.066	1.906ValHis: 1.906 ± 0.029	3.126ValIle: 3.126 ± 0.046	1.607ValLys: 1.607 ± 0.035	9.686ValLeu: 9.686 ± 0.078	1.381ValMet: 1.381 ± 0.03	1.728ValAsn: 1.728 ± 0.03	5.218ValPro: 5.218 ± 0.051	2.143ValGln: 2.143 ± 0.033	7.171ValArg: 7.171 ± 0.058	4.438ValSer: 4.438 ± 0.054	6.01ValThr: 6.01 ± 0.059	8.752ValVal: 8.752 ± 0.084	1.131ValTrp: 1.131 ± 0.026	1.484ValTyr: 1.484 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.697TrpAla: 1.697 ± 0.031	0.146TrpCys: 0.146 ± 0.008	0.76TrpAsp: 0.76 ± 0.022	0.668TrpGlu: 0.668 ± 0.017	0.502TrpPhe: 0.502 ± 0.016	0.994TrpGly: 0.994 ± 0.02	0.428TrpHis: 0.428 ± 0.015	0.609TrpIle: 0.609 ± 0.018	0.332TrpLys: 0.332 ± 0.012	1.903TrpLeu: 1.903 ± 0.032	0.305TrpMet: 0.305 ± 0.012	0.384TrpAsn: 0.384 ± 0.015	0.873TrpPro: 0.873 ± 0.022	0.632TrpGln: 0.632 ± 0.019	1.481TrpArg: 1.481 ± 0.027	0.994TrpSer: 0.994 ± 0.025	1.045TrpThr: 1.045 ± 0.024	1.056TrpVal: 1.056 ± 0.023	0.388TrpTrp: 0.388 ± 0.014	0.353TrpTyr: 0.353 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.865TyrAla: 2.865 ± 0.036	0.168TyrCys: 0.168 ± 0.009	1.379TyrAsp: 1.379 ± 0.035	1.102TyrGlu: 1.102 ± 0.023	0.625TyrPhe: 0.625 ± 0.018	2.122TyrGly: 2.122 ± 0.036	0.412TyrHis: 0.412 ± 0.014	0.439TyrIle: 0.439 ± 0.014	0.326TyrLys: 0.326 ± 0.013	2.263TyrLeu: 2.263 ± 0.036	0.213TyrMet: 0.213 ± 0.011	0.367TyrAsn: 0.367 ± 0.015	1.143TyrPro: 1.143 ± 0.025	0.629TyrGln: 0.629 ± 0.019	1.909TyrArg: 1.909 ± 0.031	0.897TyrSer: 0.897 ± 0.023	1.105TyrThr: 1.105 ± 0.024	1.678TyrVal: 1.678 ± 0.03	0.342TyrTrp: 0.342 ± 0.013	0.43TyrTyr: 0.43 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6851 proteins (2182960 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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