Amino acid dipepetide frequency for Paraburkholderia fungorum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.84AlaAla: 16.84 ± 0.149
1.245AlaCys: 1.245 ± 0.026
6.64AlaAsp: 6.64 ± 0.065
5.816AlaGlu: 5.816 ± 0.063
4.303AlaPhe: 4.303 ± 0.046
10.036AlaGly: 10.036 ± 0.081
2.704AlaHis: 2.704 ± 0.038
5.776AlaIle: 5.776 ± 0.052
3.711AlaLys: 3.711 ± 0.056
13.692AlaLeu: 13.692 ± 0.094
3.152AlaMet: 3.152 ± 0.043
3.513AlaAsn: 3.513 ± 0.052
5.628AlaPro: 5.628 ± 0.064
5.364AlaGln: 5.364 ± 0.056
8.147AlaArg: 8.147 ± 0.073
7.947AlaSer: 7.947 ± 0.083
6.697AlaThr: 6.697 ± 0.072
8.661AlaVal: 8.661 ± 0.069
1.603AlaTrp: 1.603 ± 0.025
2.679AlaTyr: 2.679 ± 0.033
0.0AlaXaa: 0.0 ± 0.0
Cys
1.165CysAla: 1.165 ± 0.023
0.113CysCys: 0.113 ± 0.008
0.519CysAsp: 0.519 ± 0.016
0.479CysGlu: 0.479 ± 0.015
0.322CysPhe: 0.322 ± 0.012
0.961CysGly: 0.961 ± 0.022
0.258CysHis: 0.258 ± 0.012
0.41CysIle: 0.41 ± 0.014
0.239CysLys: 0.239 ± 0.01
0.771CysLeu: 0.771 ± 0.018
0.217CysMet: 0.217 ± 0.009
0.253CysAsn: 0.253 ± 0.012
0.4CysPro: 0.4 ± 0.015
0.208CysGln: 0.208 ± 0.009
0.578CysArg: 0.578 ± 0.016
0.523CysSer: 0.523 ± 0.017
0.47CysThr: 0.47 ± 0.014
0.813CysVal: 0.813 ± 0.018
0.123CysTrp: 0.123 ± 0.008
0.211CysTyr: 0.211 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
7.407AspAla: 7.407 ± 0.072
0.47AspCys: 0.47 ± 0.013
3.202AspAsp: 3.202 ± 0.043
3.28AspGlu: 3.28 ± 0.046
1.989AspPhe: 1.989 ± 0.029
4.537AspGly: 4.537 ± 0.045
1.18AspHis: 1.18 ± 0.025
2.599AspIle: 2.599 ± 0.035
1.587AspLys: 1.587 ± 0.033
5.106AspLeu: 5.106 ± 0.051
1.171AspMet: 1.171 ± 0.021
1.492AspAsn: 1.492 ± 0.03
2.879AspPro: 2.879 ± 0.036
1.753AspGln: 1.753 ± 0.03
3.226AspArg: 3.226 ± 0.04
2.826AspSer: 2.826 ± 0.037
2.996AspThr: 2.996 ± 0.038
4.29AspVal: 4.29 ± 0.049
0.912AspTrp: 0.912 ± 0.021
1.54AspTyr: 1.54 ± 0.027
0.0AspXaa: 0.0 ± 0.0
Glu
6.0GluAla: 6.0 ± 0.063
0.381GluCys: 0.381 ± 0.014
2.001GluAsp: 2.001 ± 0.032
2.295GluGlu: 2.295 ± 0.04
1.773GluPhe: 1.773 ± 0.033
3.238GluGly: 3.238 ± 0.042
1.356GluHis: 1.356 ± 0.026
2.677GluIle: 2.677 ± 0.039
1.827GluLys: 1.827 ± 0.033
5.31GluLeu: 5.31 ± 0.062
1.178GluMet: 1.178 ± 0.021
1.476GluAsn: 1.476 ± 0.027
2.452GluPro: 2.452 ± 0.035
2.358GluGln: 2.358 ± 0.036
4.475GluArg: 4.475 ± 0.052
2.762GluSer: 2.762 ± 0.037
2.803GluThr: 2.803 ± 0.04
3.414GluVal: 3.414 ± 0.049
0.711GluTrp: 0.711 ± 0.019
1.101GluTyr: 1.101 ± 0.024
0.0GluXaa: 0.0 ± 0.0
Phe
4.741PheAla: 4.741 ± 0.046
0.446PheCys: 0.446 ± 0.015
2.806PheAsp: 2.806 ± 0.042
2.003PheGlu: 2.003 ± 0.031
1.499PhePhe: 1.499 ± 0.03
3.794PheGly: 3.794 ± 0.047
0.765PheHis: 0.765 ± 0.018
1.712PheIle: 1.712 ± 0.028
1.039PheLys: 1.039 ± 0.024
2.969PheLeu: 2.969 ± 0.038
0.809PheMet: 0.809 ± 0.019
1.249PheAsn: 1.249 ± 0.023
1.597PhePro: 1.597 ± 0.022
1.057PheGln: 1.057 ± 0.019
2.004PheArg: 2.004 ± 0.032
2.469PheSer: 2.469 ± 0.037
2.029PheThr: 2.029 ± 0.029
3.141PheVal: 3.141 ± 0.038
0.527PheTrp: 0.527 ± 0.015
0.994PheTyr: 0.994 ± 0.021
0.0PheXaa: 0.0 ± 0.0
Gly
9.161GlyAla: 9.161 ± 0.092
0.837GlyCys: 0.837 ± 0.02
3.929GlyAsp: 3.929 ± 0.043
4.104GlyGlu: 4.104 ± 0.04
3.463GlyPhe: 3.463 ± 0.046
6.793GlyGly: 6.793 ± 0.088
1.9GlyHis: 1.9 ± 0.03
4.308GlyIle: 4.308 ± 0.047
3.21GlyLys: 3.21 ± 0.043
7.924GlyLeu: 7.924 ± 0.075
2.203GlyMet: 2.203 ± 0.029
2.529GlyAsn: 2.529 ± 0.045
2.855GlyPro: 2.855 ± 0.039
2.738GlyGln: 2.738 ± 0.036
4.886GlyArg: 4.886 ± 0.054
5.036GlySer: 5.036 ± 0.058
4.756GlyThr: 4.756 ± 0.084
6.781GlyVal: 6.781 ± 0.06
1.356GlyTrp: 1.356 ± 0.027
2.419GlyTyr: 2.419 ± 0.033
0.0GlyXaa: 0.0 ± 0.0
His
3.019HisAla: 3.019 ± 0.035
0.252HisCys: 0.252 ± 0.01
1.362HisAsp: 1.362 ± 0.027
1.169HisGlu: 1.169 ± 0.023
0.947HisPhe: 0.947 ± 0.021
2.065HisGly: 2.065 ± 0.032
0.652HisHis: 0.652 ± 0.017
0.951HisIle: 0.951 ± 0.022
0.538HisLys: 0.538 ± 0.015
2.151HisLeu: 2.151 ± 0.034
0.499HisMet: 0.499 ± 0.015
0.58HisAsn: 0.58 ± 0.015
1.389HisPro: 1.389 ± 0.023
0.676HisGln: 0.676 ± 0.016
1.48HisArg: 1.48 ± 0.026
1.159HisSer: 1.159 ± 0.02
1.111HisThr: 1.111 ± 0.021
1.725HisVal: 1.725 ± 0.025
0.404HisTrp: 0.404 ± 0.012
0.656HisTyr: 0.656 ± 0.016
0.0HisXaa: 0.0 ± 0.0
Ile
7.017IleAla: 7.017 ± 0.062
0.476IleCys: 0.476 ± 0.014
3.575IleAsp: 3.575 ± 0.038
3.211IleGlu: 3.211 ± 0.04
1.576IlePhe: 1.576 ± 0.033
4.921IleGly: 4.921 ± 0.052
0.93IleHis: 0.93 ± 0.022
1.724IleIle: 1.724 ± 0.029
1.418IleLys: 1.418 ± 0.028
3.452IleLeu: 3.452 ± 0.042
0.758IleMet: 0.758 ± 0.021
1.487IleAsn: 1.487 ± 0.023
2.161IlePro: 2.161 ± 0.032
1.28IleGln: 1.28 ± 0.025
2.786IleArg: 2.786 ± 0.036
2.763IleSer: 2.763 ± 0.038
2.548IleThr: 2.548 ± 0.039
4.464IleVal: 4.464 ± 0.052
0.541IleTrp: 0.541 ± 0.016
1.093IleTyr: 1.093 ± 0.022
0.0IleXaa: 0.0 ± 0.0
Lys
3.602LysAla: 3.602 ± 0.056
0.168LysCys: 0.168 ± 0.009
1.491LysAsp: 1.491 ± 0.027
1.433LysGlu: 1.433 ± 0.03
0.947LysPhe: 0.947 ± 0.023
2.111LysGly: 2.111 ± 0.033
0.695LysHis: 0.695 ± 0.019
1.607LysIle: 1.607 ± 0.029
1.281LysLys: 1.281 ± 0.034
3.422LysLeu: 3.422 ± 0.042
0.823LysMet: 0.823 ± 0.021
0.973LysAsn: 0.973 ± 0.024
2.014LysPro: 2.014 ± 0.034
1.324LysGln: 1.324 ± 0.024
2.336LysArg: 2.336 ± 0.032
1.843LysSer: 1.843 ± 0.03
1.922LysThr: 1.922 ± 0.033
2.377LysVal: 2.377 ± 0.038
0.393LysTrp: 0.393 ± 0.015
0.708LysTyr: 0.708 ± 0.019
0.0LysXaa: 0.0 ± 0.0
Leu
13.369LeuAla: 13.369 ± 0.097
0.974LeuCys: 0.974 ± 0.021
5.91LeuAsp: 5.91 ± 0.054
4.755LeuGlu: 4.755 ± 0.051
3.757LeuPhe: 3.757 ± 0.048
8.008LeuGly: 8.008 ± 0.067
2.232LeuHis: 2.232 ± 0.032
4.932LeuIle: 4.932 ± 0.052
3.434LeuLys: 3.434 ± 0.045
10.024LeuLeu: 10.024 ± 0.092
2.28LeuMet: 2.28 ± 0.034
2.97LeuAsn: 2.97 ± 0.037
5.592LeuPro: 5.592 ± 0.054
3.403LeuGln: 3.403 ± 0.042
6.75LeuArg: 6.75 ± 0.056
6.722LeuSer: 6.722 ± 0.072
5.802LeuThr: 5.802 ± 0.062
7.284LeuVal: 7.284 ± 0.065
1.124LeuTrp: 1.124 ± 0.028
2.178LeuTyr: 2.178 ± 0.029
0.0LeuXaa: 0.0 ± 0.0
Met
2.447MetAla: 2.447 ± 0.037
0.181MetCys: 0.181 ± 0.008
0.925MetAsp: 0.925 ± 0.018
0.87MetGlu: 0.87 ± 0.022
0.791MetPhe: 0.791 ± 0.017
1.52MetGly: 1.52 ± 0.027
0.544MetHis: 0.544 ± 0.014
1.14MetIle: 1.14 ± 0.025
1.06MetLys: 1.06 ± 0.02
2.668MetLeu: 2.668 ± 0.04
0.582MetMet: 0.582 ± 0.016
0.948MetAsn: 0.948 ± 0.022
1.469MetPro: 1.469 ± 0.025
1.031MetGln: 1.031 ± 0.023
1.733MetArg: 1.733 ± 0.025
1.861MetSer: 1.861 ± 0.026
1.676MetThr: 1.676 ± 0.024
1.51MetVal: 1.51 ± 0.027
0.22MetTrp: 0.22 ± 0.01
0.417MetTyr: 0.417 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
3.825AsnAla: 3.825 ± 0.041
0.267AsnCys: 0.267 ± 0.01
1.572AsnAsp: 1.572 ± 0.027
1.382AsnGlu: 1.382 ± 0.025
1.124AsnPhe: 1.124 ± 0.023
2.837AsnGly: 2.837 ± 0.048
0.594AsnHis: 0.594 ± 0.018
1.323AsnIle: 1.323 ± 0.024
0.726AsnLys: 0.726 ± 0.018
2.909AsnLeu: 2.909 ± 0.04
0.578AsnMet: 0.578 ± 0.017
0.959AsnAsn: 0.959 ± 0.031
1.909AsnPro: 1.909 ± 0.028
0.994AsnGln: 0.994 ± 0.025
1.897AsnArg: 1.897 ± 0.031
1.66AsnSer: 1.66 ± 0.032
1.657AsnThr: 1.657 ± 0.034
2.436AsnVal: 2.436 ± 0.038
0.46AsnTrp: 0.46 ± 0.015
0.805AsnTyr: 0.805 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
6.301ProAla: 6.301 ± 0.072
0.327ProCys: 0.327 ± 0.012
3.209ProAsp: 3.209 ± 0.043
2.83ProGlu: 2.83 ± 0.043
1.997ProPhe: 1.997 ± 0.032
4.049ProGly: 4.049 ± 0.048
1.227ProHis: 1.227 ± 0.026
2.045ProIle: 2.045 ± 0.031
1.434ProLys: 1.434 ± 0.029
5.128ProLeu: 5.128 ± 0.052
1.128ProMet: 1.128 ± 0.025
1.49ProAsn: 1.49 ± 0.026
2.297ProPro: 2.297 ± 0.038
1.977ProGln: 1.977 ± 0.031
2.751ProArg: 2.751 ± 0.036
3.003ProSer: 3.003 ± 0.04
2.69ProThr: 2.69 ± 0.037
4.367ProVal: 4.367 ± 0.051
0.629ProTrp: 0.629 ± 0.017
1.3ProTyr: 1.3 ± 0.024
0.0ProXaa: 0.0 ± 0.0
Gln
4.428GlnAla: 4.428 ± 0.051
0.279GlnCys: 0.279 ± 0.012
1.366GlnAsp: 1.366 ± 0.025
1.323GlnGlu: 1.323 ± 0.026
1.357GlnPhe: 1.357 ± 0.023
2.426GlnGly: 2.426 ± 0.03
0.931GlnHis: 0.931 ± 0.023
2.123GlnIle: 2.123 ± 0.027
1.178GlnLys: 1.178 ± 0.024
3.87GlnLeu: 3.87 ± 0.043
1.058GlnMet: 1.058 ± 0.021
1.022GlnAsn: 1.022 ± 0.022
2.125GlnPro: 2.125 ± 0.032
2.054GlnGln: 2.054 ± 0.045
2.965GlnArg: 2.965 ± 0.04
2.297GlnSer: 2.297 ± 0.031
2.18GlnThr: 2.18 ± 0.035
2.512GlnVal: 2.512 ± 0.031
0.583GlnTrp: 0.583 ± 0.014
0.97GlnTyr: 0.97 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
7.543ArgAla: 7.543 ± 0.066
0.563ArgCys: 0.563 ± 0.018
3.751ArgAsp: 3.751 ± 0.047
3.966ArgGlu: 3.966 ± 0.051
2.848ArgPhe: 2.848 ± 0.04
4.346ArgGly: 4.346 ± 0.048
1.758ArgHis: 1.758 ± 0.029
3.493ArgIle: 3.493 ± 0.039
2.102ArgLys: 2.102 ± 0.032
6.779ArgLeu: 6.779 ± 0.058
1.724ArgMet: 1.724 ± 0.024
1.965ArgAsn: 1.965 ± 0.031
2.883ArgPro: 2.883 ± 0.042
2.459ArgGln: 2.459 ± 0.038
4.88ArgArg: 4.88 ± 0.052
3.617ArgSer: 3.617 ± 0.042
3.396ArgThr: 3.396 ± 0.039
5.092ArgVal: 5.092 ± 0.047
1.013ArgTrp: 1.013 ± 0.02
1.911ArgTyr: 1.911 ± 0.03
0.0ArgXaa: 0.0 ± 0.0
Ser
7.548SerAla: 7.548 ± 0.072
0.459SerCys: 0.459 ± 0.014
3.019SerAsp: 3.019 ± 0.038
2.648SerGlu: 2.648 ± 0.035
2.368SerPhe: 2.368 ± 0.031
5.775SerGly: 5.775 ± 0.072
1.326SerHis: 1.326 ± 0.023
3.044SerIle: 3.044 ± 0.04
1.775SerLys: 1.775 ± 0.029
6.239SerLeu: 6.239 ± 0.062
1.479SerMet: 1.479 ± 0.024
1.978SerAsn: 1.978 ± 0.038
3.015SerPro: 3.015 ± 0.037
2.053SerGln: 2.053 ± 0.025
3.811SerArg: 3.811 ± 0.044
4.04SerSer: 4.04 ± 0.066
3.71SerThr: 3.71 ± 0.081
4.754SerVal: 4.754 ± 0.041
0.742SerTrp: 0.742 ± 0.018
1.45SerTyr: 1.45 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
6.28ThrAla: 6.28 ± 0.069
0.414ThrCys: 0.414 ± 0.015
2.763ThrAsp: 2.763 ± 0.035
2.283ThrGlu: 2.283 ± 0.032
2.069ThrPhe: 2.069 ± 0.028
5.038ThrGly: 5.038 ± 0.073
1.285ThrHis: 1.285 ± 0.023
2.738ThrIle: 2.738 ± 0.041
1.336ThrLys: 1.336 ± 0.024
6.792ThrLeu: 6.792 ± 0.089
1.203ThrMet: 1.203 ± 0.021
1.568ThrAsn: 1.568 ± 0.037
3.69ThrPro: 3.69 ± 0.048
2.164ThrGln: 2.164 ± 0.033
3.533ThrArg: 3.533 ± 0.043
3.429ThrSer: 3.429 ± 0.05
3.299ThrThr: 3.299 ± 0.06
4.539ThrVal: 4.539 ± 0.043
0.74ThrTrp: 0.74 ± 0.016
1.351ThrTyr: 1.351 ± 0.029
0.0ThrXaa: 0.0 ± 0.0
Val
9.52ValAla: 9.52 ± 0.076
0.785ValCys: 0.785 ± 0.017
4.356ValAsp: 4.356 ± 0.055
4.016ValGlu: 4.016 ± 0.043
2.919ValPhe: 2.919 ± 0.039
5.679ValGly: 5.679 ± 0.051
1.523ValHis: 1.523 ± 0.025
3.951ValIle: 3.951 ± 0.044
2.482ValLys: 2.482 ± 0.04
7.811ValLeu: 7.811 ± 0.079
1.914ValMet: 1.914 ± 0.03
2.308ValAsn: 2.308 ± 0.034
3.902ValPro: 3.902 ± 0.051
2.562ValGln: 2.562 ± 0.031
4.837ValArg: 4.837 ± 0.049
4.976ValSer: 4.976 ± 0.054
4.705ValThr: 4.705 ± 0.053
6.311ValVal: 6.311 ± 0.066
0.954ValTrp: 0.954 ± 0.022
1.742ValTyr: 1.742 ± 0.028
0.0ValXaa: 0.0 ± 0.0
Trp
1.101TrpAla: 1.101 ± 0.025
0.136TrpCys: 0.136 ± 0.007
0.627TrpAsp: 0.627 ± 0.018
0.505TrpGlu: 0.505 ± 0.017
0.549TrpPhe: 0.549 ± 0.019
0.858TrpGly: 0.858 ± 0.022
0.395TrpHis: 0.395 ± 0.012
0.736TrpIle: 0.736 ± 0.018
0.451TrpLys: 0.451 ± 0.014
1.928TrpLeu: 1.928 ± 0.029
0.37TrpMet: 0.37 ± 0.015
0.479TrpAsn: 0.479 ± 0.015
0.626TrpPro: 0.626 ± 0.018
0.694TrpGln: 0.694 ± 0.019
1.17TrpArg: 1.17 ± 0.023
0.843TrpSer: 0.843 ± 0.018
0.746TrpThr: 0.746 ± 0.02
0.904TrpVal: 0.904 ± 0.02
0.231TrpTrp: 0.231 ± 0.01
0.32TrpTyr: 0.32 ± 0.011
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.84TyrAla: 2.84 ± 0.039
0.258TyrCys: 0.258 ± 0.01
1.42TyrAsp: 1.42 ± 0.03
1.22TyrGlu: 1.22 ± 0.021
1.054TyrPhe: 1.054 ± 0.022
2.196TyrGly: 2.196 ± 0.032
0.531TyrHis: 0.531 ± 0.018
0.892TyrIle: 0.892 ± 0.019
0.643TyrLys: 0.643 ± 0.019
2.557TyrLeu: 2.557 ± 0.034
0.463TyrMet: 0.463 ± 0.014
0.673TyrAsn: 0.673 ± 0.021
1.296TyrPro: 1.296 ± 0.022
0.9TyrGln: 0.9 ± 0.021
1.845TyrArg: 1.845 ± 0.029
1.456TyrSer: 1.456 ± 0.027
1.322TyrThr: 1.322 ± 0.029
1.877TyrVal: 1.877 ± 0.029
0.402TyrTrp: 0.402 ± 0.013
0.678TyrTyr: 0.678 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7450 proteins (2406725 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski