Amino acid dipepetide frequency for Salmonella phage f18SE

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.957AlaAla: 11.957 ± 1.732
0.808AlaCys: 0.808 ± 0.254
6.544AlaAsp: 6.544 ± 0.862
6.705AlaGlu: 6.705 ± 0.947
3.797AlaPhe: 3.797 ± 0.477
7.352AlaGly: 7.352 ± 0.782
2.101AlaHis: 2.101 ± 0.468
3.959AlaIle: 3.959 ± 0.655
5.898AlaLys: 5.898 ± 0.957
7.998AlaLeu: 7.998 ± 0.998
2.424AlaMet: 2.424 ± 0.561
3.232AlaAsn: 3.232 ± 0.433
3.797AlaPro: 3.797 ± 0.488
3.797AlaGln: 3.797 ± 0.689
4.443AlaArg: 4.443 ± 0.548
6.625AlaSer: 6.625 ± 0.926
6.059AlaThr: 6.059 ± 0.652
7.271AlaVal: 7.271 ± 0.762
1.293AlaTrp: 1.293 ± 0.28
3.312AlaTyr: 3.312 ± 0.508
0.0AlaXaa: 0.0 ± 0.0
Cys
0.646CysAla: 0.646 ± 0.186
0.162CysCys: 0.162 ± 0.113
0.969CysAsp: 0.969 ± 0.295
0.808CysGlu: 0.808 ± 0.33
0.323CysPhe: 0.323 ± 0.167
0.566CysGly: 0.566 ± 0.198
0.162CysHis: 0.162 ± 0.109
0.162CysIle: 0.162 ± 0.087
0.889CysLys: 0.889 ± 0.268
0.727CysLeu: 0.727 ± 0.262
0.323CysMet: 0.323 ± 0.144
0.485CysAsn: 0.485 ± 0.219
0.404CysPro: 0.404 ± 0.166
0.162CysGln: 0.162 ± 0.169
0.646CysArg: 0.646 ± 0.236
0.162CysSer: 0.162 ± 0.121
0.404CysThr: 0.404 ± 0.13
0.646CysVal: 0.646 ± 0.226
0.242CysTrp: 0.242 ± 0.109
0.242CysTyr: 0.242 ± 0.147
0.0CysXaa: 0.0 ± 0.0
Asp
7.029AspAla: 7.029 ± 0.998
0.808AspCys: 0.808 ± 0.248
3.474AspAsp: 3.474 ± 0.449
4.363AspGlu: 4.363 ± 0.609
2.989AspPhe: 2.989 ± 0.531
6.463AspGly: 6.463 ± 0.868
0.727AspHis: 0.727 ± 0.254
3.635AspIle: 3.635 ± 0.411
3.312AspLys: 3.312 ± 0.383
4.605AspLeu: 4.605 ± 0.611
1.616AspMet: 1.616 ± 0.277
3.151AspAsn: 3.151 ± 0.586
2.02AspPro: 2.02 ± 0.473
0.566AspGln: 0.566 ± 0.221
2.908AspArg: 2.908 ± 0.345
3.555AspSer: 3.555 ± 0.57
4.363AspThr: 4.363 ± 0.565
3.959AspVal: 3.959 ± 0.631
0.646AspTrp: 0.646 ± 0.264
1.939AspTyr: 1.939 ± 0.381
0.0AspXaa: 0.0 ± 0.0
Glu
6.463GluAla: 6.463 ± 0.839
0.323GluCys: 0.323 ± 0.154
3.635GluAsp: 3.635 ± 0.535
5.009GluGlu: 5.009 ± 1.035
3.232GluPhe: 3.232 ± 0.736
4.928GluGly: 4.928 ± 0.829
0.969GluHis: 0.969 ± 0.257
3.635GluIle: 3.635 ± 0.501
4.201GluLys: 4.201 ± 0.688
6.382GluLeu: 6.382 ± 0.733
2.424GluMet: 2.424 ± 0.367
2.666GluAsn: 2.666 ± 0.462
2.02GluPro: 2.02 ± 0.562
3.232GluGln: 3.232 ± 0.566
4.039GluArg: 4.039 ± 0.748
3.716GluSer: 3.716 ± 0.525
3.797GluThr: 3.797 ± 0.561
4.363GluVal: 4.363 ± 0.607
0.889GluTrp: 0.889 ± 0.307
1.858GluTyr: 1.858 ± 0.468
0.0GluXaa: 0.0 ± 0.0
Phe
2.908PheAla: 2.908 ± 0.495
0.485PheCys: 0.485 ± 0.228
3.393PheAsp: 3.393 ± 0.573
2.989PheGlu: 2.989 ± 0.533
0.808PhePhe: 0.808 ± 0.208
3.151PheGly: 3.151 ± 0.454
0.808PheHis: 0.808 ± 0.255
2.504PheIle: 2.504 ± 0.423
1.858PheLys: 1.858 ± 0.462
1.939PheLeu: 1.939 ± 0.369
0.566PheMet: 0.566 ± 0.223
1.535PheAsn: 1.535 ± 0.447
1.697PhePro: 1.697 ± 0.416
1.454PheGln: 1.454 ± 0.328
2.343PheArg: 2.343 ± 0.355
2.343PheSer: 2.343 ± 0.63
3.151PheThr: 3.151 ± 0.614
2.504PheVal: 2.504 ± 0.481
0.808PheTrp: 0.808 ± 0.264
0.889PheTyr: 0.889 ± 0.272
0.0PheXaa: 0.0 ± 0.0
Gly
7.836GlyAla: 7.836 ± 0.86
0.889GlyCys: 0.889 ± 0.239
3.635GlyAsp: 3.635 ± 0.642
5.817GlyGlu: 5.817 ± 0.8
2.908GlyPhe: 2.908 ± 0.573
6.786GlyGly: 6.786 ± 0.811
1.454GlyHis: 1.454 ± 0.47
3.312GlyIle: 3.312 ± 0.458
5.655GlyLys: 5.655 ± 0.621
5.332GlyLeu: 5.332 ± 0.607
2.343GlyMet: 2.343 ± 0.634
3.393GlyAsn: 3.393 ± 0.514
1.777GlyPro: 1.777 ± 0.358
2.908GlyGln: 2.908 ± 0.486
4.524GlyArg: 4.524 ± 0.68
5.009GlySer: 5.009 ± 0.757
3.797GlyThr: 3.797 ± 0.686
5.736GlyVal: 5.736 ± 0.778
0.969GlyTrp: 0.969 ± 0.232
2.908GlyTyr: 2.908 ± 0.55
0.0GlyXaa: 0.0 ± 0.0
His
0.969HisAla: 0.969 ± 0.297
0.242HisCys: 0.242 ± 0.148
0.808HisAsp: 0.808 ± 0.222
0.969HisGlu: 0.969 ± 0.265
0.646HisPhe: 0.646 ± 0.263
0.808HisGly: 0.808 ± 0.353
0.727HisHis: 0.727 ± 0.251
1.05HisIle: 1.05 ± 0.356
0.969HisLys: 0.969 ± 0.262
1.373HisLeu: 1.373 ± 0.377
0.646HisMet: 0.646 ± 0.232
0.404HisAsn: 0.404 ± 0.175
1.131HisPro: 1.131 ± 0.329
0.808HisGln: 0.808 ± 0.207
1.05HisArg: 1.05 ± 0.284
0.969HisSer: 0.969 ± 0.32
0.566HisThr: 0.566 ± 0.287
0.808HisVal: 0.808 ± 0.246
0.081HisTrp: 0.081 ± 0.074
0.889HisTyr: 0.889 ± 0.336
0.0HisXaa: 0.0 ± 0.0
Ile
4.605IleAla: 4.605 ± 0.72
0.727IleCys: 0.727 ± 0.257
4.201IleAsp: 4.201 ± 0.615
2.828IleGlu: 2.828 ± 0.458
1.293IlePhe: 1.293 ± 0.363
3.312IleGly: 3.312 ± 0.414
0.646IleHis: 0.646 ± 0.226
2.504IleIle: 2.504 ± 0.425
3.312IleLys: 3.312 ± 0.572
2.989IleLeu: 2.989 ± 0.501
1.373IleMet: 1.373 ± 0.36
2.343IleAsn: 2.343 ± 0.476
2.343IlePro: 2.343 ± 0.405
1.858IleGln: 1.858 ± 0.494
2.666IleArg: 2.666 ± 0.422
2.828IleSer: 2.828 ± 0.608
4.686IleThr: 4.686 ± 0.696
3.474IleVal: 3.474 ± 0.49
0.566IleTrp: 0.566 ± 0.183
1.05IleTyr: 1.05 ± 0.373
0.0IleXaa: 0.0 ± 0.0
Lys
5.817LysAla: 5.817 ± 0.857
0.566LysCys: 0.566 ± 0.226
3.635LysAsp: 3.635 ± 0.586
4.363LysGlu: 4.363 ± 0.71
2.262LysPhe: 2.262 ± 0.37
3.797LysGly: 3.797 ± 0.514
0.969LysHis: 0.969 ± 0.26
2.02LysIle: 2.02 ± 0.414
3.232LysLys: 3.232 ± 0.543
5.332LysLeu: 5.332 ± 0.675
2.504LysMet: 2.504 ± 0.518
2.504LysAsn: 2.504 ± 0.413
2.666LysPro: 2.666 ± 0.601
2.424LysGln: 2.424 ± 0.514
3.797LysArg: 3.797 ± 0.677
2.908LysSer: 2.908 ± 0.516
4.201LysThr: 4.201 ± 0.548
3.635LysVal: 3.635 ± 0.619
0.889LysTrp: 0.889 ± 0.279
2.504LysTyr: 2.504 ± 0.379
0.0LysXaa: 0.0 ± 0.0
Leu
7.433LeuAla: 7.433 ± 0.731
0.727LeuCys: 0.727 ± 0.266
4.363LeuAsp: 4.363 ± 0.52
4.847LeuGlu: 4.847 ± 0.722
1.858LeuPhe: 1.858 ± 0.442
4.363LeuGly: 4.363 ± 0.452
1.05LeuHis: 1.05 ± 0.277
4.443LeuIle: 4.443 ± 0.542
5.494LeuLys: 5.494 ± 0.903
5.17LeuLeu: 5.17 ± 0.657
2.02LeuMet: 2.02 ± 0.339
4.363LeuAsn: 4.363 ± 0.666
3.555LeuPro: 3.555 ± 0.587
2.908LeuGln: 2.908 ± 0.484
5.413LeuArg: 5.413 ± 0.648
3.959LeuSer: 3.959 ± 0.514
5.09LeuThr: 5.09 ± 0.499
5.494LeuVal: 5.494 ± 0.541
1.05LeuTrp: 1.05 ± 0.334
2.262LeuTyr: 2.262 ± 0.347
0.0LeuXaa: 0.0 ± 0.0
Met
2.908MetAla: 2.908 ± 0.416
0.242MetCys: 0.242 ± 0.135
1.131MetAsp: 1.131 ± 0.308
1.373MetGlu: 1.373 ± 0.275
1.05MetPhe: 1.05 ± 0.302
1.939MetGly: 1.939 ± 0.34
0.242MetHis: 0.242 ± 0.134
1.05MetIle: 1.05 ± 0.37
1.05MetLys: 1.05 ± 0.351
2.02MetLeu: 2.02 ± 0.462
0.646MetMet: 0.646 ± 0.267
1.373MetAsn: 1.373 ± 0.361
1.454MetPro: 1.454 ± 0.345
0.889MetGln: 0.889 ± 0.257
1.535MetArg: 1.535 ± 0.307
2.262MetSer: 2.262 ± 0.375
2.101MetThr: 2.101 ± 0.375
1.939MetVal: 1.939 ± 0.416
0.566MetTrp: 0.566 ± 0.172
0.566MetTyr: 0.566 ± 0.235
0.0MetXaa: 0.0 ± 0.0
Asn
3.878AsnAla: 3.878 ± 0.574
0.323AsnCys: 0.323 ± 0.132
2.908AsnAsp: 2.908 ± 0.394
2.343AsnGlu: 2.343 ± 0.457
1.697AsnPhe: 1.697 ± 0.359
4.363AsnGly: 4.363 ± 0.696
0.727AsnHis: 0.727 ± 0.302
2.666AsnIle: 2.666 ± 0.351
1.939AsnLys: 1.939 ± 0.409
4.039AsnLeu: 4.039 ± 0.504
0.646AsnMet: 0.646 ± 0.306
2.343AsnAsn: 2.343 ± 0.471
1.777AsnPro: 1.777 ± 0.415
1.373AsnGln: 1.373 ± 0.353
2.747AsnArg: 2.747 ± 0.378
2.02AsnSer: 2.02 ± 0.363
2.343AsnThr: 2.343 ± 0.463
3.635AsnVal: 3.635 ± 0.467
0.808AsnTrp: 0.808 ± 0.257
1.373AsnTyr: 1.373 ± 0.332
0.0AsnXaa: 0.0 ± 0.0
Pro
3.232ProAla: 3.232 ± 0.502
0.242ProCys: 0.242 ± 0.138
3.151ProAsp: 3.151 ± 0.509
3.555ProGlu: 3.555 ± 0.453
1.697ProPhe: 1.697 ± 0.302
3.07ProGly: 3.07 ± 0.469
0.566ProHis: 0.566 ± 0.218
1.697ProIle: 1.697 ± 0.363
2.666ProLys: 2.666 ± 0.448
3.797ProLeu: 3.797 ± 0.512
0.646ProMet: 0.646 ± 0.241
1.373ProAsn: 1.373 ± 0.624
1.373ProPro: 1.373 ± 0.336
1.212ProGln: 1.212 ± 0.314
1.858ProArg: 1.858 ± 0.388
2.424ProSer: 2.424 ± 0.468
1.373ProThr: 1.373 ± 0.329
3.797ProVal: 3.797 ± 0.454
0.404ProTrp: 0.404 ± 0.231
1.293ProTyr: 1.293 ± 0.443
0.0ProXaa: 0.0 ± 0.0
Gln
4.847GlnAla: 4.847 ± 0.516
0.162GlnCys: 0.162 ± 0.098
1.454GlnAsp: 1.454 ± 0.287
2.262GlnGlu: 2.262 ± 0.525
1.616GlnPhe: 1.616 ± 0.462
2.181GlnGly: 2.181 ± 0.47
0.646GlnHis: 0.646 ± 0.291
1.616GlnIle: 1.616 ± 0.422
2.343GlnLys: 2.343 ± 0.378
2.989GlnLeu: 2.989 ± 0.423
1.212GlnMet: 1.212 ± 0.397
1.616GlnAsn: 1.616 ± 0.333
2.262GlnPro: 2.262 ± 0.33
2.02GlnGln: 2.02 ± 0.507
1.939GlnArg: 1.939 ± 0.359
1.858GlnSer: 1.858 ± 0.331
1.777GlnThr: 1.777 ± 0.347
2.666GlnVal: 2.666 ± 0.472
0.646GlnTrp: 0.646 ± 0.202
1.373GlnTyr: 1.373 ± 0.25
0.0GlnXaa: 0.0 ± 0.0
Arg
4.686ArgAla: 4.686 ± 0.516
0.404ArgCys: 0.404 ± 0.144
3.635ArgAsp: 3.635 ± 0.464
3.878ArgGlu: 3.878 ± 0.551
2.262ArgPhe: 2.262 ± 0.443
3.959ArgGly: 3.959 ± 0.579
0.808ArgHis: 0.808 ± 0.242
3.232ArgIle: 3.232 ± 0.573
4.039ArgLys: 4.039 ± 0.656
3.635ArgLeu: 3.635 ± 0.563
1.616ArgMet: 1.616 ± 0.355
2.989ArgAsn: 2.989 ± 0.522
1.939ArgPro: 1.939 ± 0.331
2.989ArgGln: 2.989 ± 0.475
4.847ArgArg: 4.847 ± 0.699
2.585ArgSer: 2.585 ± 0.444
2.989ArgThr: 2.989 ± 0.498
4.282ArgVal: 4.282 ± 0.563
0.969ArgTrp: 0.969 ± 0.262
1.777ArgTyr: 1.777 ± 0.442
0.0ArgXaa: 0.0 ± 0.0
Ser
6.705SerAla: 6.705 ± 0.979
0.323SerCys: 0.323 ± 0.182
3.151SerAsp: 3.151 ± 0.511
3.07SerGlu: 3.07 ± 0.597
2.504SerPhe: 2.504 ± 0.387
6.625SerGly: 6.625 ± 0.702
0.646SerHis: 0.646 ± 0.17
2.908SerIle: 2.908 ± 0.487
2.424SerLys: 2.424 ± 0.496
5.009SerLeu: 5.009 ± 0.59
1.373SerMet: 1.373 ± 0.357
2.747SerAsn: 2.747 ± 0.391
1.535SerPro: 1.535 ± 0.472
2.424SerGln: 2.424 ± 0.37
3.312SerArg: 3.312 ± 0.569
3.07SerSer: 3.07 ± 0.51
3.878SerThr: 3.878 ± 0.694
4.847SerVal: 4.847 ± 0.78
0.808SerTrp: 0.808 ± 0.229
2.02SerTyr: 2.02 ± 0.334
0.0SerXaa: 0.0 ± 0.0
Thr
6.059ThrAla: 6.059 ± 0.799
0.485ThrCys: 0.485 ± 0.165
4.686ThrAsp: 4.686 ± 0.585
3.474ThrGlu: 3.474 ± 0.405
2.908ThrPhe: 2.908 ± 0.503
6.059ThrGly: 6.059 ± 0.748
0.808ThrHis: 0.808 ± 0.248
2.989ThrIle: 2.989 ± 0.495
2.908ThrLys: 2.908 ± 0.465
5.09ThrLeu: 5.09 ± 0.626
1.131ThrMet: 1.131 ± 0.306
1.939ThrAsn: 1.939 ± 0.374
3.555ThrPro: 3.555 ± 0.561
1.777ThrGln: 1.777 ± 0.372
2.908ThrArg: 2.908 ± 0.394
4.767ThrSer: 4.767 ± 0.597
3.716ThrThr: 3.716 ± 0.556
4.363ThrVal: 4.363 ± 0.778
0.889ThrTrp: 0.889 ± 0.246
2.343ThrTyr: 2.343 ± 0.514
0.0ThrXaa: 0.0 ± 0.0
Val
7.19ValAla: 7.19 ± 0.822
0.727ValCys: 0.727 ± 0.22
3.878ValAsp: 3.878 ± 0.523
6.221ValGlu: 6.221 ± 0.708
2.101ValPhe: 2.101 ± 0.503
3.555ValGly: 3.555 ± 0.607
1.05ValHis: 1.05 ± 0.268
4.039ValIle: 4.039 ± 0.632
4.767ValLys: 4.767 ± 0.708
4.12ValLeu: 4.12 ± 0.559
1.454ValMet: 1.454 ± 0.361
3.393ValAsn: 3.393 ± 0.566
2.424ValPro: 2.424 ± 0.777
2.424ValGln: 2.424 ± 0.466
3.232ValArg: 3.232 ± 0.487
5.817ValSer: 5.817 ± 0.929
5.817ValThr: 5.817 ± 0.742
5.332ValVal: 5.332 ± 0.872
1.131ValTrp: 1.131 ± 0.29
2.747ValTyr: 2.747 ± 0.354
0.0ValXaa: 0.0 ± 0.0
Trp
1.293TrpAla: 1.293 ± 0.375
0.081TrpCys: 0.081 ± 0.084
1.293TrpAsp: 1.293 ± 0.318
0.485TrpGlu: 0.485 ± 0.19
0.808TrpPhe: 0.808 ± 0.336
0.969TrpGly: 0.969 ± 0.188
0.162TrpHis: 0.162 ± 0.125
0.566TrpIle: 0.566 ± 0.172
0.808TrpLys: 0.808 ± 0.282
1.616TrpLeu: 1.616 ± 0.352
0.404TrpMet: 0.404 ± 0.178
0.566TrpAsn: 0.566 ± 0.238
0.323TrpPro: 0.323 ± 0.188
0.727TrpGln: 0.727 ± 0.214
1.05TrpArg: 1.05 ± 0.344
0.566TrpSer: 0.566 ± 0.176
0.727TrpThr: 0.727 ± 0.204
1.131TrpVal: 1.131 ± 0.295
0.242TrpTrp: 0.242 ± 0.138
0.162TrpTyr: 0.162 ± 0.121
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.908TyrAla: 2.908 ± 0.491
0.404TyrCys: 0.404 ± 0.196
2.181TyrAsp: 2.181 ± 0.64
2.504TyrGlu: 2.504 ± 0.495
1.373TyrPhe: 1.373 ± 0.338
2.747TyrGly: 2.747 ± 0.394
0.646TyrHis: 0.646 ± 0.213
1.616TyrIle: 1.616 ± 0.317
2.262TyrLys: 2.262 ± 0.514
1.697TyrLeu: 1.697 ± 0.311
0.889TyrMet: 0.889 ± 0.197
1.535TyrAsn: 1.535 ± 0.354
1.373TyrPro: 1.373 ± 0.373
1.535TyrGln: 1.535 ± 0.33
2.262TyrArg: 2.262 ± 0.557
1.939TyrSer: 1.939 ± 0.381
2.02TyrThr: 2.02 ± 0.397
1.535TyrVal: 1.535 ± 0.358
0.081TyrTrp: 0.081 ± 0.081
1.212TyrTyr: 1.212 ± 0.243
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 53 proteins (12379 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski