Amino acid dipepetide frequency for Clostridium ventriculi (Sarcina ventriculi)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.117AlaAla: 3.117 ± 0.096	0.746AlaCys: 0.746 ± 0.038	2.309AlaAsp: 2.309 ± 0.065	2.77AlaGlu: 2.77 ± 0.069	2.498AlaPhe: 2.498 ± 0.078	3.385AlaGly: 3.385 ± 0.081	0.806AlaHis: 0.806 ± 0.036	5.978AlaIle: 5.978 ± 0.117	4.993AlaLys: 4.993 ± 0.087	5.782AlaLeu: 5.782 ± 0.101	1.651AlaMet: 1.651 ± 0.054	2.73AlaAsn: 2.73 ± 0.072	1.395AlaPro: 1.395 ± 0.05	1.325AlaGln: 1.325 ± 0.045	1.833AlaArg: 1.833 ± 0.053	3.281AlaSer: 3.281 ± 0.077	2.915AlaThr: 2.915 ± 0.072	3.648AlaVal: 3.648 ± 0.092	0.393AlaTrp: 0.393 ± 0.023	2.057AlaTyr: 2.057 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.665CysAla: 0.665 ± 0.032	0.221CysCys: 0.221 ± 0.021	0.712CysAsp: 0.712 ± 0.032	0.86CysGlu: 0.86 ± 0.038	0.558CysPhe: 0.558 ± 0.027	1.173CysGly: 1.173 ± 0.048	0.236CysHis: 0.236 ± 0.018	1.234CysIle: 1.234 ± 0.048	1.126CysLys: 1.126 ± 0.042	1.023CysLeu: 1.023 ± 0.042	0.285CysMet: 0.285 ± 0.02	0.783CysAsn: 0.783 ± 0.033	0.495CysPro: 0.495 ± 0.03	0.231CysGln: 0.231 ± 0.017	0.384CysArg: 0.384 ± 0.024	0.759CysSer: 0.759 ± 0.033	0.632CysThr: 0.632 ± 0.03	0.764CysVal: 0.764 ± 0.036	0.065CysTrp: 0.065 ± 0.01	0.512CysTyr: 0.512 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	2.505AspAla: 2.505 ± 0.071	0.669AspCys: 0.669 ± 0.027	2.948AspAsp: 2.948 ± 0.084	4.607AspGlu: 4.607 ± 0.083	2.818AspPhe: 2.818 ± 0.06	3.203AspGly: 3.203 ± 0.071	0.461AspHis: 0.461 ± 0.03	6.585AspIle: 6.585 ± 0.112	5.457AspLys: 5.457 ± 0.089	5.16AspLeu: 5.16 ± 0.094	1.52AspMet: 1.52 ± 0.049	3.496AspAsn: 3.496 ± 0.073	1.083AspPro: 1.083 ± 0.043	0.561AspGln: 0.561 ± 0.025	1.793AspArg: 1.793 ± 0.057	3.321AspSer: 3.321 ± 0.071	2.433AspThr: 2.433 ± 0.066	3.708AspVal: 3.708 ± 0.075	0.246AspTrp: 0.246 ± 0.02	2.546AspTyr: 2.546 ± 0.065	0.0AspXaa: 0.0 ± 0.0
Glu	3.889GluAla: 3.889 ± 0.083	0.762GluCys: 0.762 ± 0.035	4.084GluAsp: 4.084 ± 0.079	6.388GluGlu: 6.388 ± 0.132	3.312GluPhe: 3.312 ± 0.075	3.8GluGly: 3.8 ± 0.082	0.897GluHis: 0.897 ± 0.037	7.145GluIle: 7.145 ± 0.118	8.066GluLys: 8.066 ± 0.142	6.271GluLeu: 6.271 ± 0.11	1.751GluMet: 1.751 ± 0.052	5.857GluAsn: 5.857 ± 0.11	1.194GluPro: 1.194 ± 0.048	1.551GluGln: 1.551 ± 0.049	2.497GluArg: 2.497 ± 0.061	3.635GluSer: 3.635 ± 0.076	2.898GluThr: 2.898 ± 0.057	4.629GluVal: 4.629 ± 0.107	0.333GluTrp: 0.333 ± 0.021	2.912GluTyr: 2.912 ± 0.077	0.0GluXaa: 0.0 ± 0.0
Phe	2.349PheAla: 2.349 ± 0.069	0.619PheCys: 0.619 ± 0.027	2.457PheAsp: 2.457 ± 0.062	2.642PheGlu: 2.642 ± 0.069	2.134PhePhe: 2.134 ± 0.072	2.956PheGly: 2.956 ± 0.083	0.535PheHis: 0.535 ± 0.028	5.136PheIle: 5.136 ± 0.123	4.273PheLys: 4.273 ± 0.077	4.482PheLeu: 4.482 ± 0.108	1.201PheMet: 1.201 ± 0.042	3.429PheAsn: 3.429 ± 0.084	1.123PhePro: 1.123 ± 0.038	0.847PheGln: 0.847 ± 0.033	1.331PheArg: 1.331 ± 0.046	3.14PheSer: 3.14 ± 0.082	2.266PheThr: 2.266 ± 0.061	2.76PheVal: 2.76 ± 0.075	0.272PheTrp: 0.272 ± 0.026	1.943PheTyr: 1.943 ± 0.059	0.0PheXaa: 0.0 ± 0.0
Gly	3.934GlyAla: 3.934 ± 0.102	0.922GlyCys: 0.922 ± 0.041	3.136GlyAsp: 3.136 ± 0.073	4.217GlyGlu: 4.217 ± 0.091	3.282GlyPhe: 3.282 ± 0.084	4.223GlyGly: 4.223 ± 0.099	1.016GlyHis: 1.016 ± 0.041	6.71GlyIle: 6.71 ± 0.139	5.269GlyLys: 5.269 ± 0.095	5.37GlyLeu: 5.37 ± 0.099	1.638GlyMet: 1.638 ± 0.052	3.408GlyAsn: 3.408 ± 0.082	1.197GlyPro: 1.197 ± 0.063	1.402GlyGln: 1.402 ± 0.052	2.166GlyArg: 2.166 ± 0.065	3.615GlySer: 3.615 ± 0.07	3.235GlyThr: 3.235 ± 0.073	4.781GlyVal: 4.781 ± 0.086	0.494GlyTrp: 0.494 ± 0.029	3.003GlyTyr: 3.003 ± 0.081	0.0GlyXaa: 0.0 ± 0.0
His	0.559HisAla: 0.559 ± 0.031	0.211HisCys: 0.211 ± 0.018	0.707HisAsp: 0.707 ± 0.036	0.834HisGlu: 0.834 ± 0.035	0.65HisPhe: 0.65 ± 0.035	1.043HisGly: 1.043 ± 0.042	0.272HisHis: 0.272 ± 0.025	1.3HisIle: 1.3 ± 0.049	1.042HisLys: 1.042 ± 0.047	1.106HisLeu: 1.106 ± 0.038	0.305HisMet: 0.305 ± 0.021	0.769HisAsn: 0.769 ± 0.033	0.51HisPro: 0.51 ± 0.031	0.256HisGln: 0.256 ± 0.018	0.517HisArg: 0.517 ± 0.029	0.763HisSer: 0.763 ± 0.034	0.649HisThr: 0.649 ± 0.032	0.786HisVal: 0.786 ± 0.038	0.091HisTrp: 0.091 ± 0.012	0.52HisTyr: 0.52 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.928IleAla: 5.928 ± 0.132	1.372IleCys: 1.372 ± 0.049	6.0IleAsp: 6.0 ± 0.103	7.281IleGlu: 7.281 ± 0.111	4.576IlePhe: 4.576 ± 0.121	6.205IleGly: 6.205 ± 0.118	1.263IleHis: 1.263 ± 0.043	10.344IleIle: 10.344 ± 0.195	9.53IleLys: 9.53 ± 0.136	10.073IleLeu: 10.073 ± 0.168	2.43IleMet: 2.43 ± 0.061	7.202IleAsn: 7.202 ± 0.124	3.232IlePro: 3.232 ± 0.075	2.09IleGln: 2.09 ± 0.052	2.868IleArg: 2.868 ± 0.075	7.017IleSer: 7.017 ± 0.119	4.929IleThr: 4.929 ± 0.088	6.414IleVal: 6.414 ± 0.099	0.535IleTrp: 0.535 ± 0.036	3.87IleTyr: 3.87 ± 0.073	0.001IleXaa: 0.001 ± 0.001
Lys	4.525LysAla: 4.525 ± 0.086	1.033LysCys: 1.033 ± 0.041	6.091LysAsp: 6.091 ± 0.105	9.087LysGlu: 9.087 ± 0.154	3.652LysPhe: 3.652 ± 0.072	4.938LysGly: 4.938 ± 0.089	1.134LysHis: 1.134 ± 0.042	9.161LysIle: 9.161 ± 0.138	8.754LysLys: 8.754 ± 0.135	7.266LysLeu: 7.266 ± 0.103	2.391LysMet: 2.391 ± 0.066	7.538LysAsn: 7.538 ± 0.139	2.018LysPro: 2.018 ± 0.052	2.188LysGln: 2.188 ± 0.055	3.1LysArg: 3.1 ± 0.062	5.285LysSer: 5.285 ± 0.094	4.31LysThr: 4.31 ± 0.086	5.896LysVal: 5.896 ± 0.118	0.528LysTrp: 0.528 ± 0.029	4.21LysTyr: 4.21 ± 0.079	0.0LysXaa: 0.0 ± 0.0
Leu	5.111LeuAla: 5.111 ± 0.091	1.213LeuCys: 1.213 ± 0.043	5.659LeuAsp: 5.659 ± 0.099	6.782LeuGlu: 6.782 ± 0.13	3.759LeuPhe: 3.759 ± 0.099	6.405LeuGly: 6.405 ± 0.118	1.006LeuHis: 1.006 ± 0.038	8.543LeuIle: 8.543 ± 0.148	8.966LeuLys: 8.966 ± 0.136	7.456LeuLeu: 7.456 ± 0.13	2.196LeuMet: 2.196 ± 0.057	7.18LeuAsn: 7.18 ± 0.131	2.632LeuPro: 2.632 ± 0.064	1.812LeuGln: 1.812 ± 0.048	2.952LeuArg: 2.952 ± 0.074	6.411LeuSer: 6.411 ± 0.093	4.511LeuThr: 4.511 ± 0.082	5.469LeuVal: 5.469 ± 0.096	0.525LeuTrp: 0.525 ± 0.027	3.188LeuTyr: 3.188 ± 0.069	0.001LeuXaa: 0.001 ± 0.001
Met	1.745MetAla: 1.745 ± 0.049	0.295MetCys: 0.295 ± 0.022	1.395MetAsp: 1.395 ± 0.044	1.724MetGlu: 1.724 ± 0.057	1.045MetPhe: 1.045 ± 0.037	1.724MetGly: 1.724 ± 0.057	0.305MetHis: 0.305 ± 0.021	2.296MetIle: 2.296 ± 0.06	2.24MetLys: 2.24 ± 0.053	2.31MetLeu: 2.31 ± 0.062	0.613MetMet: 0.613 ± 0.031	1.711MetAsn: 1.711 ± 0.051	0.885MetPro: 0.885 ± 0.035	0.665MetGln: 0.665 ± 0.033	0.851MetArg: 0.851 ± 0.04	1.712MetSer: 1.712 ± 0.046	1.123MetThr: 1.123 ± 0.043	1.567MetVal: 1.567 ± 0.046	0.175MetTrp: 0.175 ± 0.016	0.811MetTyr: 0.811 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	3.029AsnAla: 3.029 ± 0.07	0.75AsnCys: 0.75 ± 0.034	3.608AsnAsp: 3.608 ± 0.077	4.726AsnGlu: 4.726 ± 0.101	3.177AsnPhe: 3.177 ± 0.071	4.087AsnGly: 4.087 ± 0.093	0.823AsnHis: 0.823 ± 0.042	8.266AsnIle: 8.266 ± 0.142	6.976AsnLys: 6.976 ± 0.124	6.442AsnLeu: 6.442 ± 0.1	1.725AsnMet: 1.725 ± 0.048	5.671AsnAsn: 5.671 ± 0.152	2.118AsnPro: 2.118 ± 0.061	1.349AsnGln: 1.349 ± 0.053	1.939AsnArg: 1.939 ± 0.053	4.468AsnSer: 4.468 ± 0.11	3.166AsnThr: 3.166 ± 0.083	4.001AsnVal: 4.001 ± 0.087	0.396AsnTrp: 0.396 ± 0.023	2.894AsnTyr: 2.894 ± 0.08	0.0AsnXaa: 0.0 ± 0.0
Pro	1.275ProAla: 1.275 ± 0.05	0.35ProCys: 0.35 ± 0.023	1.224ProAsp: 1.224 ± 0.041	1.765ProGlu: 1.765 ± 0.058	1.345ProPhe: 1.345 ± 0.042	1.574ProGly: 1.574 ± 0.052	0.431ProHis: 0.431 ± 0.023	2.66ProIle: 2.66 ± 0.059	2.319ProLys: 2.319 ± 0.058	2.454ProLeu: 2.454 ± 0.063	0.675ProMet: 0.675 ± 0.032	1.702ProAsn: 1.702 ± 0.053	0.494ProPro: 0.494 ± 0.027	0.739ProGln: 0.739 ± 0.035	0.824ProArg: 0.824 ± 0.032	1.628ProSer: 1.628 ± 0.048	1.411ProThr: 1.411 ± 0.054	1.819ProVal: 1.819 ± 0.067	0.232ProTrp: 0.232 ± 0.02	1.29ProTyr: 1.29 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	1.103GlnAla: 1.103 ± 0.044	0.273GlnCys: 0.273 ± 0.019	1.193GlnAsp: 1.193 ± 0.045	1.607GlnGlu: 1.607 ± 0.053	0.882GlnPhe: 0.882 ± 0.037	1.557GlnGly: 1.557 ± 0.047	0.269GlnHis: 0.269 ± 0.017	2.081GlnIle: 2.081 ± 0.056	1.768GlnLys: 1.768 ± 0.057	1.875GlnLeu: 1.875 ± 0.055	0.554GlnMet: 0.554 ± 0.032	1.499GlnAsn: 1.499 ± 0.054	0.541GlnPro: 0.541 ± 0.026	0.612GlnGln: 0.612 ± 0.034	0.874GlnArg: 0.874 ± 0.035	1.258GlnSer: 1.258 ± 0.043	1.043GlnThr: 1.043 ± 0.043	1.401GlnVal: 1.401 ± 0.052	0.221GlnTrp: 0.221 ± 0.019	0.885GlnTyr: 0.885 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	1.789ArgAla: 1.789 ± 0.055	0.434ArgCys: 0.434 ± 0.023	1.836ArgAsp: 1.836 ± 0.055	3.012ArgGlu: 3.012 ± 0.07	1.416ArgPhe: 1.416 ± 0.046	1.987ArgGly: 1.987 ± 0.064	0.458ArgHis: 0.458 ± 0.026	3.003ArgIle: 3.003 ± 0.082	2.936ArgLys: 2.936 ± 0.084	2.754ArgLeu: 2.754 ± 0.065	0.828ArgMet: 0.828 ± 0.036	1.97ArgAsn: 1.97 ± 0.055	0.771ArgPro: 0.771 ± 0.036	0.905ArgGln: 0.905 ± 0.039	1.378ArgArg: 1.378 ± 0.053	1.345ArgSer: 1.345 ± 0.043	1.359ArgThr: 1.359 ± 0.042	2.302ArgVal: 2.302 ± 0.07	0.233ArgTrp: 0.233 ± 0.02	1.354ArgTyr: 1.354 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	3.092SerAla: 3.092 ± 0.071	0.709SerCys: 0.709 ± 0.029	3.05SerAsp: 3.05 ± 0.06	3.51SerGlu: 3.51 ± 0.075	3.15SerPhe: 3.15 ± 0.079	4.047SerGly: 4.047 ± 0.092	0.837SerHis: 0.837 ± 0.04	6.688SerIle: 6.688 ± 0.107	5.879SerLys: 5.879 ± 0.091	6.449SerLeu: 6.449 ± 0.125	1.633SerMet: 1.633 ± 0.055	4.217SerAsn: 4.217 ± 0.1	1.479SerPro: 1.479 ± 0.047	1.446SerGln: 1.446 ± 0.05	1.859SerArg: 1.859 ± 0.054	4.343SerSer: 4.343 ± 0.108	3.18SerThr: 3.18 ± 0.075	3.862SerVal: 3.862 ± 0.076	0.424SerTrp: 0.424 ± 0.024	2.768SerTyr: 2.768 ± 0.065	0.0SerXaa: 0.0 ± 0.0
Thr	2.787ThrAla: 2.787 ± 0.07	0.568ThrCys: 0.568 ± 0.032	2.333ThrAsp: 2.333 ± 0.06	2.562ThrGlu: 2.562 ± 0.064	2.34ThrPhe: 2.34 ± 0.062	3.514ThrGly: 3.514 ± 0.098	0.717ThrHis: 0.717 ± 0.031	4.842ThrIle: 4.842 ± 0.1	3.678ThrLys: 3.678 ± 0.075	4.875ThrLeu: 4.875 ± 0.082	1.106ThrMet: 1.106 ± 0.038	2.946ThrAsn: 2.946 ± 0.091	1.744ThrPro: 1.744 ± 0.054	1.203ThrGln: 1.203 ± 0.045	1.536ThrArg: 1.536 ± 0.045	3.25ThrSer: 3.25 ± 0.078	2.71ThrThr: 2.71 ± 0.082	3.176ThrVal: 3.176 ± 0.083	0.347ThrTrp: 0.347 ± 0.024	1.885ThrTyr: 1.885 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	3.877ValAla: 3.877 ± 0.077	0.958ValCys: 0.958 ± 0.032	3.677ValAsp: 3.677 ± 0.075	4.3ValGlu: 4.3 ± 0.093	2.971ValPhe: 2.971 ± 0.076	4.131ValGly: 4.131 ± 0.104	0.806ValHis: 0.806 ± 0.034	6.244ValIle: 6.244 ± 0.097	5.437ValLys: 5.437 ± 0.09	6.288ValLeu: 6.288 ± 0.095	1.53ValMet: 1.53 ± 0.042	3.971ValAsn: 3.971 ± 0.088	1.971ValPro: 1.971 ± 0.056	1.415ValGln: 1.415 ± 0.04	1.896ValArg: 1.896 ± 0.057	4.254ValSer: 4.254 ± 0.078	3.062ValThr: 3.062 ± 0.068	4.555ValVal: 4.555 ± 0.097	0.369ValTrp: 0.369 ± 0.026	2.431ValTyr: 2.431 ± 0.057	0.0ValXaa: 0.0 ± 0.0
Trp	0.347TrpAla: 0.347 ± 0.025	0.081TrpCys: 0.081 ± 0.011	0.3TrpAsp: 0.3 ± 0.022	0.38TrpGlu: 0.38 ± 0.023	0.307TrpPhe: 0.307 ± 0.022	0.495TrpGly: 0.495 ± 0.027	0.112TrpHis: 0.112 ± 0.014	0.665TrpIle: 0.665 ± 0.036	0.451TrpLys: 0.451 ± 0.027	0.504TrpLeu: 0.504 ± 0.029	0.165TrpMet: 0.165 ± 0.016	0.444TrpAsn: 0.444 ± 0.026	0.155TrpPro: 0.155 ± 0.016	0.195TrpGln: 0.195 ± 0.016	0.205TrpArg: 0.205 ± 0.019	0.409TrpSer: 0.409 ± 0.024	0.297TrpThr: 0.297 ± 0.022	0.354TrpVal: 0.354 ± 0.022	0.091TrpTrp: 0.091 ± 0.012	0.262TrpTyr: 0.262 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.984TyrAla: 1.984 ± 0.052	0.532TyrCys: 0.532 ± 0.024	2.401TyrAsp: 2.401 ± 0.059	2.818TyrGlu: 2.818 ± 0.075	2.02TyrPhe: 2.02 ± 0.057	2.575TyrGly: 2.575 ± 0.071	0.504TyrHis: 0.504 ± 0.03	4.279TyrIle: 4.279 ± 0.087	3.946TyrLys: 3.946 ± 0.09	3.836TyrLeu: 3.836 ± 0.094	0.994TyrMet: 0.994 ± 0.039	3.086TyrAsn: 3.086 ± 0.072	1.173TyrPro: 1.173 ± 0.043	0.703TyrGln: 0.703 ± 0.032	1.27TyrArg: 1.27 ± 0.043	2.727TyrSer: 2.727 ± 0.071	1.99TyrThr: 1.99 ± 0.062	2.253TyrVal: 2.253 ± 0.054	0.252TyrTrp: 0.252 ± 0.021	1.783TyrTyr: 1.783 ± 0.054	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.016XaaXaa: 0.016 ± 0.014

Statistics based on 2228 proteins (702555 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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