Amino acid dipepetide frequency for Torque teno mini virus 6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.121AlaAla: 1.121 ± 0.602
0.0AlaCys: 0.0 ± 0.0
1.121AlaAsp: 1.121 ± 0.602
1.121AlaGlu: 1.121 ± 2.182
1.121AlaPhe: 1.121 ± 0.602
1.121AlaGly: 1.121 ± 0.602
2.242AlaHis: 2.242 ± 1.558
2.242AlaIle: 2.242 ± 1.205
1.121AlaLys: 1.121 ± 0.602
2.242AlaLeu: 2.242 ± 4.364
2.242AlaMet: 2.242 ± 1.205
1.121AlaAsn: 1.121 ± 0.602
1.121AlaPro: 1.121 ± 0.602
0.0AlaGln: 0.0 ± 0.0
0.0AlaArg: 0.0 ± 0.0
3.363AlaSer: 3.363 ± 1.807
4.484AlaThr: 4.484 ± 2.409
0.0AlaVal: 0.0 ± 0.0
0.0AlaTrp: 0.0 ± 0.0
0.0AlaTyr: 0.0 ± 0.0
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
1.121CysAsp: 1.121 ± 0.602
1.121CysGlu: 1.121 ± 0.602
0.0CysPhe: 0.0 ± 0.0
1.121CysGly: 1.121 ± 0.602
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
2.242CysLys: 2.242 ± 1.801
1.121CysLeu: 1.121 ± 2.182
1.121CysMet: 1.121 ± 0.602
2.242CysAsn: 2.242 ± 1.205
2.242CysPro: 2.242 ± 1.205
0.0CysGln: 0.0 ± 0.0
2.242CysArg: 2.242 ± 1.558
1.121CysSer: 1.121 ± 0.602
1.121CysThr: 1.121 ± 2.182
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
1.121CysTyr: 1.121 ± 0.602
0.0CysXaa: 0.0 ± 0.0
Asp
1.121AspAla: 1.121 ± 2.182
0.0AspCys: 0.0 ± 0.0
2.242AspAsp: 2.242 ± 1.205
2.242AspGlu: 2.242 ± 1.205
1.121AspPhe: 1.121 ± 0.602
3.363AspGly: 3.363 ± 6.546
0.0AspHis: 0.0 ± 0.0
1.121AspIle: 1.121 ± 0.602
3.363AspLys: 3.363 ± 1.807
4.484AspLeu: 4.484 ± 1.545
0.0AspMet: 0.0 ± 0.0
3.363AspAsn: 3.363 ± 1.807
3.363AspPro: 3.363 ± 1.807
3.363AspGln: 3.363 ± 1.807
1.121AspArg: 1.121 ± 0.602
4.484AspSer: 4.484 ± 5.618
3.363AspThr: 3.363 ± 1.566
1.121AspVal: 1.121 ± 2.042
1.121AspTrp: 1.121 ± 0.602
4.484AspTyr: 4.484 ± 1.545
0.0AspXaa: 0.0 ± 0.0
Glu
2.242GluAla: 2.242 ± 1.801
2.242GluCys: 2.242 ± 1.205
5.605GluAsp: 5.605 ± 6.807
5.605GluGlu: 5.605 ± 3.012
0.0GluPhe: 0.0 ± 0.0
1.121GluGly: 1.121 ± 2.042
1.121GluHis: 1.121 ± 2.182
0.0GluIle: 0.0 ± 0.0
6.726GluLys: 6.726 ± 3.654
5.605GluLeu: 5.605 ± 4.171
1.121GluMet: 1.121 ± 0.558
1.121GluAsn: 1.121 ± 2.182
2.242GluPro: 2.242 ± 1.801
3.363GluGln: 3.363 ± 1.187
1.121GluArg: 1.121 ± 0.602
2.242GluSer: 2.242 ± 4.084
3.363GluThr: 3.363 ± 1.566
2.242GluVal: 2.242 ± 1.205
1.121GluTrp: 1.121 ± 0.602
3.363GluTyr: 3.363 ± 1.566
0.0GluXaa: 0.0 ± 0.0
Phe
1.121PheAla: 1.121 ± 2.182
2.242PheCys: 2.242 ± 1.558
2.242PheAsp: 2.242 ± 1.205
3.363PheGlu: 3.363 ± 1.566
2.242PhePhe: 2.242 ± 1.205
2.242PheGly: 2.242 ± 1.205
1.121PheHis: 1.121 ± 0.602
2.242PheIle: 2.242 ± 1.205
1.121PheLys: 1.121 ± 0.602
1.121PheLeu: 1.121 ± 0.602
0.0PheMet: 0.0 ± 0.0
1.121PheAsn: 1.121 ± 0.602
3.363PhePro: 3.363 ± 1.807
4.484PheGln: 4.484 ± 1.057
3.363PheArg: 3.363 ± 1.807
0.0PheSer: 0.0 ± 0.0
2.242PheThr: 2.242 ± 1.205
2.242PheVal: 2.242 ± 1.558
1.121PheTrp: 1.121 ± 0.602
2.242PheTyr: 2.242 ± 1.205
0.0PheXaa: 0.0 ± 0.0
Gly
0.0GlyAla: 0.0 ± 0.0
1.121GlyCys: 1.121 ± 0.602
1.121GlyAsp: 1.121 ± 2.182
2.242GlyGlu: 2.242 ± 4.364
2.242GlyPhe: 2.242 ± 1.205
5.605GlyGly: 5.605 ± 3.012
0.0GlyHis: 0.0 ± 0.0
5.605GlyIle: 5.605 ± 1.746
0.0GlyLys: 0.0 ± 0.0
5.605GlyLeu: 5.605 ± 1.746
0.0GlyMet: 0.0 ± 1.565
4.484GlyAsn: 4.484 ± 1.057
2.242GlyPro: 2.242 ± 1.205
1.121GlyGln: 1.121 ± 0.602
1.121GlyArg: 1.121 ± 0.602
3.363GlySer: 3.363 ± 1.566
6.726GlyThr: 6.726 ± 3.614
0.0GlyVal: 0.0 ± 0.0
1.121GlyTrp: 1.121 ± 0.602
1.121GlyTyr: 1.121 ± 0.602
0.0GlyXaa: 0.0 ± 0.0
His
1.121HisAla: 1.121 ± 0.602
0.0HisCys: 0.0 ± 0.0
2.242HisAsp: 2.242 ± 1.801
1.121HisGlu: 1.121 ± 0.602
2.242HisPhe: 2.242 ± 1.205
1.121HisGly: 1.121 ± 2.182
2.242HisHis: 2.242 ± 1.558
1.121HisIle: 1.121 ± 2.042
1.121HisLys: 1.121 ± 2.042
0.0HisLeu: 0.0 ± 0.0
0.0HisMet: 0.0 ± 0.0
1.121HisAsn: 1.121 ± 0.602
0.0HisPro: 0.0 ± 0.0
3.363HisGln: 3.363 ± 3.582
2.242HisArg: 2.242 ± 4.084
1.121HisSer: 1.121 ± 0.602
3.363HisThr: 3.363 ± 3.956
0.0HisVal: 0.0 ± 0.0
2.242HisTrp: 2.242 ± 1.205
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
1.121IleAla: 1.121 ± 0.602
0.0IleCys: 0.0 ± 0.0
2.242IleAsp: 2.242 ± 1.205
3.363IleGlu: 3.363 ± 1.807
1.121IlePhe: 1.121 ± 0.602
3.363IleGly: 3.363 ± 1.807
1.121IleHis: 1.121 ± 2.182
4.484IleIle: 4.484 ± 1.545
6.726IleLys: 6.726 ± 2.105
7.848IleLeu: 7.848 ± 2.166
0.0IleMet: 0.0 ± 0.0
2.242IleAsn: 2.242 ± 3.341
5.605IlePro: 5.605 ± 1.246
4.484IleGln: 4.484 ± 2.409
5.605IleArg: 5.605 ± 3.012
4.484IleSer: 4.484 ± 1.057
3.363IleThr: 3.363 ± 1.807
2.242IleVal: 2.242 ± 1.801
1.121IleTrp: 1.121 ± 0.602
2.242IleTyr: 2.242 ± 1.205
0.0IleXaa: 0.0 ± 0.0
Lys
6.726LysAla: 6.726 ± 1.647
2.242LysCys: 2.242 ± 4.364
3.363LysAsp: 3.363 ± 1.187
5.605LysGlu: 5.605 ± 4.171
1.121LysPhe: 1.121 ± 0.602
4.484LysGly: 4.484 ± 2.409
4.484LysHis: 4.484 ± 3.115
2.242LysIle: 2.242 ± 1.205
7.848LysLys: 7.848 ± 7.826
11.211LysLeu: 11.211 ± 1.024
0.0LysMet: 0.0 ± 0.0
3.363LysAsn: 3.363 ± 1.187
3.363LysPro: 3.363 ± 2.746
5.605LysGln: 5.605 ± 1.573
3.363LysArg: 3.363 ± 1.187
4.484LysSer: 4.484 ± 1.057
7.848LysThr: 7.848 ± 2.166
3.363LysVal: 3.363 ± 1.807
1.121LysTrp: 1.121 ± 0.602
3.363LysTyr: 3.363 ± 1.807
0.0LysXaa: 0.0 ± 0.0
Leu
1.121LeuAla: 1.121 ± 0.602
4.484LeuCys: 4.484 ± 1.545
4.484LeuAsp: 4.484 ± 1.545
5.605LeuGlu: 5.605 ± 9.448
3.363LeuPhe: 3.363 ± 2.746
2.242LeuGly: 2.242 ± 1.801
0.0LeuHis: 0.0 ± 0.0
4.484LeuIle: 4.484 ± 2.409
5.605LeuLys: 5.605 ± 1.246
7.848LeuLeu: 7.848 ± 3.166
2.242LeuMet: 2.242 ± 1.205
8.969LeuAsn: 8.969 ± 3.874
5.605LeuPro: 5.605 ± 3.012
12.332LeuGln: 12.332 ± 7.196
4.484LeuArg: 4.484 ± 4.492
3.363LeuSer: 3.363 ± 1.187
7.848LeuThr: 7.848 ± 0.555
3.363LeuVal: 3.363 ± 2.746
0.0LeuTrp: 0.0 ± 0.0
4.484LeuTyr: 4.484 ± 2.409
0.0LeuXaa: 0.0 ± 0.0
Met
0.0MetAla: 0.0 ± 0.0
0.0MetCys: 0.0 ± 0.0
2.242MetAsp: 2.242 ± 1.205
2.242MetGlu: 2.242 ± 1.558
0.0MetPhe: 0.0 ± 0.0
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
1.121MetIle: 1.121 ± 2.042
1.121MetLys: 1.121 ± 0.602
0.0MetLeu: 0.0 ± 0.0
0.0MetMet: 0.0 ± 0.0
1.121MetAsn: 1.121 ± 2.182
1.121MetPro: 1.121 ± 0.602
2.242MetGln: 2.242 ± 1.205
1.121MetArg: 1.121 ± 0.602
0.0MetSer: 0.0 ± 0.0
2.242MetThr: 2.242 ± 1.558
1.121MetVal: 1.121 ± 0.602
2.242MetTrp: 2.242 ± 1.205
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.121AsnAla: 1.121 ± 0.602
1.121AsnCys: 1.121 ± 0.602
4.484AsnAsp: 4.484 ± 1.057
2.242AsnGlu: 2.242 ± 1.558
4.484AsnPhe: 4.484 ± 1.545
3.363AsnGly: 3.363 ± 1.807
2.242AsnHis: 2.242 ± 1.205
4.484AsnIle: 4.484 ± 2.155
4.484AsnLys: 4.484 ± 3.115
4.484AsnLeu: 4.484 ± 2.155
3.363AsnMet: 3.363 ± 1.187
5.605AsnAsn: 5.605 ± 1.573
3.363AsnPro: 3.363 ± 1.807
1.121AsnGln: 1.121 ± 0.602
1.121AsnArg: 1.121 ± 0.602
2.242AsnSer: 2.242 ± 1.558
5.605AsnThr: 5.605 ± 1.746
1.121AsnVal: 1.121 ± 0.602
2.242AsnTrp: 2.242 ± 1.205
3.363AsnTyr: 3.363 ± 1.807
0.0AsnXaa: 0.0 ± 0.0
Pro
3.363ProAla: 3.363 ± 1.807
1.121ProCys: 1.121 ± 0.602
2.242ProAsp: 2.242 ± 1.801
1.121ProGlu: 1.121 ± 0.602
3.363ProPhe: 3.363 ± 1.807
2.242ProGly: 2.242 ± 1.205
1.121ProHis: 1.121 ± 0.602
8.969ProIle: 8.969 ± 2.115
3.363ProLys: 3.363 ± 1.566
8.969ProLeu: 8.969 ± 2.126
0.0ProMet: 0.0 ± 0.0
5.605ProAsn: 5.605 ± 1.746
4.484ProPro: 4.484 ± 2.409
3.363ProGln: 3.363 ± 1.807
2.242ProArg: 2.242 ± 1.205
2.242ProSer: 2.242 ± 1.205
3.363ProThr: 3.363 ± 1.807
1.121ProVal: 1.121 ± 0.602
0.0ProTrp: 0.0 ± 0.0
4.484ProTyr: 4.484 ± 1.057
0.0ProXaa: 0.0 ± 0.0
Gln
0.0GlnAla: 0.0 ± 0.0
0.0GlnCys: 0.0 ± 0.0
3.363GlnAsp: 3.363 ± 1.807
4.484GlnGlu: 4.484 ± 2.155
2.242GlnPhe: 2.242 ± 1.205
1.121GlnGly: 1.121 ± 0.602
1.121GlnHis: 1.121 ± 2.042
3.363GlnIle: 3.363 ± 1.807
3.363GlnLys: 3.363 ± 1.187
4.484GlnLeu: 4.484 ± 2.155
1.121GlnMet: 1.121 ± 0.602
2.242GlnAsn: 2.242 ± 1.558
6.726GlnPro: 6.726 ± 1.647
1.121GlnGln: 1.121 ± 2.042
4.484GlnArg: 4.484 ± 1.057
6.726GlnSer: 6.726 ± 1.647
10.09GlnThr: 10.09 ± 5.421
0.0GlnVal: 0.0 ± 0.0
3.363GlnTrp: 3.363 ± 5.089
2.242GlnTyr: 2.242 ± 1.205
0.0GlnXaa: 0.0 ± 0.0
Arg
0.0ArgAla: 0.0 ± 0.0
1.121ArgCys: 1.121 ± 0.602
1.121ArgAsp: 1.121 ± 0.602
0.0ArgGlu: 0.0 ± 0.0
3.363ArgPhe: 3.363 ± 1.187
1.121ArgGly: 1.121 ± 0.602
3.363ArgHis: 3.363 ± 3.582
4.484ArgIle: 4.484 ± 2.409
8.969ArgLys: 8.969 ± 2.685
5.605ArgLeu: 5.605 ± 3.895
0.0ArgMet: 0.0 ± 0.0
1.121ArgAsn: 1.121 ± 0.602
1.121ArgPro: 1.121 ± 0.602
1.121ArgGln: 1.121 ± 2.042
13.453ArgArg: 13.453 ± 4.991
1.121ArgSer: 1.121 ± 0.602
3.363ArgThr: 3.363 ± 1.187
0.0ArgVal: 0.0 ± 0.0
1.121ArgTrp: 1.121 ± 0.602
5.605ArgTyr: 5.605 ± 1.246
0.0ArgXaa: 0.0 ± 0.0
Ser
1.121SerAla: 1.121 ± 0.602
2.242SerCys: 2.242 ± 1.205
3.363SerAsp: 3.363 ± 1.187
3.363SerGlu: 3.363 ± 3.582
2.242SerPhe: 2.242 ± 1.205
0.0SerGly: 0.0 ± 0.0
1.121SerHis: 1.121 ± 0.602
4.484SerIle: 4.484 ± 2.409
6.726SerLys: 6.726 ± 4.673
5.605SerLeu: 5.605 ± 1.573
0.0SerMet: 0.0 ± 0.0
4.484SerAsn: 4.484 ± 2.409
3.363SerPro: 3.363 ± 1.566
4.484SerGln: 4.484 ± 2.409
2.242SerArg: 2.242 ± 1.558
13.453SerSer: 13.453 ± 19.397
4.484SerThr: 4.484 ± 2.155
1.121SerVal: 1.121 ± 2.042
1.121SerTrp: 1.121 ± 0.602
1.121SerTyr: 1.121 ± 2.042
0.0SerXaa: 0.0 ± 0.0
Thr
3.363ThrAla: 3.363 ± 1.807
0.0ThrCys: 0.0 ± 0.0
0.0ThrAsp: 0.0 ± 0.0
3.363ThrGlu: 3.363 ± 1.566
3.363ThrPhe: 3.363 ± 1.187
7.848ThrGly: 7.848 ± 3.052
2.242ThrHis: 2.242 ± 1.801
6.726ThrIle: 6.726 ± 2.105
10.09ThrLys: 10.09 ± 3.725
7.848ThrLeu: 7.848 ± 2.166
2.242ThrMet: 2.242 ± 1.558
7.848ThrAsn: 7.848 ± 2.144
4.484ThrPro: 4.484 ± 2.409
6.726ThrGln: 6.726 ± 3.614
0.0ThrArg: 0.0 ± 0.0
6.726ThrSer: 6.726 ± 1.014
6.726ThrThr: 6.726 ± 1.647
2.242ThrVal: 2.242 ± 1.205
1.121ThrTrp: 1.121 ± 0.602
2.242ThrTyr: 2.242 ± 1.205
0.0ThrXaa: 0.0 ± 0.0
Val
0.0ValAla: 0.0 ± 0.0
0.0ValCys: 0.0 ± 0.0
1.121ValAsp: 1.121 ± 0.602
2.242ValGlu: 2.242 ± 1.801
1.121ValPhe: 1.121 ± 0.602
0.0ValGly: 0.0 ± 0.0
1.121ValHis: 1.121 ± 2.182
1.121ValIle: 1.121 ± 0.602
6.726ValLys: 6.726 ± 1.647
2.242ValLeu: 2.242 ± 1.558
0.0ValMet: 0.0 ± 0.0
1.121ValAsn: 1.121 ± 0.602
2.242ValPro: 2.242 ± 1.558
0.0ValGln: 0.0 ± 0.0
2.242ValArg: 2.242 ± 1.205
3.363ValSer: 3.363 ± 1.807
1.121ValThr: 1.121 ± 2.042
3.363ValVal: 3.363 ± 1.807
0.0ValTrp: 0.0 ± 0.0
0.0ValTyr: 0.0 ± 0.0
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.0TrpGlu: 0.0 ± 0.0
3.363TrpPhe: 3.363 ± 1.807
3.363TrpGly: 3.363 ± 1.807
0.0TrpHis: 0.0 ± 0.0
1.121TrpIle: 1.121 ± 2.182
1.121TrpLys: 1.121 ± 2.042
1.121TrpLeu: 1.121 ± 0.602
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
3.363TrpGln: 3.363 ± 1.807
2.242TrpArg: 2.242 ± 1.205
0.0TrpSer: 0.0 ± 0.0
2.242TrpThr: 2.242 ± 1.558
1.121TrpVal: 1.121 ± 0.602
1.121TrpTrp: 1.121 ± 0.602
2.242TrpTyr: 2.242 ± 1.205
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.121TyrAla: 1.121 ± 0.602
0.0TyrCys: 0.0 ± 0.0
1.121TyrAsp: 1.121 ± 0.602
1.121TyrGlu: 1.121 ± 0.602
1.121TyrPhe: 1.121 ± 0.602
1.121TyrGly: 1.121 ± 0.602
1.121TyrHis: 1.121 ± 0.602
3.363TyrIle: 3.363 ± 1.807
3.363TyrLys: 3.363 ± 1.807
4.484TyrLeu: 4.484 ± 2.409
3.363TyrMet: 3.363 ± 0.968
3.363TyrAsn: 3.363 ± 1.807
6.726TyrPro: 6.726 ± 1.014
0.0TyrGln: 0.0 ± 0.0
3.363TyrArg: 3.363 ± 1.187
2.242TyrSer: 2.242 ± 1.801
2.242TyrThr: 2.242 ± 1.205
3.363TyrVal: 3.363 ± 1.807
1.121TyrTrp: 1.121 ± 0.602
2.242TyrTyr: 2.242 ± 1.205
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (893 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski