Amino acid dipepetide frequency for Marinococcus luteus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.888AlaAla: 8.888 ± 0.149
0.662AlaCys: 0.662 ± 0.031
4.374AlaAsp: 4.374 ± 0.075
6.942AlaGlu: 6.942 ± 0.105
3.74AlaPhe: 3.74 ± 0.069
7.543AlaGly: 7.543 ± 0.116
1.509AlaHis: 1.509 ± 0.039
4.627AlaIle: 4.627 ± 0.085
3.852AlaLys: 3.852 ± 0.076
8.145AlaLeu: 8.145 ± 0.108
2.354AlaMet: 2.354 ± 0.054
2.341AlaAsn: 2.341 ± 0.049
2.842AlaPro: 2.842 ± 0.067
2.406AlaGln: 2.406 ± 0.059
3.63AlaArg: 3.63 ± 0.063
5.346AlaSer: 5.346 ± 0.079
3.224AlaThr: 3.224 ± 0.07
7.52AlaVal: 7.52 ± 0.12
0.887AlaTrp: 0.887 ± 0.032
2.687AlaTyr: 2.687 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
0.434CysAla: 0.434 ± 0.027
0.072CysCys: 0.072 ± 0.009
0.381CysAsp: 0.381 ± 0.023
0.393CysGlu: 0.393 ± 0.024
0.298CysPhe: 0.298 ± 0.021
0.633CysGly: 0.633 ± 0.028
0.164CysHis: 0.164 ± 0.015
0.392CysIle: 0.392 ± 0.022
0.212CysLys: 0.212 ± 0.017
0.588CysLeu: 0.588 ± 0.028
0.18CysMet: 0.18 ± 0.016
0.173CysAsn: 0.173 ± 0.013
0.349CysPro: 0.349 ± 0.022
0.153CysGln: 0.153 ± 0.014
0.412CysArg: 0.412 ± 0.026
0.484CysSer: 0.484 ± 0.026
0.381CysThr: 0.381 ± 0.023
0.394CysVal: 0.394 ± 0.021
0.08CysTrp: 0.08 ± 0.01
0.212CysTyr: 0.212 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
3.815AspAla: 3.815 ± 0.067
0.304AspCys: 0.304 ± 0.021
2.556AspAsp: 2.556 ± 0.066
4.594AspGlu: 4.594 ± 0.078
2.127AspPhe: 2.127 ± 0.052
3.709AspGly: 3.709 ± 0.088
1.309AspHis: 1.309 ± 0.041
3.853AspIle: 3.853 ± 0.072
2.509AspLys: 2.509 ± 0.063
4.55AspLeu: 4.55 ± 0.085
1.618AspMet: 1.618 ± 0.044
1.816AspAsn: 1.816 ± 0.046
2.241AspPro: 2.241 ± 0.057
1.968AspGln: 1.968 ± 0.051
2.677AspArg: 2.677 ± 0.064
2.724AspSer: 2.724 ± 0.058
2.89AspThr: 2.89 ± 0.062
4.032AspVal: 4.032 ± 0.072
0.706AspTrp: 0.706 ± 0.031
2.115AspTyr: 2.115 ± 0.056
0.0AspXaa: 0.0 ± 0.0
Glu
8.188GluAla: 8.188 ± 0.109
0.375GluCys: 0.375 ± 0.022
4.685GluAsp: 4.685 ± 0.084
9.715GluGlu: 9.715 ± 0.163
2.292GluPhe: 2.292 ± 0.053
5.167GluGly: 5.167 ± 0.089
1.848GluHis: 1.848 ± 0.049
4.429GluIle: 4.429 ± 0.081
5.694GluLys: 5.694 ± 0.101
6.845GluLeu: 6.845 ± 0.104
2.446GluMet: 2.446 ± 0.056
3.879GluAsn: 3.879 ± 0.08
2.59GluPro: 2.59 ± 0.058
4.37GluGln: 4.37 ± 0.082
4.594GluArg: 4.594 ± 0.078
4.074GluSer: 4.074 ± 0.079
4.817GluThr: 4.817 ± 0.087
5.098GluVal: 5.098 ± 0.09
1.233GluTrp: 1.233 ± 0.039
2.306GluTyr: 2.306 ± 0.055
0.0GluXaa: 0.0 ± 0.0
Phe
3.13PheAla: 3.13 ± 0.069
0.311PheCys: 0.311 ± 0.02
2.186PheAsp: 2.186 ± 0.05
2.844PheGlu: 2.844 ± 0.055
2.218PhePhe: 2.218 ± 0.071
3.403PheGly: 3.403 ± 0.072
1.041PheHis: 1.041 ± 0.037
3.137PheIle: 3.137 ± 0.075
1.449PheLys: 1.449 ± 0.044
4.138PheLeu: 4.138 ± 0.088
1.175PheMet: 1.175 ± 0.037
1.413PheAsn: 1.413 ± 0.047
1.713PhePro: 1.713 ± 0.045
1.732PheGln: 1.732 ± 0.047
1.849PheArg: 1.849 ± 0.044
3.034PheSer: 3.034 ± 0.067
2.541PheThr: 2.541 ± 0.063
2.975PheVal: 2.975 ± 0.07
0.472PheTrp: 0.472 ± 0.025
1.531PheTyr: 1.531 ± 0.047
0.0PheXaa: 0.0 ± 0.0
Gly
6.183GlyAla: 6.183 ± 0.114
0.551GlyCys: 0.551 ± 0.026
3.441GlyAsp: 3.441 ± 0.069
5.479GlyGlu: 5.479 ± 0.085
3.35GlyPhe: 3.35 ± 0.073
5.682GlyGly: 5.682 ± 0.11
1.556GlyHis: 1.556 ± 0.049
5.377GlyIle: 5.377 ± 0.096
3.988GlyLys: 3.988 ± 0.079
6.733GlyLeu: 6.733 ± 0.104
2.429GlyMet: 2.429 ± 0.065
2.404GlyAsn: 2.404 ± 0.054
2.214GlyPro: 2.214 ± 0.052
2.163GlyGln: 2.163 ± 0.049
3.728GlyArg: 3.728 ± 0.076
4.848GlySer: 4.848 ± 0.08
4.347GlyThr: 4.347 ± 0.073
5.503GlyVal: 5.503 ± 0.092
0.996GlyTrp: 0.996 ± 0.037
2.633GlyTyr: 2.633 ± 0.057
0.0GlyXaa: 0.0 ± 0.0
His
1.734HisAla: 1.734 ± 0.052
0.166HisCys: 0.166 ± 0.013
1.047HisAsp: 1.047 ± 0.036
1.643HisGlu: 1.643 ± 0.043
0.992HisPhe: 0.992 ± 0.035
1.689HisGly: 1.689 ± 0.043
0.661HisHis: 0.661 ± 0.028
1.461HisIle: 1.461 ± 0.045
0.867HisLys: 0.867 ± 0.033
2.172HisLeu: 2.172 ± 0.056
0.617HisMet: 0.617 ± 0.028
0.671HisAsn: 0.671 ± 0.031
1.284HisPro: 1.284 ± 0.042
0.997HisGln: 0.997 ± 0.035
1.172HisArg: 1.172 ± 0.036
1.268HisSer: 1.268 ± 0.044
1.233HisThr: 1.233 ± 0.04
1.721HisVal: 1.721 ± 0.051
0.312HisTrp: 0.312 ± 0.02
0.894HisTyr: 0.894 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
5.707IleAla: 5.707 ± 0.088
0.501IleCys: 0.501 ± 0.026
3.807IleAsp: 3.807 ± 0.065
4.88IleGlu: 4.88 ± 0.101
2.702IlePhe: 2.702 ± 0.067
5.344IleGly: 5.344 ± 0.095
1.574IleHis: 1.574 ± 0.045
4.31IleIle: 4.31 ± 0.083
2.592IleLys: 2.592 ± 0.063
5.199IleLeu: 5.199 ± 0.09
1.548IleMet: 1.548 ± 0.043
2.393IleAsn: 2.393 ± 0.06
2.862IlePro: 2.862 ± 0.06
2.609IleGln: 2.609 ± 0.049
2.963IleArg: 2.963 ± 0.064
3.931IleSer: 3.931 ± 0.072
3.744IleThr: 3.744 ± 0.067
4.827IleVal: 4.827 ± 0.08
0.639IleTrp: 0.639 ± 0.03
1.949IleTyr: 1.949 ± 0.049
0.0IleXaa: 0.0 ± 0.0
Lys
4.325LysAla: 4.325 ± 0.078
0.203LysCys: 0.203 ± 0.015
2.992LysAsp: 2.992 ± 0.066
5.694LysGlu: 5.694 ± 0.088
1.24LysPhe: 1.24 ± 0.038
3.295LysGly: 3.295 ± 0.069
1.248LysHis: 1.248 ± 0.041
2.802LysIle: 2.802 ± 0.07
4.175LysLys: 4.175 ± 0.1
3.829LysLeu: 3.829 ± 0.068
1.614LysMet: 1.614 ± 0.049
2.423LysAsn: 2.423 ± 0.065
1.854LysPro: 1.854 ± 0.047
2.825LysGln: 2.825 ± 0.061
2.976LysArg: 2.976 ± 0.072
2.551LysSer: 2.551 ± 0.057
2.957LysThr: 2.957 ± 0.071
3.258LysVal: 3.258 ± 0.085
0.63LysTrp: 0.63 ± 0.033
1.669LysTyr: 1.669 ± 0.046
0.0LysXaa: 0.0 ± 0.0
Leu
7.523LeuAla: 7.523 ± 0.114
0.54LeuCys: 0.54 ± 0.026
4.474LeuAsp: 4.474 ± 0.083
7.277LeuGlu: 7.277 ± 0.115
4.431LeuPhe: 4.431 ± 0.103
6.525LeuGly: 6.525 ± 0.095
2.222LeuHis: 2.222 ± 0.058
5.731LeuIle: 5.731 ± 0.103
4.606LeuLys: 4.606 ± 0.079
9.52LeuLeu: 9.52 ± 0.157
2.47LeuMet: 2.47 ± 0.053
3.325LeuAsn: 3.325 ± 0.068
4.355LeuPro: 4.355 ± 0.074
4.054LeuGln: 4.054 ± 0.064
4.205LeuArg: 4.205 ± 0.081
5.934LeuSer: 5.934 ± 0.093
5.192LeuThr: 5.192 ± 0.079
5.788LeuVal: 5.788 ± 0.091
0.912LeuTrp: 0.912 ± 0.037
2.973LeuTyr: 2.973 ± 0.065
0.0LeuXaa: 0.0 ± 0.0
Met
2.4MetAla: 2.4 ± 0.057
0.139MetCys: 0.139 ± 0.013
1.62MetAsp: 1.62 ± 0.046
2.388MetGlu: 2.388 ± 0.062
1.074MetPhe: 1.074 ± 0.037
1.808MetGly: 1.808 ± 0.049
0.679MetHis: 0.679 ± 0.031
1.909MetIle: 1.909 ± 0.043
2.179MetLys: 2.179 ± 0.054
2.692MetLeu: 2.692 ± 0.058
0.881MetMet: 0.881 ± 0.035
1.614MetAsn: 1.614 ± 0.047
1.18MetPro: 1.18 ± 0.042
1.318MetGln: 1.318 ± 0.039
1.142MetArg: 1.142 ± 0.033
1.668MetSer: 1.668 ± 0.043
1.657MetThr: 1.657 ± 0.046
1.752MetVal: 1.752 ± 0.041
0.199MetTrp: 0.199 ± 0.017
0.832MetTyr: 0.832 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
2.802AsnAla: 2.802 ± 0.06
0.224AsnCys: 0.224 ± 0.018
2.095AsnAsp: 2.095 ± 0.055
3.346AsnGlu: 3.346 ± 0.072
1.301AsnPhe: 1.301 ± 0.042
2.886AsnGly: 2.886 ± 0.057
0.881AsnHis: 0.881 ± 0.032
2.743AsnIle: 2.743 ± 0.057
2.042AsnLys: 2.042 ± 0.053
2.723AsnLeu: 2.723 ± 0.059
1.124AsnMet: 1.124 ± 0.037
1.672AsnAsn: 1.672 ± 0.051
1.737AsnPro: 1.737 ± 0.048
1.462AsnGln: 1.462 ± 0.046
1.847AsnArg: 1.847 ± 0.045
1.858AsnSer: 1.858 ± 0.056
2.08AsnThr: 2.08 ± 0.054
2.718AsnVal: 2.718 ± 0.062
0.433AsnTrp: 0.433 ± 0.024
1.218AsnTyr: 1.218 ± 0.043
0.0AsnXaa: 0.0 ± 0.0
Pro
3.43ProAla: 3.43 ± 0.079
0.218ProCys: 0.218 ± 0.018
2.513ProAsp: 2.513 ± 0.06
4.245ProGlu: 4.245 ± 0.077
1.921ProPhe: 1.921 ± 0.047
3.129ProGly: 3.129 ± 0.061
0.836ProHis: 0.836 ± 0.035
2.084ProIle: 2.084 ± 0.053
1.852ProLys: 1.852 ± 0.052
3.702ProLeu: 3.702 ± 0.074
0.951ProMet: 0.951 ± 0.033
1.226ProAsn: 1.226 ± 0.043
1.217ProPro: 1.217 ± 0.046
1.104ProGln: 1.104 ± 0.033
1.287ProArg: 1.287 ± 0.035
2.521ProSer: 2.521 ± 0.054
1.69ProThr: 1.69 ± 0.049
3.657ProVal: 3.657 ± 0.057
0.469ProTrp: 0.469 ± 0.025
1.432ProTyr: 1.432 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
3.573GlnAla: 3.573 ± 0.073
0.182GlnCys: 0.182 ± 0.015
1.65GlnAsp: 1.65 ± 0.045
3.671GlnGlu: 3.671 ± 0.07
1.479GlnPhe: 1.479 ± 0.041
2.394GlnGly: 2.394 ± 0.052
0.818GlnHis: 0.818 ± 0.03
2.062GlnIle: 2.062 ± 0.058
2.47GlnLys: 2.47 ± 0.064
3.931GlnLeu: 3.931 ± 0.063
1.335GlnMet: 1.335 ± 0.042
1.516GlnAsn: 1.516 ± 0.046
1.41GlnPro: 1.41 ± 0.042
2.202GlnGln: 2.202 ± 0.062
1.951GlnArg: 1.951 ± 0.051
2.192GlnSer: 2.192 ± 0.054
2.37GlnThr: 2.37 ± 0.049
2.531GlnVal: 2.531 ± 0.063
0.567GlnTrp: 0.567 ± 0.028
1.23GlnTyr: 1.23 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
3.432ArgAla: 3.432 ± 0.065
0.262ArgCys: 0.262 ± 0.02
2.277ArgAsp: 2.277 ± 0.048
4.169ArgGlu: 4.169 ± 0.069
2.126ArgPhe: 2.126 ± 0.05
2.831ArgGly: 2.831 ± 0.061
1.106ArgHis: 1.106 ± 0.034
3.046ArgIle: 3.046 ± 0.055
2.912ArgLys: 2.912 ± 0.06
4.856ArgLeu: 4.856 ± 0.092
1.543ArgMet: 1.543 ± 0.041
1.659ArgAsn: 1.659 ± 0.043
1.928ArgPro: 1.928 ± 0.047
2.112ArgGln: 2.112 ± 0.045
2.858ArgArg: 2.858 ± 0.072
2.795ArgSer: 2.795 ± 0.057
2.662ArgThr: 2.662 ± 0.047
3.161ArgVal: 3.161 ± 0.072
0.629ArgTrp: 0.629 ± 0.029
1.703ArgTyr: 1.703 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
4.626SerAla: 4.626 ± 0.078
0.362SerCys: 0.362 ± 0.021
2.933SerAsp: 2.933 ± 0.06
4.285SerGlu: 4.285 ± 0.086
3.147SerPhe: 3.147 ± 0.066
5.13SerGly: 5.13 ± 0.088
1.177SerHis: 1.177 ± 0.039
4.251SerIle: 4.251 ± 0.075
2.658SerLys: 2.658 ± 0.058
5.717SerLeu: 5.717 ± 0.094
1.929SerMet: 1.929 ± 0.047
2.005SerAsn: 2.005 ± 0.054
2.308SerPro: 2.308 ± 0.057
1.712SerGln: 1.712 ± 0.046
3.027SerArg: 3.027 ± 0.068
4.558SerSer: 4.558 ± 0.112
3.207SerThr: 3.207 ± 0.064
4.354SerVal: 4.354 ± 0.071
0.748SerTrp: 0.748 ± 0.033
2.204SerTyr: 2.204 ± 0.054
0.0SerXaa: 0.0 ± 0.0
Thr
5.097ThrAla: 5.097 ± 0.091
0.347ThrCys: 0.347 ± 0.021
2.862ThrAsp: 2.862 ± 0.058
4.114ThrGlu: 4.114 ± 0.076
2.47ThrPhe: 2.47 ± 0.057
4.738ThrGly: 4.738 ± 0.087
1.065ThrHis: 1.065 ± 0.032
3.86ThrIle: 3.86 ± 0.068
2.596ThrLys: 2.596 ± 0.058
5.138ThrLeu: 5.138 ± 0.085
1.505ThrMet: 1.505 ± 0.043
2.056ThrAsn: 2.056 ± 0.054
2.414ThrPro: 2.414 ± 0.055
1.48ThrGln: 1.48 ± 0.043
2.091ThrArg: 2.091 ± 0.052
3.292ThrSer: 3.292 ± 0.059
2.82ThrThr: 2.82 ± 0.059
4.373ThrVal: 4.373 ± 0.073
0.598ThrTrp: 0.598 ± 0.029
1.91ThrTyr: 1.91 ± 0.052
0.0ThrXaa: 0.0 ± 0.0
Val
5.007ValAla: 5.007 ± 0.097
0.615ValCys: 0.615 ± 0.029
3.756ValAsp: 3.756 ± 0.07
5.401ValGlu: 5.401 ± 0.09
3.201ValPhe: 3.201 ± 0.063
4.471ValGly: 4.471 ± 0.092
1.778ValHis: 1.778 ± 0.043
5.095ValIle: 5.095 ± 0.088
3.576ValLys: 3.576 ± 0.081
7.255ValLeu: 7.255 ± 0.102
2.025ValMet: 2.025 ± 0.048
2.749ValAsn: 2.749 ± 0.063
3.245ValPro: 3.245 ± 0.058
2.921ValGln: 2.921 ± 0.063
3.327ValArg: 3.327 ± 0.059
4.709ValSer: 4.709 ± 0.071
4.41ValThr: 4.41 ± 0.068
5.207ValVal: 5.207 ± 0.093
0.766ValTrp: 0.766 ± 0.034
2.464ValTyr: 2.464 ± 0.055
0.0ValXaa: 0.0 ± 0.0
Trp
0.758TrpAla: 0.758 ± 0.027
0.088TrpCys: 0.088 ± 0.01
0.538TrpAsp: 0.538 ± 0.026
0.919TrpGlu: 0.919 ± 0.033
0.55TrpPhe: 0.55 ± 0.028
0.691TrpGly: 0.691 ± 0.028
0.256TrpHis: 0.256 ± 0.016
0.811TrpIle: 0.811 ± 0.032
0.891TrpLys: 0.891 ± 0.033
1.271TrpLeu: 1.271 ± 0.04
0.433TrpMet: 0.433 ± 0.02
0.592TrpAsn: 0.592 ± 0.031
0.37TrpPro: 0.37 ± 0.021
0.516TrpGln: 0.516 ± 0.028
0.491TrpArg: 0.491 ± 0.028
0.662TrpSer: 0.662 ± 0.031
0.68TrpThr: 0.68 ± 0.031
0.744TrpVal: 0.744 ± 0.033
0.189TrpTrp: 0.189 ± 0.015
0.402TrpTyr: 0.402 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.464TyrAla: 2.464 ± 0.059
0.264TyrCys: 0.264 ± 0.021
1.928TyrAsp: 1.928 ± 0.054
2.648TyrGlu: 2.648 ± 0.051
1.634TyrPhe: 1.634 ± 0.05
2.534TyrGly: 2.534 ± 0.062
0.874TyrHis: 0.874 ± 0.035
2.101TyrIle: 2.101 ± 0.053
1.441TyrLys: 1.441 ± 0.046
3.053TyrLeu: 3.053 ± 0.063
0.952TyrMet: 0.952 ± 0.034
1.265TyrAsn: 1.265 ± 0.043
1.371TyrPro: 1.371 ± 0.036
1.432TyrGln: 1.432 ± 0.044
1.84TyrArg: 1.84 ± 0.053
1.887TyrSer: 1.887 ± 0.048
1.924TyrThr: 1.924 ± 0.046
2.364TyrVal: 2.364 ± 0.053
0.389TyrTrp: 0.389 ± 0.022
1.375TyrTyr: 1.375 ± 0.045
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2897 proteins (842470 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski