Amino acid dipepetide frequency for Pseudomonas sp. S-6-2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.969AlaAla: 11.969 ± 0.134	1.206AlaCys: 1.206 ± 0.032	5.959AlaAsp: 5.959 ± 0.073	7.729AlaGlu: 7.729 ± 0.093	3.459AlaPhe: 3.459 ± 0.053	9.299AlaGly: 9.299 ± 0.128	2.092AlaHis: 2.092 ± 0.041	5.07AlaIle: 5.07 ± 0.069	2.913AlaLys: 2.913 ± 0.062	13.801AlaLeu: 13.801 ± 0.127	2.969AlaMet: 2.969 ± 0.054	3.03AlaAsn: 3.03 ± 0.061	4.208AlaPro: 4.208 ± 0.067	4.91AlaGln: 4.91 ± 0.076	7.237AlaArg: 7.237 ± 0.085	6.045AlaSer: 6.045 ± 0.079	4.441AlaThr: 4.441 ± 0.061	7.315AlaVal: 7.315 ± 0.08	1.614AlaTrp: 1.614 ± 0.045	2.307AlaTyr: 2.307 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	1.041CysAla: 1.041 ± 0.032	0.154CysCys: 0.154 ± 0.012	0.531CysAsp: 0.531 ± 0.021	0.569CysGlu: 0.569 ± 0.026	0.333CysPhe: 0.333 ± 0.016	0.925CysGly: 0.925 ± 0.027	0.288CysHis: 0.288 ± 0.017	0.468CysIle: 0.468 ± 0.018	0.255CysLys: 0.255 ± 0.016	1.167CysLeu: 1.167 ± 0.031	0.222CysMet: 0.222 ± 0.013	0.282CysAsn: 0.282 ± 0.014	0.529CysPro: 0.529 ± 0.021	0.511CysGln: 0.511 ± 0.021	0.691CysArg: 0.691 ± 0.026	0.584CysSer: 0.584 ± 0.022	0.43CysThr: 0.43 ± 0.017	0.594CysVal: 0.594 ± 0.023	0.176CysTrp: 0.176 ± 0.012	0.243CysTyr: 0.243 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	5.201AspAla: 5.201 ± 0.066	0.576AspCys: 0.576 ± 0.024	2.997AspAsp: 2.997 ± 0.059	3.51AspGlu: 3.51 ± 0.061	1.953AspPhe: 1.953 ± 0.044	4.275AspGly: 4.275 ± 0.065	1.11AspHis: 1.11 ± 0.033	2.944AspIle: 2.944 ± 0.052	1.709AspLys: 1.709 ± 0.05	5.936AspLeu: 5.936 ± 0.073	1.336AspMet: 1.336 ± 0.037	1.856AspAsn: 1.856 ± 0.053	2.95AspPro: 2.95 ± 0.05	2.718AspGln: 2.718 ± 0.048	3.032AspArg: 3.032 ± 0.057	3.249AspSer: 3.249 ± 0.051	2.389AspThr: 2.389 ± 0.046	3.336AspVal: 3.336 ± 0.061	1.086AspTrp: 1.086 ± 0.033	1.823AspTyr: 1.823 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	6.76GluAla: 6.76 ± 0.093	0.437GluCys: 0.437 ± 0.021	2.704GluAsp: 2.704 ± 0.053	3.061GluGlu: 3.061 ± 0.068	1.871GluPhe: 1.871 ± 0.046	3.923GluGly: 3.923 ± 0.065	1.795GluHis: 1.795 ± 0.042	2.803GluIle: 2.803 ± 0.051	1.733GluLys: 1.733 ± 0.05	7.858GluLeu: 7.858 ± 0.086	1.311GluMet: 1.311 ± 0.033	1.393GluAsn: 1.393 ± 0.04	2.862GluPro: 2.862 ± 0.051	4.754GluGln: 4.754 ± 0.072	5.509GluArg: 5.509 ± 0.075	2.794GluSer: 2.794 ± 0.053	2.603GluThr: 2.603 ± 0.045	4.363GluVal: 4.363 ± 0.063	0.75GluTrp: 0.75 ± 0.025	1.28GluTyr: 1.28 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.733PheAla: 3.733 ± 0.07	0.418PheCys: 0.418 ± 0.02	2.281PheAsp: 2.281 ± 0.045	2.09PheGlu: 2.09 ± 0.045	1.405PhePhe: 1.405 ± 0.043	2.999PheGly: 2.999 ± 0.064	0.737PheHis: 0.737 ± 0.025	1.911PheIle: 1.911 ± 0.043	1.132PheLys: 1.132 ± 0.035	3.121PheLeu: 3.121 ± 0.059	0.922PheMet: 0.922 ± 0.026	1.417PheAsn: 1.417 ± 0.039	1.375PhePro: 1.375 ± 0.039	1.224PheGln: 1.224 ± 0.029	1.921PheArg: 1.921 ± 0.04	2.434PheSer: 2.434 ± 0.052	1.813PheThr: 1.813 ± 0.039	2.389PheVal: 2.389 ± 0.046	0.511PheTrp: 0.511 ± 0.024	1.053PheTyr: 1.053 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	6.956GlyAla: 6.956 ± 0.099	0.975GlyCys: 0.975 ± 0.029	3.854GlyAsp: 3.854 ± 0.065	4.703GlyGlu: 4.703 ± 0.059	3.241GlyPhe: 3.241 ± 0.053	5.949GlyGly: 5.949 ± 0.136	1.869GlyHis: 1.869 ± 0.038	4.232GlyIle: 4.232 ± 0.069	2.925GlyLys: 2.925 ± 0.058	9.649GlyLeu: 9.649 ± 0.107	2.349GlyMet: 2.349 ± 0.049	2.564GlyAsn: 2.564 ± 0.069	2.739GlyPro: 2.739 ± 0.05	4.191GlyGln: 4.191 ± 0.068	5.262GlyArg: 5.262 ± 0.072	4.511GlySer: 4.511 ± 0.092	3.459GlyThr: 3.459 ± 0.066	5.916GlyVal: 5.916 ± 0.08	1.462GlyTrp: 1.462 ± 0.035	2.501GlyTyr: 2.501 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.151HisAla: 2.151 ± 0.046	0.371HisCys: 0.371 ± 0.018	1.22HisAsp: 1.22 ± 0.036	1.233HisGlu: 1.233 ± 0.029	0.975HisPhe: 0.975 ± 0.029	1.965HisGly: 1.965 ± 0.043	0.646HisHis: 0.646 ± 0.023	1.076HisIle: 1.076 ± 0.03	0.637HisLys: 0.637 ± 0.023	2.508HisLeu: 2.508 ± 0.049	0.528HisMet: 0.528 ± 0.021	0.698HisAsn: 0.698 ± 0.023	1.49HisPro: 1.49 ± 0.037	1.151HisGln: 1.151 ± 0.037	1.354HisArg: 1.354 ± 0.034	1.323HisSer: 1.323 ± 0.033	0.98HisThr: 0.98 ± 0.026	1.267HisVal: 1.267 ± 0.033	0.485HisTrp: 0.485 ± 0.019	0.832HisTyr: 0.832 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.589IleAla: 5.589 ± 0.073	0.457IleCys: 0.457 ± 0.02	3.453IleAsp: 3.453 ± 0.061	3.616IleGlu: 3.616 ± 0.055	1.411IlePhe: 1.411 ± 0.038	4.362IleGly: 4.362 ± 0.072	1.046IleHis: 1.046 ± 0.03	2.267IleIle: 2.267 ± 0.054	1.582IleLys: 1.582 ± 0.042	4.259IleLeu: 4.259 ± 0.069	0.936IleMet: 0.936 ± 0.03	1.949IleAsn: 1.949 ± 0.046	2.309IlePro: 2.309 ± 0.047	1.79IleGln: 1.79 ± 0.038	3.174IleArg: 3.174 ± 0.049	3.128IleSer: 3.128 ± 0.058	2.565IleThr: 2.565 ± 0.049	3.003IleVal: 3.003 ± 0.047	0.535IleTrp: 0.535 ± 0.021	1.107IleTyr: 1.107 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.593LysAla: 3.593 ± 0.082	0.171LysCys: 0.171 ± 0.013	1.517LysAsp: 1.517 ± 0.042	1.391LysGlu: 1.391 ± 0.042	0.727LysPhe: 0.727 ± 0.028	2.239LysGly: 2.239 ± 0.046	0.678LysHis: 0.678 ± 0.027	1.293LysIle: 1.293 ± 0.041	1.01LysLys: 1.01 ± 0.038	3.238LysLeu: 3.238 ± 0.063	0.599LysMet: 0.599 ± 0.026	0.788LysAsn: 0.788 ± 0.029	1.853LysPro: 1.853 ± 0.044	1.437LysGln: 1.437 ± 0.038	2.233LysArg: 2.233 ± 0.044	1.467LysSer: 1.467 ± 0.042	1.553LysThr: 1.553 ± 0.032	2.368LysVal: 2.368 ± 0.054	0.281LysTrp: 0.281 ± 0.015	0.587LysTyr: 0.587 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	14.446LeuAla: 14.446 ± 0.137	1.246LeuCys: 1.246 ± 0.035	6.888LeuAsp: 6.888 ± 0.088	7.34LeuGlu: 7.34 ± 0.088	4.065LeuPhe: 4.065 ± 0.069	9.396LeuGly: 9.396 ± 0.095	2.518LeuHis: 2.518 ± 0.051	5.782LeuIle: 5.782 ± 0.073	3.792LeuLys: 3.792 ± 0.067	14.082LeuLeu: 14.082 ± 0.174	2.727LeuMet: 2.727 ± 0.049	3.785LeuAsn: 3.785 ± 0.069	6.306LeuPro: 6.306 ± 0.085	4.893LeuGln: 4.893 ± 0.08	7.775LeuArg: 7.775 ± 0.092	7.291LeuSer: 7.291 ± 0.103	5.644LeuThr: 5.644 ± 0.08	8.183LeuVal: 8.183 ± 0.101	1.555LeuTrp: 1.555 ± 0.047	2.583LeuTyr: 2.583 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.837MetAla: 2.837 ± 0.044	0.166MetCys: 0.166 ± 0.01	1.118MetAsp: 1.118 ± 0.033	1.001MetGlu: 1.001 ± 0.025	0.65MetPhe: 0.65 ± 0.025	1.766MetGly: 1.766 ± 0.045	0.539MetHis: 0.539 ± 0.024	1.209MetIle: 1.209 ± 0.041	0.78MetLys: 0.78 ± 0.028	2.899MetLeu: 2.899 ± 0.045	0.521MetMet: 0.521 ± 0.019	0.804MetAsn: 0.804 ± 0.026	1.42MetPro: 1.42 ± 0.035	1.196MetGln: 1.196 ± 0.032	1.546MetArg: 1.546 ± 0.038	1.684MetSer: 1.684 ± 0.033	1.471MetThr: 1.471 ± 0.035	1.611MetVal: 1.611 ± 0.04	0.168MetTrp: 0.168 ± 0.011	0.398MetTyr: 0.398 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.078AsnAla: 3.078 ± 0.063	0.283AsnCys: 0.283 ± 0.016	1.535AsnAsp: 1.535 ± 0.039	1.529AsnGlu: 1.529 ± 0.034	1.01AsnPhe: 1.01 ± 0.032	2.445AsnGly: 2.445 ± 0.053	0.694AsnHis: 0.694 ± 0.022	1.45AsnIle: 1.45 ± 0.041	0.845AsnLys: 0.845 ± 0.028	3.512AsnLeu: 3.512 ± 0.067	0.649AsnMet: 0.649 ± 0.023	1.021AsnAsn: 1.021 ± 0.04	2.106AsnPro: 2.106 ± 0.045	1.536AsnGln: 1.536 ± 0.043	2.054AsnArg: 2.054 ± 0.05	1.719AsnSer: 1.719 ± 0.045	1.55AsnThr: 1.55 ± 0.036	1.84AsnVal: 1.84 ± 0.042	0.46AsnTrp: 0.46 ± 0.02	0.815AsnTyr: 0.815 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	5.59ProAla: 5.59 ± 0.069	0.389ProCys: 0.389 ± 0.016	3.044ProAsp: 3.044 ± 0.051	3.838ProGlu: 3.838 ± 0.067	1.702ProPhe: 1.702 ± 0.037	4.421ProGly: 4.421 ± 0.072	0.977ProHis: 0.977 ± 0.03	1.933ProIle: 1.933 ± 0.039	1.283ProLys: 1.283 ± 0.032	5.723ProLeu: 5.723 ± 0.077	1.112ProMet: 1.112 ± 0.032	1.308ProAsn: 1.308 ± 0.035	1.963ProPro: 1.963 ± 0.05	2.193ProGln: 2.193 ± 0.044	2.573ProArg: 2.573 ± 0.049	2.461ProSer: 2.461 ± 0.043	2.0ProThr: 2.0 ± 0.046	4.085ProVal: 4.085 ± 0.064	0.753ProTrp: 0.753 ± 0.026	1.142ProTyr: 1.142 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	6.898GlnAla: 6.898 ± 0.085	0.389GlnCys: 0.389 ± 0.017	1.94GlnAsp: 1.94 ± 0.04	2.16GlnGlu: 2.16 ± 0.045	1.483GlnPhe: 1.483 ± 0.033	3.776GlnGly: 3.776 ± 0.067	1.324GlnHis: 1.324 ± 0.037	2.211GlnIle: 2.211 ± 0.044	0.97GlnLys: 0.97 ± 0.031	6.098GlnLeu: 6.098 ± 0.098	1.035GlnMet: 1.035 ± 0.031	1.017GlnAsn: 1.017 ± 0.033	2.894GlnPro: 2.894 ± 0.055	3.338GlnGln: 3.338 ± 0.079	4.423GlnArg: 4.423 ± 0.073	2.358GlnSer: 2.358 ± 0.047	2.048GlnThr: 2.048 ± 0.046	3.955GlnVal: 3.955 ± 0.057	0.729GlnTrp: 0.729 ± 0.029	1.003GlnTyr: 1.003 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	6.172ArgAla: 6.172 ± 0.071	0.604ArgCys: 0.604 ± 0.025	3.657ArgAsp: 3.657 ± 0.056	4.556ArgGlu: 4.556 ± 0.067	2.869ArgPhe: 2.869 ± 0.054	4.033ArgGly: 4.033 ± 0.06	1.871ArgHis: 1.871 ± 0.045	3.682ArgIle: 3.682 ± 0.056	1.939ArgLys: 1.939 ± 0.046	9.092ArgLeu: 9.092 ± 0.106	1.662ArgMet: 1.662 ± 0.036	1.989ArgAsn: 1.989 ± 0.037	2.807ArgPro: 2.807 ± 0.046	4.261ArgGln: 4.261 ± 0.072	4.719ArgArg: 4.719 ± 0.074	3.593ArgSer: 3.593 ± 0.065	2.69ArgThr: 2.69 ± 0.052	4.612ArgVal: 4.612 ± 0.065	1.163ArgTrp: 1.163 ± 0.032	2.195ArgTyr: 2.195 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.977SerAla: 5.977 ± 0.074	0.502SerCys: 0.502 ± 0.022	2.98SerAsp: 2.98 ± 0.05	3.316SerGlu: 3.316 ± 0.055	2.165SerPhe: 2.165 ± 0.047	5.31SerGly: 5.31 ± 0.095	1.293SerHis: 1.293 ± 0.034	2.705SerIle: 2.705 ± 0.049	1.505SerLys: 1.505 ± 0.043	7.149SerLeu: 7.149 ± 0.091	1.379SerMet: 1.379 ± 0.032	1.705SerAsn: 1.705 ± 0.043	2.641SerPro: 2.641 ± 0.044	2.729SerGln: 2.729 ± 0.061	3.762SerArg: 3.762 ± 0.063	3.451SerSer: 3.451 ± 0.059	2.607SerThr: 2.607 ± 0.052	3.725SerVal: 3.725 ± 0.057	0.842SerTrp: 0.842 ± 0.027	1.489SerTyr: 1.489 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	4.624ThrAla: 4.624 ± 0.069	0.452ThrCys: 0.452 ± 0.02	2.416ThrAsp: 2.416 ± 0.048	2.477ThrGlu: 2.477 ± 0.047	1.553ThrPhe: 1.553 ± 0.042	4.257ThrGly: 4.257 ± 0.076	0.982ThrHis: 0.982 ± 0.025	1.926ThrIle: 1.926 ± 0.041	0.912ThrLys: 0.912 ± 0.033	6.592ThrLeu: 6.592 ± 0.083	0.836ThrMet: 0.836 ± 0.024	1.2ThrAsn: 1.2 ± 0.033	2.8ThrPro: 2.8 ± 0.049	1.988ThrGln: 1.988 ± 0.039	3.115ThrArg: 3.115 ± 0.054	2.57ThrSer: 2.57 ± 0.052	2.256ThrThr: 2.256 ± 0.051	3.12ThrVal: 3.12 ± 0.062	0.619ThrTrp: 0.619 ± 0.021	1.06ThrTyr: 1.06 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	7.331ValAla: 7.331 ± 0.098	0.719ValCys: 0.719 ± 0.027	3.895ValAsp: 3.895 ± 0.061	4.58ValGlu: 4.58 ± 0.068	2.512ValPhe: 2.512 ± 0.045	5.032ValGly: 5.032 ± 0.08	1.422ValHis: 1.422 ± 0.034	3.929ValIle: 3.929 ± 0.055	2.096ValLys: 2.096 ± 0.048	8.096ValLeu: 8.096 ± 0.093	1.849ValMet: 1.849 ± 0.041	2.233ValAsn: 2.233 ± 0.049	3.184ValPro: 3.184 ± 0.054	2.591ValGln: 2.591 ± 0.045	4.479ValArg: 4.479 ± 0.066	4.327ValSer: 4.327 ± 0.058	3.482ValThr: 3.482 ± 0.06	5.424ValVal: 5.424 ± 0.075	0.848ValTrp: 0.848 ± 0.03	1.536ValTyr: 1.536 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.147TrpAla: 1.147 ± 0.034	0.164TrpCys: 0.164 ± 0.012	0.659TrpAsp: 0.659 ± 0.023	0.674TrpGlu: 0.674 ± 0.022	0.56TrpPhe: 0.56 ± 0.024	0.921TrpGly: 0.921 ± 0.032	0.41TrpHis: 0.41 ± 0.02	0.638TrpIle: 0.638 ± 0.026	0.357TrpLys: 0.357 ± 0.014	2.445TrpLeu: 2.445 ± 0.054	0.358TrpMet: 0.358 ± 0.017	0.379TrpAsn: 0.379 ± 0.017	0.728TrpPro: 0.728 ± 0.027	1.127TrpGln: 1.127 ± 0.037	1.187TrpArg: 1.187 ± 0.036	0.768TrpSer: 0.768 ± 0.028	0.622TrpThr: 0.622 ± 0.024	0.98TrpVal: 0.98 ± 0.03	0.246TrpTrp: 0.246 ± 0.014	0.354TrpTyr: 0.354 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.481TyrAla: 2.481 ± 0.046	0.31TyrCys: 0.31 ± 0.016	1.339TyrAsp: 1.339 ± 0.039	1.191TyrGlu: 1.191 ± 0.03	0.943TyrPhe: 0.943 ± 0.028	2.013TyrGly: 2.013 ± 0.042	0.596TyrHis: 0.596 ± 0.021	1.01TyrIle: 1.01 ± 0.031	0.652TyrLys: 0.652 ± 0.021	3.073TyrLeu: 3.073 ± 0.05	0.485TyrMet: 0.485 ± 0.019	0.713TyrAsn: 0.713 ± 0.026	1.326TyrPro: 1.326 ± 0.036	1.51TyrGln: 1.51 ± 0.038	2.12TyrArg: 2.12 ± 0.047	1.475TyrSer: 1.475 ± 0.032	1.152TyrThr: 1.152 ± 0.031	1.477TyrVal: 1.477 ± 0.034	0.442TyrTrp: 0.442 ± 0.02	0.738TyrTyr: 0.738 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3645 proteins (1217832 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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