Amino acid dipepetide frequency for Gordonia phage Marteena

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.699AlaAla: 16.699 ± 1.702
0.616AlaCys: 0.616 ± 0.206
8.072AlaAsp: 8.072 ± 0.601
7.764AlaGlu: 7.764 ± 0.715
3.266AlaPhe: 3.266 ± 0.635
10.352AlaGly: 10.352 ± 0.903
2.834AlaHis: 2.834 ± 0.478
4.868AlaIle: 4.868 ± 0.636
4.19AlaLys: 4.19 ± 0.457
8.503AlaLeu: 8.503 ± 0.748
3.944AlaMet: 3.944 ± 0.629
3.574AlaAsn: 3.574 ± 0.718
4.991AlaPro: 4.991 ± 0.539
4.621AlaGln: 4.621 ± 0.828
8.257AlaArg: 8.257 ± 0.791
7.394AlaSer: 7.394 ± 0.701
7.702AlaThr: 7.702 ± 0.687
7.148AlaVal: 7.148 ± 0.635
2.341AlaTrp: 2.341 ± 0.266
1.849AlaTyr: 1.849 ± 0.344
0.0AlaXaa: 0.0 ± 0.0
Cys
1.109CysAla: 1.109 ± 0.297
0.062CysCys: 0.062 ± 0.058
0.678CysAsp: 0.678 ± 0.283
0.555CysGlu: 0.555 ± 0.197
0.123CysPhe: 0.123 ± 0.092
1.232CysGly: 1.232 ± 0.341
0.185CysHis: 0.185 ± 0.117
0.246CysIle: 0.246 ± 0.124
0.308CysLys: 0.308 ± 0.15
0.308CysLeu: 0.308 ± 0.131
0.185CysMet: 0.185 ± 0.104
0.37CysAsn: 0.37 ± 0.148
0.37CysPro: 0.37 ± 0.172
0.308CysGln: 0.308 ± 0.164
1.109CysArg: 1.109 ± 0.327
0.431CysSer: 0.431 ± 0.17
0.555CysThr: 0.555 ± 0.181
0.493CysVal: 0.493 ± 0.16
0.185CysTrp: 0.185 ± 0.105
0.246CysTyr: 0.246 ± 0.126
0.0CysXaa: 0.0 ± 0.0
Asp
8.503AspAla: 8.503 ± 0.624
0.924AspCys: 0.924 ± 0.251
5.792AspAsp: 5.792 ± 0.664
3.759AspGlu: 3.759 ± 0.623
1.849AspPhe: 1.849 ± 0.306
6.963AspGly: 6.963 ± 0.745
2.033AspHis: 2.033 ± 0.319
2.773AspIle: 2.773 ± 0.308
1.232AspLys: 1.232 ± 0.297
7.209AspLeu: 7.209 ± 0.585
1.171AspMet: 1.171 ± 0.252
1.417AspAsn: 1.417 ± 0.319
4.929AspPro: 4.929 ± 0.564
2.958AspGln: 2.958 ± 0.525
5.915AspArg: 5.915 ± 0.631
2.341AspSer: 2.341 ± 0.35
3.143AspThr: 3.143 ± 0.503
4.56AspVal: 4.56 ± 0.581
1.356AspTrp: 1.356 ± 0.319
1.294AspTyr: 1.294 ± 0.322
0.0AspXaa: 0.0 ± 0.0
Glu
6.347GluAla: 6.347 ± 0.613
0.678GluCys: 0.678 ± 0.266
2.526GluAsp: 2.526 ± 0.378
2.588GluGlu: 2.588 ± 0.444
2.218GluPhe: 2.218 ± 0.386
2.711GluGly: 2.711 ± 0.373
1.417GluHis: 1.417 ± 0.256
3.019GluIle: 3.019 ± 0.505
2.28GluLys: 2.28 ± 0.382
5.73GluLeu: 5.73 ± 0.551
1.479GluMet: 1.479 ± 0.253
1.849GluAsn: 1.849 ± 0.314
2.711GluPro: 2.711 ± 0.407
2.341GluGln: 2.341 ± 0.427
3.944GluArg: 3.944 ± 0.499
3.389GluSer: 3.389 ± 0.577
3.143GluThr: 3.143 ± 0.334
4.313GluVal: 4.313 ± 0.613
1.232GluTrp: 1.232 ± 0.343
1.725GluTyr: 1.725 ± 0.33
0.0GluXaa: 0.0 ± 0.0
Phe
2.403PheAla: 2.403 ± 0.405
0.246PheCys: 0.246 ± 0.121
2.157PheAsp: 2.157 ± 0.392
1.479PheGlu: 1.479 ± 0.341
0.246PhePhe: 0.246 ± 0.139
3.081PheGly: 3.081 ± 0.567
0.431PheHis: 0.431 ± 0.156
1.171PheIle: 1.171 ± 0.242
0.555PheLys: 0.555 ± 0.176
1.787PheLeu: 1.787 ± 0.392
0.37PheMet: 0.37 ± 0.16
0.678PheAsn: 0.678 ± 0.175
1.725PhePro: 1.725 ± 0.361
0.863PheGln: 0.863 ± 0.193
1.972PheArg: 1.972 ± 0.311
1.725PheSer: 1.725 ± 0.344
2.095PheThr: 2.095 ± 0.399
2.157PheVal: 2.157 ± 0.383
0.616PheTrp: 0.616 ± 0.244
0.616PheTyr: 0.616 ± 0.164
0.0PheXaa: 0.0 ± 0.0
Gly
8.257GlyAla: 8.257 ± 0.953
0.431GlyCys: 0.431 ± 0.18
5.792GlyAsp: 5.792 ± 0.731
4.19GlyGlu: 4.19 ± 0.427
1.972GlyPhe: 1.972 ± 0.366
8.811GlyGly: 8.811 ± 1.536
1.725GlyHis: 1.725 ± 0.318
3.759GlyIle: 3.759 ± 0.474
3.82GlyLys: 3.82 ± 0.43
5.546GlyLeu: 5.546 ± 0.566
1.602GlyMet: 1.602 ± 0.296
3.389GlyAsn: 3.389 ± 0.375
3.697GlyPro: 3.697 ± 0.407
4.128GlyGln: 4.128 ± 0.591
7.024GlyArg: 7.024 ± 0.634
4.437GlySer: 4.437 ± 0.771
5.238GlyThr: 5.238 ± 0.571
6.162GlyVal: 6.162 ± 0.584
1.602GlyTrp: 1.602 ± 0.307
1.91GlyTyr: 1.91 ± 0.363
0.0GlyXaa: 0.0 ± 0.0
His
2.28HisAla: 2.28 ± 0.384
0.308HisCys: 0.308 ± 0.163
1.602HisAsp: 1.602 ± 0.358
1.171HisGlu: 1.171 ± 0.251
0.062HisPhe: 0.062 ± 0.064
1.972HisGly: 1.972 ± 0.376
0.863HisHis: 0.863 ± 0.209
0.801HisIle: 0.801 ± 0.261
0.555HisLys: 0.555 ± 0.172
1.91HisLeu: 1.91 ± 0.37
0.185HisMet: 0.185 ± 0.091
0.986HisAsn: 0.986 ± 0.269
1.602HisPro: 1.602 ± 0.355
0.801HisGln: 0.801 ± 0.264
1.787HisArg: 1.787 ± 0.364
0.924HisSer: 0.924 ± 0.33
1.479HisThr: 1.479 ± 0.311
1.294HisVal: 1.294 ± 0.264
0.308HisTrp: 0.308 ± 0.154
0.986HisTyr: 0.986 ± 0.279
0.0HisXaa: 0.0 ± 0.0
Ile
6.408IleAla: 6.408 ± 0.621
0.246IleCys: 0.246 ± 0.129
4.313IleAsp: 4.313 ± 0.519
3.204IleGlu: 3.204 ± 0.421
0.678IlePhe: 0.678 ± 0.216
3.635IleGly: 3.635 ± 0.403
0.863IleHis: 0.863 ± 0.281
1.664IleIle: 1.664 ± 0.33
1.294IleLys: 1.294 ± 0.336
3.143IleLeu: 3.143 ± 0.449
0.123IleMet: 0.123 ± 0.086
1.171IleAsn: 1.171 ± 0.222
2.896IlePro: 2.896 ± 0.444
1.91IleGln: 1.91 ± 0.342
3.882IleArg: 3.882 ± 0.431
2.28IleSer: 2.28 ± 0.363
3.204IleThr: 3.204 ± 0.49
2.958IleVal: 2.958 ± 0.477
0.493IleTrp: 0.493 ± 0.176
1.171IleTyr: 1.171 ± 0.323
0.0IleXaa: 0.0 ± 0.0
Lys
3.451LysAla: 3.451 ± 0.508
0.123LysCys: 0.123 ± 0.111
1.602LysAsp: 1.602 ± 0.31
1.294LysGlu: 1.294 ± 0.296
0.863LysPhe: 0.863 ± 0.223
2.28LysGly: 2.28 ± 0.426
0.678LysHis: 0.678 ± 0.223
1.356LysIle: 1.356 ± 0.32
1.171LysLys: 1.171 ± 0.329
2.958LysLeu: 2.958 ± 0.428
0.555LysMet: 0.555 ± 0.16
0.986LysAsn: 0.986 ± 0.264
2.465LysPro: 2.465 ± 0.491
0.801LysGln: 0.801 ± 0.235
2.465LysArg: 2.465 ± 0.334
2.341LysSer: 2.341 ± 0.331
2.588LysThr: 2.588 ± 0.437
2.465LysVal: 2.465 ± 0.419
0.246LysTrp: 0.246 ± 0.154
0.555LysTyr: 0.555 ± 0.17
0.0LysXaa: 0.0 ± 0.0
Leu
9.736LeuAla: 9.736 ± 0.861
0.616LeuCys: 0.616 ± 0.235
5.422LeuAsp: 5.422 ± 0.61
4.929LeuGlu: 4.929 ± 0.47
2.588LeuPhe: 2.588 ± 0.374
6.162LeuGly: 6.162 ± 0.836
1.232LeuHis: 1.232 ± 0.276
3.759LeuIle: 3.759 ± 0.622
2.403LeuLys: 2.403 ± 0.521
4.128LeuLeu: 4.128 ± 0.408
2.033LeuMet: 2.033 ± 0.381
2.403LeuAsn: 2.403 ± 0.384
4.991LeuPro: 4.991 ± 0.563
2.465LeuGln: 2.465 ± 0.396
6.223LeuArg: 6.223 ± 0.856
4.929LeuSer: 4.929 ± 0.573
6.223LeuThr: 6.223 ± 0.682
4.56LeuVal: 4.56 ± 0.676
1.664LeuTrp: 1.664 ± 0.391
1.664LeuTyr: 1.664 ± 0.292
0.0LeuXaa: 0.0 ± 0.0
Met
2.711MetAla: 2.711 ± 0.414
0.308MetCys: 0.308 ± 0.146
0.986MetAsp: 0.986 ± 0.212
0.924MetGlu: 0.924 ± 0.244
0.555MetPhe: 0.555 ± 0.193
1.294MetGly: 1.294 ± 0.316
0.431MetHis: 0.431 ± 0.168
0.678MetIle: 0.678 ± 0.205
0.555MetLys: 0.555 ± 0.168
1.54MetLeu: 1.54 ± 0.301
0.493MetMet: 0.493 ± 0.195
0.555MetAsn: 0.555 ± 0.173
0.986MetPro: 0.986 ± 0.234
0.801MetGln: 0.801 ± 0.347
1.91MetArg: 1.91 ± 0.308
1.787MetSer: 1.787 ± 0.282
3.327MetThr: 3.327 ± 0.421
1.171MetVal: 1.171 ± 0.167
0.616MetTrp: 0.616 ± 0.217
0.431MetTyr: 0.431 ± 0.213
0.0MetXaa: 0.0 ± 0.0
Asn
4.252AsnAla: 4.252 ± 0.816
0.185AsnCys: 0.185 ± 0.12
1.725AsnAsp: 1.725 ± 0.387
1.356AsnGlu: 1.356 ± 0.267
1.048AsnPhe: 1.048 ± 0.267
3.204AsnGly: 3.204 ± 0.531
0.924AsnHis: 0.924 ± 0.263
1.109AsnIle: 1.109 ± 0.322
0.801AsnLys: 0.801 ± 0.212
2.218AsnLeu: 2.218 ± 0.363
0.493AsnMet: 0.493 ± 0.163
0.678AsnAsn: 0.678 ± 0.246
2.403AsnPro: 2.403 ± 0.395
1.232AsnGln: 1.232 ± 0.372
1.91AsnArg: 1.91 ± 0.309
2.28AsnSer: 2.28 ± 0.371
1.356AsnThr: 1.356 ± 0.335
1.972AsnVal: 1.972 ± 0.383
0.493AsnTrp: 0.493 ± 0.184
0.616AsnTyr: 0.616 ± 0.208
0.0AsnXaa: 0.0 ± 0.0
Pro
6.1ProAla: 6.1 ± 0.546
0.308ProCys: 0.308 ± 0.182
5.361ProAsp: 5.361 ± 0.673
3.697ProGlu: 3.697 ± 0.423
1.048ProPhe: 1.048 ± 0.243
5.299ProGly: 5.299 ± 0.464
0.986ProHis: 0.986 ± 0.28
2.341ProIle: 2.341 ± 0.437
1.479ProLys: 1.479 ± 0.267
4.067ProLeu: 4.067 ± 0.498
1.048ProMet: 1.048 ± 0.29
1.849ProAsn: 1.849 ± 0.325
2.711ProPro: 2.711 ± 0.488
1.602ProGln: 1.602 ± 0.305
3.82ProArg: 3.82 ± 0.627
3.143ProSer: 3.143 ± 0.392
3.759ProThr: 3.759 ± 0.492
4.19ProVal: 4.19 ± 0.539
1.479ProTrp: 1.479 ± 0.358
1.048ProTyr: 1.048 ± 0.225
0.0ProXaa: 0.0 ± 0.0
Gln
4.128GlnAla: 4.128 ± 0.721
0.37GlnCys: 0.37 ± 0.152
1.849GlnAsp: 1.849 ± 0.31
1.356GlnGlu: 1.356 ± 0.283
1.356GlnPhe: 1.356 ± 0.304
2.465GlnGly: 2.465 ± 0.618
0.924GlnHis: 0.924 ± 0.236
2.773GlnIle: 2.773 ± 0.497
0.863GlnLys: 0.863 ± 0.377
3.451GlnLeu: 3.451 ± 0.733
0.678GlnMet: 0.678 ± 0.203
1.294GlnAsn: 1.294 ± 0.35
1.725GlnPro: 1.725 ± 0.295
2.711GlnGln: 2.711 ± 0.708
3.512GlnArg: 3.512 ± 0.54
2.465GlnSer: 2.465 ± 0.464
2.157GlnThr: 2.157 ± 0.364
2.896GlnVal: 2.896 ± 0.417
0.924GlnTrp: 0.924 ± 0.262
0.739GlnTyr: 0.739 ± 0.22
0.0GlnXaa: 0.0 ± 0.0
Arg
7.456ArgAla: 7.456 ± 0.743
1.109ArgCys: 1.109 ± 0.299
5.546ArgAsp: 5.546 ± 0.563
4.437ArgGlu: 4.437 ± 0.675
2.341ArgPhe: 2.341 ± 0.325
4.498ArgGly: 4.498 ± 0.465
1.664ArgHis: 1.664 ± 0.371
4.375ArgIle: 4.375 ± 0.525
3.143ArgLys: 3.143 ± 0.402
6.532ArgLeu: 6.532 ± 0.581
2.403ArgMet: 2.403 ± 0.359
2.711ArgAsn: 2.711 ± 0.401
4.313ArgPro: 4.313 ± 0.586
3.019ArgGln: 3.019 ± 0.472
6.716ArgArg: 6.716 ± 0.831
3.882ArgSer: 3.882 ± 0.461
4.313ArgThr: 4.313 ± 0.72
5.114ArgVal: 5.114 ± 0.65
1.849ArgTrp: 1.849 ± 0.364
2.157ArgTyr: 2.157 ± 0.299
0.0ArgXaa: 0.0 ± 0.0
Ser
7.641SerAla: 7.641 ± 1.101
0.246SerCys: 0.246 ± 0.126
3.635SerAsp: 3.635 ± 0.406
3.759SerGlu: 3.759 ± 0.395
1.664SerPhe: 1.664 ± 0.268
5.607SerGly: 5.607 ± 0.723
0.986SerHis: 0.986 ± 0.219
2.588SerIle: 2.588 ± 0.339
1.602SerLys: 1.602 ± 0.428
4.19SerLeu: 4.19 ± 0.577
1.602SerMet: 1.602 ± 0.262
1.171SerAsn: 1.171 ± 0.266
2.65SerPro: 2.65 ± 0.377
2.834SerGln: 2.834 ± 0.49
3.697SerArg: 3.697 ± 0.49
3.266SerSer: 3.266 ± 0.484
4.128SerThr: 4.128 ± 0.449
3.697SerVal: 3.697 ± 0.425
1.048SerTrp: 1.048 ± 0.21
1.048SerTyr: 1.048 ± 0.22
0.0SerXaa: 0.0 ± 0.0
Thr
8.935ThrAla: 8.935 ± 0.877
0.739ThrCys: 0.739 ± 0.24
4.19ThrAsp: 4.19 ± 0.495
3.204ThrGlu: 3.204 ± 0.5
1.91ThrPhe: 1.91 ± 0.355
5.73ThrGly: 5.73 ± 0.743
0.986ThrHis: 0.986 ± 0.285
3.882ThrIle: 3.882 ± 0.535
1.787ThrLys: 1.787 ± 0.344
6.039ThrLeu: 6.039 ± 0.538
0.924ThrMet: 0.924 ± 0.269
1.849ThrAsn: 1.849 ± 0.297
4.19ThrPro: 4.19 ± 0.625
1.479ThrGln: 1.479 ± 0.337
5.053ThrArg: 5.053 ± 0.797
3.697ThrSer: 3.697 ± 0.454
5.73ThrThr: 5.73 ± 0.678
5.361ThrVal: 5.361 ± 0.647
0.986ThrTrp: 0.986 ± 0.194
1.787ThrTyr: 1.787 ± 0.339
0.0ThrXaa: 0.0 ± 0.0
Val
7.148ValAla: 7.148 ± 0.462
0.863ValCys: 0.863 ± 0.23
5.854ValAsp: 5.854 ± 0.628
3.882ValGlu: 3.882 ± 0.526
1.479ValPhe: 1.479 ± 0.303
5.176ValGly: 5.176 ± 0.393
1.54ValHis: 1.54 ± 0.403
2.711ValIle: 2.711 ± 0.407
2.095ValLys: 2.095 ± 0.372
5.114ValLeu: 5.114 ± 0.586
1.356ValMet: 1.356 ± 0.278
2.341ValAsn: 2.341 ± 0.327
4.19ValPro: 4.19 ± 0.478
2.341ValGln: 2.341 ± 0.419
4.683ValArg: 4.683 ± 0.533
4.252ValSer: 4.252 ± 0.472
6.1ValThr: 6.1 ± 0.698
5.361ValVal: 5.361 ± 0.537
1.602ValTrp: 1.602 ± 0.343
0.801ValTyr: 0.801 ± 0.191
0.0ValXaa: 0.0 ± 0.0
Trp
2.65TrpAla: 2.65 ± 0.595
0.431TrpCys: 0.431 ± 0.214
1.232TrpAsp: 1.232 ± 0.252
1.109TrpGlu: 1.109 ± 0.273
0.308TrpPhe: 0.308 ± 0.145
1.294TrpGly: 1.294 ± 0.212
0.739TrpHis: 0.739 ± 0.239
0.924TrpIle: 0.924 ± 0.265
0.555TrpLys: 0.555 ± 0.166
2.157TrpLeu: 2.157 ± 0.414
0.739TrpMet: 0.739 ± 0.194
0.431TrpAsn: 0.431 ± 0.184
0.739TrpPro: 0.739 ± 0.206
0.801TrpGln: 0.801 ± 0.245
1.479TrpArg: 1.479 ± 0.285
0.863TrpSer: 0.863 ± 0.199
1.048TrpThr: 1.048 ± 0.244
1.725TrpVal: 1.725 ± 0.276
0.493TrpTrp: 0.493 ± 0.229
0.308TrpTyr: 0.308 ± 0.129
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.773TyrAla: 2.773 ± 0.435
0.246TyrCys: 0.246 ± 0.12
1.787TyrAsp: 1.787 ± 0.268
0.986TyrGlu: 0.986 ± 0.183
0.801TyrPhe: 0.801 ± 0.165
1.725TyrGly: 1.725 ± 0.228
0.431TyrHis: 0.431 ± 0.227
0.739TyrIle: 0.739 ± 0.203
0.555TyrLys: 0.555 ± 0.187
1.602TyrLeu: 1.602 ± 0.311
0.616TyrMet: 0.616 ± 0.231
0.555TyrAsn: 0.555 ± 0.161
1.048TyrPro: 1.048 ± 0.286
0.678TyrGln: 0.678 ± 0.205
2.218TyrArg: 2.218 ± 0.444
1.232TyrSer: 1.232 ± 0.294
1.171TyrThr: 1.171 ± 0.256
1.294TyrVal: 1.294 ± 0.28
0.493TyrTrp: 0.493 ± 0.193
0.308TyrTyr: 0.308 ± 0.133
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 77 proteins (16230 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski