Amino acid dipepetide frequency for Gallid alphaherpesvirus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.816AlaAla: 5.816 ± 0.508
1.859AlaCys: 1.859 ± 0.337
3.422AlaAsp: 3.422 ± 0.239
3.758AlaGlu: 3.758 ± 0.317
2.848AlaPhe: 2.848 ± 0.259
3.66AlaGly: 3.66 ± 0.31
1.484AlaHis: 1.484 ± 0.18
4.827AlaIle: 4.827 ± 0.354
2.215AlaLys: 2.215 ± 0.193
7.754AlaLeu: 7.754 ± 0.529
2.136AlaMet: 2.136 ± 0.311
3.165AlaAsn: 3.165 ± 0.215
3.996AlaPro: 3.996 ± 0.391
1.741AlaGln: 1.741 ± 0.198
5.104AlaArg: 5.104 ± 0.588
5.559AlaSer: 5.559 ± 0.438
4.312AlaThr: 4.312 ± 0.244
4.431AlaVal: 4.431 ± 0.322
0.851AlaTrp: 0.851 ± 0.144
2.077AlaTyr: 2.077 ± 0.187
0.0AlaXaa: 0.0 ± 0.0
Cys
1.662CysAla: 1.662 ± 0.246
0.613CysCys: 0.613 ± 0.099
1.424CysAsp: 1.424 ± 0.24
1.108CysGlu: 1.108 ± 0.142
0.93CysPhe: 0.93 ± 0.139
1.662CysGly: 1.662 ± 0.204
0.633CysHis: 0.633 ± 0.134
2.037CysIle: 2.037 ± 0.2
1.009CysLys: 1.009 ± 0.139
2.769CysLeu: 2.769 ± 0.374
0.87CysMet: 0.87 ± 0.136
0.989CysAsn: 0.989 ± 0.198
1.266CysPro: 1.266 ± 0.198
0.415CysGln: 0.415 ± 0.104
2.255CysArg: 2.255 ± 0.374
2.295CysSer: 2.295 ± 0.336
1.523CysThr: 1.523 ± 0.242
1.444CysVal: 1.444 ± 0.165
0.237CysTrp: 0.237 ± 0.065
0.752CysTyr: 0.752 ± 0.132
0.0CysXaa: 0.0 ± 0.0
Asp
4.016AspAla: 4.016 ± 0.272
1.167AspCys: 1.167 ± 0.147
2.987AspAsp: 2.987 ± 0.273
3.125AspGlu: 3.125 ± 0.198
1.8AspPhe: 1.8 ± 0.241
2.947AspGly: 2.947 ± 0.242
1.108AspHis: 1.108 ± 0.155
4.213AspIle: 4.213 ± 0.287
1.701AspLys: 1.701 ± 0.204
4.886AspLeu: 4.886 ± 0.345
1.543AspMet: 1.543 ± 0.172
1.899AspAsn: 1.899 ± 0.216
2.848AspPro: 2.848 ± 0.351
0.771AspGln: 0.771 ± 0.113
2.928AspArg: 2.928 ± 0.248
4.016AspSer: 4.016 ± 0.354
3.383AspThr: 3.383 ± 0.289
3.719AspVal: 3.719 ± 0.27
0.752AspTrp: 0.752 ± 0.162
1.622AspTyr: 1.622 ± 0.165
0.0AspXaa: 0.0 ± 0.0
Glu
3.462GluAla: 3.462 ± 0.326
1.345GluCys: 1.345 ± 0.196
2.769GluAsp: 2.769 ± 0.325
2.809GluGlu: 2.809 ± 0.257
1.84GluPhe: 1.84 ± 0.199
2.651GluGly: 2.651 ± 0.282
1.523GluHis: 1.523 ± 0.19
2.848GluIle: 2.848 ± 0.222
2.255GluLys: 2.255 ± 0.244
5.104GluLeu: 5.104 ± 0.369
1.424GluMet: 1.424 ± 0.194
2.492GluAsn: 2.492 ± 0.209
1.919GluPro: 1.919 ± 0.212
1.147GluGln: 1.147 ± 0.149
3.699GluArg: 3.699 ± 0.301
4.213GluSer: 4.213 ± 0.334
3.086GluThr: 3.086 ± 0.25
2.295GluVal: 2.295 ± 0.184
0.653GluTrp: 0.653 ± 0.096
1.662GluTyr: 1.662 ± 0.184
0.0GluXaa: 0.0 ± 0.0
Phe
2.552PheAla: 2.552 ± 0.227
1.088PheCys: 1.088 ± 0.152
2.314PheAsp: 2.314 ± 0.249
1.939PheGlu: 1.939 ± 0.171
1.701PhePhe: 1.701 ± 0.254
2.374PheGly: 2.374 ± 0.238
0.989PheHis: 0.989 ± 0.174
2.492PheIle: 2.492 ± 0.261
1.84PheLys: 1.84 ± 0.248
4.233PheLeu: 4.233 ± 0.438
1.048PheMet: 1.048 ± 0.143
1.048PheAsn: 1.048 ± 0.136
2.136PhePro: 2.136 ± 0.241
1.128PheGln: 1.128 ± 0.153
1.82PheArg: 1.82 ± 0.197
3.956PheSer: 3.956 ± 0.255
1.958PheThr: 1.958 ± 0.228
2.374PheVal: 2.374 ± 0.203
0.475PheTrp: 0.475 ± 0.087
1.424PheTyr: 1.424 ± 0.196
0.0PheXaa: 0.0 ± 0.0
Gly
3.956GlyAla: 3.956 ± 0.426
1.286GlyCys: 1.286 ± 0.183
2.928GlyAsp: 2.928 ± 0.228
3.185GlyGlu: 3.185 ± 0.249
1.582GlyPhe: 1.582 ± 0.202
4.767GlyGly: 4.767 ± 0.675
1.484GlyHis: 1.484 ± 0.202
3.62GlyIle: 3.62 ± 0.28
2.255GlyLys: 2.255 ± 0.22
4.728GlyLeu: 4.728 ± 0.33
1.761GlyMet: 1.761 ± 0.21
2.453GlyAsn: 2.453 ± 0.185
2.769GlyPro: 2.769 ± 0.374
1.642GlyGln: 1.642 ± 0.203
4.253GlyArg: 4.253 ± 0.384
4.886GlySer: 4.886 ± 0.339
4.035GlyThr: 4.035 ± 0.273
3.027GlyVal: 3.027 ± 0.275
0.732GlyTrp: 0.732 ± 0.114
1.879GlyTyr: 1.879 ± 0.235
0.0GlyXaa: 0.0 ± 0.0
His
1.78HisAla: 1.78 ± 0.187
0.593HisCys: 0.593 ± 0.111
1.345HisAsp: 1.345 ± 0.165
1.246HisGlu: 1.246 ± 0.151
0.87HisPhe: 0.87 ± 0.147
1.701HisGly: 1.701 ± 0.161
0.831HisHis: 0.831 ± 0.137
1.939HisIle: 1.939 ± 0.226
1.108HisLys: 1.108 ± 0.148
2.492HisLeu: 2.492 ± 0.199
0.732HisMet: 0.732 ± 0.136
1.167HisAsn: 1.167 ± 0.164
1.325HisPro: 1.325 ± 0.199
0.415HisGln: 0.415 ± 0.111
2.018HisArg: 2.018 ± 0.212
2.275HisSer: 2.275 ± 0.18
1.543HisThr: 1.543 ± 0.302
2.097HisVal: 2.097 ± 0.206
0.119HisTrp: 0.119 ± 0.056
0.435HisTyr: 0.435 ± 0.089
0.0HisXaa: 0.0 ± 0.0
Ile
4.154IleAla: 4.154 ± 0.28
2.196IleCys: 2.196 ± 0.401
3.699IleAsp: 3.699 ± 0.37
2.967IleGlu: 2.967 ± 0.229
2.611IlePhe: 2.611 ± 0.245
3.323IleGly: 3.323 ± 0.299
1.741IleHis: 1.741 ± 0.214
4.293IleIle: 4.293 ± 0.339
2.413IleLys: 2.413 ± 0.223
5.341IleLeu: 5.341 ± 0.376
1.424IleMet: 1.424 ± 0.148
2.67IleAsn: 2.67 ± 0.256
3.996IlePro: 3.996 ± 0.325
2.077IleGln: 2.077 ± 0.205
3.996IleArg: 3.996 ± 0.293
5.737IleSer: 5.737 ± 0.351
4.273IleThr: 4.273 ± 0.299
3.818IleVal: 3.818 ± 0.397
0.712IleTrp: 0.712 ± 0.121
3.027IleTyr: 3.027 ± 0.296
0.0IleXaa: 0.0 ± 0.0
Lys
2.334LysAla: 2.334 ± 0.211
1.009LysCys: 1.009 ± 0.142
1.939LysAsp: 1.939 ± 0.187
1.958LysGlu: 1.958 ± 0.188
2.037LysPhe: 2.037 ± 0.347
1.306LysGly: 1.306 ± 0.169
1.167LysHis: 1.167 ± 0.19
2.314LysIle: 2.314 ± 0.295
2.314LysLys: 2.314 ± 0.32
3.798LysLeu: 3.798 ± 0.346
1.128LysMet: 1.128 ± 0.149
2.117LysAsn: 2.117 ± 0.236
2.433LysPro: 2.433 ± 0.758
1.444LysGln: 1.444 ± 0.194
3.244LysArg: 3.244 ± 0.252
3.402LysSer: 3.402 ± 0.292
3.007LysThr: 3.007 ± 0.224
2.117LysVal: 2.117 ± 0.246
0.534LysTrp: 0.534 ± 0.105
1.761LysTyr: 1.761 ± 0.187
0.0LysXaa: 0.0 ± 0.0
Leu
7.121LeuAla: 7.121 ± 0.604
3.363LeuCys: 3.363 ± 0.398
4.451LeuAsp: 4.451 ± 0.338
4.747LeuGlu: 4.747 ± 0.337
4.53LeuPhe: 4.53 ± 0.311
4.965LeuGly: 4.965 ± 0.326
2.928LeuHis: 2.928 ± 0.352
5.262LeuIle: 5.262 ± 0.399
3.936LeuLys: 3.936 ± 0.394
10.286LeuLeu: 10.286 ± 0.644
2.473LeuMet: 2.473 ± 0.287
3.58LeuAsn: 3.58 ± 0.352
4.886LeuPro: 4.886 ± 0.575
2.651LeuGln: 2.651 ± 0.214
6.409LeuArg: 6.409 ± 0.347
7.715LeuSer: 7.715 ± 0.354
5.341LeuThr: 5.341 ± 0.371
4.55LeuVal: 4.55 ± 0.386
1.325LeuTrp: 1.325 ± 0.142
3.244LeuTyr: 3.244 ± 0.239
0.0LeuXaa: 0.0 ± 0.0
Met
1.899MetAla: 1.899 ± 0.187
0.376MetCys: 0.376 ± 0.1
1.385MetAsp: 1.385 ± 0.172
1.286MetGlu: 1.286 ± 0.183
1.029MetPhe: 1.029 ± 0.158
1.978MetGly: 1.978 ± 0.255
0.831MetHis: 0.831 ± 0.134
1.523MetIle: 1.523 ± 0.165
1.207MetLys: 1.207 ± 0.184
2.71MetLeu: 2.71 ± 0.364
0.692MetMet: 0.692 ± 0.135
1.167MetAsn: 1.167 ± 0.175
1.167MetPro: 1.167 ± 0.176
0.811MetGln: 0.811 ± 0.126
2.077MetArg: 2.077 ± 0.342
2.295MetSer: 2.295 ± 0.208
1.543MetThr: 1.543 ± 0.165
1.345MetVal: 1.345 ± 0.172
0.435MetTrp: 0.435 ± 0.106
0.969MetTyr: 0.969 ± 0.137
0.0MetXaa: 0.0 ± 0.0
Asn
2.809AsnAla: 2.809 ± 0.266
0.91AsnCys: 0.91 ± 0.136
1.978AsnAsp: 1.978 ± 0.194
1.602AsnGlu: 1.602 ± 0.168
1.464AsnPhe: 1.464 ± 0.196
2.611AsnGly: 2.611 ± 0.215
1.009AsnHis: 1.009 ± 0.139
3.739AsnIle: 3.739 ± 0.294
2.394AsnLys: 2.394 ± 0.389
3.303AsnLeu: 3.303 ± 0.286
1.187AsnMet: 1.187 ± 0.158
2.314AsnAsn: 2.314 ± 0.215
2.117AsnPro: 2.117 ± 0.228
1.108AsnGln: 1.108 ± 0.171
2.69AsnArg: 2.69 ± 0.255
3.699AsnSer: 3.699 ± 0.27
2.71AsnThr: 2.71 ± 0.217
3.481AsnVal: 3.481 ± 0.372
0.455AsnTrp: 0.455 ± 0.091
1.286AsnTyr: 1.286 ± 0.118
0.0AsnXaa: 0.0 ± 0.0
Pro
3.422ProAla: 3.422 ± 0.494
1.325ProCys: 1.325 ± 0.154
2.829ProAsp: 2.829 ± 0.395
2.829ProGlu: 2.829 ± 0.382
1.8ProPhe: 1.8 ± 0.222
2.69ProGly: 2.69 ± 0.306
1.8ProHis: 1.8 ± 0.276
3.462ProIle: 3.462 ± 0.296
2.117ProLys: 2.117 ± 0.525
4.055ProLeu: 4.055 ± 0.468
1.424ProMet: 1.424 ± 0.13
1.919ProAsn: 1.919 ± 0.21
5.38ProPro: 5.38 ± 0.848
1.939ProGln: 1.939 ± 0.326
4.095ProArg: 4.095 ± 0.508
5.361ProSer: 5.361 ± 0.628
3.917ProThr: 3.917 ± 0.334
3.303ProVal: 3.303 ± 0.357
0.613ProTrp: 0.613 ± 0.122
1.404ProTyr: 1.404 ± 0.159
0.0ProXaa: 0.0 ± 0.0
Gln
1.681GlnAla: 1.681 ± 0.193
0.771GlnCys: 0.771 ± 0.128
1.108GlnAsp: 1.108 ± 0.163
1.167GlnGlu: 1.167 ± 0.159
1.147GlnPhe: 1.147 ± 0.19
1.721GlnGly: 1.721 ± 0.293
0.692GlnHis: 0.692 ± 0.122
1.622GlnIle: 1.622 ± 0.165
1.266GlnLys: 1.266 ± 0.171
2.473GlnLeu: 2.473 ± 0.224
0.811GlnMet: 0.811 ± 0.17
1.167GlnAsn: 1.167 ± 0.154
1.424GlnPro: 1.424 ± 0.21
0.949GlnGln: 0.949 ± 0.151
1.919GlnArg: 1.919 ± 0.201
2.67GlnSer: 2.67 ± 0.258
1.741GlnThr: 1.741 ± 0.213
1.325GlnVal: 1.325 ± 0.154
0.218GlnTrp: 0.218 ± 0.061
1.108GlnTyr: 1.108 ± 0.135
0.0GlnXaa: 0.0 ± 0.0
Arg
5.005ArgAla: 5.005 ± 0.444
1.662ArgCys: 1.662 ± 0.241
3.343ArgAsp: 3.343 ± 0.269
3.046ArgGlu: 3.046 ± 0.291
2.611ArgPhe: 2.611 ± 0.245
4.312ArgGly: 4.312 ± 0.395
1.998ArgHis: 1.998 ± 0.188
3.284ArgIle: 3.284 ± 0.239
3.007ArgLys: 3.007 ± 0.309
6.112ArgLeu: 6.112 ± 0.349
1.859ArgMet: 1.859 ± 0.282
3.481ArgAsn: 3.481 ± 0.399
3.798ArgPro: 3.798 ± 0.407
1.82ArgGln: 1.82 ± 0.166
6.726ArgArg: 6.726 ± 0.704
5.578ArgSer: 5.578 ± 0.407
4.629ArgThr: 4.629 ± 0.391
3.956ArgVal: 3.956 ± 0.373
0.811ArgTrp: 0.811 ± 0.155
2.136ArgTyr: 2.136 ± 0.198
0.0ArgXaa: 0.0 ± 0.0
Ser
6.646SerAla: 6.646 ± 0.428
2.117SerCys: 2.117 ± 0.219
4.293SerAsp: 4.293 ± 0.437
4.055SerGlu: 4.055 ± 0.398
3.027SerPhe: 3.027 ± 0.273
4.926SerGly: 4.926 ± 0.309
1.84SerHis: 1.84 ± 0.188
5.42SerIle: 5.42 ± 0.361
3.244SerLys: 3.244 ± 0.284
7.952SerLeu: 7.952 ± 0.441
2.037SerMet: 2.037 ± 0.233
3.758SerAsn: 3.758 ± 0.261
5.519SerPro: 5.519 ± 0.945
2.473SerGln: 2.473 ± 0.27
5.855SerArg: 5.855 ± 0.452
9.693SerSer: 9.693 ± 0.929
6.449SerThr: 6.449 ± 0.345
5.539SerVal: 5.539 ± 0.39
0.732SerTrp: 0.732 ± 0.119
3.145SerTyr: 3.145 ± 0.236
0.0SerXaa: 0.0 ± 0.0
Thr
5.479ThrAla: 5.479 ± 0.403
1.622ThrCys: 1.622 ± 0.204
3.066ThrAsp: 3.066 ± 0.333
3.165ThrGlu: 3.165 ± 0.262
2.789ThrPhe: 2.789 ± 0.284
3.402ThrGly: 3.402 ± 0.285
1.563ThrHis: 1.563 ± 0.189
4.846ThrIle: 4.846 ± 0.389
2.631ThrLys: 2.631 ± 0.303
5.479ThrLeu: 5.479 ± 0.299
1.187ThrMet: 1.187 ± 0.179
3.145ThrAsn: 3.145 ± 0.275
3.343ThrPro: 3.343 ± 0.395
1.484ThrGln: 1.484 ± 0.172
3.778ThrArg: 3.778 ± 0.33
6.587ThrSer: 6.587 ± 0.455
5.183ThrThr: 5.183 ± 0.382
4.352ThrVal: 4.352 ± 0.373
0.712ThrTrp: 0.712 ± 0.115
1.939ThrTyr: 1.939 ± 0.186
0.0ThrXaa: 0.0 ± 0.0
Val
3.877ValAla: 3.877 ± 0.305
1.701ValCys: 1.701 ± 0.218
3.402ValAsp: 3.402 ± 0.27
3.244ValGlu: 3.244 ± 0.32
2.492ValPhe: 2.492 ± 0.277
3.205ValGly: 3.205 ± 0.27
1.068ValHis: 1.068 ± 0.165
3.561ValIle: 3.561 ± 0.289
2.295ValLys: 2.295 ± 0.249
6.211ValLeu: 6.211 ± 0.373
1.701ValMet: 1.701 ± 0.219
2.394ValAsn: 2.394 ± 0.217
2.967ValPro: 2.967 ± 0.318
1.879ValGln: 1.879 ± 0.196
3.561ValArg: 3.561 ± 0.269
5.202ValSer: 5.202 ± 0.359
4.194ValThr: 4.194 ± 0.312
3.501ValVal: 3.501 ± 0.292
0.514ValTrp: 0.514 ± 0.101
2.453ValTyr: 2.453 ± 0.175
0.0ValXaa: 0.0 ± 0.0
Trp
0.673TrpAla: 0.673 ± 0.095
0.119TrpCys: 0.119 ± 0.046
0.692TrpAsp: 0.692 ± 0.09
0.673TrpGlu: 0.673 ± 0.114
0.495TrpPhe: 0.495 ± 0.113
0.851TrpGly: 0.851 ± 0.156
0.336TrpHis: 0.336 ± 0.09
0.712TrpIle: 0.712 ± 0.116
0.673TrpLys: 0.673 ± 0.09
0.949TrpLeu: 0.949 ± 0.129
0.277TrpMet: 0.277 ± 0.077
0.613TrpAsn: 0.613 ± 0.125
0.514TrpPro: 0.514 ± 0.104
0.277TrpGln: 0.277 ± 0.075
0.87TrpArg: 0.87 ± 0.16
1.068TrpSer: 1.068 ± 0.163
0.574TrpThr: 0.574 ± 0.102
0.435TrpVal: 0.435 ± 0.11
0.218TrpTrp: 0.218 ± 0.073
0.376TrpTyr: 0.376 ± 0.077
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.67TyrAla: 2.67 ± 0.23
0.771TyrCys: 0.771 ± 0.141
2.077TyrAsp: 2.077 ± 0.232
1.286TyrGlu: 1.286 ± 0.183
1.286TyrPhe: 1.286 ± 0.174
2.176TyrGly: 2.176 ± 0.189
1.009TyrHis: 1.009 ± 0.133
2.453TyrIle: 2.453 ± 0.226
1.484TyrLys: 1.484 ± 0.157
3.125TyrLeu: 3.125 ± 0.233
0.989TyrMet: 0.989 ± 0.151
1.325TyrAsn: 1.325 ± 0.153
1.879TyrPro: 1.879 ± 0.245
0.811TyrGln: 0.811 ± 0.134
1.879TyrArg: 1.879 ± 0.173
2.512TyrSer: 2.512 ± 0.222
2.354TyrThr: 2.354 ± 0.193
2.314TyrVal: 2.314 ± 0.22
0.297TyrTrp: 0.297 ± 0.076
1.306TyrTyr: 1.306 ± 0.121
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 158 proteins (50554 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski