Amino acid dipepetide frequency for Clostridiales bacterium oral taxon 876 str. F0540

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.402AlaAla: 5.402 ± 0.09
0.688AlaCys: 0.688 ± 0.018
2.906AlaAsp: 2.906 ± 0.048
3.934AlaGlu: 3.934 ± 0.057
2.867AlaPhe: 2.867 ± 0.047
4.099AlaGly: 4.099 ± 0.063
0.878AlaHis: 0.878 ± 0.023
5.395AlaIle: 5.395 ± 0.066
4.627AlaLys: 4.627 ± 0.057
6.379AlaLeu: 6.379 ± 0.074
1.784AlaMet: 1.784 ± 0.039
2.531AlaAsn: 2.531 ± 0.046
1.524AlaPro: 1.524 ± 0.04
1.699AlaGln: 1.699 ± 0.039
2.037AlaArg: 2.037 ± 0.04
3.871AlaSer: 3.871 ± 0.057
2.444AlaThr: 2.444 ± 0.048
5.171AlaVal: 5.171 ± 0.069
0.465AlaTrp: 0.465 ± 0.019
2.395AlaTyr: 2.395 ± 0.048
0.0AlaXaa: 0.0 ± 0.0
Cys
0.596CysAla: 0.596 ± 0.021
0.195CysCys: 0.195 ± 0.013
0.603CysAsp: 0.603 ± 0.02
0.733CysGlu: 0.733 ± 0.025
0.493CysPhe: 0.493 ± 0.015
0.96CysGly: 0.96 ± 0.031
0.198CysHis: 0.198 ± 0.013
1.041CysIle: 1.041 ± 0.028
0.822CysLys: 0.822 ± 0.03
0.866CysLeu: 0.866 ± 0.027
0.263CysMet: 0.263 ± 0.013
0.567CysAsn: 0.567 ± 0.022
0.423CysPro: 0.423 ± 0.02
0.215CysGln: 0.215 ± 0.013
0.407CysArg: 0.407 ± 0.017
0.865CysSer: 0.865 ± 0.023
0.527CysThr: 0.527 ± 0.019
0.575CysVal: 0.575 ± 0.021
0.085CysTrp: 0.085 ± 0.009
0.452CysTyr: 0.452 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
2.756AspAla: 2.756 ± 0.043
0.6AspCys: 0.6 ± 0.024
2.403AspAsp: 2.403 ± 0.051
4.287AspGlu: 4.287 ± 0.068
2.725AspPhe: 2.725 ± 0.046
3.284AspGly: 3.284 ± 0.064
0.514AspHis: 0.514 ± 0.018
6.12AspIle: 6.12 ± 0.076
5.498AspLys: 5.498 ± 0.064
4.642AspLeu: 4.642 ± 0.065
1.538AspMet: 1.538 ± 0.034
3.443AspAsn: 3.443 ± 0.056
1.269AspPro: 1.269 ± 0.034
0.842AspGln: 0.842 ± 0.025
1.998AspArg: 1.998 ± 0.044
3.307AspSer: 3.307 ± 0.047
2.618AspThr: 2.618 ± 0.043
3.27AspVal: 3.27 ± 0.047
0.449AspTrp: 0.449 ± 0.017
2.669AspTyr: 2.669 ± 0.045
0.0AspXaa: 0.0 ± 0.0
Glu
4.849GluAla: 4.849 ± 0.066
0.628GluCys: 0.628 ± 0.026
4.166GluAsp: 4.166 ± 0.06
6.534GluGlu: 6.534 ± 0.094
2.933GluPhe: 2.933 ± 0.048
4.222GluGly: 4.222 ± 0.066
1.027GluHis: 1.027 ± 0.03
6.394GluIle: 6.394 ± 0.084
7.031GluLys: 7.031 ± 0.084
6.885GluLeu: 6.885 ± 0.095
1.846GluMet: 1.846 ± 0.038
4.786GluAsn: 4.786 ± 0.062
1.535GluPro: 1.535 ± 0.034
2.002GluGln: 2.002 ± 0.04
2.72GluArg: 2.72 ± 0.045
3.414GluSer: 3.414 ± 0.054
3.057GluThr: 3.057 ± 0.045
4.699GluVal: 4.699 ± 0.063
0.496GluTrp: 0.496 ± 0.021
2.915GluTyr: 2.915 ± 0.047
0.0GluXaa: 0.0 ± 0.0
Phe
2.473PheAla: 2.473 ± 0.047
0.51PheCys: 0.51 ± 0.02
2.625PheAsp: 2.625 ± 0.051
2.746PheGlu: 2.746 ± 0.041
2.014PhePhe: 2.014 ± 0.044
2.959PheGly: 2.959 ± 0.05
0.587PheHis: 0.587 ± 0.021
4.756PheIle: 4.756 ± 0.076
3.755PheLys: 3.755 ± 0.058
3.945PheLeu: 3.945 ± 0.068
1.278PheMet: 1.278 ± 0.03
2.952PheAsn: 2.952 ± 0.04
1.296PhePro: 1.296 ± 0.033
0.993PheGln: 0.993 ± 0.023
1.373PheArg: 1.373 ± 0.033
3.36PheSer: 3.36 ± 0.064
2.481PheThr: 2.481 ± 0.044
2.68PheVal: 2.68 ± 0.049
0.402PheTrp: 0.402 ± 0.019
1.946PheTyr: 1.946 ± 0.044
0.0PheXaa: 0.0 ± 0.0
Gly
4.056GlyAla: 4.056 ± 0.068
0.826GlyCys: 0.826 ± 0.025
3.185GlyAsp: 3.185 ± 0.05
4.066GlyGlu: 4.066 ± 0.058
3.305GlyPhe: 3.305 ± 0.048
4.197GlyGly: 4.197 ± 0.07
1.008GlyHis: 1.008 ± 0.032
6.427GlyIle: 6.427 ± 0.09
5.333GlyLys: 5.333 ± 0.078
5.482GlyLeu: 5.482 ± 0.071
1.757GlyMet: 1.757 ± 0.038
3.128GlyAsn: 3.128 ± 0.055
1.227GlyPro: 1.227 ± 0.029
1.597GlyGln: 1.597 ± 0.037
2.364GlyArg: 2.364 ± 0.043
3.903GlySer: 3.903 ± 0.061
3.552GlyThr: 3.552 ± 0.057
4.38GlyVal: 4.38 ± 0.059
0.553GlyTrp: 0.553 ± 0.02
2.996GlyTyr: 2.996 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
0.719HisAla: 0.719 ± 0.021
0.187HisCys: 0.187 ± 0.012
0.697HisAsp: 0.697 ± 0.023
0.951HisGlu: 0.951 ± 0.025
0.647HisPhe: 0.647 ± 0.021
0.972HisGly: 0.972 ± 0.03
0.318HisHis: 0.318 ± 0.02
1.336HisIle: 1.336 ± 0.036
1.058HisLys: 1.058 ± 0.032
1.183HisLeu: 1.183 ± 0.027
0.367HisMet: 0.367 ± 0.015
0.818HisAsn: 0.818 ± 0.028
0.617HisPro: 0.617 ± 0.022
0.335HisGln: 0.335 ± 0.015
0.613HisArg: 0.613 ± 0.023
0.893HisSer: 0.893 ± 0.026
0.707HisThr: 0.707 ± 0.023
0.802HisVal: 0.802 ± 0.024
0.125HisTrp: 0.125 ± 0.01
0.656HisTyr: 0.656 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
5.899IleAla: 5.899 ± 0.077
1.119IleCys: 1.119 ± 0.028
5.705IleAsp: 5.705 ± 0.063
6.687IleGlu: 6.687 ± 0.086
4.117IlePhe: 4.117 ± 0.074
5.822IleGly: 5.822 ± 0.087
1.291IleHis: 1.291 ± 0.032
8.993IleIle: 8.993 ± 0.109
8.191IleLys: 8.191 ± 0.083
8.578IleLeu: 8.578 ± 0.113
2.321IleMet: 2.321 ± 0.036
6.073IleAsn: 6.073 ± 0.079
3.139IlePro: 3.139 ± 0.05
2.153IleGln: 2.153 ± 0.041
3.13IleArg: 3.13 ± 0.046
6.735IleSer: 6.735 ± 0.073
4.871IleThr: 4.871 ± 0.062
5.914IleVal: 5.914 ± 0.071
0.596IleTrp: 0.596 ± 0.021
3.575IleTyr: 3.575 ± 0.057
0.0IleXaa: 0.0 ± 0.0
Lys
5.468LysAla: 5.468 ± 0.071
0.725LysCys: 0.725 ± 0.028
5.736LysAsp: 5.736 ± 0.078
7.954LysGlu: 7.954 ± 0.092
3.104LysPhe: 3.104 ± 0.052
5.077LysGly: 5.077 ± 0.061
1.197LysHis: 1.197 ± 0.03
7.284LysIle: 7.284 ± 0.076
7.283LysLys: 7.283 ± 0.08
8.07LysLeu: 8.07 ± 0.088
2.369LysMet: 2.369 ± 0.04
5.878LysAsn: 5.878 ± 0.07
2.316LysPro: 2.316 ± 0.04
2.382LysGln: 2.382 ± 0.043
3.05LysArg: 3.05 ± 0.049
4.936LysSer: 4.936 ± 0.062
4.029LysThr: 4.029 ± 0.056
5.677LysVal: 5.677 ± 0.065
0.683LysTrp: 0.683 ± 0.023
3.906LysTyr: 3.906 ± 0.059
0.0LysXaa: 0.0 ± 0.0
Leu
5.326LeuAla: 5.326 ± 0.075
1.112LeuCys: 1.112 ± 0.029
4.887LeuAsp: 4.887 ± 0.065
6.027LeuGlu: 6.027 ± 0.088
4.025LeuPhe: 4.025 ± 0.067
5.962LeuGly: 5.962 ± 0.076
1.153LeuHis: 1.153 ± 0.03
8.333LeuIle: 8.333 ± 0.098
8.717LeuLys: 8.717 ± 0.094
8.241LeuLeu: 8.241 ± 0.091
2.484LeuMet: 2.484 ± 0.041
5.807LeuAsn: 5.807 ± 0.078
2.971LeuPro: 2.971 ± 0.047
2.391LeuGln: 2.391 ± 0.044
3.333LeuArg: 3.333 ± 0.058
7.179LeuSer: 7.179 ± 0.073
4.589LeuThr: 4.589 ± 0.049
5.361LeuVal: 5.361 ± 0.066
0.743LeuTrp: 0.743 ± 0.026
3.529LeuTyr: 3.529 ± 0.057
0.0LeuXaa: 0.0 ± 0.0
Met
1.757MetAla: 1.757 ± 0.042
0.25MetCys: 0.25 ± 0.013
1.518MetAsp: 1.518 ± 0.033
1.864MetGlu: 1.864 ± 0.038
1.093MetPhe: 1.093 ± 0.027
1.737MetGly: 1.737 ± 0.037
0.407MetHis: 0.407 ± 0.018
2.118MetIle: 2.118 ± 0.042
2.514MetLys: 2.514 ± 0.041
2.731MetLeu: 2.731 ± 0.049
0.749MetMet: 0.749 ± 0.024
1.596MetAsn: 1.596 ± 0.035
0.979MetPro: 0.979 ± 0.026
0.776MetGln: 0.776 ± 0.024
0.961MetArg: 0.961 ± 0.027
1.712MetSer: 1.712 ± 0.034
1.222MetThr: 1.222 ± 0.029
1.564MetVal: 1.564 ± 0.031
0.187MetTrp: 0.187 ± 0.012
0.932MetTyr: 0.932 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
3.025AsnAla: 3.025 ± 0.05
0.67AsnCys: 0.67 ± 0.025
2.802AsnAsp: 2.802 ± 0.042
4.024AsnGlu: 4.024 ± 0.061
2.588AsnPhe: 2.588 ± 0.048
3.482AsnGly: 3.482 ± 0.061
0.777AsnHis: 0.777 ± 0.026
6.665AsnIle: 6.665 ± 0.075
5.633AsnLys: 5.633 ± 0.062
5.449AsnLeu: 5.449 ± 0.072
1.678AsnMet: 1.678 ± 0.034
4.26AsnAsn: 4.26 ± 0.074
2.01AsnPro: 2.01 ± 0.035
1.408AsnGln: 1.408 ± 0.033
2.066AsnArg: 2.066 ± 0.033
4.027AsnSer: 4.027 ± 0.062
3.056AsnThr: 3.056 ± 0.048
3.309AsnVal: 3.309 ± 0.051
0.501AsnTrp: 0.501 ± 0.019
2.752AsnTyr: 2.752 ± 0.052
0.0AsnXaa: 0.0 ± 0.0
Pro
1.608ProAla: 1.608 ± 0.042
0.294ProCys: 0.294 ± 0.015
1.615ProAsp: 1.615 ± 0.035
2.355ProGlu: 2.355 ± 0.043
1.459ProPhe: 1.459 ± 0.035
1.719ProGly: 1.719 ± 0.037
0.498ProHis: 0.498 ± 0.021
2.55ProIle: 2.55 ± 0.047
2.26ProLys: 2.26 ± 0.047
2.571ProLeu: 2.571 ± 0.05
0.75ProMet: 0.75 ± 0.026
1.538ProAsn: 1.538 ± 0.032
0.697ProPro: 0.697 ± 0.025
0.873ProGln: 0.873 ± 0.027
0.858ProArg: 0.858 ± 0.028
1.918ProSer: 1.918 ± 0.037
1.436ProThr: 1.436 ± 0.035
2.276ProVal: 2.276 ± 0.043
0.263ProTrp: 0.263 ± 0.016
1.356ProTyr: 1.356 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
1.621GlnAla: 1.621 ± 0.04
0.238GlnCys: 0.238 ± 0.014
1.262GlnAsp: 1.262 ± 0.031
1.772GlnGlu: 1.772 ± 0.036
1.071GlnPhe: 1.071 ± 0.03
1.59GlnGly: 1.59 ± 0.035
0.363GlnHis: 0.363 ± 0.017
2.232GlnIle: 2.232 ± 0.037
2.219GlnLys: 2.219 ± 0.042
2.303GlnLeu: 2.303 ± 0.042
0.696GlnMet: 0.696 ± 0.023
1.559GlnAsn: 1.559 ± 0.037
0.656GlnPro: 0.656 ± 0.025
0.781GlnGln: 0.781 ± 0.032
1.049GlnArg: 1.049 ± 0.028
1.5GlnSer: 1.5 ± 0.036
1.151GlnThr: 1.151 ± 0.033
1.541GlnVal: 1.541 ± 0.033
0.255GlnTrp: 0.255 ± 0.014
1.139GlnTyr: 1.139 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
2.03ArgAla: 2.03 ± 0.036
0.368ArgCys: 0.368 ± 0.017
1.881ArgAsp: 1.881 ± 0.034
2.953ArgGlu: 2.953 ± 0.052
1.619ArgPhe: 1.619 ± 0.036
2.073ArgGly: 2.073 ± 0.038
0.514ArgHis: 0.514 ± 0.021
3.275ArgIle: 3.275 ± 0.051
3.116ArgLys: 3.116 ± 0.048
3.284ArgLeu: 3.284 ± 0.048
0.991ArgMet: 0.991 ± 0.028
2.122ArgAsn: 2.122 ± 0.039
0.957ArgPro: 0.957 ± 0.028
1.092ArgGln: 1.092 ± 0.029
1.66ArgArg: 1.66 ± 0.039
1.778ArgSer: 1.778 ± 0.036
1.715ArgThr: 1.715 ± 0.039
2.304ArgVal: 2.304 ± 0.042
0.322ArgTrp: 0.322 ± 0.017
1.513ArgTyr: 1.513 ± 0.031
0.0ArgXaa: 0.0 ± 0.0
Ser
3.683SerAla: 3.683 ± 0.056
0.667SerCys: 0.667 ± 0.023
3.254SerAsp: 3.254 ± 0.054
4.435SerGlu: 4.435 ± 0.061
3.419SerPhe: 3.419 ± 0.051
4.464SerGly: 4.464 ± 0.058
0.929SerHis: 0.929 ± 0.025
6.561SerIle: 6.561 ± 0.078
5.787SerLys: 5.787 ± 0.066
6.244SerLeu: 6.244 ± 0.071
1.732SerMet: 1.732 ± 0.038
3.714SerAsn: 3.714 ± 0.056
1.702SerPro: 1.702 ± 0.032
1.612SerGln: 1.612 ± 0.041
2.3SerArg: 2.3 ± 0.039
4.711SerSer: 4.711 ± 0.075
3.164SerThr: 3.164 ± 0.049
3.937SerVal: 3.937 ± 0.051
0.484SerTrp: 0.484 ± 0.021
2.717SerTyr: 2.717 ± 0.047
0.0SerXaa: 0.0 ± 0.0
Thr
3.545ThrAla: 3.545 ± 0.055
0.433ThrCys: 0.433 ± 0.017
2.476ThrAsp: 2.476 ± 0.043
3.081ThrGlu: 3.081 ± 0.047
2.125ThrPhe: 2.125 ± 0.049
3.674ThrGly: 3.674 ± 0.054
0.746ThrHis: 0.746 ± 0.024
4.509ThrIle: 4.509 ± 0.065
3.585ThrLys: 3.585 ± 0.052
4.689ThrLeu: 4.689 ± 0.057
1.166ThrMet: 1.166 ± 0.027
2.621ThrAsn: 2.621 ± 0.051
1.839ThrPro: 1.839 ± 0.037
1.163ThrGln: 1.163 ± 0.029
1.516ThrArg: 1.516 ± 0.034
3.29ThrSer: 3.29 ± 0.045
2.606ThrThr: 2.606 ± 0.056
3.492ThrVal: 3.492 ± 0.061
0.355ThrTrp: 0.355 ± 0.019
1.922ThrTyr: 1.922 ± 0.04
0.0ThrXaa: 0.0 ± 0.0
Val
3.686ValAla: 3.686 ± 0.06
0.757ValCys: 0.757 ± 0.023
3.649ValAsp: 3.649 ± 0.055
4.262ValGlu: 4.262 ± 0.062
2.987ValPhe: 2.987 ± 0.044
3.883ValGly: 3.883 ± 0.071
0.889ValHis: 0.889 ± 0.029
6.15ValIle: 6.15 ± 0.077
5.297ValLys: 5.297 ± 0.071
6.246ValLeu: 6.246 ± 0.077
1.658ValMet: 1.658 ± 0.03
3.526ValAsn: 3.526 ± 0.054
2.193ValPro: 2.193 ± 0.042
1.584ValGln: 1.584 ± 0.035
2.171ValArg: 2.171 ± 0.046
4.587ValSer: 4.587 ± 0.058
3.259ValThr: 3.259 ± 0.051
4.46ValVal: 4.46 ± 0.068
0.458ValTrp: 0.458 ± 0.022
2.563ValTyr: 2.563 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
0.468TrpAla: 0.468 ± 0.02
0.109TrpCys: 0.109 ± 0.01
0.45TrpAsp: 0.45 ± 0.021
0.496TrpGlu: 0.496 ± 0.02
0.384TrpPhe: 0.384 ± 0.017
0.547TrpGly: 0.547 ± 0.02
0.133TrpHis: 0.133 ± 0.009
0.719TrpIle: 0.719 ± 0.024
0.597TrpLys: 0.597 ± 0.019
0.67TrpLeu: 0.67 ± 0.021
0.228TrpMet: 0.228 ± 0.011
0.511TrpAsn: 0.511 ± 0.021
0.196TrpPro: 0.196 ± 0.013
0.263TrpGln: 0.263 ± 0.013
0.345TrpArg: 0.345 ± 0.018
0.503TrpSer: 0.503 ± 0.022
0.356TrpThr: 0.356 ± 0.017
0.485TrpVal: 0.485 ± 0.02
0.111TrpTrp: 0.111 ± 0.01
0.325TrpTyr: 0.325 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.127TyrAla: 2.127 ± 0.038
0.51TyrCys: 0.51 ± 0.02
2.41TyrAsp: 2.41 ± 0.044
2.975TyrGlu: 2.975 ± 0.05
2.155TyrPhe: 2.155 ± 0.043
2.618TyrGly: 2.618 ± 0.043
0.572TyrHis: 0.572 ± 0.02
4.051TyrIle: 4.051 ± 0.063
3.804TyrLys: 3.804 ± 0.049
3.712TyrLeu: 3.712 ± 0.052
1.011TyrMet: 1.011 ± 0.027
2.751TyrAsn: 2.751 ± 0.051
1.349TyrPro: 1.349 ± 0.029
0.835TyrGln: 0.835 ± 0.026
1.619TyrArg: 1.619 ± 0.036
3.027TyrSer: 3.027 ± 0.044
1.994TyrThr: 1.994 ± 0.04
2.37TyrVal: 2.37 ± 0.037
0.365TyrTrp: 0.365 ± 0.017
1.903TyrTyr: 1.903 ± 0.046
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4702 proteins (1392343 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski