Amino acid dipepetide frequency for Coriobacteriales bacterium DNF00809

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.155AlaAla: 10.155 ± 0.195
2.591AlaCys: 2.591 ± 0.089
5.117AlaAsp: 5.117 ± 0.132
4.051AlaGlu: 4.051 ± 0.106
4.2AlaPhe: 4.2 ± 0.097
6.805AlaGly: 6.805 ± 0.144
3.594AlaHis: 3.594 ± 0.093
5.234AlaIle: 5.234 ± 0.116
4.259AlaLys: 4.259 ± 0.124
11.847AlaLeu: 11.847 ± 0.206
2.223AlaMet: 2.223 ± 0.068
3.225AlaAsn: 3.225 ± 0.096
4.469AlaPro: 4.469 ± 0.114
5.648AlaGln: 5.648 ± 0.129
6.151AlaArg: 6.151 ± 0.143
6.968AlaSer: 6.968 ± 0.137
5.117AlaThr: 5.117 ± 0.102
5.989AlaVal: 5.989 ± 0.141
0.903AlaTrp: 0.903 ± 0.047
3.144AlaTyr: 3.144 ± 0.09
0.0AlaXaa: 0.0 ± 0.0
Cys
2.591CysAla: 2.591 ± 0.087
0.412CysCys: 0.412 ± 0.034
1.137CysAsp: 1.137 ± 0.058
1.117CysGlu: 1.117 ± 0.049
0.685CysPhe: 0.685 ± 0.039
1.529CysGly: 1.529 ± 0.058
0.325CysHis: 0.325 ± 0.03
1.256CysIle: 1.256 ± 0.051
0.828CysLys: 0.828 ± 0.041
1.391CysLeu: 1.391 ± 0.057
0.519CysMet: 0.519 ± 0.032
0.685CysAsn: 0.685 ± 0.041
0.588CysPro: 0.588 ± 0.039
0.331CysGln: 0.331 ± 0.027
0.594CysArg: 0.594 ± 0.036
1.389CysSer: 1.389 ± 0.046
1.103CysThr: 1.103 ± 0.046
1.702CysVal: 1.702 ± 0.069
0.147CysTrp: 0.147 ± 0.018
0.555CysTyr: 0.555 ± 0.037
0.0CysXaa: 0.0 ± 0.0
Asp
6.773AspAla: 6.773 ± 0.129
0.685AspCys: 0.685 ± 0.041
3.136AspAsp: 3.136 ± 0.108
4.059AspGlu: 4.059 ± 0.11
1.963AspPhe: 1.963 ± 0.062
3.645AspGly: 3.645 ± 0.127
0.895AspHis: 0.895 ± 0.045
3.77AspIle: 3.77 ± 0.09
2.92AspLys: 2.92 ± 0.102
3.859AspLeu: 3.859 ± 0.099
1.426AspMet: 1.426 ± 0.049
2.171AspAsn: 2.171 ± 0.093
1.914AspPro: 1.914 ± 0.076
1.512AspGln: 1.512 ± 0.055
1.823AspArg: 1.823 ± 0.062
2.867AspSer: 2.867 ± 0.086
3.932AspThr: 3.932 ± 0.112
4.612AspVal: 4.612 ± 0.103
0.424AspTrp: 0.424 ± 0.034
1.722AspTyr: 1.722 ± 0.073
0.0AspXaa: 0.0 ± 0.0
Glu
5.238GluAla: 5.238 ± 0.127
0.846GluCys: 0.846 ± 0.045
2.429GluAsp: 2.429 ± 0.082
3.277GluGlu: 3.277 ± 0.105
2.102GluPhe: 2.102 ± 0.064
3.138GluGly: 3.138 ± 0.083
2.054GluHis: 2.054 ± 0.079
3.184GluIle: 3.184 ± 0.098
3.631GluLys: 3.631 ± 0.09
5.389GluLeu: 5.389 ± 0.125
1.516GluMet: 1.516 ± 0.056
2.647GluAsn: 2.647 ± 0.072
1.708GluPro: 1.708 ± 0.059
3.578GluGln: 3.578 ± 0.096
3.594GluArg: 3.594 ± 0.102
2.659GluSer: 2.659 ± 0.067
2.912GluThr: 2.912 ± 0.088
3.469GluVal: 3.469 ± 0.093
0.472GluTrp: 0.472 ± 0.034
1.706GluTyr: 1.706 ± 0.068
0.0GluXaa: 0.0 ± 0.0
Phe
3.774PheAla: 3.774 ± 0.09
0.719PheCys: 0.719 ± 0.041
2.583PheAsp: 2.583 ± 0.074
2.292PheGlu: 2.292 ± 0.071
1.658PhePhe: 1.658 ± 0.065
2.732PheGly: 2.732 ± 0.083
0.788PheHis: 0.788 ± 0.041
2.645PheIle: 2.645 ± 0.09
1.932PheLys: 1.932 ± 0.065
3.437PheLeu: 3.437 ± 0.101
1.147PheMet: 1.147 ± 0.056
1.502PheAsn: 1.502 ± 0.061
1.494PhePro: 1.494 ± 0.051
1.171PheGln: 1.171 ± 0.042
1.438PheArg: 1.438 ± 0.052
3.134PheSer: 3.134 ± 0.092
2.314PheThr: 2.314 ± 0.065
3.011PheVal: 3.011 ± 0.091
0.37PheTrp: 0.37 ± 0.025
1.329PheTyr: 1.329 ± 0.059
0.0PheXaa: 0.0 ± 0.0
Gly
7.096GlyAla: 7.096 ± 0.131
1.296GlyCys: 1.296 ± 0.054
3.211GlyAsp: 3.211 ± 0.091
3.467GlyGlu: 3.467 ± 0.093
2.716GlyPhe: 2.716 ± 0.075
4.469GlyGly: 4.469 ± 0.125
1.313GlyHis: 1.313 ± 0.056
4.846GlyIle: 4.846 ± 0.108
4.047GlyLys: 4.047 ± 0.104
5.089GlyLeu: 5.089 ± 0.118
1.781GlyMet: 1.781 ± 0.068
2.54GlyAsn: 2.54 ± 0.089
1.201GlyPro: 1.201 ± 0.049
1.666GlyGln: 1.666 ± 0.054
2.74GlyArg: 2.74 ± 0.087
4.608GlySer: 4.608 ± 0.1
4.396GlyThr: 4.396 ± 0.133
5.391GlyVal: 5.391 ± 0.131
0.616GlyTrp: 0.616 ± 0.039
2.181GlyTyr: 2.181 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
3.043HisAla: 3.043 ± 0.088
0.424HisCys: 0.424 ± 0.031
1.755HisAsp: 1.755 ± 0.059
1.597HisGlu: 1.597 ± 0.059
1.016HisPhe: 1.016 ± 0.046
1.65HisGly: 1.65 ± 0.06
0.777HisHis: 0.777 ± 0.043
1.809HisIle: 1.809 ± 0.056
1.286HisLys: 1.286 ± 0.052
1.985HisLeu: 1.985 ± 0.067
0.745HisMet: 0.745 ± 0.036
1.248HisAsn: 1.248 ± 0.056
1.147HisPro: 1.147 ± 0.047
0.798HisGln: 0.798 ± 0.038
1.058HisArg: 1.058 ± 0.046
1.551HisSer: 1.551 ± 0.06
1.938HisThr: 1.938 ± 0.074
2.306HisVal: 2.306 ± 0.062
0.184HisTrp: 0.184 ± 0.022
0.888HisTyr: 0.888 ± 0.046
0.0HisXaa: 0.0 ± 0.0
Ile
6.637IleAla: 6.637 ± 0.129
0.995IleCys: 0.995 ± 0.044
3.905IleAsp: 3.905 ± 0.1
3.73IleGlu: 3.73 ± 0.091
2.151IlePhe: 2.151 ± 0.073
3.869IleGly: 3.869 ± 0.101
1.246IleHis: 1.246 ± 0.051
3.766IleIle: 3.766 ± 0.114
2.837IleLys: 2.837 ± 0.083
4.711IleLeu: 4.711 ± 0.119
1.46IleMet: 1.46 ± 0.054
2.153IleAsn: 2.153 ± 0.08
2.942IlePro: 2.942 ± 0.073
1.844IleGln: 1.844 ± 0.059
2.558IleArg: 2.558 ± 0.078
4.473IleSer: 4.473 ± 0.097
3.861IleThr: 3.861 ± 0.096
4.693IleVal: 4.693 ± 0.1
0.353IleTrp: 0.353 ± 0.026
1.597IleTyr: 1.597 ± 0.063
0.0IleXaa: 0.0 ± 0.0
Lys
4.564LysAla: 4.564 ± 0.144
0.529LysCys: 0.529 ± 0.031
2.932LysAsp: 2.932 ± 0.134
3.231LysGlu: 3.231 ± 0.097
1.319LysPhe: 1.319 ± 0.052
3.096LysGly: 3.096 ± 0.097
1.527LysHis: 1.527 ± 0.058
2.593LysIle: 2.593 ± 0.094
3.568LysLys: 3.568 ± 0.161
4.358LysLeu: 4.358 ± 0.106
1.082LysMet: 1.082 ± 0.053
2.463LysAsn: 2.463 ± 0.09
2.314LysPro: 2.314 ± 0.086
2.744LysGln: 2.744 ± 0.1
3.764LysArg: 3.764 ± 0.095
2.898LysSer: 2.898 ± 0.085
3.534LysThr: 3.534 ± 0.116
3.003LysVal: 3.003 ± 0.107
0.341LysTrp: 0.341 ± 0.029
1.373LysTyr: 1.373 ± 0.058
0.0LysXaa: 0.0 ± 0.0
Leu
8.844LeuAla: 8.844 ± 0.145
2.019LeuCys: 2.019 ± 0.063
5.22LeuAsp: 5.22 ± 0.109
5.036LeuGlu: 5.036 ± 0.115
3.861LeuPhe: 3.861 ± 0.112
5.892LeuGly: 5.892 ± 0.118
2.647LeuHis: 2.647 ± 0.083
5.179LeuIle: 5.179 ± 0.15
4.58LeuLys: 4.58 ± 0.123
8.725LeuLeu: 8.725 ± 0.192
2.33LeuMet: 2.33 ± 0.088
3.386LeuAsn: 3.386 ± 0.086
4.224LeuPro: 4.224 ± 0.101
3.495LeuGln: 3.495 ± 0.089
4.85LeuArg: 4.85 ± 0.133
7.061LeuSer: 7.061 ± 0.128
5.139LeuThr: 5.139 ± 0.123
6.53LeuVal: 6.53 ± 0.14
0.729LeuTrp: 0.729 ± 0.036
2.754LeuTyr: 2.754 ± 0.078
0.0LeuXaa: 0.0 ± 0.0
Met
1.938MetAla: 1.938 ± 0.065
0.473MetCys: 0.473 ± 0.035
1.024MetAsp: 1.024 ± 0.049
1.119MetGlu: 1.119 ± 0.045
0.989MetPhe: 0.989 ± 0.044
1.615MetGly: 1.615 ± 0.066
0.808MetHis: 0.808 ± 0.038
1.345MetIle: 1.345 ± 0.055
1.45MetLys: 1.45 ± 0.06
2.466MetLeu: 2.466 ± 0.088
0.511MetMet: 0.511 ± 0.029
1.171MetAsn: 1.171 ± 0.044
1.28MetPro: 1.28 ± 0.054
1.179MetGln: 1.179 ± 0.045
1.678MetArg: 1.678 ± 0.062
1.676MetSer: 1.676 ± 0.058
1.244MetThr: 1.244 ± 0.055
1.502MetVal: 1.502 ± 0.058
0.224MetTrp: 0.224 ± 0.024
0.719MetTyr: 0.719 ± 0.035
0.0MetXaa: 0.0 ± 0.0
Asn
4.485AsnAla: 4.485 ± 0.126
0.521AsnCys: 0.521 ± 0.029
2.255AsnAsp: 2.255 ± 0.075
2.282AsnGlu: 2.282 ± 0.075
1.331AsnPhe: 1.331 ± 0.044
2.486AsnGly: 2.486 ± 0.102
0.822AsnHis: 0.822 ± 0.042
2.375AsnIle: 2.375 ± 0.074
2.26AsnLys: 2.26 ± 0.091
3.029AsnLeu: 3.029 ± 0.096
0.977AsnMet: 0.977 ± 0.042
1.87AsnAsn: 1.87 ± 0.08
2.122AsnPro: 2.122 ± 0.079
1.228AsnGln: 1.228 ± 0.053
1.432AsnArg: 1.432 ± 0.06
2.421AsnSer: 2.421 ± 0.072
2.918AsnThr: 2.918 ± 0.101
2.855AsnVal: 2.855 ± 0.071
0.361AsnTrp: 0.361 ± 0.027
1.165AsnTyr: 1.165 ± 0.048
0.0AsnXaa: 0.0 ± 0.0
Pro
4.065ProAla: 4.065 ± 0.116
0.783ProCys: 0.783 ± 0.048
2.591ProAsp: 2.591 ± 0.086
2.463ProGlu: 2.463 ± 0.066
1.823ProPhe: 1.823 ± 0.064
2.55ProGly: 2.55 ± 0.079
1.391ProHis: 1.391 ± 0.058
1.85ProIle: 1.85 ± 0.066
1.626ProLys: 1.626 ± 0.064
3.98ProLeu: 3.98 ± 0.092
0.666ProMet: 0.666 ± 0.038
1.317ProAsn: 1.317 ± 0.06
1.109ProPro: 1.109 ± 0.055
1.856ProGln: 1.856 ± 0.074
1.906ProArg: 1.906 ± 0.063
3.001ProSer: 3.001 ± 0.089
2.439ProThr: 2.439 ± 0.082
2.976ProVal: 2.976 ± 0.07
0.345ProTrp: 0.345 ± 0.027
1.424ProTyr: 1.424 ± 0.051
0.0ProXaa: 0.0 ± 0.0
Gln
4.634GlnAla: 4.634 ± 0.108
0.543GlnCys: 0.543 ± 0.042
1.607GlnAsp: 1.607 ± 0.057
2.486GlnGlu: 2.486 ± 0.075
1.351GlnPhe: 1.351 ± 0.054
2.647GlnGly: 2.647 ± 0.07
1.494GlnHis: 1.494 ± 0.059
1.731GlnIle: 1.731 ± 0.062
2.098GlnLys: 2.098 ± 0.087
3.986GlnLeu: 3.986 ± 0.099
0.818GlnMet: 0.818 ± 0.04
1.646GlnAsn: 1.646 ± 0.064
1.508GlnPro: 1.508 ± 0.058
2.468GlnGln: 2.468 ± 0.082
2.538GlnArg: 2.538 ± 0.072
2.494GlnSer: 2.494 ± 0.077
2.461GlnThr: 2.461 ± 0.087
2.393GlnVal: 2.393 ± 0.066
0.406GlnTrp: 0.406 ± 0.032
0.981GlnTyr: 0.981 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
5.202ArgAla: 5.202 ± 0.129
0.957ArgCys: 0.957 ± 0.053
2.645ArgAsp: 2.645 ± 0.085
3.411ArgGlu: 3.411 ± 0.1
2.258ArgPhe: 2.258 ± 0.075
2.833ArgGly: 2.833 ± 0.082
1.109ArgHis: 1.109 ± 0.049
3.649ArgIle: 3.649 ± 0.084
2.591ArgLys: 2.591 ± 0.08
4.448ArgLeu: 4.448 ± 0.116
1.573ArgMet: 1.573 ± 0.057
1.985ArgAsn: 1.985 ± 0.057
1.446ArgPro: 1.446 ± 0.059
1.387ArgGln: 1.387 ± 0.055
2.524ArgArg: 2.524 ± 0.089
3.443ArgSer: 3.443 ± 0.101
2.807ArgThr: 2.807 ± 0.078
4.034ArgVal: 4.034 ± 0.104
0.432ArgTrp: 0.432 ± 0.033
1.813ArgTyr: 1.813 ± 0.072
0.0ArgXaa: 0.0 ± 0.0
Ser
7.409SerAla: 7.409 ± 0.155
1.304SerCys: 1.304 ± 0.062
3.907SerAsp: 3.907 ± 0.096
3.437SerGlu: 3.437 ± 0.081
3.001SerPhe: 3.001 ± 0.067
4.588SerGly: 4.588 ± 0.098
1.67SerHis: 1.67 ± 0.059
4.244SerIle: 4.244 ± 0.105
3.027SerLys: 3.027 ± 0.1
6.371SerLeu: 6.371 ± 0.145
1.692SerMet: 1.692 ± 0.06
2.524SerAsn: 2.524 ± 0.078
2.354SerPro: 2.354 ± 0.081
2.435SerGln: 2.435 ± 0.077
3.059SerArg: 3.059 ± 0.081
5.365SerSer: 5.365 ± 0.132
4.24SerThr: 4.24 ± 0.103
4.981SerVal: 4.981 ± 0.113
0.626SerTrp: 0.626 ± 0.037
2.346SerTyr: 2.346 ± 0.066
0.0SerXaa: 0.0 ± 0.0
Thr
4.794ThrAla: 4.794 ± 0.121
1.183ThrCys: 1.183 ± 0.049
2.548ThrAsp: 2.548 ± 0.09
2.486ThrGlu: 2.486 ± 0.075
2.356ThrPhe: 2.356 ± 0.075
3.859ThrGly: 3.859 ± 0.101
1.969ThrHis: 1.969 ± 0.072
3.711ThrIle: 3.711 ± 0.104
2.884ThrLys: 2.884 ± 0.099
6.298ThrLeu: 6.298 ± 0.128
1.31ThrMet: 1.31 ± 0.05
2.445ThrAsn: 2.445 ± 0.093
3.693ThrPro: 3.693 ± 0.13
2.682ThrGln: 2.682 ± 0.1
2.995ThrArg: 2.995 ± 0.089
4.669ThrSer: 4.669 ± 0.126
3.891ThrThr: 3.891 ± 0.134
3.663ThrVal: 3.663 ± 0.12
0.608ThrTrp: 0.608 ± 0.032
2.092ThrTyr: 2.092 ± 0.073
0.0ThrXaa: 0.0 ± 0.0
Val
6.637ValAla: 6.637 ± 0.13
1.86ValCys: 1.86 ± 0.056
3.655ValAsp: 3.655 ± 0.097
3.526ValGlu: 3.526 ± 0.093
3.091ValPhe: 3.091 ± 0.092
4.549ValGly: 4.549 ± 0.113
1.741ValHis: 1.741 ± 0.063
4.315ValIle: 4.315 ± 0.1
3.156ValLys: 3.156 ± 0.083
7.512ValLeu: 7.512 ± 0.161
1.733ValMet: 1.733 ± 0.063
2.401ValAsn: 2.401 ± 0.065
3.235ValPro: 3.235 ± 0.097
2.736ValGln: 2.736 ± 0.075
3.778ValArg: 3.778 ± 0.095
5.551ValSer: 5.551 ± 0.124
3.548ValThr: 3.548 ± 0.111
5.747ValVal: 5.747 ± 0.149
0.652ValTrp: 0.652 ± 0.033
2.217ValTyr: 2.217 ± 0.071
0.0ValXaa: 0.0 ± 0.0
Trp
0.654TrpAla: 0.654 ± 0.034
0.212TrpCys: 0.212 ± 0.022
0.499TrpAsp: 0.499 ± 0.033
0.521TrpGlu: 0.521 ± 0.035
0.365TrpPhe: 0.365 ± 0.031
0.61TrpGly: 0.61 ± 0.037
0.271TrpHis: 0.271 ± 0.024
0.533TrpIle: 0.533 ± 0.033
0.525TrpLys: 0.525 ± 0.036
0.858TrpLeu: 0.858 ± 0.044
0.236TrpMet: 0.236 ± 0.023
0.493TrpAsn: 0.493 ± 0.035
0.22TrpPro: 0.22 ± 0.02
0.329TrpGln: 0.329 ± 0.024
0.43TrpArg: 0.43 ± 0.029
0.571TrpSer: 0.571 ± 0.032
0.309TrpThr: 0.309 ± 0.026
0.529TrpVal: 0.529 ± 0.034
0.139TrpTrp: 0.139 ± 0.016
0.303TrpTyr: 0.303 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.158TyrAla: 3.158 ± 0.08
0.535TyrCys: 0.535 ± 0.034
1.953TyrAsp: 1.953 ± 0.07
1.955TyrGlu: 1.955 ± 0.071
1.234TyrPhe: 1.234 ± 0.055
2.108TyrGly: 2.108 ± 0.073
0.761TyrHis: 0.761 ± 0.035
1.747TyrIle: 1.747 ± 0.064
1.73TyrLys: 1.73 ± 0.074
2.758TyrLeu: 2.758 ± 0.073
0.666TyrMet: 0.666 ± 0.036
1.323TyrAsn: 1.323 ± 0.056
1.195TyrPro: 1.195 ± 0.054
1.203TyrGln: 1.203 ± 0.046
1.638TyrArg: 1.638 ± 0.069
1.779TyrSer: 1.779 ± 0.076
2.033TyrThr: 2.033 ± 0.092
2.256TyrVal: 2.256 ± 0.065
0.275TyrTrp: 0.275 ± 0.023
1.028TyrTyr: 1.028 ± 0.048
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1709 proteins (504769 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski