Amino acid dipepetide frequency for Alkalibaculum bacchi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.876AlaAla: 3.876 ± 0.097	0.721AlaCys: 0.721 ± 0.031	2.916AlaAsp: 2.916 ± 0.062	3.715AlaGlu: 3.715 ± 0.077	2.615AlaPhe: 2.615 ± 0.057	4.086AlaGly: 4.086 ± 0.085	1.008AlaHis: 1.008 ± 0.039	6.159AlaIle: 6.159 ± 0.099	4.634AlaLys: 4.634 ± 0.067	6.24AlaLeu: 6.24 ± 0.092	1.787AlaMet: 1.787 ± 0.05	2.695AlaAsn: 2.695 ± 0.061	1.628AlaPro: 1.628 ± 0.052	2.005AlaGln: 2.005 ± 0.046	2.201AlaArg: 2.201 ± 0.051	3.429AlaSer: 3.429 ± 0.078	3.137AlaThr: 3.137 ± 0.07	4.129AlaVal: 4.129 ± 0.081	0.356AlaTrp: 0.356 ± 0.021	2.163AlaTyr: 2.163 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.705CysAla: 0.705 ± 0.028	0.165CysCys: 0.165 ± 0.016	0.672CysAsp: 0.672 ± 0.027	0.682CysGlu: 0.682 ± 0.028	0.428CysPhe: 0.428 ± 0.021	1.084CysGly: 1.084 ± 0.043	0.244CysHis: 0.244 ± 0.02	1.024CysIle: 1.024 ± 0.038	0.847CysLys: 0.847 ± 0.035	0.861CysLeu: 0.861 ± 0.036	0.251CysMet: 0.251 ± 0.018	0.615CysAsn: 0.615 ± 0.028	0.545CysPro: 0.545 ± 0.026	0.306CysGln: 0.306 ± 0.018	0.385CysArg: 0.385 ± 0.017	0.801CysSer: 0.801 ± 0.034	0.581CysThr: 0.581 ± 0.03	0.65CysVal: 0.65 ± 0.031	0.054CysTrp: 0.054 ± 0.008	0.437CysTyr: 0.437 ± 0.032	0.0CysXaa: 0.0 ± 0.0
Asp	3.04AspAla: 3.04 ± 0.063	0.633AspCys: 0.633 ± 0.031	2.649AspAsp: 2.649 ± 0.062	4.635AspGlu: 4.635 ± 0.077	2.745AspPhe: 2.745 ± 0.068	3.371AspGly: 3.371 ± 0.071	0.977AspHis: 0.977 ± 0.035	5.699AspIle: 5.699 ± 0.083	4.473AspLys: 4.473 ± 0.081	5.311AspLeu: 5.311 ± 0.072	1.626AspMet: 1.626 ± 0.039	2.697AspAsn: 2.697 ± 0.061	1.736AspPro: 1.736 ± 0.046	1.508AspGln: 1.508 ± 0.044	1.957AspArg: 1.957 ± 0.049	3.082AspSer: 3.082 ± 0.062	2.665AspThr: 2.665 ± 0.05	3.641AspVal: 3.641 ± 0.073	0.451AspTrp: 0.451 ± 0.023	2.867AspTyr: 2.867 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	4.407GluAla: 4.407 ± 0.079	0.69GluCys: 0.69 ± 0.031	4.601GluAsp: 4.601 ± 0.074	7.438GluGlu: 7.438 ± 0.137	2.77GluPhe: 2.77 ± 0.06	4.311GluGly: 4.311 ± 0.081	1.193GluHis: 1.193 ± 0.039	7.226GluIle: 7.226 ± 0.091	7.35GluLys: 7.35 ± 0.108	6.92GluLeu: 6.92 ± 0.092	2.181GluMet: 2.181 ± 0.05	4.609GluAsn: 4.609 ± 0.085	1.713GluPro: 1.713 ± 0.05	2.445GluGln: 2.445 ± 0.06	2.868GluArg: 2.868 ± 0.067	3.822GluSer: 3.822 ± 0.071	3.153GluThr: 3.153 ± 0.059	4.853GluVal: 4.853 ± 0.087	0.486GluTrp: 0.486 ± 0.024	3.07GluTyr: 3.07 ± 0.068	0.0GluXaa: 0.0 ± 0.0
Phe	2.445PheAla: 2.445 ± 0.054	0.487PheCys: 0.487 ± 0.026	2.586PheAsp: 2.586 ± 0.055	2.854PheGlu: 2.854 ± 0.072	1.965PhePhe: 1.965 ± 0.059	2.792PheGly: 2.792 ± 0.073	0.758PheHis: 0.758 ± 0.027	4.03PheIle: 4.03 ± 0.075	2.823PheLys: 2.823 ± 0.061	3.836PheLeu: 3.836 ± 0.082	1.147PheMet: 1.147 ± 0.037	2.149PheAsn: 2.149 ± 0.051	1.408PhePro: 1.408 ± 0.045	1.227PheGln: 1.227 ± 0.037	1.344PheArg: 1.344 ± 0.04	3.087PheSer: 3.087 ± 0.062	2.328PheThr: 2.328 ± 0.057	2.799PheVal: 2.799 ± 0.061	0.326PheTrp: 0.326 ± 0.022	1.744PheTyr: 1.744 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	4.286GlyAla: 4.286 ± 0.083	0.868GlyCys: 0.868 ± 0.031	3.477GlyAsp: 3.477 ± 0.062	4.383GlyGlu: 4.383 ± 0.072	3.067GlyPhe: 3.067 ± 0.068	4.522GlyGly: 4.522 ± 0.1	1.228GlyHis: 1.228 ± 0.037	6.557GlyIle: 6.557 ± 0.106	5.259GlyLys: 5.259 ± 0.071	5.952GlyLeu: 5.952 ± 0.093	2.012GlyMet: 2.012 ± 0.059	3.047GlyAsn: 3.047 ± 0.06	1.388GlyPro: 1.388 ± 0.045	1.993GlyGln: 1.993 ± 0.048	2.39GlyArg: 2.39 ± 0.047	3.878GlySer: 3.878 ± 0.065	3.593GlyThr: 3.593 ± 0.069	4.685GlyVal: 4.685 ± 0.068	0.5GlyTrp: 0.5 ± 0.03	2.839GlyTyr: 2.839 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	0.852HisAla: 0.852 ± 0.03	0.24HisCys: 0.24 ± 0.017	0.867HisAsp: 0.867 ± 0.035	1.119HisGlu: 1.119 ± 0.036	0.879HisPhe: 0.879 ± 0.037	1.147HisGly: 1.147 ± 0.04	0.474HisHis: 0.474 ± 0.026	1.679HisIle: 1.679 ± 0.044	1.18HisLys: 1.18 ± 0.037	1.65HisLeu: 1.65 ± 0.049	0.485HisMet: 0.485 ± 0.026	0.888HisAsn: 0.888 ± 0.028	0.841HisPro: 0.841 ± 0.031	0.506HisGln: 0.506 ± 0.028	0.649HisArg: 0.649 ± 0.025	1.134HisSer: 1.134 ± 0.034	0.895HisThr: 0.895 ± 0.035	0.97HisVal: 0.97 ± 0.035	0.132HisTrp: 0.132 ± 0.013	0.758HisTyr: 0.758 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.164IleAla: 6.164 ± 0.073	1.213IleCys: 1.213 ± 0.041	5.61IleAsp: 5.61 ± 0.081	7.108IleGlu: 7.108 ± 0.102	3.681IlePhe: 3.681 ± 0.068	6.319IleGly: 6.319 ± 0.11	1.632IleHis: 1.632 ± 0.048	8.564IleIle: 8.564 ± 0.117	7.01IleLys: 7.01 ± 0.1	8.754IleLeu: 8.754 ± 0.122	2.351IleMet: 2.351 ± 0.052	4.755IleAsn: 4.755 ± 0.081	3.417IlePro: 3.417 ± 0.06	3.0IleGln: 3.0 ± 0.068	3.29IleArg: 3.29 ± 0.069	6.487IleSer: 6.487 ± 0.098	4.902IleThr: 4.902 ± 0.08	6.28IleVal: 6.28 ± 0.106	0.521IleTrp: 0.521 ± 0.028	3.312IleTyr: 3.312 ± 0.069	0.0IleXaa: 0.0 ± 0.0
Lys	4.622LysAla: 4.622 ± 0.078	0.722LysCys: 0.722 ± 0.027	5.266LysAsp: 5.266 ± 0.089	7.929LysGlu: 7.929 ± 0.113	2.283LysPhe: 2.283 ± 0.059	4.871LysGly: 4.871 ± 0.082	1.168LysHis: 1.168 ± 0.035	7.135LysIle: 7.135 ± 0.092	7.073LysLys: 7.073 ± 0.119	6.38LysLeu: 6.38 ± 0.088	2.255LysMet: 2.255 ± 0.048	4.789LysAsn: 4.789 ± 0.094	2.091LysPro: 2.091 ± 0.055	2.409LysGln: 2.409 ± 0.054	3.201LysArg: 3.201 ± 0.062	4.637LysSer: 4.637 ± 0.082	3.854LysThr: 3.854 ± 0.069	5.392LysVal: 5.392 ± 0.072	0.586LysTrp: 0.586 ± 0.03	3.423LysTyr: 3.423 ± 0.071	0.0LysXaa: 0.0 ± 0.0
Leu	5.632LeuAla: 5.632 ± 0.082	1.071LeuCys: 1.071 ± 0.038	5.242LeuAsp: 5.242 ± 0.09	6.824LeuGlu: 6.824 ± 0.108	4.132LeuPhe: 4.132 ± 0.077	6.343LeuGly: 6.343 ± 0.107	1.53LeuHis: 1.53 ± 0.042	7.864LeuIle: 7.864 ± 0.115	7.266LeuLys: 7.266 ± 0.097	8.97LeuLeu: 8.97 ± 0.12	2.56LeuMet: 2.56 ± 0.055	4.808LeuAsn: 4.808 ± 0.09	3.162LeuPro: 3.162 ± 0.065	2.922LeuGln: 2.922 ± 0.063	3.27LeuArg: 3.27 ± 0.061	6.805LeuSer: 6.805 ± 0.102	4.521LeuThr: 4.521 ± 0.068	5.567LeuVal: 5.567 ± 0.085	0.646LeuTrp: 0.646 ± 0.027	3.34LeuTyr: 3.34 ± 0.068	0.0LeuXaa: 0.0 ± 0.0
Met	1.912MetAla: 1.912 ± 0.053	0.252MetCys: 0.252 ± 0.019	1.719MetAsp: 1.719 ± 0.045	2.097MetGlu: 2.097 ± 0.044	0.967MetPhe: 0.967 ± 0.039	1.882MetGly: 1.882 ± 0.045	0.376MetHis: 0.376 ± 0.021	2.398MetIle: 2.398 ± 0.057	2.57MetLys: 2.57 ± 0.055	2.139MetLeu: 2.139 ± 0.048	0.766MetMet: 0.766 ± 0.032	1.734MetAsn: 1.734 ± 0.049	1.001MetPro: 1.001 ± 0.034	0.754MetGln: 0.754 ± 0.034	0.967MetArg: 0.967 ± 0.031	1.809MetSer: 1.809 ± 0.049	1.474MetThr: 1.474 ± 0.044	1.716MetVal: 1.716 ± 0.046	0.155MetTrp: 0.155 ± 0.013	0.87MetTyr: 0.87 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	2.743AsnAla: 2.743 ± 0.059	0.603AsnCys: 0.603 ± 0.028	2.469AsnAsp: 2.469 ± 0.055	3.703AsnGlu: 3.703 ± 0.06	1.978AsnPhe: 1.978 ± 0.054	3.229AsnGly: 3.229 ± 0.069	1.043AsnHis: 1.043 ± 0.034	5.564AsnIle: 5.564 ± 0.085	4.507AsnLys: 4.507 ± 0.077	4.671AsnLeu: 4.671 ± 0.08	1.469AsnMet: 1.469 ± 0.042	2.947AsnAsn: 2.947 ± 0.088	2.173AsnPro: 2.173 ± 0.055	1.911AsnGln: 1.911 ± 0.057	2.212AsnArg: 2.212 ± 0.049	3.053AsnSer: 3.053 ± 0.063	2.839AsnThr: 2.839 ± 0.064	3.126AsnVal: 3.126 ± 0.069	0.404AsnTrp: 0.404 ± 0.023	2.237AsnTyr: 2.237 ± 0.054	0.0AsnXaa: 0.0 ± 0.0
Pro	1.72ProAla: 1.72 ± 0.053	0.336ProCys: 0.336 ± 0.023	1.743ProAsp: 1.743 ± 0.045	2.463ProGlu: 2.463 ± 0.057	1.502ProPhe: 1.502 ± 0.047	1.957ProGly: 1.957 ± 0.058	0.606ProHis: 0.606 ± 0.028	2.948ProIle: 2.948 ± 0.072	2.24ProLys: 2.24 ± 0.057	2.767ProLeu: 2.767 ± 0.056	0.817ProMet: 0.817 ± 0.028	1.525ProAsn: 1.525 ± 0.04	0.719ProPro: 0.719 ± 0.03	1.023ProGln: 1.023 ± 0.034	0.984ProArg: 0.984 ± 0.034	1.908ProSer: 1.908 ± 0.05	1.829ProThr: 1.829 ± 0.053	2.287ProVal: 2.287 ± 0.059	0.268ProTrp: 0.268 ± 0.018	1.373ProTyr: 1.373 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	1.732GlnAla: 1.732 ± 0.05	0.332GlnCys: 0.332 ± 0.02	1.611GlnAsp: 1.611 ± 0.048	2.568GlnGlu: 2.568 ± 0.064	1.186GlnPhe: 1.186 ± 0.035	2.043GlnGly: 2.043 ± 0.054	0.415GlnHis: 0.415 ± 0.023	3.068GlnIle: 3.068 ± 0.063	2.685GlnLys: 2.685 ± 0.053	2.95GlnLeu: 2.95 ± 0.063	0.93GlnMet: 0.93 ± 0.033	1.746GlnAsn: 1.746 ± 0.05	0.694GlnPro: 0.694 ± 0.03	0.974GlnGln: 0.974 ± 0.041	1.296GlnArg: 1.296 ± 0.048	1.823GlnSer: 1.823 ± 0.049	1.468GlnThr: 1.468 ± 0.048	2.012GlnVal: 2.012 ± 0.053	0.293GlnTrp: 0.293 ± 0.019	1.373GlnTyr: 1.373 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.091ArgAla: 2.091 ± 0.051	0.418ArgCys: 0.418 ± 0.025	2.06ArgAsp: 2.06 ± 0.051	3.139ArgGlu: 3.139 ± 0.073	1.529ArgPhe: 1.529 ± 0.047	2.224ArgGly: 2.224 ± 0.048	0.549ArgHis: 0.549 ± 0.024	3.364ArgIle: 3.364 ± 0.066	3.2ArgLys: 3.2 ± 0.069	3.257ArgLeu: 3.257 ± 0.063	1.172ArgMet: 1.172 ± 0.038	1.976ArgAsn: 1.976 ± 0.055	1.05ArgPro: 1.05 ± 0.044	1.228ArgGln: 1.228 ± 0.04	1.653ArgArg: 1.653 ± 0.049	1.91ArgSer: 1.91 ± 0.05	1.733ArgThr: 1.733 ± 0.045	2.409ArgVal: 2.409 ± 0.051	0.289ArgTrp: 0.289 ± 0.017	1.501ArgTyr: 1.501 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	3.396SerAla: 3.396 ± 0.076	0.73SerCys: 0.73 ± 0.035	2.991SerAsp: 2.991 ± 0.057	3.826SerGlu: 3.826 ± 0.072	3.005SerPhe: 3.005 ± 0.061	4.254SerGly: 4.254 ± 0.075	1.179SerHis: 1.179 ± 0.039	6.254SerIle: 6.254 ± 0.092	4.856SerLys: 4.856 ± 0.087	6.084SerLeu: 6.084 ± 0.081	1.732SerMet: 1.732 ± 0.044	3.265SerAsn: 3.265 ± 0.079	1.857SerPro: 1.857 ± 0.044	2.058SerGln: 2.058 ± 0.053	2.268SerArg: 2.268 ± 0.053	4.11SerSer: 4.11 ± 0.084	3.385SerThr: 3.385 ± 0.052	3.88SerVal: 3.88 ± 0.071	0.486SerTrp: 0.486 ± 0.027	2.524SerTyr: 2.524 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	3.212ThrAla: 3.212 ± 0.066	0.487ThrCys: 0.487 ± 0.028	2.528ThrAsp: 2.528 ± 0.059	3.299ThrGlu: 3.299 ± 0.065	2.157ThrPhe: 2.157 ± 0.051	3.816ThrGly: 3.816 ± 0.065	0.917ThrHis: 0.917 ± 0.036	4.827ThrIle: 4.827 ± 0.074	3.639ThrLys: 3.639 ± 0.057	4.983ThrLeu: 4.983 ± 0.087	1.245ThrMet: 1.245 ± 0.038	2.548ThrAsn: 2.548 ± 0.055	1.939ThrPro: 1.939 ± 0.053	1.535ThrGln: 1.535 ± 0.047	1.735ThrArg: 1.735 ± 0.047	3.182ThrSer: 3.182 ± 0.06	2.873ThrThr: 2.873 ± 0.067	3.635ThrVal: 3.635 ± 0.073	0.327ThrTrp: 0.327 ± 0.018	1.94ThrTyr: 1.94 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	4.104ValAla: 4.104 ± 0.084	0.786ValCys: 0.786 ± 0.033	3.968ValAsp: 3.968 ± 0.077	4.908ValGlu: 4.908 ± 0.072	2.963ValPhe: 2.963 ± 0.062	4.464ValGly: 4.464 ± 0.081	1.119ValHis: 1.119 ± 0.041	5.752ValIle: 5.752 ± 0.088	4.832ValLys: 4.832 ± 0.074	6.431ValLeu: 6.431 ± 0.09	1.593ValMet: 1.593 ± 0.039	3.326ValAsn: 3.326 ± 0.069	2.112ValPro: 2.112 ± 0.05	1.92ValGln: 1.92 ± 0.052	2.274ValArg: 2.274 ± 0.054	4.139ValSer: 4.139 ± 0.073	3.163ValThr: 3.163 ± 0.06	4.605ValVal: 4.605 ± 0.086	0.376ValTrp: 0.376 ± 0.022	2.379ValTyr: 2.379 ± 0.056	0.0ValXaa: 0.0 ± 0.0
Trp	0.418TrpAla: 0.418 ± 0.026	0.068TrpCys: 0.068 ± 0.009	0.374TrpAsp: 0.374 ± 0.02	0.485TrpGlu: 0.485 ± 0.024	0.354TrpPhe: 0.354 ± 0.023	0.463TrpGly: 0.463 ± 0.025	0.132TrpHis: 0.132 ± 0.012	0.694TrpIle: 0.694 ± 0.029	0.566TrpLys: 0.566 ± 0.025	0.631TrpLeu: 0.631 ± 0.031	0.212TrpMet: 0.212 ± 0.017	0.435TrpAsn: 0.435 ± 0.023	0.153TrpPro: 0.153 ± 0.015	0.255TrpGln: 0.255 ± 0.019	0.279TrpArg: 0.279 ± 0.018	0.426TrpSer: 0.426 ± 0.026	0.339TrpThr: 0.339 ± 0.02	0.378TrpVal: 0.378 ± 0.02	0.086TrpTrp: 0.086 ± 0.009	0.288TrpTyr: 0.288 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.142TyrAla: 2.142 ± 0.052	0.515TyrCys: 0.515 ± 0.025	2.415TyrAsp: 2.415 ± 0.051	2.931TyrGlu: 2.931 ± 0.06	1.932TyrPhe: 1.932 ± 0.052	2.747TyrGly: 2.747 ± 0.067	0.798TyrHis: 0.798 ± 0.035	3.565TyrIle: 3.565 ± 0.077	3.078TyrLys: 3.078 ± 0.064	3.687TyrLeu: 3.687 ± 0.067	0.965TyrMet: 0.965 ± 0.034	2.324TyrAsn: 2.324 ± 0.053	1.386TyrPro: 1.386 ± 0.045	1.218TyrGln: 1.218 ± 0.042	1.528TyrArg: 1.528 ± 0.045	2.617TyrSer: 2.617 ± 0.058	2.094TyrThr: 2.094 ± 0.049	2.201TyrVal: 2.201 ± 0.056	0.294TyrTrp: 0.294 ± 0.019	1.905TyrTyr: 1.905 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2857 proteins (853553 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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