Amino acid dipepetide frequency for Mycoplasma conjunctivae (strain ATCC 25834 / HRC/581 / NCTC 10147)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.231AlaAla: 3.231 ± 0.134
0.215AlaCys: 0.215 ± 0.036
2.329AlaAsp: 2.329 ± 0.101
2.446AlaGlu: 2.446 ± 0.113
3.098AlaPhe: 3.098 ± 0.116
2.704AlaGly: 2.704 ± 0.129
0.839AlaHis: 0.839 ± 0.062
5.658AlaIle: 5.658 ± 0.171
6.146AlaLys: 6.146 ± 0.176
5.065AlaLeu: 5.065 ± 0.151
0.73AlaMet: 0.73 ± 0.063
4.452AlaAsn: 4.452 ± 0.156
1.658AlaPro: 1.658 ± 0.114
2.739AlaGln: 2.739 ± 0.129
2.052AlaArg: 2.052 ± 0.107
3.996AlaSer: 3.996 ± 0.151
3.504AlaThr: 3.504 ± 0.203
2.283AlaVal: 2.283 ± 0.111
0.398AlaTrp: 0.398 ± 0.043
1.697AlaTyr: 1.697 ± 0.078
0.0AlaXaa: 0.0 ± 0.0
Cys
0.164CysAla: 0.164 ± 0.029
0.02CysCys: 0.02 ± 0.011
0.211CysAsp: 0.211 ± 0.031
0.137CysGlu: 0.137 ± 0.023
0.195CysPhe: 0.195 ± 0.027
0.285CysGly: 0.285 ± 0.036
0.094CysHis: 0.094 ± 0.019
0.258CysIle: 0.258 ± 0.036
0.222CysLys: 0.222 ± 0.028
0.312CysLeu: 0.312 ± 0.04
0.02CysMet: 0.02 ± 0.008
0.164CysAsn: 0.164 ± 0.024
0.148CysPro: 0.148 ± 0.027
0.261CysGln: 0.261 ± 0.035
0.094CysArg: 0.094 ± 0.021
0.281CysSer: 0.281 ± 0.037
0.09CysThr: 0.09 ± 0.021
0.121CysVal: 0.121 ± 0.02
0.023CysTrp: 0.023 ± 0.009
0.125CysTyr: 0.125 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
2.7AspAla: 2.7 ± 0.099
0.109AspCys: 0.109 ± 0.026
2.716AspAsp: 2.716 ± 0.124
3.715AspGlu: 3.715 ± 0.116
4.671AspPhe: 4.671 ± 0.143
2.341AspGly: 2.341 ± 0.112
0.687AspHis: 0.687 ± 0.051
4.667AspIle: 4.667 ± 0.134
5.58AspLys: 5.58 ± 0.159
5.494AspLeu: 5.494 ± 0.14
0.554AspMet: 0.554 ± 0.044
4.105AspAsn: 4.105 ± 0.132
1.732AspPro: 1.732 ± 0.096
2.247AspGln: 2.247 ± 0.106
1.272AspArg: 1.272 ± 0.081
3.687AspSer: 3.687 ± 0.141
2.169AspThr: 2.169 ± 0.094
2.993AspVal: 2.993 ± 0.124
0.468AspTrp: 0.468 ± 0.049
2.716AspTyr: 2.716 ± 0.104
0.0AspXaa: 0.0 ± 0.0
Glu
3.071GluAla: 3.071 ± 0.133
0.113GluCys: 0.113 ± 0.02
2.942GluAsp: 2.942 ± 0.115
3.781GluGlu: 3.781 ± 0.152
3.547GluPhe: 3.547 ± 0.117
2.088GluGly: 2.088 ± 0.105
0.847GluHis: 0.847 ± 0.066
6.848GluIle: 6.848 ± 0.188
6.961GluLys: 6.961 ± 0.185
5.525GluLeu: 5.525 ± 0.158
0.929GluMet: 0.929 ± 0.07
5.564GluAsn: 5.564 ± 0.163
1.155GluPro: 1.155 ± 0.065
3.141GluGln: 3.141 ± 0.125
1.494GluArg: 1.494 ± 0.089
3.332GluSer: 3.332 ± 0.121
2.431GluThr: 2.431 ± 0.086
3.317GluVal: 3.317 ± 0.13
0.41GluTrp: 0.41 ± 0.04
2.037GluTyr: 2.037 ± 0.079
0.0GluXaa: 0.0 ± 0.0
Phe
4.089PheAla: 4.089 ± 0.141
0.265PheCys: 0.265 ± 0.032
4.206PheAsp: 4.206 ± 0.151
3.82PheGlu: 3.82 ± 0.122
3.871PhePhe: 3.871 ± 0.172
2.841PheGly: 2.841 ± 0.135
0.706PheHis: 0.706 ± 0.052
5.494PheIle: 5.494 ± 0.185
4.959PheLys: 4.959 ± 0.162
6.235PheLeu: 6.235 ± 0.219
0.659PheMet: 0.659 ± 0.05
4.366PheAsn: 4.366 ± 0.134
1.37PhePro: 1.37 ± 0.073
1.99PheGln: 1.99 ± 0.095
1.327PheArg: 1.327 ± 0.071
5.268PheSer: 5.268 ± 0.162
2.649PheThr: 2.649 ± 0.107
3.937PheVal: 3.937 ± 0.131
0.882PheTrp: 0.882 ± 0.072
2.622PheTyr: 2.622 ± 0.098
0.0PheXaa: 0.0 ± 0.0
Gly
2.802GlyAla: 2.802 ± 0.131
0.133GlyCys: 0.133 ± 0.023
2.446GlyAsp: 2.446 ± 0.097
2.376GlyGlu: 2.376 ± 0.1
2.95GlyPhe: 2.95 ± 0.113
2.95GlyGly: 2.95 ± 0.173
0.819GlyHis: 0.819 ± 0.061
4.596GlyIle: 4.596 ± 0.164
4.503GlyLys: 4.503 ± 0.123
3.925GlyLeu: 3.925 ± 0.153
0.71GlyMet: 0.71 ± 0.06
2.486GlyAsn: 2.486 ± 0.107
0.987GlyPro: 0.987 ± 0.074
2.337GlyGln: 2.337 ± 0.12
1.596GlyArg: 1.596 ± 0.091
3.434GlySer: 3.434 ± 0.157
2.271GlyThr: 2.271 ± 0.105
2.844GlyVal: 2.844 ± 0.135
0.429GlyTrp: 0.429 ± 0.046
1.787GlyTyr: 1.787 ± 0.096
0.0GlyXaa: 0.0 ± 0.0
His
0.652HisAla: 0.652 ± 0.051
0.078HisCys: 0.078 ± 0.02
0.593HisAsp: 0.593 ± 0.048
0.695HisGlu: 0.695 ± 0.054
1.089HisPhe: 1.089 ± 0.061
0.671HisGly: 0.671 ± 0.056
0.281HisHis: 0.281 ± 0.035
1.432HisIle: 1.432 ± 0.071
1.249HisLys: 1.249 ± 0.087
1.459HisLeu: 1.459 ± 0.096
0.156HisMet: 0.156 ± 0.025
0.979HisAsn: 0.979 ± 0.073
0.55HisPro: 0.55 ± 0.052
0.613HisGln: 0.613 ± 0.049
0.48HisArg: 0.48 ± 0.043
1.007HisSer: 1.007 ± 0.066
0.636HisThr: 0.636 ± 0.051
0.628HisVal: 0.628 ± 0.057
0.09HisTrp: 0.09 ± 0.019
0.538HisTyr: 0.538 ± 0.054
0.0HisXaa: 0.0 ± 0.0
Ile
5.986IleAla: 5.986 ± 0.173
0.406IleCys: 0.406 ± 0.048
5.935IleAsp: 5.935 ± 0.165
6.403IleGlu: 6.403 ± 0.169
6.177IlePhe: 6.177 ± 0.216
4.421IleGly: 4.421 ± 0.155
1.085IleHis: 1.085 ± 0.082
9.185IleIle: 9.185 ± 0.257
9.29IleLys: 9.29 ± 0.238
8.861IleLeu: 8.861 ± 0.277
1.147IleMet: 1.147 ± 0.079
7.359IleAsn: 7.359 ± 0.204
2.817IlePro: 2.817 ± 0.131
3.207IleGln: 3.207 ± 0.109
2.751IleArg: 2.751 ± 0.113
7.999IleSer: 7.999 ± 0.178
4.721IleThr: 4.721 ± 0.121
5.197IleVal: 5.197 ± 0.154
0.788IleTrp: 0.788 ± 0.057
3.629IleTyr: 3.629 ± 0.14
0.0IleXaa: 0.0 ± 0.0
Lys
4.397LysAla: 4.397 ± 0.152
0.203LysCys: 0.203 ± 0.032
5.225LysAsp: 5.225 ± 0.182
6.185LysGlu: 6.185 ± 0.184
4.831LysPhe: 4.831 ± 0.148
3.523LysGly: 3.523 ± 0.137
1.51LysHis: 1.51 ± 0.086
11.312LysIle: 11.312 ± 0.262
9.755LysLys: 9.755 ± 0.274
8.873LysLeu: 8.873 ± 0.201
1.994LysMet: 1.994 ± 0.106
8.959LysAsn: 8.959 ± 0.257
2.482LysPro: 2.482 ± 0.126
4.815LysGln: 4.815 ± 0.153
2.595LysArg: 2.595 ± 0.1
6.231LysSer: 6.231 ± 0.168
5.837LysThr: 5.837 ± 0.181
5.014LysVal: 5.014 ± 0.158
0.979LysTrp: 0.979 ± 0.068
4.113LysTyr: 4.113 ± 0.146
0.0LysXaa: 0.0 ± 0.0
Leu
6.013LeuAla: 6.013 ± 0.167
0.222LeuCys: 0.222 ± 0.029
6.071LeuAsp: 6.071 ± 0.174
6.899LeuGlu: 6.899 ± 0.156
5.166LeuPhe: 5.166 ± 0.208
4.21LeuGly: 4.21 ± 0.165
1.163LeuHis: 1.163 ± 0.068
8.612LeuIle: 8.612 ± 0.266
9.123LeuLys: 9.123 ± 0.217
8.124LeuLeu: 8.124 ± 0.247
1.108LeuMet: 1.108 ± 0.074
6.785LeuAsn: 6.785 ± 0.177
2.942LeuPro: 2.942 ± 0.109
3.621LeuGln: 3.621 ± 0.103
2.579LeuArg: 2.579 ± 0.102
7.004LeuSer: 7.004 ± 0.196
4.823LeuThr: 4.823 ± 0.144
5.615LeuVal: 5.615 ± 0.17
0.667LeuTrp: 0.667 ± 0.064
2.938LeuTyr: 2.938 ± 0.114
0.0LeuXaa: 0.0 ± 0.0
Met
0.784MetAla: 0.784 ± 0.059
0.07MetCys: 0.07 ± 0.017
0.64MetAsp: 0.64 ± 0.056
0.675MetGlu: 0.675 ± 0.052
0.648MetPhe: 0.648 ± 0.061
0.617MetGly: 0.617 ± 0.052
0.222MetHis: 0.222 ± 0.03
1.221MetIle: 1.221 ± 0.078
1.416MetLys: 1.416 ± 0.076
1.303MetLeu: 1.303 ± 0.071
0.215MetMet: 0.215 ± 0.031
0.894MetAsn: 0.894 ± 0.065
0.472MetPro: 0.472 ± 0.045
0.679MetGln: 0.679 ± 0.056
0.328MetArg: 0.328 ± 0.044
1.014MetSer: 1.014 ± 0.06
0.558MetThr: 0.558 ± 0.056
0.819MetVal: 0.819 ± 0.063
0.082MetTrp: 0.082 ± 0.02
0.312MetTyr: 0.312 ± 0.035
0.0MetXaa: 0.0 ± 0.0
Asn
3.129AsnAla: 3.129 ± 0.111
0.199AsnCys: 0.199 ± 0.024
3.484AsnAsp: 3.484 ± 0.123
3.824AsnGlu: 3.824 ± 0.143
5.283AsnPhe: 5.283 ± 0.162
2.895AsnGly: 2.895 ± 0.13
1.065AsnHis: 1.065 ± 0.063
7.347AsnIle: 7.347 ± 0.178
8.151AsnLys: 8.151 ± 0.191
8.241AsnLeu: 8.241 ± 0.203
0.89AsnMet: 0.89 ± 0.062
6.594AsnAsn: 6.594 ± 0.238
2.493AsnPro: 2.493 ± 0.094
4.089AsnGln: 4.089 ± 0.156
2.212AsnArg: 2.212 ± 0.099
6.001AsnSer: 6.001 ± 0.197
3.371AsnThr: 3.371 ± 0.136
3.317AsnVal: 3.317 ± 0.12
0.823AsnTrp: 0.823 ± 0.059
3.278AsnTyr: 3.278 ± 0.13
0.0AsnXaa: 0.0 ± 0.0
Pro
1.576ProAla: 1.576 ± 0.117
0.101ProCys: 0.101 ± 0.022
1.436ProAsp: 1.436 ± 0.084
1.732ProGlu: 1.732 ± 0.1
1.705ProPhe: 1.705 ± 0.075
1.572ProGly: 1.572 ± 0.089
0.527ProHis: 0.527 ± 0.052
2.704ProIle: 2.704 ± 0.112
2.404ProLys: 2.404 ± 0.101
2.677ProLeu: 2.677 ± 0.1
0.285ProMet: 0.285 ± 0.036
2.013ProAsn: 2.013 ± 0.089
0.64ProPro: 0.64 ± 0.072
1.381ProGln: 1.381 ± 0.097
0.663ProArg: 0.663 ± 0.063
2.115ProSer: 2.115 ± 0.115
2.033ProThr: 2.033 ± 0.124
1.522ProVal: 1.522 ± 0.093
0.203ProTrp: 0.203 ± 0.027
1.034ProTyr: 1.034 ± 0.065
0.0ProXaa: 0.0 ± 0.0
Gln
2.61GlnAla: 2.61 ± 0.116
0.082GlnCys: 0.082 ± 0.017
2.521GlnAsp: 2.521 ± 0.109
3.122GlnGlu: 3.122 ± 0.107
2.088GlnPhe: 2.088 ± 0.099
2.064GlnGly: 2.064 ± 0.09
0.511GlnHis: 0.511 ± 0.043
4.952GlnIle: 4.952 ± 0.161
4.967GlnLys: 4.967 ± 0.15
4.066GlnLeu: 4.066 ± 0.135
0.589GlnMet: 0.589 ± 0.049
3.594GlnAsn: 3.594 ± 0.129
1.354GlnPro: 1.354 ± 0.119
2.603GlnGln: 2.603 ± 0.161
1.35GlnArg: 1.35 ± 0.07
2.439GlnSer: 2.439 ± 0.125
2.368GlnThr: 2.368 ± 0.119
2.431GlnVal: 2.431 ± 0.104
0.347GlnTrp: 0.347 ± 0.042
1.331GlnTyr: 1.331 ± 0.076
0.0GlnXaa: 0.0 ± 0.0
Arg
1.569ArgAla: 1.569 ± 0.104
0.086ArgCys: 0.086 ± 0.018
1.623ArgAsp: 1.623 ± 0.072
1.604ArgGlu: 1.604 ± 0.095
1.951ArgPhe: 1.951 ± 0.082
1.409ArgGly: 1.409 ± 0.102
0.394ArgHis: 0.394 ± 0.037
2.532ArgIle: 2.532 ± 0.123
2.606ArgLys: 2.606 ± 0.115
2.517ArgLeu: 2.517 ± 0.107
0.421ArgMet: 0.421 ± 0.046
1.9ArgAsn: 1.9 ± 0.093
0.901ArgPro: 0.901 ± 0.058
1.401ArgGln: 1.401 ± 0.078
1.054ArgArg: 1.054 ± 0.068
2.025ArgSer: 2.025 ± 0.09
1.171ArgThr: 1.171 ± 0.071
1.627ArgVal: 1.627 ± 0.078
0.285ArgTrp: 0.285 ± 0.032
1.233ArgTyr: 1.233 ± 0.08
0.0ArgXaa: 0.0 ± 0.0
Ser
4.093SerAla: 4.093 ± 0.171
0.347SerCys: 0.347 ± 0.043
3.859SerAsp: 3.859 ± 0.137
3.859SerGlu: 3.859 ± 0.118
4.62SerPhe: 4.62 ± 0.17
3.984SerGly: 3.984 ± 0.135
1.03SerHis: 1.03 ± 0.066
6.43SerIle: 6.43 ± 0.163
7.098SerLys: 7.098 ± 0.19
7.464SerLeu: 7.464 ± 0.192
0.878SerMet: 0.878 ± 0.068
4.838SerAsn: 4.838 ± 0.161
1.943SerPro: 1.943 ± 0.088
3.906SerGln: 3.906 ± 0.139
1.998SerArg: 1.998 ± 0.084
5.837SerSer: 5.837 ± 0.29
3.992SerThr: 3.992 ± 0.168
3.531SerVal: 3.531 ± 0.137
0.574SerTrp: 0.574 ± 0.046
2.739SerTyr: 2.739 ± 0.114
0.0SerXaa: 0.0 ± 0.0
Thr
2.279ThrAla: 2.279 ± 0.14
0.109ThrCys: 0.109 ± 0.023
2.095ThrAsp: 2.095 ± 0.114
1.896ThrGlu: 1.896 ± 0.095
3.348ThrPhe: 3.348 ± 0.134
2.536ThrGly: 2.536 ± 0.132
0.741ThrHis: 0.741 ± 0.057
5.342ThrIle: 5.342 ± 0.148
5.162ThrLys: 5.162 ± 0.148
4.491ThrLeu: 4.491 ± 0.138
0.535ThrMet: 0.535 ± 0.051
4.534ThrAsn: 4.534 ± 0.186
2.029ThrPro: 2.029 ± 0.107
2.072ThrGln: 2.072 ± 0.088
1.424ThrArg: 1.424 ± 0.098
4.214ThrSer: 4.214 ± 0.182
3.867ThrThr: 3.867 ± 0.22
2.263ThrVal: 2.263 ± 0.119
0.363ThrTrp: 0.363 ± 0.042
1.744ThrTyr: 1.744 ± 0.091
0.0ThrXaa: 0.0 ± 0.0
Val
3.812ValAla: 3.812 ± 0.129
0.254ValCys: 0.254 ± 0.038
3.656ValAsp: 3.656 ± 0.143
3.754ValGlu: 3.754 ± 0.121
3.075ValPhe: 3.075 ± 0.117
3.102ValGly: 3.102 ± 0.146
0.644ValHis: 0.644 ± 0.056
4.749ValIle: 4.749 ± 0.153
4.62ValLys: 4.62 ± 0.155
4.37ValLeu: 4.37 ± 0.146
0.597ValMet: 0.597 ± 0.044
3.461ValAsn: 3.461 ± 0.12
1.412ValPro: 1.412 ± 0.082
1.693ValGln: 1.693 ± 0.088
1.471ValArg: 1.471 ± 0.073
3.999ValSer: 3.999 ± 0.145
2.368ValThr: 2.368 ± 0.123
3.492ValVal: 3.492 ± 0.117
0.46ValTrp: 0.46 ± 0.045
2.006ValTyr: 2.006 ± 0.086
0.0ValXaa: 0.0 ± 0.0
Trp
0.449TrpAla: 0.449 ± 0.04
0.016TrpCys: 0.016 ± 0.008
0.484TrpAsp: 0.484 ± 0.049
0.484TrpGlu: 0.484 ± 0.048
0.527TrpPhe: 0.527 ± 0.046
0.394TrpGly: 0.394 ± 0.04
0.109TrpHis: 0.109 ± 0.021
0.964TrpIle: 0.964 ± 0.078
0.886TrpLys: 0.886 ± 0.062
0.812TrpLeu: 0.812 ± 0.065
0.148TrpMet: 0.148 ± 0.026
0.73TrpAsn: 0.73 ± 0.056
0.246TrpPro: 0.246 ± 0.033
0.378TrpGln: 0.378 ± 0.038
0.304TrpArg: 0.304 ± 0.032
0.535TrpSer: 0.535 ± 0.049
0.39TrpThr: 0.39 ± 0.037
0.48TrpVal: 0.48 ± 0.049
0.101TrpTrp: 0.101 ± 0.02
0.375TrpTyr: 0.375 ± 0.038
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.834TyrAla: 1.834 ± 0.089
0.195TyrCys: 0.195 ± 0.032
2.15TyrAsp: 2.15 ± 0.098
2.127TyrGlu: 2.127 ± 0.099
2.72TyrPhe: 2.72 ± 0.117
1.775TyrGly: 1.775 ± 0.086
0.601TyrHis: 0.601 ± 0.051
3.063TyrIle: 3.063 ± 0.127
3.738TyrLys: 3.738 ± 0.134
3.871TyrLeu: 3.871 ± 0.125
0.402TyrMet: 0.402 ± 0.044
2.911TyrAsn: 2.911 ± 0.11
0.991TyrPro: 0.991 ± 0.062
2.212TyrGln: 2.212 ± 0.091
1.264TyrArg: 1.264 ± 0.075
2.603TyrSer: 2.603 ± 0.112
1.795TyrThr: 1.795 ± 0.101
1.565TyrVal: 1.565 ± 0.077
0.437TyrTrp: 0.437 ± 0.046
1.889TyrTyr: 1.889 ± 0.096
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 695 proteins (256286 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski