Amino acid dipepetide frequency for Kiloniella litopenaei

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.036AlaAla: 9.036 ± 0.122
0.942AlaCys: 0.942 ± 0.029
5.137AlaAsp: 5.137 ± 0.077
5.914AlaGlu: 5.914 ± 0.089
3.664AlaPhe: 3.664 ± 0.064
7.24AlaGly: 7.24 ± 0.096
1.661AlaHis: 1.661 ± 0.043
5.848AlaIle: 5.848 ± 0.072
4.709AlaLys: 4.709 ± 0.083
9.856AlaLeu: 9.856 ± 0.113
2.609AlaMet: 2.609 ± 0.049
2.997AlaAsn: 2.997 ± 0.054
3.385AlaPro: 3.385 ± 0.05
3.377AlaGln: 3.377 ± 0.059
4.47AlaArg: 4.47 ± 0.071
5.422AlaSer: 5.422 ± 0.073
4.611AlaThr: 4.611 ± 0.077
6.538AlaVal: 6.538 ± 0.075
1.0AlaTrp: 1.0 ± 0.029
2.321AlaTyr: 2.321 ± 0.048
0.0AlaXaa: 0.0 ± 0.0
Cys
0.838CysAla: 0.838 ± 0.029
0.152CysCys: 0.152 ± 0.013
0.631CysAsp: 0.631 ± 0.024
0.539CysGlu: 0.539 ± 0.022
0.454CysPhe: 0.454 ± 0.022
0.937CysGly: 0.937 ± 0.031
0.282CysHis: 0.282 ± 0.015
0.511CysIle: 0.511 ± 0.023
0.373CysLys: 0.373 ± 0.018
0.969CysLeu: 0.969 ± 0.026
0.187CysMet: 0.187 ± 0.013
0.33CysAsn: 0.33 ± 0.016
0.476CysPro: 0.476 ± 0.02
0.323CysGln: 0.323 ± 0.016
0.551CysArg: 0.551 ± 0.026
0.641CysSer: 0.641 ± 0.025
0.433CysThr: 0.433 ± 0.02
0.607CysVal: 0.607 ± 0.024
0.132CysTrp: 0.132 ± 0.011
0.287CysTyr: 0.287 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
5.068AspAla: 5.068 ± 0.077
0.548AspCys: 0.548 ± 0.024
3.572AspAsp: 3.572 ± 0.099
4.003AspGlu: 4.003 ± 0.071
2.581AspPhe: 2.581 ± 0.053
4.771AspGly: 4.771 ± 0.131
1.399AspHis: 1.399 ± 0.033
4.205AspIle: 4.205 ± 0.068
2.902AspLys: 2.902 ± 0.054
6.66AspLeu: 6.66 ± 0.089
1.449AspMet: 1.449 ± 0.037
2.233AspAsn: 2.233 ± 0.047
2.95AspPro: 2.95 ± 0.055
2.354AspGln: 2.354 ± 0.048
3.231AspArg: 3.231 ± 0.06
2.745AspSer: 2.745 ± 0.059
2.881AspThr: 2.881 ± 0.06
4.14AspVal: 4.14 ± 0.066
0.875AspTrp: 0.875 ± 0.026
1.894AspTyr: 1.894 ± 0.041
0.0AspXaa: 0.0 ± 0.0
Glu
6.08GluAla: 6.08 ± 0.085
0.447GluCys: 0.447 ± 0.021
3.598GluAsp: 3.598 ± 0.065
4.535GluGlu: 4.535 ± 0.085
2.109GluPhe: 2.109 ± 0.041
4.406GluGly: 4.406 ± 0.072
1.276GluHis: 1.276 ± 0.035
4.794GluIle: 4.794 ± 0.079
4.155GluLys: 4.155 ± 0.079
6.228GluLeu: 6.228 ± 0.08
1.709GluMet: 1.709 ± 0.04
3.102GluAsn: 3.102 ± 0.057
2.158GluPro: 2.158 ± 0.045
2.738GluGln: 2.738 ± 0.052
3.618GluArg: 3.618 ± 0.064
2.95GluSer: 2.95 ± 0.056
3.796GluThr: 3.796 ± 0.061
4.253GluVal: 4.253 ± 0.065
0.661GluTrp: 0.661 ± 0.026
1.412GluTyr: 1.412 ± 0.043
0.0GluXaa: 0.0 ± 0.0
Phe
3.554PheAla: 3.554 ± 0.064
0.503PheCys: 0.503 ± 0.022
2.844PheAsp: 2.844 ± 0.054
2.417PheGlu: 2.417 ± 0.044
1.803PhePhe: 1.803 ± 0.049
3.44PheGly: 3.44 ± 0.062
0.793PheHis: 0.793 ± 0.027
2.557PheIle: 2.557 ± 0.062
1.784PheLys: 1.784 ± 0.038
3.958PheLeu: 3.958 ± 0.067
1.013PheMet: 1.013 ± 0.03
1.476PheAsn: 1.476 ± 0.04
1.569PhePro: 1.569 ± 0.041
1.201PheGln: 1.201 ± 0.033
1.745PheArg: 1.745 ± 0.044
2.996PheSer: 2.996 ± 0.05
2.219PheThr: 2.219 ± 0.047
2.865PheVal: 2.865 ± 0.052
0.574PheTrp: 0.574 ± 0.024
1.214PheTyr: 1.214 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
6.423GlyAla: 6.423 ± 0.088
0.877GlyCys: 0.877 ± 0.029
4.369GlyAsp: 4.369 ± 0.1
4.527GlyGlu: 4.527 ± 0.071
3.434GlyPhe: 3.434 ± 0.054
6.081GlyGly: 6.081 ± 0.122
1.689GlyHis: 1.689 ± 0.037
5.179GlyIle: 5.179 ± 0.071
4.221GlyLys: 4.221 ± 0.056
7.924GlyLeu: 7.924 ± 0.1
2.167GlyMet: 2.167 ± 0.048
2.687GlyAsn: 2.687 ± 0.065
2.598GlyPro: 2.598 ± 0.053
2.92GlyGln: 2.92 ± 0.048
3.907GlyArg: 3.907 ± 0.059
4.619GlySer: 4.619 ± 0.083
4.265GlyThr: 4.265 ± 0.078
5.73GlyVal: 5.73 ± 0.079
1.079GlyTrp: 1.079 ± 0.034
2.514GlyTyr: 2.514 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
1.667HisAla: 1.667 ± 0.039
0.276HisCys: 0.276 ± 0.017
1.244HisAsp: 1.244 ± 0.038
1.162HisGlu: 1.162 ± 0.032
0.875HisPhe: 0.875 ± 0.028
1.574HisGly: 1.574 ± 0.033
0.611HisHis: 0.611 ± 0.026
1.241HisIle: 1.241 ± 0.034
0.989HisLys: 0.989 ± 0.03
2.106HisLeu: 2.106 ± 0.045
0.517HisMet: 0.517 ± 0.02
0.776HisAsn: 0.776 ± 0.026
1.274HisPro: 1.274 ± 0.037
0.72HisGln: 0.72 ± 0.027
1.105HisArg: 1.105 ± 0.025
1.183HisSer: 1.183 ± 0.034
0.915HisThr: 0.915 ± 0.03
1.286HisVal: 1.286 ± 0.034
0.306HisTrp: 0.306 ± 0.018
0.643HisTyr: 0.643 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
6.363IleAla: 6.363 ± 0.074
0.679IleCys: 0.679 ± 0.024
4.092IleAsp: 4.092 ± 0.068
4.26IleGlu: 4.26 ± 0.06
2.425IlePhe: 2.425 ± 0.054
5.056IleGly: 5.056 ± 0.071
1.154IleHis: 1.154 ± 0.034
3.905IleIle: 3.905 ± 0.071
3.239IleLys: 3.239 ± 0.051
6.012IleLeu: 6.012 ± 0.084
1.375IleMet: 1.375 ± 0.032
2.501IleAsn: 2.501 ± 0.06
2.924IlePro: 2.924 ± 0.054
1.926IleGln: 1.926 ± 0.042
3.024IleArg: 3.024 ± 0.057
4.687IleSer: 4.687 ± 0.068
3.953IleThr: 3.953 ± 0.055
4.285IleVal: 4.285 ± 0.063
0.704IleTrp: 0.704 ± 0.029
1.659IleTyr: 1.659 ± 0.04
0.0IleXaa: 0.0 ± 0.0
Lys
5.087LysAla: 5.087 ± 0.077
0.299LysCys: 0.299 ± 0.015
3.065LysAsp: 3.065 ± 0.054
3.604LysGlu: 3.604 ± 0.067
1.533LysPhe: 1.533 ± 0.036
3.839LysGly: 3.839 ± 0.066
1.037LysHis: 1.037 ± 0.028
3.277LysIle: 3.277 ± 0.062
3.272LysLys: 3.272 ± 0.078
5.064LysLeu: 5.064 ± 0.077
1.275LysMet: 1.275 ± 0.03
2.124LysAsn: 2.124 ± 0.045
2.24LysPro: 2.24 ± 0.048
1.933LysGln: 1.933 ± 0.046
2.914LysArg: 2.914 ± 0.054
3.402LysSer: 3.402 ± 0.065
3.0LysThr: 3.0 ± 0.058
3.437LysVal: 3.437 ± 0.058
0.555LysTrp: 0.555 ± 0.023
1.184LysTyr: 1.184 ± 0.035
0.0LysXaa: 0.0 ± 0.0
Leu
9.479LeuAla: 9.479 ± 0.11
1.06LeuCys: 1.06 ± 0.033
6.052LeuAsp: 6.052 ± 0.082
6.444LeuGlu: 6.444 ± 0.087
4.098LeuPhe: 4.098 ± 0.08
7.61LeuGly: 7.61 ± 0.089
1.786LeuHis: 1.786 ± 0.044
6.281LeuIle: 6.281 ± 0.095
5.403LeuLys: 5.403 ± 0.076
9.599LeuLeu: 9.599 ± 0.126
2.437LeuMet: 2.437 ± 0.055
3.82LeuAsn: 3.82 ± 0.061
4.879LeuPro: 4.879 ± 0.064
2.976LeuGln: 2.976 ± 0.054
5.054LeuArg: 5.054 ± 0.081
8.084LeuSer: 8.084 ± 0.097
5.561LeuThr: 5.561 ± 0.07
6.801LeuVal: 6.801 ± 0.077
1.128LeuTrp: 1.128 ± 0.042
2.53LeuTyr: 2.53 ± 0.057
0.0LeuXaa: 0.0 ± 0.0
Met
2.605MetAla: 2.605 ± 0.055
0.16MetCys: 0.16 ± 0.011
1.368MetAsp: 1.368 ± 0.038
1.399MetGlu: 1.399 ± 0.033
0.772MetPhe: 0.772 ± 0.028
1.949MetGly: 1.949 ± 0.041
0.463MetHis: 0.463 ± 0.021
1.666MetIle: 1.666 ± 0.043
1.37MetLys: 1.37 ± 0.031
2.264MetLeu: 2.264 ± 0.045
0.704MetMet: 0.704 ± 0.026
0.975MetAsn: 0.975 ± 0.025
1.275MetPro: 1.275 ± 0.034
0.784MetGln: 0.784 ± 0.023
1.294MetArg: 1.294 ± 0.035
1.907MetSer: 1.907 ± 0.041
1.741MetThr: 1.741 ± 0.036
1.816MetVal: 1.816 ± 0.045
0.208MetTrp: 0.208 ± 0.014
0.376MetTyr: 0.376 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.324AsnAla: 3.324 ± 0.057
0.376AsnCys: 0.376 ± 0.019
2.294AsnAsp: 2.294 ± 0.059
2.082AsnGlu: 2.082 ± 0.041
1.492AsnPhe: 1.492 ± 0.033
2.834AsnGly: 2.834 ± 0.06
0.819AsnHis: 0.819 ± 0.028
2.434AsnIle: 2.434 ± 0.047
2.0AsnLys: 2.0 ± 0.046
3.905AsnLeu: 3.905 ± 0.061
0.925AsnMet: 0.925 ± 0.029
1.597AsnAsn: 1.597 ± 0.041
2.178AsnPro: 2.178 ± 0.043
1.352AsnGln: 1.352 ± 0.035
2.016AsnArg: 2.016 ± 0.042
2.277AsnSer: 2.277 ± 0.052
1.921AsnThr: 1.921 ± 0.043
2.369AsnVal: 2.369 ± 0.045
0.558AsnTrp: 0.558 ± 0.024
1.094AsnTyr: 1.094 ± 0.033
0.0AsnXaa: 0.0 ± 0.0
Pro
3.536ProAla: 3.536 ± 0.056
0.366ProCys: 0.366 ± 0.021
3.253ProAsp: 3.253 ± 0.059
3.622ProGlu: 3.622 ± 0.059
1.87ProPhe: 1.87 ± 0.043
3.176ProGly: 3.176 ± 0.052
0.924ProHis: 0.924 ± 0.03
2.411ProIle: 2.411 ± 0.045
2.299ProLys: 2.299 ± 0.048
4.288ProLeu: 4.288 ± 0.058
0.988ProMet: 0.988 ± 0.029
1.609ProAsn: 1.609 ± 0.038
1.568ProPro: 1.568 ± 0.042
1.465ProGln: 1.465 ± 0.036
1.76ProArg: 1.76 ± 0.038
2.742ProSer: 2.742 ± 0.051
2.187ProThr: 2.187 ± 0.049
3.546ProVal: 3.546 ± 0.056
0.584ProTrp: 0.584 ± 0.025
1.241ProTyr: 1.241 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
3.51GlnAla: 3.51 ± 0.064
0.247GlnCys: 0.247 ± 0.013
2.101GlnAsp: 2.101 ± 0.04
2.372GlnGlu: 2.372 ± 0.047
1.138GlnPhe: 1.138 ± 0.031
2.589GlnGly: 2.589 ± 0.047
0.707GlnHis: 0.707 ± 0.028
2.337GlnIle: 2.337 ± 0.046
2.083GlnLys: 2.083 ± 0.047
3.229GlnLeu: 3.229 ± 0.058
0.937GlnMet: 0.937 ± 0.029
1.508GlnAsn: 1.508 ± 0.034
1.333GlnPro: 1.333 ± 0.037
1.482GlnGln: 1.482 ± 0.045
1.984GlnArg: 1.984 ± 0.046
2.32GlnSer: 2.32 ± 0.048
1.981GlnThr: 1.981 ± 0.04
2.34GlnVal: 2.34 ± 0.048
0.398GlnTrp: 0.398 ± 0.017
0.777GlnTyr: 0.777 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
4.146ArgAla: 4.146 ± 0.067
0.465ArgCys: 0.465 ± 0.023
3.086ArgAsp: 3.086 ± 0.054
3.43ArgGlu: 3.43 ± 0.063
2.254ArgPhe: 2.254 ± 0.048
3.314ArgGly: 3.314 ± 0.056
1.202ArgHis: 1.202 ± 0.033
3.294ArgIle: 3.294 ± 0.06
2.763ArgLys: 2.763 ± 0.057
5.406ArgLeu: 5.406 ± 0.084
1.308ArgMet: 1.308 ± 0.035
1.907ArgAsn: 1.907 ± 0.044
2.073ArgPro: 2.073 ± 0.041
2.088ArgGln: 2.088 ± 0.046
2.976ArgArg: 2.976 ± 0.059
2.991ArgSer: 2.991 ± 0.05
2.314ArgThr: 2.314 ± 0.043
3.466ArgVal: 3.466 ± 0.058
0.615ArgTrp: 0.615 ± 0.023
1.61ArgTyr: 1.61 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
5.401SerAla: 5.401 ± 0.081
0.641SerCys: 0.641 ± 0.024
3.87SerAsp: 3.87 ± 0.072
3.863SerGlu: 3.863 ± 0.058
3.099SerPhe: 3.099 ± 0.061
5.641SerGly: 5.641 ± 0.085
1.329SerHis: 1.329 ± 0.039
3.823SerIle: 3.823 ± 0.062
3.012SerLys: 3.012 ± 0.061
6.796SerLeu: 6.796 ± 0.093
1.609SerMet: 1.609 ± 0.035
2.305SerAsn: 2.305 ± 0.044
2.803SerPro: 2.803 ± 0.054
2.278SerGln: 2.278 ± 0.046
3.077SerArg: 3.077 ± 0.052
4.303SerSer: 4.303 ± 0.08
3.104SerThr: 3.104 ± 0.053
4.417SerVal: 4.417 ± 0.073
0.819SerTrp: 0.819 ± 0.029
1.933SerTyr: 1.933 ± 0.044
0.0SerXaa: 0.0 ± 0.0
Thr
5.126ThrAla: 5.126 ± 0.073
0.454ThrCys: 0.454 ± 0.02
3.217ThrAsp: 3.217 ± 0.074
3.2ThrGlu: 3.2 ± 0.054
2.168ThrPhe: 2.168 ± 0.05
4.619ThrGly: 4.619 ± 0.079
1.066ThrHis: 1.066 ± 0.037
3.446ThrIle: 3.446 ± 0.061
2.441ThrLys: 2.441 ± 0.047
5.615ThrLeu: 5.615 ± 0.077
1.207ThrMet: 1.207 ± 0.03
1.878ThrAsn: 1.878 ± 0.039
2.951ThrPro: 2.951 ± 0.041
1.735ThrGln: 1.735 ± 0.038
2.432ThrArg: 2.432 ± 0.043
3.468ThrSer: 3.468 ± 0.055
3.044ThrThr: 3.044 ± 0.061
4.074ThrVal: 4.074 ± 0.073
0.595ThrTrp: 0.595 ± 0.024
1.397ThrTyr: 1.397 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
6.348ValAla: 6.348 ± 0.08
0.736ValCys: 0.736 ± 0.027
4.199ValAsp: 4.199 ± 0.074
4.488ValGlu: 4.488 ± 0.063
2.973ValPhe: 2.973 ± 0.055
5.135ValGly: 5.135 ± 0.075
1.31ValHis: 1.31 ± 0.039
4.786ValIle: 4.786 ± 0.073
3.222ValLys: 3.222 ± 0.057
6.935ValLeu: 6.935 ± 0.081
1.777ValMet: 1.777 ± 0.039
2.491ValAsn: 2.491 ± 0.056
3.041ValPro: 3.041 ± 0.05
2.123ValGln: 2.123 ± 0.044
3.294ValArg: 3.294 ± 0.063
4.977ValSer: 4.977 ± 0.074
4.241ValThr: 4.241 ± 0.074
5.302ValVal: 5.302 ± 0.083
0.748ValTrp: 0.748 ± 0.027
1.605ValTyr: 1.605 ± 0.04
0.0ValXaa: 0.0 ± 0.0
Trp
0.917TrpAla: 0.917 ± 0.027
0.129TrpCys: 0.129 ± 0.012
0.701TrpAsp: 0.701 ± 0.025
0.618TrpGlu: 0.618 ± 0.024
0.54TrpPhe: 0.54 ± 0.024
0.843TrpGly: 0.843 ± 0.03
0.311TrpHis: 0.311 ± 0.016
0.764TrpIle: 0.764 ± 0.025
0.63TrpLys: 0.63 ± 0.025
1.434TrpLeu: 1.434 ± 0.038
0.322TrpMet: 0.322 ± 0.017
0.462TrpAsn: 0.462 ± 0.021
0.508TrpPro: 0.508 ± 0.022
0.577TrpGln: 0.577 ± 0.022
0.715TrpArg: 0.715 ± 0.025
0.764TrpSer: 0.764 ± 0.028
0.597TrpThr: 0.597 ± 0.028
0.825TrpVal: 0.825 ± 0.031
0.186TrpTrp: 0.186 ± 0.014
0.316TrpTyr: 0.316 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.229TyrAla: 2.229 ± 0.05
0.301TyrCys: 0.301 ± 0.013
1.765TyrAsp: 1.765 ± 0.043
1.549TyrGlu: 1.549 ± 0.039
1.243TyrPhe: 1.243 ± 0.036
2.158TyrGly: 2.158 ± 0.051
0.651TyrHis: 0.651 ± 0.027
1.462TyrIle: 1.462 ± 0.037
1.273TyrLys: 1.273 ± 0.039
2.832TyrLeu: 2.832 ± 0.05
0.58TyrMet: 0.58 ± 0.022
1.069TyrAsn: 1.069 ± 0.034
1.254TyrPro: 1.254 ± 0.037
1.02TyrGln: 1.02 ± 0.03
1.54TyrArg: 1.54 ± 0.041
1.645TyrSer: 1.645 ± 0.038
1.369TyrThr: 1.369 ± 0.038
1.634TyrVal: 1.634 ± 0.038
0.432TyrTrp: 0.432 ± 0.022
0.868TyrTyr: 0.868 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3735 proteins (1159452 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski