Amino acid dipepetide frequency for candidate division MSBL1 archaeon SCGC-AAA382F02

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.276AlaAla: 5.276 ± 0.326
0.65AlaCys: 0.65 ± 0.085
3.657AlaAsp: 3.657 ± 0.187
6.234AlaGlu: 6.234 ± 0.292
2.368AlaPhe: 2.368 ± 0.185
5.32AlaGly: 5.32 ± 0.276
0.991AlaHis: 0.991 ± 0.101
5.067AlaIle: 5.067 ± 0.273
4.274AlaLys: 4.274 ± 0.204
6.322AlaLeu: 6.322 ± 0.29
1.366AlaMet: 1.366 ± 0.135
2.214AlaAsn: 2.214 ± 0.171
1.983AlaPro: 1.983 ± 0.14
1.663AlaGln: 1.663 ± 0.138
3.194AlaArg: 3.194 ± 0.178
3.91AlaSer: 3.91 ± 0.218
3.282AlaThr: 3.282 ± 0.259
4.659AlaVal: 4.659 ± 0.272
0.551AlaTrp: 0.551 ± 0.077
1.972AlaTyr: 1.972 ± 0.159
0.0AlaXaa: 0.0 ± 0.0
Cys
0.584CysAla: 0.584 ± 0.096
0.121CysCys: 0.121 ± 0.032
0.463CysAsp: 0.463 ± 0.082
0.793CysGlu: 0.793 ± 0.093
0.308CysPhe: 0.308 ± 0.058
0.925CysGly: 0.925 ± 0.108
0.286CysHis: 0.286 ± 0.059
0.474CysIle: 0.474 ± 0.074
0.54CysLys: 0.54 ± 0.086
0.65CysLeu: 0.65 ± 0.083
0.165CysMet: 0.165 ± 0.043
0.374CysAsn: 0.374 ± 0.064
0.705CysPro: 0.705 ± 0.098
0.231CysGln: 0.231 ± 0.06
0.397CysArg: 0.397 ± 0.068
0.518CysSer: 0.518 ± 0.079
0.408CysThr: 0.408 ± 0.085
0.639CysVal: 0.639 ± 0.081
0.099CysTrp: 0.099 ± 0.04
0.286CysTyr: 0.286 ± 0.063
0.0CysXaa: 0.0 ± 0.0
Asp
3.491AspAla: 3.491 ± 0.199
0.452AspCys: 0.452 ± 0.067
2.137AspAsp: 2.137 ± 0.181
5.474AspGlu: 5.474 ± 0.3
2.875AspPhe: 2.875 ± 0.145
3.48AspGly: 3.48 ± 0.248
1.212AspHis: 1.212 ± 0.116
4.384AspIle: 4.384 ± 0.259
3.227AspLys: 3.227 ± 0.184
7.093AspLeu: 7.093 ± 0.33
1.19AspMet: 1.19 ± 0.112
1.806AspAsn: 1.806 ± 0.23
2.467AspPro: 2.467 ± 0.151
1.168AspGln: 1.168 ± 0.1
2.544AspArg: 2.544 ± 0.155
3.381AspSer: 3.381 ± 0.195
2.5AspThr: 2.5 ± 0.171
4.141AspVal: 4.141 ± 0.233
0.793AspTrp: 0.793 ± 0.109
2.049AspTyr: 2.049 ± 0.136
0.0AspXaa: 0.0 ± 0.0
Glu
6.355GluAla: 6.355 ± 0.281
0.639GluCys: 0.639 ± 0.081
5.815GluAsp: 5.815 ± 0.261
12.821GluGlu: 12.821 ± 0.533
3.315GluPhe: 3.315 ± 0.186
6.719GluGly: 6.719 ± 0.277
1.586GluHis: 1.586 ± 0.15
8.415GluIle: 8.415 ± 0.318
11.378GluLys: 11.378 ± 0.447
8.492GluLeu: 8.492 ± 0.32
2.247GluMet: 2.247 ± 0.178
5.782GluAsn: 5.782 ± 0.365
3.018GluPro: 3.018 ± 0.218
1.707GluGln: 1.707 ± 0.136
4.648GluArg: 4.648 ± 0.273
5.408GluSer: 5.408 ± 0.258
4.989GluThr: 4.989 ± 0.267
7.104GluVal: 7.104 ± 0.291
0.87GluTrp: 0.87 ± 0.101
2.401GluTyr: 2.401 ± 0.16
0.0GluXaa: 0.0 ± 0.0
Phe
2.434PheAla: 2.434 ± 0.178
0.33PheCys: 0.33 ± 0.069
2.489PheAsp: 2.489 ± 0.172
3.514PheGlu: 3.514 ± 0.212
1.432PhePhe: 1.432 ± 0.151
3.018PheGly: 3.018 ± 0.216
0.683PheHis: 0.683 ± 0.078
1.894PheIle: 1.894 ± 0.153
2.016PheLys: 2.016 ± 0.155
4.02PheLeu: 4.02 ± 0.277
0.705PheMet: 0.705 ± 0.077
0.881PheAsn: 0.881 ± 0.092
1.399PhePro: 1.399 ± 0.117
0.969PheGln: 0.969 ± 0.124
1.454PheArg: 1.454 ± 0.149
2.952PheSer: 2.952 ± 0.229
1.861PheThr: 1.861 ± 0.141
2.412PheVal: 2.412 ± 0.181
0.408PheTrp: 0.408 ± 0.073
1.112PheTyr: 1.112 ± 0.128
0.0PheXaa: 0.0 ± 0.0
Gly
5.32GlyAla: 5.32 ± 0.287
0.804GlyCys: 0.804 ± 0.089
4.307GlyAsp: 4.307 ± 0.245
6.851GlyGlu: 6.851 ± 0.288
2.864GlyPhe: 2.864 ± 0.191
5.771GlyGly: 5.771 ± 0.367
1.388GlyHis: 1.388 ± 0.118
6.256GlyIle: 6.256 ± 0.273
6.058GlyLys: 6.058 ± 0.234
6.322GlyLeu: 6.322 ± 0.335
1.806GlyMet: 1.806 ± 0.198
2.665GlyAsn: 2.665 ± 0.229
2.478GlyPro: 2.478 ± 0.193
1.432GlyGln: 1.432 ± 0.143
3.646GlyArg: 3.646 ± 0.208
4.417GlySer: 4.417 ± 0.304
4.097GlyThr: 4.097 ± 0.215
5.309GlyVal: 5.309 ± 0.268
0.826GlyTrp: 0.826 ± 0.091
1.927GlyTyr: 1.927 ± 0.136
0.0GlyXaa: 0.0 ± 0.0
His
1.035HisAla: 1.035 ± 0.111
0.231HisCys: 0.231 ± 0.049
0.925HisAsp: 0.925 ± 0.085
1.63HisGlu: 1.63 ± 0.141
0.65HisPhe: 0.65 ± 0.098
1.828HisGly: 1.828 ± 0.159
0.319HisHis: 0.319 ± 0.064
1.112HisIle: 1.112 ± 0.112
0.991HisLys: 0.991 ± 0.095
1.663HisLeu: 1.663 ± 0.147
0.297HisMet: 0.297 ± 0.05
0.485HisAsn: 0.485 ± 0.073
1.101HisPro: 1.101 ± 0.127
0.584HisGln: 0.584 ± 0.08
0.936HisArg: 0.936 ± 0.104
1.201HisSer: 1.201 ± 0.117
0.804HisThr: 0.804 ± 0.086
1.145HisVal: 1.145 ± 0.127
0.198HisTrp: 0.198 ± 0.049
0.584HisTyr: 0.584 ± 0.08
0.0HisXaa: 0.0 ± 0.0
Ile
5.254IleAla: 5.254 ± 0.248
0.716IleCys: 0.716 ± 0.094
4.384IleAsp: 4.384 ± 0.216
7.677IleGlu: 7.677 ± 0.293
2.434IlePhe: 2.434 ± 0.192
5.716IleGly: 5.716 ± 0.269
1.454IleHis: 1.454 ± 0.136
4.758IleIle: 4.758 ± 0.231
4.67IleLys: 4.67 ± 0.251
6.531IleLeu: 6.531 ± 0.327
1.256IleMet: 1.256 ± 0.136
2.577IleAsn: 2.577 ± 0.204
3.514IlePro: 3.514 ± 0.184
2.236IleGln: 2.236 ± 0.22
3.503IleArg: 3.503 ± 0.222
5.441IleSer: 5.441 ± 0.245
3.811IleThr: 3.811 ± 0.261
4.516IleVal: 4.516 ± 0.251
0.573IleTrp: 0.573 ± 0.076
1.994IleTyr: 1.994 ± 0.156
0.0IleXaa: 0.0 ± 0.0
Lys
4.736LysAla: 4.736 ± 0.244
0.683LysCys: 0.683 ± 0.082
4.009LysAsp: 4.009 ± 0.203
8.712LysGlu: 8.712 ± 0.379
2.599LysPhe: 2.599 ± 0.182
5.0LysGly: 5.0 ± 0.235
1.41LysHis: 1.41 ± 0.126
6.851LysIle: 6.851 ± 0.323
7.49LysLys: 7.49 ± 0.333
6.829LysLeu: 6.829 ± 0.283
1.575LysMet: 1.575 ± 0.146
4.119LysAsn: 4.119 ± 0.232
2.709LysPro: 2.709 ± 0.16
1.542LysGln: 1.542 ± 0.154
3.425LysArg: 3.425 ± 0.21
4.307LysSer: 4.307 ± 0.205
3.932LysThr: 3.932 ± 0.216
5.562LysVal: 5.562 ± 0.256
0.859LysTrp: 0.859 ± 0.115
1.95LysTyr: 1.95 ± 0.168
0.0LysXaa: 0.0 ± 0.0
Leu
6.377LeuAla: 6.377 ± 0.28
0.65LeuCys: 0.65 ± 0.099
5.926LeuAsp: 5.926 ± 0.262
10.276LeuGlu: 10.276 ± 0.346
2.853LeuPhe: 2.853 ± 0.202
7.457LeuGly: 7.457 ± 0.33
1.256LeuHis: 1.256 ± 0.128
5.849LeuIle: 5.849 ± 0.314
7.6LeuLys: 7.6 ± 0.314
7.49LeuLeu: 7.49 ± 0.309
1.828LeuMet: 1.828 ± 0.163
3.503LeuAsn: 3.503 ± 0.248
3.668LeuPro: 3.668 ± 0.198
2.269LeuGln: 2.269 ± 0.179
4.736LeuArg: 4.736 ± 0.258
7.203LeuSer: 7.203 ± 0.266
4.824LeuThr: 4.824 ± 0.244
5.54LeuVal: 5.54 ± 0.253
0.793LeuTrp: 0.793 ± 0.11
2.269LeuTyr: 2.269 ± 0.149
0.0LeuXaa: 0.0 ± 0.0
Met
1.377MetAla: 1.377 ± 0.151
0.121MetCys: 0.121 ± 0.033
1.101MetAsp: 1.101 ± 0.091
1.641MetGlu: 1.641 ± 0.14
0.639MetPhe: 0.639 ± 0.098
1.828MetGly: 1.828 ± 0.2
0.352MetHis: 0.352 ± 0.061
1.553MetIle: 1.553 ± 0.133
2.005MetLys: 2.005 ± 0.154
1.674MetLeu: 1.674 ± 0.147
0.529MetMet: 0.529 ± 0.073
0.98MetAsn: 0.98 ± 0.094
1.134MetPro: 1.134 ± 0.108
0.419MetGln: 0.419 ± 0.065
1.168MetArg: 1.168 ± 0.109
1.399MetSer: 1.399 ± 0.116
0.848MetThr: 0.848 ± 0.091
1.311MetVal: 1.311 ± 0.131
0.253MetTrp: 0.253 ± 0.062
0.33MetTyr: 0.33 ± 0.059
0.0MetXaa: 0.0 ± 0.0
Asn
2.346AsnAla: 2.346 ± 0.163
0.374AsnCys: 0.374 ± 0.059
1.63AsnAsp: 1.63 ± 0.163
3.337AsnGlu: 3.337 ± 0.223
1.674AsnPhe: 1.674 ± 0.143
2.291AsnGly: 2.291 ± 0.214
0.738AsnHis: 0.738 ± 0.088
3.194AsnIle: 3.194 ± 0.212
2.732AsnLys: 2.732 ± 0.192
4.835AsnLeu: 4.835 ± 0.242
0.76AsnMet: 0.76 ± 0.1
1.575AsnAsn: 1.575 ± 0.179
2.5AsnPro: 2.5 ± 0.179
1.245AsnGln: 1.245 ± 0.14
1.983AsnArg: 1.983 ± 0.127
2.665AsnSer: 2.665 ± 0.182
1.883AsnThr: 1.883 ± 0.176
2.698AsnVal: 2.698 ± 0.189
0.518AsnTrp: 0.518 ± 0.087
1.234AsnTyr: 1.234 ± 0.142
0.0AsnXaa: 0.0 ± 0.0
Pro
2.137ProAla: 2.137 ± 0.142
0.363ProCys: 0.363 ± 0.065
2.401ProAsp: 2.401 ± 0.157
4.835ProGlu: 4.835 ± 0.247
1.366ProPhe: 1.366 ± 0.128
3.304ProGly: 3.304 ± 0.218
0.881ProHis: 0.881 ± 0.091
2.754ProIle: 2.754 ± 0.175
2.787ProLys: 2.787 ± 0.16
3.073ProLeu: 3.073 ± 0.221
0.716ProMet: 0.716 ± 0.084
1.861ProAsn: 1.861 ± 0.128
1.795ProPro: 1.795 ± 0.133
1.388ProGln: 1.388 ± 0.131
1.718ProArg: 1.718 ± 0.129
2.974ProSer: 2.974 ± 0.178
2.104ProThr: 2.104 ± 0.141
2.61ProVal: 2.61 ± 0.165
0.397ProTrp: 0.397 ± 0.066
1.344ProTyr: 1.344 ± 0.108
0.0ProXaa: 0.0 ± 0.0
Gln
1.861GlnAla: 1.861 ± 0.135
0.121GlnCys: 0.121 ± 0.043
1.19GlnAsp: 1.19 ± 0.109
2.809GlnGlu: 2.809 ± 0.21
0.705GlnPhe: 0.705 ± 0.092
1.421GlnGly: 1.421 ± 0.155
0.397GlnHis: 0.397 ± 0.059
2.17GlnIle: 2.17 ± 0.169
2.071GlnLys: 2.071 ± 0.171
1.961GlnLeu: 1.961 ± 0.154
0.562GlnMet: 0.562 ± 0.074
1.19GlnAsn: 1.19 ± 0.122
0.782GlnPro: 0.782 ± 0.083
0.749GlnGln: 0.749 ± 0.125
1.046GlnArg: 1.046 ± 0.11
1.366GlnSer: 1.366 ± 0.125
1.443GlnThr: 1.443 ± 0.171
1.861GlnVal: 1.861 ± 0.181
0.22GlnTrp: 0.22 ± 0.053
0.672GlnTyr: 0.672 ± 0.085
0.0GlnXaa: 0.0 ± 0.0
Arg
2.842ArgAla: 2.842 ± 0.171
0.485ArgCys: 0.485 ± 0.073
2.555ArgAsp: 2.555 ± 0.153
5.133ArgGlu: 5.133 ± 0.287
1.784ArgPhe: 1.784 ± 0.145
3.293ArgGly: 3.293 ± 0.221
0.694ArgHis: 0.694 ± 0.083
3.833ArgIle: 3.833 ± 0.208
4.56ArgLys: 4.56 ± 0.269
4.097ArgLeu: 4.097 ± 0.235
1.344ArgMet: 1.344 ± 0.114
1.817ArgAsn: 1.817 ± 0.134
1.74ArgPro: 1.74 ± 0.158
0.969ArgGln: 0.969 ± 0.107
2.93ArgArg: 2.93 ± 0.208
2.555ArgSer: 2.555 ± 0.173
2.192ArgThr: 2.192 ± 0.163
3.139ArgVal: 3.139 ± 0.205
0.341ArgTrp: 0.341 ± 0.055
1.168ArgTyr: 1.168 ± 0.126
0.0ArgXaa: 0.0 ± 0.0
Ser
3.833SerAla: 3.833 ± 0.245
0.606SerCys: 0.606 ± 0.09
3.877SerAsp: 3.877 ± 0.247
7.424SerGlu: 7.424 ± 0.282
2.324SerPhe: 2.324 ± 0.187
5.221SerGly: 5.221 ± 0.262
1.168SerHis: 1.168 ± 0.111
4.163SerIle: 4.163 ± 0.275
4.868SerLys: 4.868 ± 0.252
6.223SerLeu: 6.223 ± 0.271
1.333SerMet: 1.333 ± 0.112
2.467SerAsn: 2.467 ± 0.177
2.864SerPro: 2.864 ± 0.158
1.861SerGln: 1.861 ± 0.165
2.886SerArg: 2.886 ± 0.184
4.505SerSer: 4.505 ± 0.25
3.073SerThr: 3.073 ± 0.202
4.274SerVal: 4.274 ± 0.213
0.584SerTrp: 0.584 ± 0.096
1.905SerTyr: 1.905 ± 0.159
0.0SerXaa: 0.0 ± 0.0
Thr
3.414ThrAla: 3.414 ± 0.197
0.529ThrCys: 0.529 ± 0.095
2.522ThrAsp: 2.522 ± 0.2
4.185ThrGlu: 4.185 ± 0.22
1.685ThrPhe: 1.685 ± 0.144
4.318ThrGly: 4.318 ± 0.238
1.057ThrHis: 1.057 ± 0.103
3.69ThrIle: 3.69 ± 0.249
3.304ThrLys: 3.304 ± 0.208
4.802ThrLeu: 4.802 ± 0.25
0.749ThrMet: 0.749 ± 0.095
1.872ThrAsn: 1.872 ± 0.159
2.698ThrPro: 2.698 ± 0.182
1.068ThrGln: 1.068 ± 0.11
2.324ThrArg: 2.324 ± 0.162
3.591ThrSer: 3.591 ± 0.195
2.842ThrThr: 2.842 ± 0.238
3.767ThrVal: 3.767 ± 0.252
0.33ThrTrp: 0.33 ± 0.063
1.597ThrTyr: 1.597 ± 0.18
0.0ThrXaa: 0.0 ± 0.0
Val
4.086ValAla: 4.086 ± 0.235
0.683ValCys: 0.683 ± 0.087
4.108ValAsp: 4.108 ± 0.243
6.785ValGlu: 6.785 ± 0.308
2.533ValPhe: 2.533 ± 0.185
4.912ValGly: 4.912 ± 0.258
1.156ValHis: 1.156 ± 0.102
4.538ValIle: 4.538 ± 0.266
5.122ValLys: 5.122 ± 0.281
6.355ValLeu: 6.355 ± 0.276
1.278ValMet: 1.278 ± 0.141
2.566ValAsn: 2.566 ± 0.18
2.897ValPro: 2.897 ± 0.189
1.729ValGln: 1.729 ± 0.138
2.985ValArg: 2.985 ± 0.199
5.022ValSer: 5.022 ± 0.287
3.624ValThr: 3.624 ± 0.228
4.901ValVal: 4.901 ± 0.278
0.595ValTrp: 0.595 ± 0.079
1.773ValTyr: 1.773 ± 0.12
0.0ValXaa: 0.0 ± 0.0
Trp
0.529TrpAla: 0.529 ± 0.077
0.077TrpCys: 0.077 ± 0.038
0.782TrpAsp: 0.782 ± 0.101
0.892TrpGlu: 0.892 ± 0.135
0.374TrpPhe: 0.374 ± 0.069
0.518TrpGly: 0.518 ± 0.07
0.143TrpHis: 0.143 ± 0.038
0.727TrpIle: 0.727 ± 0.085
0.936TrpLys: 0.936 ± 0.092
0.76TrpLeu: 0.76 ± 0.106
0.308TrpMet: 0.308 ± 0.052
0.485TrpAsn: 0.485 ± 0.074
0.264TrpPro: 0.264 ± 0.055
0.264TrpGln: 0.264 ± 0.06
0.551TrpArg: 0.551 ± 0.087
0.639TrpSer: 0.639 ± 0.102
0.507TrpThr: 0.507 ± 0.095
0.617TrpVal: 0.617 ± 0.08
0.143TrpTrp: 0.143 ± 0.049
0.176TrpTyr: 0.176 ± 0.041
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.663TyrAla: 1.663 ± 0.148
0.33TyrCys: 0.33 ± 0.058
1.586TyrAsp: 1.586 ± 0.138
2.687TyrGlu: 2.687 ± 0.164
1.201TyrPhe: 1.201 ± 0.113
2.203TyrGly: 2.203 ± 0.159
0.551TyrHis: 0.551 ± 0.068
1.344TyrIle: 1.344 ± 0.136
1.674TyrLys: 1.674 ± 0.119
3.172TyrLeu: 3.172 ± 0.217
0.639TyrMet: 0.639 ± 0.076
0.991TyrAsn: 0.991 ± 0.109
1.09TyrPro: 1.09 ± 0.096
1.101TyrGln: 1.101 ± 0.119
1.399TyrArg: 1.399 ± 0.142
2.005TyrSer: 2.005 ± 0.159
1.322TyrThr: 1.322 ± 0.114
1.443TyrVal: 1.443 ± 0.123
0.341TyrTrp: 0.341 ± 0.072
0.947TyrTyr: 0.947 ± 0.087
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 344 proteins (90793 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski