Amino acid dipepetide frequency for Corynebacterium phocae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.612AlaAla: 15.612 ± 0.28	0.882AlaCys: 0.882 ± 0.039	6.682AlaAsp: 6.682 ± 0.108	7.471AlaGlu: 7.471 ± 0.129	3.604AlaPhe: 3.604 ± 0.077	10.459AlaGly: 10.459 ± 0.145	2.447AlaHis: 2.447 ± 0.069	5.229AlaIle: 5.229 ± 0.093	4.448AlaLys: 4.448 ± 0.086	11.366AlaLeu: 11.366 ± 0.179	2.525AlaMet: 2.525 ± 0.072	3.01AlaAsn: 3.01 ± 0.066	5.63AlaPro: 5.63 ± 0.147	4.844AlaGln: 4.844 ± 0.102	7.022AlaArg: 7.022 ± 0.124	5.587AlaSer: 5.587 ± 0.103	6.892AlaThr: 6.892 ± 0.109	9.576AlaVal: 9.576 ± 0.14	1.576AlaTrp: 1.576 ± 0.053	2.285AlaTyr: 2.285 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	0.838CysAla: 0.838 ± 0.035	0.064CysCys: 0.064 ± 0.01	0.362CysAsp: 0.362 ± 0.021	0.389CysGlu: 0.389 ± 0.026	0.255CysPhe: 0.255 ± 0.02	0.742CysGly: 0.742 ± 0.036	0.172CysHis: 0.172 ± 0.014	0.291CysIle: 0.291 ± 0.02	0.145CysLys: 0.145 ± 0.014	0.593CysLeu: 0.593 ± 0.028	0.134CysMet: 0.134 ± 0.013	0.201CysAsn: 0.201 ± 0.016	0.391CysPro: 0.391 ± 0.025	0.266CysGln: 0.266 ± 0.021	0.346CysArg: 0.346 ± 0.021	0.496CysSer: 0.496 ± 0.03	0.432CysThr: 0.432 ± 0.025	0.549CysVal: 0.549 ± 0.03	0.097CysTrp: 0.097 ± 0.011	0.142CysTyr: 0.142 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.354AspAla: 6.354 ± 0.09	0.406AspCys: 0.406 ± 0.026	3.036AspAsp: 3.036 ± 0.078	3.661AspGlu: 3.661 ± 0.085	2.397AspPhe: 2.397 ± 0.066	5.047AspGly: 5.047 ± 0.167	1.24AspHis: 1.24 ± 0.048	3.282AspIle: 3.282 ± 0.066	2.507AspLys: 2.507 ± 0.081	5.506AspLeu: 5.506 ± 0.092	1.252AspMet: 1.252 ± 0.044	2.065AspAsn: 2.065 ± 0.058	3.669AspPro: 3.669 ± 0.083	1.723AspGln: 1.723 ± 0.053	3.246AspArg: 3.246 ± 0.07	3.572AspSer: 3.572 ± 0.08	3.253AspThr: 3.253 ± 0.072	4.497AspVal: 4.497 ± 0.088	0.828AspTrp: 0.828 ± 0.041	1.611AspTyr: 1.611 ± 0.059	0.0AspXaa: 0.0 ± 0.0
Glu	6.336GluAla: 6.336 ± 0.129	0.341GluCys: 0.341 ± 0.023	4.027GluAsp: 4.027 ± 0.092	4.478GluGlu: 4.478 ± 0.095	2.268GluPhe: 2.268 ± 0.062	4.526GluGly: 4.526 ± 0.079	1.45GluHis: 1.45 ± 0.049	3.548GluIle: 3.548 ± 0.077	2.875GluLys: 2.875 ± 0.083	7.092GluLeu: 7.092 ± 0.107	1.262GluMet: 1.262 ± 0.042	1.868GluAsn: 1.868 ± 0.051	2.784GluPro: 2.784 ± 0.078	2.567GluGln: 2.567 ± 0.064	3.604GluArg: 3.604 ± 0.08	3.331GluSer: 3.331 ± 0.088	3.463GluThr: 3.463 ± 0.072	5.372GluVal: 5.372 ± 0.107	0.826GluTrp: 0.826 ± 0.036	1.497GluTyr: 1.497 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	4.053PheAla: 4.053 ± 0.076	0.321PheCys: 0.321 ± 0.019	2.417PheAsp: 2.417 ± 0.071	2.006PheGlu: 2.006 ± 0.064	1.329PhePhe: 1.329 ± 0.056	3.418PheGly: 3.418 ± 0.076	0.698PheHis: 0.698 ± 0.032	1.788PheIle: 1.788 ± 0.064	1.057PheLys: 1.057 ± 0.036	3.115PheLeu: 3.115 ± 0.077	0.703PheMet: 0.703 ± 0.031	1.136PheAsn: 1.136 ± 0.041	1.553PhePro: 1.553 ± 0.043	0.957PheGln: 0.957 ± 0.037	1.695PheArg: 1.695 ± 0.049	2.24PheSer: 2.24 ± 0.055	2.177PheThr: 2.177 ± 0.061	2.585PheVal: 2.585 ± 0.069	0.457PheTrp: 0.457 ± 0.024	0.858PheTyr: 0.858 ± 0.038	0.003PheXaa: 0.003 ± 0.002
Gly	8.805GlyAla: 8.805 ± 0.116	0.586GlyCys: 0.586 ± 0.031	4.34GlyAsp: 4.34 ± 0.104	4.939GlyGlu: 4.939 ± 0.097	3.228GlyPhe: 3.228 ± 0.074	6.805GlyGly: 6.805 ± 0.14	1.941GlyHis: 1.941 ± 0.062	4.474GlyIle: 4.474 ± 0.085	3.716GlyLys: 3.716 ± 0.088	8.134GlyLeu: 8.134 ± 0.12	2.059GlyMet: 2.059 ± 0.059	2.675GlyAsn: 2.675 ± 0.056	3.462GlyPro: 3.462 ± 0.082	3.327GlyGln: 3.327 ± 0.076	4.769GlyArg: 4.769 ± 0.079	4.913GlySer: 4.913 ± 0.109	5.3GlyThr: 5.3 ± 0.114	6.967GlyVal: 6.967 ± 0.113	1.312GlyTrp: 1.312 ± 0.047	2.248GlyTyr: 2.248 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	2.169HisAla: 2.169 ± 0.056	0.193HisCys: 0.193 ± 0.015	1.103HisAsp: 1.103 ± 0.046	1.191HisGlu: 1.191 ± 0.04	0.694HisPhe: 0.694 ± 0.026	1.895HisGly: 1.895 ± 0.056	0.617HisHis: 0.617 ± 0.031	1.013HisIle: 1.013 ± 0.042	0.579HisLys: 0.579 ± 0.031	2.128HisLeu: 2.128 ± 0.056	0.423HisMet: 0.423 ± 0.023	0.679HisAsn: 0.679 ± 0.028	1.448HisPro: 1.448 ± 0.051	0.725HisGln: 0.725 ± 0.034	1.381HisArg: 1.381 ± 0.047	1.204HisSer: 1.204 ± 0.038	1.26HisThr: 1.26 ± 0.05	1.499HisVal: 1.499 ± 0.041	0.259HisTrp: 0.259 ± 0.02	0.594HisTyr: 0.594 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.883IleAla: 5.883 ± 0.096	0.385IleCys: 0.385 ± 0.025	3.403IleAsp: 3.403 ± 0.065	3.052IleGlu: 3.052 ± 0.069	1.733IlePhe: 1.733 ± 0.06	3.988IleGly: 3.988 ± 0.089	1.049IleHis: 1.049 ± 0.045	2.597IleIle: 2.597 ± 0.077	1.711IleLys: 1.711 ± 0.056	3.885IleLeu: 3.885 ± 0.085	0.959IleMet: 0.959 ± 0.037	1.662IleAsn: 1.662 ± 0.051	2.772IlePro: 2.772 ± 0.069	1.248IleGln: 1.248 ± 0.04	2.555IleArg: 2.555 ± 0.066	3.223IleSer: 3.223 ± 0.071	3.116IleThr: 3.116 ± 0.066	3.865IleVal: 3.865 ± 0.076	0.53IleTrp: 0.53 ± 0.035	1.161IleTyr: 1.161 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	4.437LysAla: 4.437 ± 0.103	0.167LysCys: 0.167 ± 0.017	2.388LysAsp: 2.388 ± 0.072	2.364LysGlu: 2.364 ± 0.064	1.277LysPhe: 1.277 ± 0.048	2.379LysGly: 2.379 ± 0.07	0.778LysHis: 0.778 ± 0.034	1.943LysIle: 1.943 ± 0.06	2.005LysLys: 2.005 ± 0.079	3.634LysLeu: 3.634 ± 0.079	0.909LysMet: 0.909 ± 0.038	1.222LysAsn: 1.222 ± 0.038	2.164LysPro: 2.164 ± 0.068	1.374LysGln: 1.374 ± 0.045	2.218LysArg: 2.218 ± 0.065	2.072LysSer: 2.072 ± 0.056	2.107LysThr: 2.107 ± 0.062	3.004LysVal: 3.004 ± 0.072	0.444LysTrp: 0.444 ± 0.022	0.849LysTyr: 0.849 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	11.99LeuAla: 11.99 ± 0.17	0.683LeuCys: 0.683 ± 0.03	6.199LeuAsp: 6.199 ± 0.106	5.889LeuGlu: 5.889 ± 0.098	2.849LeuPhe: 2.849 ± 0.078	8.53LeuGly: 8.53 ± 0.121	1.849LeuHis: 1.849 ± 0.05	4.493LeuIle: 4.493 ± 0.094	3.323LeuLys: 3.323 ± 0.084	8.516LeuLeu: 8.516 ± 0.153	1.931LeuMet: 1.931 ± 0.055	2.689LeuAsn: 2.689 ± 0.061	5.053LeuPro: 5.053 ± 0.093	2.592LeuGln: 2.592 ± 0.063	5.968LeuArg: 5.968 ± 0.093	6.029LeuSer: 6.029 ± 0.097	5.506LeuThr: 5.506 ± 0.102	7.626LeuVal: 7.626 ± 0.103	1.098LeuTrp: 1.098 ± 0.041	1.815LeuTyr: 1.815 ± 0.053	0.001LeuXaa: 0.001 ± 0.001
Met	2.675MetAla: 2.675 ± 0.068	0.156MetCys: 0.156 ± 0.015	1.206MetAsp: 1.206 ± 0.042	1.228MetGlu: 1.228 ± 0.041	0.729MetPhe: 0.729 ± 0.035	1.717MetGly: 1.717 ± 0.053	0.408MetHis: 0.408 ± 0.026	0.983MetIle: 0.983 ± 0.035	0.832MetLys: 0.832 ± 0.035	2.017MetLeu: 2.017 ± 0.059	0.423MetMet: 0.423 ± 0.027	0.716MetAsn: 0.716 ± 0.034	1.076MetPro: 1.076 ± 0.038	0.58MetGln: 0.58 ± 0.029	1.281MetArg: 1.281 ± 0.041	1.508MetSer: 1.508 ± 0.046	1.517MetThr: 1.517 ± 0.044	1.711MetVal: 1.711 ± 0.053	0.272MetTrp: 0.272 ± 0.019	0.378MetTyr: 0.378 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.126AsnAla: 3.126 ± 0.073	0.225AsnCys: 0.225 ± 0.018	1.482AsnAsp: 1.482 ± 0.057	1.596AsnGlu: 1.596 ± 0.051	1.15AsnPhe: 1.15 ± 0.048	2.466AsnGly: 2.466 ± 0.076	0.687AsnHis: 0.687 ± 0.027	1.49AsnIle: 1.49 ± 0.046	1.102AsnLys: 1.102 ± 0.043	2.892AsnLeu: 2.892 ± 0.063	0.615AsnMet: 0.615 ± 0.03	1.125AsnAsn: 1.125 ± 0.051	2.413AsnPro: 2.413 ± 0.063	1.15AsnGln: 1.15 ± 0.041	1.752AsnArg: 1.752 ± 0.05	1.934AsnSer: 1.934 ± 0.059	1.637AsnThr: 1.637 ± 0.043	2.223AsnVal: 2.223 ± 0.055	0.433AsnTrp: 0.433 ± 0.028	0.78AsnTyr: 0.78 ± 0.035	0.001AsnXaa: 0.001 ± 0.001
Pro	6.57ProAla: 6.57 ± 0.156	0.268ProCys: 0.268 ± 0.019	3.391ProAsp: 3.391 ± 0.083	4.709ProGlu: 4.709 ± 0.124	1.65ProPhe: 1.65 ± 0.052	4.889ProGly: 4.889 ± 0.097	1.133ProHis: 1.133 ± 0.04	1.953ProIle: 1.953 ± 0.055	1.852ProLys: 1.852 ± 0.058	4.224ProLeu: 4.224 ± 0.081	0.974ProMet: 0.974 ± 0.037	1.46ProAsn: 1.46 ± 0.052	2.096ProPro: 2.096 ± 0.082	2.047ProGln: 2.047 ± 0.069	2.745ProArg: 2.745 ± 0.07	2.748ProSer: 2.748 ± 0.074	3.084ProThr: 3.084 ± 0.071	4.642ProVal: 4.642 ± 0.086	0.728ProTrp: 0.728 ± 0.031	1.103ProTyr: 1.103 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	4.407GlnAla: 4.407 ± 0.081	0.161GlnCys: 0.161 ± 0.016	1.945GlnAsp: 1.945 ± 0.062	2.261GlnGlu: 2.261 ± 0.063	1.088GlnPhe: 1.088 ± 0.039	2.468GlnGly: 2.468 ± 0.06	0.676GlnHis: 0.676 ± 0.027	1.591GlnIle: 1.591 ± 0.048	1.053GlnLys: 1.053 ± 0.037	4.009GlnLeu: 4.009 ± 0.089	0.75GlnMet: 0.75 ± 0.031	0.793GlnAsn: 0.793 ± 0.032	2.002GlnPro: 2.002 ± 0.071	1.513GlnGln: 1.513 ± 0.066	2.514GlnArg: 2.514 ± 0.062	1.733GlnSer: 1.733 ± 0.052	1.636GlnThr: 1.636 ± 0.056	2.873GlnVal: 2.873 ± 0.065	0.537GlnTrp: 0.537 ± 0.028	0.686GlnTyr: 0.686 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	6.503ArgAla: 6.503 ± 0.116	0.35ArgCys: 0.35 ± 0.021	3.362ArgAsp: 3.362 ± 0.076	4.333ArgGlu: 4.333 ± 0.083	2.033ArgPhe: 2.033 ± 0.054	4.404ArgGly: 4.404 ± 0.097	1.26ArgHis: 1.26 ± 0.042	2.731ArgIle: 2.731 ± 0.072	2.402ArgLys: 2.402 ± 0.061	5.704ArgLeu: 5.704 ± 0.098	1.452ArgMet: 1.452 ± 0.048	1.85ArgAsn: 1.85 ± 0.057	2.709ArgPro: 2.709 ± 0.069	2.197ArgGln: 2.197 ± 0.062	4.425ArgArg: 4.425 ± 0.107	3.003ArgSer: 3.003 ± 0.077	3.407ArgThr: 3.407 ± 0.076	4.504ArgVal: 4.504 ± 0.095	0.858ArgTrp: 0.858 ± 0.029	1.536ArgTyr: 1.536 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	6.498SerAla: 6.498 ± 0.111	0.378SerCys: 0.378 ± 0.024	2.925SerAsp: 2.925 ± 0.069	3.021SerGlu: 3.021 ± 0.073	2.17SerPhe: 2.17 ± 0.062	5.486SerGly: 5.486 ± 0.115	1.154SerHis: 1.154 ± 0.036	2.509SerIle: 2.509 ± 0.063	2.092SerLys: 2.092 ± 0.06	5.215SerLeu: 5.215 ± 0.093	1.382SerMet: 1.382 ± 0.045	1.79SerAsn: 1.79 ± 0.053	3.201SerPro: 3.201 ± 0.08	2.203SerGln: 2.203 ± 0.059	3.538SerArg: 3.538 ± 0.07	3.491SerSer: 3.491 ± 0.091	3.587SerThr: 3.587 ± 0.076	4.487SerVal: 4.487 ± 0.086	0.885SerTrp: 0.885 ± 0.036	1.458SerTyr: 1.458 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	6.828ThrAla: 6.828 ± 0.106	0.396ThrCys: 0.396 ± 0.025	3.282ThrAsp: 3.282 ± 0.088	3.149ThrGlu: 3.149 ± 0.075	2.059ThrPhe: 2.059 ± 0.062	5.464ThrGly: 5.464 ± 0.083	1.229ThrHis: 1.229 ± 0.04	2.793ThrIle: 2.793 ± 0.068	2.099ThrLys: 2.099 ± 0.068	5.483ThrLeu: 5.483 ± 0.089	1.184ThrMet: 1.184 ± 0.041	1.764ThrAsn: 1.764 ± 0.055	3.81ThrPro: 3.81 ± 0.084	1.808ThrGln: 1.808 ± 0.054	3.138ThrArg: 3.138 ± 0.072	3.342ThrSer: 3.342 ± 0.072	3.735ThrThr: 3.735 ± 0.078	5.514ThrVal: 5.514 ± 0.099	0.802ThrTrp: 0.802 ± 0.034	1.434ThrTyr: 1.434 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	10.166ValAla: 10.166 ± 0.152	0.61ValCys: 0.61 ± 0.027	5.409ValAsp: 5.409 ± 0.093	5.647ValGlu: 5.647 ± 0.092	2.552ValPhe: 2.552 ± 0.073	6.328ValGly: 6.328 ± 0.109	1.505ValHis: 1.505 ± 0.053	4.429ValIle: 4.429 ± 0.083	2.775ValLys: 2.775 ± 0.066	7.317ValLeu: 7.317 ± 0.117	1.745ValMet: 1.745 ± 0.049	2.38ValAsn: 2.38 ± 0.062	4.203ValPro: 4.203 ± 0.087	2.091ValGln: 2.091 ± 0.057	4.415ValArg: 4.415 ± 0.077	4.77ValSer: 4.77 ± 0.086	5.243ValThr: 5.243 ± 0.107	7.303ValVal: 7.303 ± 0.127	1.013ValTrp: 1.013 ± 0.04	1.631ValTyr: 1.631 ± 0.05	0.001ValXaa: 0.001 ± 0.001
Trp	1.441TrpAla: 1.441 ± 0.05	0.116TrpCys: 0.116 ± 0.011	0.78TrpAsp: 0.78 ± 0.026	0.854TrpGlu: 0.854 ± 0.037	0.564TrpPhe: 0.564 ± 0.026	0.986TrpGly: 0.986 ± 0.038	0.299TrpHis: 0.299 ± 0.019	0.655TrpIle: 0.655 ± 0.032	0.524TrpLys: 0.524 ± 0.025	1.461TrpLeu: 1.461 ± 0.047	0.355TrpMet: 0.355 ± 0.024	0.423TrpAsn: 0.423 ± 0.023	0.624TrpPro: 0.624 ± 0.026	0.531TrpGln: 0.531 ± 0.027	0.863TrpArg: 0.863 ± 0.037	0.758TrpSer: 0.758 ± 0.036	0.662TrpThr: 0.662 ± 0.032	1.109TrpVal: 1.109 ± 0.041	0.284TrpTrp: 0.284 ± 0.022	0.269TrpTyr: 0.269 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.453TyrAla: 2.453 ± 0.053	0.216TyrCys: 0.216 ± 0.019	1.415TyrAsp: 1.415 ± 0.045	1.278TyrGlu: 1.278 ± 0.05	0.935TyrPhe: 0.935 ± 0.034	2.005TyrGly: 2.005 ± 0.052	0.462TyrHis: 0.462 ± 0.024	0.985TyrIle: 0.985 ± 0.036	0.64TyrLys: 0.64 ± 0.03	2.334TyrLeu: 2.334 ± 0.055	0.374TyrMet: 0.374 ± 0.021	0.77TyrAsn: 0.77 ± 0.039	1.202TyrPro: 1.202 ± 0.042	0.952TyrGln: 0.952 ± 0.044	1.553TyrArg: 1.553 ± 0.046	1.519TyrSer: 1.519 ± 0.049	1.296TyrThr: 1.296 ± 0.046	1.626TyrVal: 1.626 ± 0.056	0.321TyrTrp: 0.321 ± 0.022	0.627TyrTyr: 0.627 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.003XaaAla: 0.003 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2229 proteins (732272 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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