Amino acid dipepetide frequency for Pleomorphomonas diazotrophica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.386AlaAla: 19.386 ± 0.213	0.93AlaCys: 0.93 ± 0.03	7.751AlaAsp: 7.751 ± 0.077	8.239AlaGlu: 8.239 ± 0.089	4.964AlaPhe: 4.964 ± 0.062	11.52AlaGly: 11.52 ± 0.101	2.042AlaHis: 2.042 ± 0.038	6.735AlaIle: 6.735 ± 0.084	3.888AlaLys: 3.888 ± 0.067	13.919AlaLeu: 13.919 ± 0.119	3.558AlaMet: 3.558 ± 0.054	2.737AlaAsn: 2.737 ± 0.035	5.457AlaPro: 5.457 ± 0.088	2.849AlaGln: 2.849 ± 0.048	8.816AlaArg: 8.816 ± 0.097	6.847AlaSer: 6.847 ± 0.082	6.593AlaThr: 6.593 ± 0.089	10.075AlaVal: 10.075 ± 0.102	1.426AlaTrp: 1.426 ± 0.032	2.668AlaTyr: 2.668 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.747CysAla: 0.747 ± 0.024	0.099CysCys: 0.099 ± 0.009	0.461CysAsp: 0.461 ± 0.02	0.355CysGlu: 0.355 ± 0.018	0.272CysPhe: 0.272 ± 0.016	0.849CysGly: 0.849 ± 0.027	0.207CysHis: 0.207 ± 0.012	0.312CysIle: 0.312 ± 0.016	0.164CysLys: 0.164 ± 0.012	0.815CysLeu: 0.815 ± 0.024	0.114CysMet: 0.114 ± 0.009	0.18CysAsn: 0.18 ± 0.012	0.445CysPro: 0.445 ± 0.021	0.194CysGln: 0.194 ± 0.012	0.642CysArg: 0.642 ± 0.024	0.394CysSer: 0.394 ± 0.018	0.302CysThr: 0.302 ± 0.016	0.543CysVal: 0.543 ± 0.021	0.096CysTrp: 0.096 ± 0.008	0.154CysTyr: 0.154 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.157AspAla: 7.157 ± 0.082	0.491AspCys: 0.491 ± 0.019	3.407AspAsp: 3.407 ± 0.055	3.61AspGlu: 3.61 ± 0.06	2.156AspPhe: 2.156 ± 0.044	5.639AspGly: 5.639 ± 0.075	1.183AspHis: 1.183 ± 0.035	3.271AspIle: 3.271 ± 0.049	1.841AspLys: 1.841 ± 0.042	6.318AspLeu: 6.318 ± 0.07	1.342AspMet: 1.342 ± 0.029	1.339AspAsn: 1.339 ± 0.03	3.474AspPro: 3.474 ± 0.058	1.473AspGln: 1.473 ± 0.032	4.745AspArg: 4.745 ± 0.058	2.045AspSer: 2.045 ± 0.041	2.458AspThr: 2.458 ± 0.043	4.4AspVal: 4.4 ± 0.059	0.927AspTrp: 0.927 ± 0.029	1.436AspTyr: 1.436 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	8.661GluAla: 8.661 ± 0.087	0.291GluCys: 0.291 ± 0.013	2.681GluAsp: 2.681 ± 0.048	3.278GluGlu: 3.278 ± 0.067	1.702GluPhe: 1.702 ± 0.035	4.335GluGly: 4.335 ± 0.064	0.979GluHis: 0.979 ± 0.026	3.495GluIle: 3.495 ± 0.055	2.23GluLys: 2.23 ± 0.05	5.317GluLeu: 5.317 ± 0.069	1.525GluMet: 1.525 ± 0.035	1.348GluAsn: 1.348 ± 0.037	2.793GluPro: 2.793 ± 0.055	1.726GluGln: 1.726 ± 0.042	4.786GluArg: 4.786 ± 0.074	2.234GluSer: 2.234 ± 0.047	3.678GluThr: 3.678 ± 0.055	4.3GluVal: 4.3 ± 0.062	0.588GluTrp: 0.588 ± 0.021	0.843GluTyr: 0.843 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.694PheAla: 4.694 ± 0.064	0.329PheCys: 0.329 ± 0.017	2.618PheAsp: 2.618 ± 0.044	2.031PheGlu: 2.031 ± 0.041	1.392PhePhe: 1.392 ± 0.041	3.808PheGly: 3.808 ± 0.053	0.687PheHis: 0.687 ± 0.025	1.621PheIle: 1.621 ± 0.036	1.06PheLys: 1.06 ± 0.03	3.634PheLeu: 3.634 ± 0.064	0.816PheMet: 0.816 ± 0.025	0.957PheAsn: 0.957 ± 0.03	1.571PhePro: 1.571 ± 0.034	0.963PheGln: 0.963 ± 0.029	2.403PheArg: 2.403 ± 0.045	2.336PheSer: 2.336 ± 0.049	1.839PheThr: 1.839 ± 0.038	3.055PheVal: 3.055 ± 0.055	0.536PheTrp: 0.536 ± 0.023	0.794PheTyr: 0.794 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	9.415GlyAla: 9.415 ± 0.085	0.794GlyCys: 0.794 ± 0.026	4.679GlyAsp: 4.679 ± 0.063	5.072GlyGlu: 5.072 ± 0.057	3.723GlyPhe: 3.723 ± 0.055	7.279GlyGly: 7.279 ± 0.088	1.854GlyHis: 1.854 ± 0.039	4.674GlyIle: 4.674 ± 0.062	3.356GlyLys: 3.356 ± 0.056	9.436GlyLeu: 9.436 ± 0.103	2.168GlyMet: 2.168 ± 0.047	2.151GlyAsn: 2.151 ± 0.039	3.493GlyPro: 3.493 ± 0.055	2.392GlyGln: 2.392 ± 0.044	6.911GlyArg: 6.911 ± 0.072	4.709GlySer: 4.709 ± 0.063	4.542GlyThr: 4.542 ± 0.056	6.442GlyVal: 6.442 ± 0.071	1.336GlyTrp: 1.336 ± 0.037	2.235GlyTyr: 2.235 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.085HisAla: 2.085 ± 0.048	0.17HisCys: 0.17 ± 0.01	1.211HisAsp: 1.211 ± 0.033	0.948HisGlu: 0.948 ± 0.028	0.818HisPhe: 0.818 ± 0.027	1.827HisGly: 1.827 ± 0.042	0.503HisHis: 0.503 ± 0.024	0.852HisIle: 0.852 ± 0.024	0.434HisLys: 0.434 ± 0.02	2.031HisLeu: 2.031 ± 0.044	0.443HisMet: 0.443 ± 0.018	0.374HisAsn: 0.374 ± 0.017	1.207HisPro: 1.207 ± 0.031	0.506HisGln: 0.506 ± 0.021	1.401HisArg: 1.401 ± 0.028	0.804HisSer: 0.804 ± 0.026	0.665HisThr: 0.665 ± 0.023	1.493HisVal: 1.493 ± 0.032	0.251HisTrp: 0.251 ± 0.013	0.446HisTyr: 0.446 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.647IleAla: 7.647 ± 0.084	0.449IleCys: 0.449 ± 0.022	3.952IleAsp: 3.952 ± 0.059	3.641IleGlu: 3.641 ± 0.055	1.564IlePhe: 1.564 ± 0.038	5.341IleGly: 5.341 ± 0.067	0.836IleHis: 0.836 ± 0.027	2.158IleIle: 2.158 ± 0.052	1.404IleLys: 1.404 ± 0.036	4.448IleLeu: 4.448 ± 0.054	0.919IleMet: 0.919 ± 0.026	1.315IleAsn: 1.315 ± 0.035	2.159IlePro: 2.159 ± 0.045	1.095IleGln: 1.095 ± 0.031	3.274IleArg: 3.274 ± 0.052	2.885IleSer: 2.885 ± 0.048	2.604IleThr: 2.604 ± 0.051	4.473IleVal: 4.473 ± 0.06	0.572IleTrp: 0.572 ± 0.022	1.097IleTyr: 1.097 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	4.849LysAla: 4.849 ± 0.067	0.152LysCys: 0.152 ± 0.011	1.662LysAsp: 1.662 ± 0.041	1.481LysGlu: 1.481 ± 0.034	0.809LysPhe: 0.809 ± 0.024	2.679LysGly: 2.679 ± 0.053	0.481LysHis: 0.481 ± 0.023	1.664LysIle: 1.664 ± 0.036	1.139LysLys: 1.139 ± 0.038	3.224LysLeu: 3.224 ± 0.054	0.689LysMet: 0.689 ± 0.023	0.703LysAsn: 0.703 ± 0.025	2.026LysPro: 2.026 ± 0.048	0.802LysGln: 0.802 ± 0.025	2.175LysArg: 2.175 ± 0.042	1.797LysSer: 1.797 ± 0.039	1.919LysThr: 1.919 ± 0.043	2.683LysVal: 2.683 ± 0.05	0.327LysTrp: 0.327 ± 0.017	0.575LysTyr: 0.575 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	14.593LeuAla: 14.593 ± 0.142	0.746LeuCys: 0.746 ± 0.024	6.504LeuAsp: 6.504 ± 0.077	4.932LeuGlu: 4.932 ± 0.068	3.677LeuPhe: 3.677 ± 0.066	8.624LeuGly: 8.624 ± 0.095	1.721LeuHis: 1.721 ± 0.038	5.433LeuIle: 5.433 ± 0.069	3.776LeuLys: 3.776 ± 0.06	9.584LeuLeu: 9.584 ± 0.126	2.453LeuMet: 2.453 ± 0.051	2.372LeuAsn: 2.372 ± 0.043	5.881LeuPro: 5.881 ± 0.066	2.323LeuGln: 2.323 ± 0.051	6.481LeuArg: 6.481 ± 0.081	6.982LeuSer: 6.982 ± 0.082	6.013LeuThr: 6.013 ± 0.079	8.321LeuVal: 8.321 ± 0.089	1.125LeuTrp: 1.125 ± 0.032	2.112LeuTyr: 2.112 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	3.171MetAla: 3.171 ± 0.053	0.121MetCys: 0.121 ± 0.009	1.026MetAsp: 1.026 ± 0.026	1.025MetGlu: 1.025 ± 0.029	0.688MetPhe: 0.688 ± 0.027	1.679MetGly: 1.679 ± 0.038	0.355MetHis: 0.355 ± 0.014	1.381MetIle: 1.381 ± 0.034	0.846MetLys: 0.846 ± 0.025	2.397MetLeu: 2.397 ± 0.049	0.644MetMet: 0.644 ± 0.023	0.691MetAsn: 0.691 ± 0.026	1.504MetPro: 1.504 ± 0.035	0.743MetGln: 0.743 ± 0.024	1.724MetArg: 1.724 ± 0.037	1.64MetSer: 1.64 ± 0.036	1.89MetThr: 1.89 ± 0.034	1.844MetVal: 1.844 ± 0.037	0.195MetTrp: 0.195 ± 0.012	0.261MetTyr: 0.261 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.992AsnAla: 2.992 ± 0.052	0.207AsnCys: 0.207 ± 0.011	1.289AsnAsp: 1.289 ± 0.033	1.182AsnGlu: 1.182 ± 0.032	0.866AsnPhe: 0.866 ± 0.027	2.162AsnGly: 2.162 ± 0.047	0.434AsnHis: 0.434 ± 0.017	1.167AsnIle: 1.167 ± 0.031	0.637AsnLys: 0.637 ± 0.022	2.45AsnLeu: 2.45 ± 0.042	0.573AsnMet: 0.573 ± 0.024	0.547AsnAsn: 0.547 ± 0.022	1.646AsnPro: 1.646 ± 0.041	0.665AsnGln: 0.665 ± 0.021	1.717AsnArg: 1.717 ± 0.039	1.079AsnSer: 1.079 ± 0.034	1.132AsnThr: 1.132 ± 0.034	1.905AsnVal: 1.905 ± 0.049	0.352AsnTrp: 0.352 ± 0.019	0.618AsnTyr: 0.618 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.3ProAla: 6.3 ± 0.091	0.297ProCys: 0.297 ± 0.016	3.719ProAsp: 3.719 ± 0.062	3.6ProGlu: 3.6 ± 0.06	1.931ProPhe: 1.931 ± 0.041	4.281ProGly: 4.281 ± 0.059	0.992ProHis: 0.992 ± 0.03	2.386ProIle: 2.386 ± 0.044	1.715ProLys: 1.715 ± 0.036	4.931ProLeu: 4.931 ± 0.072	1.142ProMet: 1.142 ± 0.032	1.213ProAsn: 1.213 ± 0.033	2.664ProPro: 2.664 ± 0.059	1.242ProGln: 1.242 ± 0.033	2.843ProArg: 2.843 ± 0.056	2.817ProSer: 2.817 ± 0.053	2.779ProThr: 2.779 ± 0.046	4.398ProVal: 4.398 ± 0.064	0.657ProTrp: 0.657 ± 0.023	1.177ProTyr: 1.177 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.41GlnAla: 3.41 ± 0.054	0.14GlnCys: 0.14 ± 0.01	1.16GlnAsp: 1.16 ± 0.034	1.261GlnGlu: 1.261 ± 0.034	0.886GlnPhe: 0.886 ± 0.025	1.962GlnGly: 1.962 ± 0.04	0.482GlnHis: 0.482 ± 0.018	1.446GlnIle: 1.446 ± 0.036	0.932GlnLys: 0.932 ± 0.026	2.462GlnLeu: 2.462 ± 0.046	0.714GlnMet: 0.714 ± 0.019	0.702GlnAsn: 0.702 ± 0.026	1.48GlnPro: 1.48 ± 0.034	0.921GlnGln: 0.921 ± 0.033	2.034GlnArg: 2.034 ± 0.043	1.633GlnSer: 1.633 ± 0.038	1.564GlnThr: 1.564 ± 0.039	1.993GlnVal: 1.993 ± 0.044	0.287GlnTrp: 0.287 ± 0.016	0.504GlnTyr: 0.504 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	7.911ArgAla: 7.911 ± 0.092	0.448ArgCys: 0.448 ± 0.017	3.938ArgAsp: 3.938 ± 0.056	3.921ArgGlu: 3.921 ± 0.055	2.983ArgPhe: 2.983 ± 0.051	4.6ArgGly: 4.6 ± 0.057	1.657ArgHis: 1.657 ± 0.039	3.869ArgIle: 3.869 ± 0.055	2.128ArgLys: 2.128 ± 0.043	9.121ArgLeu: 9.121 ± 0.102	1.704ArgMet: 1.704 ± 0.033	1.649ArgAsn: 1.649 ± 0.037	3.793ArgPro: 3.793 ± 0.067	2.525ArgGln: 2.525 ± 0.048	6.217ArgArg: 6.217 ± 0.093	3.758ArgSer: 3.758 ± 0.059	3.28ArgThr: 3.28 ± 0.055	5.008ArgVal: 5.008 ± 0.059	0.96ArgTrp: 0.96 ± 0.03	1.604ArgTyr: 1.604 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	6.365SerAla: 6.365 ± 0.077	0.371SerCys: 0.371 ± 0.017	3.045SerAsp: 3.045 ± 0.053	2.907SerGlu: 2.907 ± 0.05	2.298SerPhe: 2.298 ± 0.041	5.632SerGly: 5.632 ± 0.063	1.073SerHis: 1.073 ± 0.03	2.872SerIle: 2.872 ± 0.055	1.464SerLys: 1.464 ± 0.034	5.786SerLeu: 5.786 ± 0.067	1.273SerMet: 1.273 ± 0.031	1.215SerAsn: 1.215 ± 0.031	2.767SerPro: 2.767 ± 0.048	1.429SerGln: 1.429 ± 0.032	3.759SerArg: 3.759 ± 0.055	3.179SerSer: 3.179 ± 0.067	2.823SerThr: 2.823 ± 0.061	4.4SerVal: 4.4 ± 0.066	0.715SerTrp: 0.715 ± 0.024	1.179SerTyr: 1.179 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.794ThrAla: 6.794 ± 0.089	0.393ThrCys: 0.393 ± 0.019	2.993ThrAsp: 2.993 ± 0.047	2.82ThrGlu: 2.82 ± 0.044	2.015ThrPhe: 2.015 ± 0.041	5.178ThrGly: 5.178 ± 0.053	0.921ThrHis: 0.921 ± 0.025	2.961ThrIle: 2.961 ± 0.048	1.284ThrLys: 1.284 ± 0.035	6.076ThrLeu: 6.076 ± 0.078	1.136ThrMet: 1.136 ± 0.03	1.197ThrAsn: 1.197 ± 0.031	3.158ThrPro: 3.158 ± 0.049	1.218ThrGln: 1.218 ± 0.031	3.271ThrArg: 3.271 ± 0.052	2.928ThrSer: 2.928 ± 0.047	2.892ThrThr: 2.892 ± 0.051	4.738ThrVal: 4.738 ± 0.068	0.605ThrTrp: 0.605 ± 0.023	1.185ThrTyr: 1.185 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	10.548ValAla: 10.548 ± 0.104	0.567ValCys: 0.567 ± 0.023	4.652ValAsp: 4.652 ± 0.062	4.802ValGlu: 4.802 ± 0.063	3.041ValPhe: 3.041 ± 0.055	6.394ValGly: 6.394 ± 0.075	1.379ValHis: 1.379 ± 0.037	4.128ValIle: 4.128 ± 0.06	2.49ValLys: 2.49 ± 0.05	7.831ValLeu: 7.831 ± 0.084	1.881ValMet: 1.881 ± 0.034	1.982ValAsn: 1.982 ± 0.04	3.804ValPro: 3.804 ± 0.046	1.71ValGln: 1.71 ± 0.039	5.14ValArg: 5.14 ± 0.064	4.607ValSer: 4.607 ± 0.063	5.037ValThr: 5.037 ± 0.066	6.93ValVal: 6.93 ± 0.089	0.904ValTrp: 0.904 ± 0.027	1.668ValTyr: 1.668 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.166TrpAla: 1.166 ± 0.028	0.137TrpCys: 0.137 ± 0.011	0.586TrpAsp: 0.586 ± 0.021	0.495TrpGlu: 0.495 ± 0.021	0.505TrpPhe: 0.505 ± 0.021	0.82TrpGly: 0.82 ± 0.027	0.259TrpHis: 0.259 ± 0.015	0.552TrpIle: 0.552 ± 0.021	0.448TrpLys: 0.448 ± 0.021	1.589TrpLeu: 1.589 ± 0.037	0.326TrpMet: 0.326 ± 0.015	0.407TrpAsn: 0.407 ± 0.018	0.686TrpPro: 0.686 ± 0.023	0.517TrpGln: 0.517 ± 0.022	1.039TrpArg: 1.039 ± 0.03	0.757TrpSer: 0.757 ± 0.03	0.753TrpThr: 0.753 ± 0.027	0.841TrpVal: 0.841 ± 0.026	0.221TrpTrp: 0.221 ± 0.014	0.275TrpTyr: 0.275 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.51TyrAla: 2.51 ± 0.044	0.212TyrCys: 0.212 ± 0.013	1.376TyrAsp: 1.376 ± 0.035	1.19TyrGlu: 1.19 ± 0.033	0.856TyrPhe: 0.856 ± 0.024	2.054TyrGly: 2.054 ± 0.041	0.426TyrHis: 0.426 ± 0.02	0.858TyrIle: 0.858 ± 0.029	0.6TyrLys: 0.6 ± 0.021	2.283TyrLeu: 2.283 ± 0.045	0.403TyrMet: 0.403 ± 0.016	0.538TyrAsn: 0.538 ± 0.02	1.077TyrPro: 1.077 ± 0.03	0.678TyrGln: 0.678 ± 0.022	1.694TyrArg: 1.694 ± 0.035	1.122TyrSer: 1.122 ± 0.031	1.0TyrThr: 1.0 ± 0.029	1.655TyrVal: 1.655 ± 0.041	0.3TyrTrp: 0.3 ± 0.014	0.553TyrTyr: 0.553 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4175 proteins (1319347 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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