Amino acid dipepetide frequency for Candidatus Nitrotoga sp. AM1P

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.428AlaAla: 10.428 ± 0.19
1.089AlaCys: 1.089 ± 0.039
4.895AlaAsp: 4.895 ± 0.079
6.01AlaGlu: 6.01 ± 0.132
3.241AlaPhe: 3.241 ± 0.064
6.95AlaGly: 6.95 ± 0.102
2.292AlaHis: 2.292 ± 0.054
5.791AlaIle: 5.791 ± 0.084
4.578AlaLys: 4.578 ± 0.103
10.873AlaLeu: 10.873 ± 0.142
2.743AlaMet: 2.743 ± 0.074
3.485AlaAsn: 3.485 ± 0.076
3.521AlaPro: 3.521 ± 0.063
4.888AlaGln: 4.888 ± 0.096
5.624AlaArg: 5.624 ± 0.08
5.322AlaSer: 5.322 ± 0.097
5.035AlaThr: 5.035 ± 0.083
6.79AlaVal: 6.79 ± 0.107
1.258AlaTrp: 1.258 ± 0.041
2.468AlaTyr: 2.468 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.919CysAla: 0.919 ± 0.035
0.139CysCys: 0.139 ± 0.012
0.565CysAsp: 0.565 ± 0.027
0.506CysGlu: 0.506 ± 0.025
0.368CysPhe: 0.368 ± 0.021
0.947CysGly: 0.947 ± 0.035
0.342CysHis: 0.342 ± 0.022
0.542CysIle: 0.542 ± 0.027
0.387CysLys: 0.387 ± 0.018
0.861CysLeu: 0.861 ± 0.033
0.216CysMet: 0.216 ± 0.016
0.38CysAsn: 0.38 ± 0.023
0.519CysPro: 0.519 ± 0.028
0.291CysGln: 0.291 ± 0.019
0.59CysArg: 0.59 ± 0.029
0.522CysSer: 0.522 ± 0.026
0.561CysThr: 0.561 ± 0.027
0.669CysVal: 0.669 ± 0.031
0.147CysTrp: 0.147 ± 0.013
0.332CysTyr: 0.332 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
5.184AspAla: 5.184 ± 0.091
0.462AspCys: 0.462 ± 0.023
2.542AspAsp: 2.542 ± 0.067
3.347AspGlu: 3.347 ± 0.073
2.292AspPhe: 2.292 ± 0.064
3.867AspGly: 3.867 ± 0.063
1.058AspHis: 1.058 ± 0.035
3.342AspIle: 3.342 ± 0.069
2.621AspLys: 2.621 ± 0.063
5.11AspLeu: 5.11 ± 0.076
1.385AspMet: 1.385 ± 0.041
1.929AspAsn: 1.929 ± 0.052
2.216AspPro: 2.216 ± 0.048
1.663AspGln: 1.663 ± 0.048
2.493AspArg: 2.493 ± 0.063
2.776AspSer: 2.776 ± 0.056
2.565AspThr: 2.565 ± 0.06
3.661AspVal: 3.661 ± 0.069
0.877AspTrp: 0.877 ± 0.035
1.855AspTyr: 1.855 ± 0.051
0.0AspXaa: 0.0 ± 0.0
Glu
5.623GluAla: 5.623 ± 0.113
0.477GluCys: 0.477 ± 0.026
2.35GluAsp: 2.35 ± 0.064
3.115GluGlu: 3.115 ± 0.072
2.19GluPhe: 2.19 ± 0.045
3.325GluGly: 3.325 ± 0.073
1.522GluHis: 1.522 ± 0.042
4.158GluIle: 4.158 ± 0.08
3.066GluLys: 3.066 ± 0.07
6.269GluLeu: 6.269 ± 0.102
1.61GluMet: 1.61 ± 0.054
2.224GluAsn: 2.224 ± 0.058
1.911GluPro: 1.911 ± 0.047
3.207GluGln: 3.207 ± 0.078
3.865GluArg: 3.865 ± 0.074
3.029GluSer: 3.029 ± 0.074
3.041GluThr: 3.041 ± 0.065
4.071GluVal: 4.071 ± 0.073
0.842GluTrp: 0.842 ± 0.039
1.557GluTyr: 1.557 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
3.605PheAla: 3.605 ± 0.071
0.416PheCys: 0.416 ± 0.023
2.431PheAsp: 2.431 ± 0.056
2.145PheGlu: 2.145 ± 0.062
1.588PhePhe: 1.588 ± 0.057
3.099PheGly: 3.099 ± 0.075
0.862PheHis: 0.862 ± 0.037
2.374PheIle: 2.374 ± 0.056
1.661PheLys: 1.661 ± 0.044
3.448PheLeu: 3.448 ± 0.066
0.943PheMet: 0.943 ± 0.034
1.752PheAsn: 1.752 ± 0.051
1.567PhePro: 1.567 ± 0.048
1.215PheGln: 1.215 ± 0.041
1.903PheArg: 1.903 ± 0.048
2.771PheSer: 2.771 ± 0.054
2.167PheThr: 2.167 ± 0.056
2.638PheVal: 2.638 ± 0.067
0.484PheTrp: 0.484 ± 0.027
1.144PheTyr: 1.144 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
6.049GlyAla: 6.049 ± 0.102
0.769GlyCys: 0.769 ± 0.035
3.433GlyAsp: 3.433 ± 0.081
4.138GlyGlu: 4.138 ± 0.08
2.986GlyPhe: 2.986 ± 0.062
5.305GlyGly: 5.305 ± 0.107
1.716GlyHis: 1.716 ± 0.047
4.822GlyIle: 4.822 ± 0.081
4.349GlyLys: 4.349 ± 0.075
7.464GlyLeu: 7.464 ± 0.102
2.305GlyMet: 2.305 ± 0.061
2.898GlyAsn: 2.898 ± 0.068
1.634GlyPro: 1.634 ± 0.046
2.786GlyGln: 2.786 ± 0.062
3.918GlyArg: 3.918 ± 0.079
4.275GlySer: 4.275 ± 0.077
3.787GlyThr: 3.787 ± 0.071
5.538GlyVal: 5.538 ± 0.093
1.17GlyTrp: 1.17 ± 0.041
2.469GlyTyr: 2.469 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
2.444HisAla: 2.444 ± 0.055
0.317HisCys: 0.317 ± 0.018
1.362HisAsp: 1.362 ± 0.036
1.319HisGlu: 1.319 ± 0.042
1.041HisPhe: 1.041 ± 0.039
1.871HisGly: 1.871 ± 0.045
0.698HisHis: 0.698 ± 0.031
1.566HisIle: 1.566 ± 0.048
0.899HisLys: 0.899 ± 0.031
2.585HisLeu: 2.585 ± 0.061
0.48HisMet: 0.48 ± 0.023
0.956HisAsn: 0.956 ± 0.033
1.426HisPro: 1.426 ± 0.045
0.907HisGln: 0.907 ± 0.032
1.281HisArg: 1.281 ± 0.048
1.332HisSer: 1.332 ± 0.038
1.281HisThr: 1.281 ± 0.046
1.492HisVal: 1.492 ± 0.045
0.366HisTrp: 0.366 ± 0.022
0.848HisTyr: 0.848 ± 0.038
0.0HisXaa: 0.0 ± 0.0
Ile
6.507IleAla: 6.507 ± 0.099
0.607IleCys: 0.607 ± 0.027
3.365IleAsp: 3.365 ± 0.064
4.071IleGlu: 4.071 ± 0.077
2.232IlePhe: 2.232 ± 0.061
4.677IleGly: 4.677 ± 0.076
1.307IleHis: 1.307 ± 0.041
3.321IleIle: 3.321 ± 0.077
3.065IleLys: 3.065 ± 0.059
5.327IleLeu: 5.327 ± 0.087
1.296IleMet: 1.296 ± 0.043
2.762IleAsn: 2.762 ± 0.063
2.834IlePro: 2.834 ± 0.06
2.016IleGln: 2.016 ± 0.05
3.144IleArg: 3.144 ± 0.065
4.132IleSer: 4.132 ± 0.074
3.708IleThr: 3.708 ± 0.07
4.128IleVal: 4.128 ± 0.073
0.609IleTrp: 0.609 ± 0.026
1.63IleTyr: 1.63 ± 0.042
0.0IleXaa: 0.0 ± 0.0
Lys
4.111LysAla: 4.111 ± 0.094
0.336LysCys: 0.336 ± 0.02
2.139LysAsp: 2.139 ± 0.06
2.572LysGlu: 2.572 ± 0.068
1.578LysPhe: 1.578 ± 0.046
2.884LysGly: 2.884 ± 0.078
1.163LysHis: 1.163 ± 0.035
3.15LysIle: 3.15 ± 0.066
2.56LysLys: 2.56 ± 0.066
5.305LysLeu: 5.305 ± 0.081
1.431LysMet: 1.431 ± 0.045
2.236LysAsn: 2.236 ± 0.058
2.456LysPro: 2.456 ± 0.06
2.391LysGln: 2.391 ± 0.066
2.855LysArg: 2.855 ± 0.067
2.798LysSer: 2.798 ± 0.065
2.732LysThr: 2.732 ± 0.063
3.166LysVal: 3.166 ± 0.068
0.548LysTrp: 0.548 ± 0.031
1.188LysTyr: 1.188 ± 0.041
0.0LysXaa: 0.0 ± 0.0
Leu
11.079LeuAla: 11.079 ± 0.145
1.054LeuCys: 1.054 ± 0.038
5.607LeuAsp: 5.607 ± 0.092
5.677LeuGlu: 5.677 ± 0.085
3.914LeuPhe: 3.914 ± 0.082
7.335LeuGly: 7.335 ± 0.115
2.626LeuHis: 2.626 ± 0.061
5.911LeuIle: 5.911 ± 0.094
5.081LeuLys: 5.081 ± 0.08
11.697LeuLeu: 11.697 ± 0.201
2.522LeuMet: 2.522 ± 0.065
4.309LeuAsn: 4.309 ± 0.085
5.69LeuPro: 5.69 ± 0.092
4.431LeuGln: 4.431 ± 0.072
6.556LeuArg: 6.556 ± 0.095
6.816LeuSer: 6.816 ± 0.103
5.936LeuThr: 5.936 ± 0.091
6.781LeuVal: 6.781 ± 0.094
1.245LeuTrp: 1.245 ± 0.044
2.519LeuTyr: 2.519 ± 0.058
0.0LeuXaa: 0.0 ± 0.0
Met
2.499MetAla: 2.499 ± 0.07
0.195MetCys: 0.195 ± 0.015
1.264MetAsp: 1.264 ± 0.039
1.326MetGlu: 1.326 ± 0.044
0.811MetPhe: 0.811 ± 0.032
1.796MetGly: 1.796 ± 0.05
0.709MetHis: 0.709 ± 0.026
1.319MetIle: 1.319 ± 0.037
1.325MetLys: 1.325 ± 0.049
3.033MetLeu: 3.033 ± 0.07
0.685MetMet: 0.685 ± 0.033
1.131MetAsn: 1.131 ± 0.035
1.336MetPro: 1.336 ± 0.041
1.342MetGln: 1.342 ± 0.036
1.633MetArg: 1.633 ± 0.039
1.642MetSer: 1.642 ± 0.045
1.41MetThr: 1.41 ± 0.045
1.831MetVal: 1.831 ± 0.055
0.212MetTrp: 0.212 ± 0.016
0.526MetTyr: 0.526 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
3.807AsnAla: 3.807 ± 0.073
0.393AsnCys: 0.393 ± 0.021
1.929AsnAsp: 1.929 ± 0.051
2.181AsnGlu: 2.181 ± 0.058
1.557AsnPhe: 1.557 ± 0.049
3.112AsnGly: 3.112 ± 0.075
0.874AsnHis: 0.874 ± 0.034
2.573AsnIle: 2.573 ± 0.051
1.895AsnLys: 1.895 ± 0.055
4.218AsnLeu: 4.218 ± 0.079
1.023AsnMet: 1.023 ± 0.036
1.738AsnAsn: 1.738 ± 0.056
2.246AsnPro: 2.246 ± 0.053
1.497AsnGln: 1.497 ± 0.043
2.183AsnArg: 2.183 ± 0.052
2.183AsnSer: 2.183 ± 0.05
2.238AsnThr: 2.238 ± 0.055
2.571AsnVal: 2.571 ± 0.067
0.577AsnTrp: 0.577 ± 0.028
1.19AsnTyr: 1.19 ± 0.043
0.0AsnXaa: 0.0 ± 0.0
Pro
3.991ProAla: 3.991 ± 0.08
0.367ProCys: 0.367 ± 0.019
2.818ProAsp: 2.818 ± 0.06
2.996ProGlu: 2.996 ± 0.06
1.724ProPhe: 1.724 ± 0.044
3.177ProGly: 3.177 ± 0.067
1.132ProHis: 1.132 ± 0.038
2.39ProIle: 2.39 ± 0.055
1.961ProLys: 1.961 ± 0.056
4.649ProLeu: 4.649 ± 0.097
1.029ProMet: 1.029 ± 0.037
1.765ProAsn: 1.765 ± 0.057
1.929ProPro: 1.929 ± 0.058
1.95ProGln: 1.95 ± 0.05
2.006ProArg: 2.006 ± 0.051
2.567ProSer: 2.567 ± 0.059
2.258ProThr: 2.258 ± 0.054
3.546ProVal: 3.546 ± 0.074
0.584ProTrp: 0.584 ± 0.029
1.247ProTyr: 1.247 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
4.632GlnAla: 4.632 ± 0.086
0.389GlnCys: 0.389 ± 0.02
1.886GlnAsp: 1.886 ± 0.048
2.212GlnGlu: 2.212 ± 0.058
1.486GlnPhe: 1.486 ± 0.042
2.92GlnGly: 2.92 ± 0.065
1.216GlnHis: 1.216 ± 0.04
2.579GlnIle: 2.579 ± 0.056
1.933GlnLys: 1.933 ± 0.05
4.629GlnLeu: 4.629 ± 0.088
1.127GlnMet: 1.127 ± 0.03
1.596GlnAsn: 1.596 ± 0.041
1.969GlnPro: 1.969 ± 0.053
2.436GlnGln: 2.436 ± 0.083
2.89GlnArg: 2.89 ± 0.063
2.394GlnSer: 2.394 ± 0.055
2.135GlnThr: 2.135 ± 0.059
2.94GlnVal: 2.94 ± 0.062
0.549GlnTrp: 0.549 ± 0.027
1.12GlnTyr: 1.12 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
5.107ArgAla: 5.107 ± 0.093
0.531ArgCys: 0.531 ± 0.028
3.021ArgAsp: 3.021 ± 0.071
3.673ArgGlu: 3.673 ± 0.072
2.509ArgPhe: 2.509 ± 0.063
3.566ArgGly: 3.566 ± 0.069
1.537ArgHis: 1.537 ± 0.047
3.901ArgIle: 3.901 ± 0.075
2.651ArgLys: 2.651 ± 0.061
6.304ArgLeu: 6.304 ± 0.093
1.6ArgMet: 1.6 ± 0.042
2.287ArgAsn: 2.287 ± 0.059
2.177ArgPro: 2.177 ± 0.056
2.462ArgGln: 2.462 ± 0.049
3.28ArgArg: 3.28 ± 0.073
2.954ArgSer: 2.954 ± 0.058
2.71ArgThr: 2.71 ± 0.06
4.017ArgVal: 4.017 ± 0.073
0.832ArgTrp: 0.832 ± 0.033
1.959ArgTyr: 1.959 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
5.48SerAla: 5.48 ± 0.099
0.614SerCys: 0.614 ± 0.028
2.976SerAsp: 2.976 ± 0.062
3.19SerGlu: 3.19 ± 0.066
2.347SerPhe: 2.347 ± 0.059
5.298SerGly: 5.298 ± 0.087
1.395SerHis: 1.395 ± 0.045
3.581SerIle: 3.581 ± 0.07
2.714SerLys: 2.714 ± 0.061
6.093SerLeu: 6.093 ± 0.087
1.539SerMet: 1.539 ± 0.048
2.344SerAsn: 2.344 ± 0.054
2.6SerPro: 2.6 ± 0.056
2.217SerGln: 2.217 ± 0.049
3.143SerArg: 3.143 ± 0.061
3.64SerSer: 3.64 ± 0.082
3.163SerThr: 3.163 ± 0.084
4.156SerVal: 4.156 ± 0.072
0.769SerTrp: 0.769 ± 0.032
1.672SerTyr: 1.672 ± 0.054
0.0SerXaa: 0.0 ± 0.0
Thr
5.147ThrAla: 5.147 ± 0.097
0.452ThrCys: 0.452 ± 0.023
2.767ThrAsp: 2.767 ± 0.06
2.761ThrGlu: 2.761 ± 0.057
1.953ThrPhe: 1.953 ± 0.046
4.204ThrGly: 4.204 ± 0.073
1.407ThrHis: 1.407 ± 0.041
3.105ThrIle: 3.105 ± 0.062
2.1ThrLys: 2.1 ± 0.062
6.437ThrLeu: 6.437 ± 0.123
1.208ThrMet: 1.208 ± 0.038
1.882ThrAsn: 1.882 ± 0.058
3.046ThrPro: 3.046 ± 0.065
2.444ThrGln: 2.444 ± 0.064
2.842ThrArg: 2.842 ± 0.057
3.091ThrSer: 3.091 ± 0.081
3.088ThrThr: 3.088 ± 0.085
3.999ThrVal: 3.999 ± 0.077
0.62ThrTrp: 0.62 ± 0.028
1.458ThrTyr: 1.458 ± 0.067
0.0ThrXaa: 0.0 ± 0.0
Val
7.069ValAla: 7.069 ± 0.088
0.731ValCys: 0.731 ± 0.031
3.693ValAsp: 3.693 ± 0.073
4.165ValGlu: 4.165 ± 0.065
2.543ValPhe: 2.543 ± 0.064
4.662ValGly: 4.662 ± 0.089
1.461ValHis: 1.461 ± 0.049
4.189ValIle: 4.189 ± 0.082
3.099ValLys: 3.099 ± 0.075
7.611ValLeu: 7.611 ± 0.121
1.973ValMet: 1.973 ± 0.054
2.697ValAsn: 2.697 ± 0.068
3.136ValPro: 3.136 ± 0.065
2.753ValGln: 2.753 ± 0.066
3.925ValArg: 3.925 ± 0.075
4.342ValSer: 4.342 ± 0.074
4.1ValThr: 4.1 ± 0.086
5.376ValVal: 5.376 ± 0.095
0.871ValTrp: 0.871 ± 0.04
1.691ValTyr: 1.691 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
0.927TrpAla: 0.927 ± 0.035
0.151TrpCys: 0.151 ± 0.015
0.628TrpAsp: 0.628 ± 0.029
0.66TrpGlu: 0.66 ± 0.029
0.574TrpPhe: 0.574 ± 0.026
0.752TrpGly: 0.752 ± 0.034
0.415TrpHis: 0.415 ± 0.022
0.747TrpIle: 0.747 ± 0.031
0.542TrpLys: 0.542 ± 0.026
1.856TrpLeu: 1.856 ± 0.057
0.373TrpMet: 0.373 ± 0.022
0.554TrpAsn: 0.554 ± 0.029
0.46TrpPro: 0.46 ± 0.028
0.833TrpGln: 0.833 ± 0.031
0.961TrpArg: 0.961 ± 0.038
0.691TrpSer: 0.691 ± 0.034
0.582TrpThr: 0.582 ± 0.028
0.908TrpVal: 0.908 ± 0.032
0.251TrpTrp: 0.251 ± 0.019
0.375TrpTyr: 0.375 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.673TyrAla: 2.673 ± 0.052
0.315TyrCys: 0.315 ± 0.02
1.572TyrAsp: 1.572 ± 0.078
1.389TyrGlu: 1.389 ± 0.044
1.28TyrPhe: 1.28 ± 0.039
2.063TyrGly: 2.063 ± 0.047
0.739TyrHis: 0.739 ± 0.028
1.377TyrIle: 1.377 ± 0.046
1.112TyrLys: 1.112 ± 0.037
3.018TyrLeu: 3.018 ± 0.069
0.54TyrMet: 0.54 ± 0.025
1.058TyrAsn: 1.058 ± 0.036
1.413TyrPro: 1.413 ± 0.041
1.311TyrGln: 1.311 ± 0.047
1.987TyrArg: 1.987 ± 0.058
1.654TyrSer: 1.654 ± 0.048
1.513TyrThr: 1.513 ± 0.045
1.808TyrVal: 1.808 ± 0.05
0.429TyrTrp: 0.429 ± 0.02
0.869TyrTyr: 0.869 ± 0.04
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2658 proteins (833905 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski