Amino acid dipepetide frequency for Corynebacterium resistens (strain DSM 45100 / JCM 12819 / GTC 2026 / SICGH 158)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.832AlaAla: 13.832 ± 0.218	0.863AlaCys: 0.863 ± 0.032	6.362AlaAsp: 6.362 ± 0.109	7.869AlaGlu: 7.869 ± 0.133	3.456AlaPhe: 3.456 ± 0.069	10.071AlaGly: 10.071 ± 0.129	2.264AlaHis: 2.264 ± 0.057	5.274AlaIle: 5.274 ± 0.088	4.638AlaLys: 4.638 ± 0.099	10.664AlaLeu: 10.664 ± 0.153	2.761AlaMet: 2.761 ± 0.056	3.173AlaAsn: 3.173 ± 0.072	5.093AlaPro: 5.093 ± 0.171	4.258AlaGln: 4.258 ± 0.078	6.962AlaArg: 6.962 ± 0.115	6.135AlaSer: 6.135 ± 0.086	6.952AlaThr: 6.952 ± 0.095	8.866AlaVal: 8.866 ± 0.143	1.439AlaTrp: 1.439 ± 0.047	2.145AlaTyr: 2.145 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.816CysAla: 0.816 ± 0.033	0.07CysCys: 0.07 ± 0.009	0.407CysAsp: 0.407 ± 0.022	0.47CysGlu: 0.47 ± 0.027	0.234CysPhe: 0.234 ± 0.017	0.765CysGly: 0.765 ± 0.032	0.187CysHis: 0.187 ± 0.015	0.347CysIle: 0.347 ± 0.022	0.167CysLys: 0.167 ± 0.014	0.651CysLeu: 0.651 ± 0.032	0.163CysMet: 0.163 ± 0.015	0.24CysAsn: 0.24 ± 0.017	0.422CysPro: 0.422 ± 0.026	0.217CysGln: 0.217 ± 0.018	0.429CysArg: 0.429 ± 0.027	0.477CysSer: 0.477 ± 0.025	0.434CysThr: 0.434 ± 0.028	0.583CysVal: 0.583 ± 0.028	0.095CysTrp: 0.095 ± 0.012	0.146CysTyr: 0.146 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.373AspAla: 6.373 ± 0.092	0.396AspCys: 0.396 ± 0.024	3.273AspAsp: 3.273 ± 0.075	4.348AspGlu: 4.348 ± 0.082	1.899AspPhe: 1.899 ± 0.047	5.087AspGly: 5.087 ± 0.098	1.397AspHis: 1.397 ± 0.047	2.9AspIle: 2.9 ± 0.06	2.304AspLys: 2.304 ± 0.079	5.381AspLeu: 5.381 ± 0.092	1.198AspMet: 1.198 ± 0.038	1.745AspAsn: 1.745 ± 0.05	3.444AspPro: 3.444 ± 0.066	1.851AspGln: 1.851 ± 0.054	3.623AspArg: 3.623 ± 0.071	3.588AspSer: 3.588 ± 0.071	2.713AspThr: 2.713 ± 0.06	4.453AspVal: 4.453 ± 0.084	0.773AspTrp: 0.773 ± 0.03	1.408AspTyr: 1.408 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	6.982GluAla: 6.982 ± 0.131	0.385GluCys: 0.385 ± 0.027	3.717GluAsp: 3.717 ± 0.08	4.336GluGlu: 4.336 ± 0.089	2.158GluPhe: 2.158 ± 0.058	4.711GluGly: 4.711 ± 0.086	1.555GluHis: 1.555 ± 0.048	3.175GluIle: 3.175 ± 0.063	2.978GluLys: 2.978 ± 0.062	6.561GluLeu: 6.561 ± 0.103	1.328GluMet: 1.328 ± 0.042	2.162GluAsn: 2.162 ± 0.057	2.72GluPro: 2.72 ± 0.063	2.818GluGln: 2.818 ± 0.066	4.099GluArg: 4.099 ± 0.077	3.3GluSer: 3.3 ± 0.076	3.296GluThr: 3.296 ± 0.065	5.082GluVal: 5.082 ± 0.077	0.87GluTrp: 0.87 ± 0.039	1.378GluTyr: 1.378 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	3.579PheAla: 3.579 ± 0.069	0.285PheCys: 0.285 ± 0.02	2.193PheAsp: 2.193 ± 0.061	1.749PheGlu: 1.749 ± 0.051	1.172PhePhe: 1.172 ± 0.048	3.286PheGly: 3.286 ± 0.075	0.678PheHis: 0.678 ± 0.035	1.619PheIle: 1.619 ± 0.051	0.904PheLys: 0.904 ± 0.043	2.807PheLeu: 2.807 ± 0.066	0.693PheMet: 0.693 ± 0.03	1.12PheAsn: 1.12 ± 0.037	1.394PhePro: 1.394 ± 0.037	0.915PheGln: 0.915 ± 0.029	1.778PheArg: 1.778 ± 0.05	2.128PheSer: 2.128 ± 0.052	2.156PheThr: 2.156 ± 0.053	2.517PheVal: 2.517 ± 0.068	0.417PheTrp: 0.417 ± 0.024	0.761PheTyr: 0.761 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	8.797GlyAla: 8.797 ± 0.135	0.665GlyCys: 0.665 ± 0.028	4.548GlyAsp: 4.548 ± 0.085	5.311GlyGlu: 5.311 ± 0.094	3.028GlyPhe: 3.028 ± 0.068	7.071GlyGly: 7.071 ± 0.141	1.937GlyHis: 1.937 ± 0.058	4.327GlyIle: 4.327 ± 0.083	3.839GlyLys: 3.839 ± 0.075	7.749GlyLeu: 7.749 ± 0.105	2.222GlyMet: 2.222 ± 0.054	2.648GlyAsn: 2.648 ± 0.083	3.26GlyPro: 3.26 ± 0.077	3.067GlyGln: 3.067 ± 0.07	5.192GlyArg: 5.192 ± 0.091	5.379GlySer: 5.379 ± 0.11	5.098GlyThr: 5.098 ± 0.107	6.899GlyVal: 6.899 ± 0.105	1.34GlyTrp: 1.34 ± 0.046	2.134GlyTyr: 2.134 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.231HisAla: 2.231 ± 0.062	0.197HisCys: 0.197 ± 0.016	1.315HisAsp: 1.315 ± 0.048	1.274HisGlu: 1.274 ± 0.042	0.653HisPhe: 0.653 ± 0.032	1.957HisGly: 1.957 ± 0.06	0.584HisHis: 0.584 ± 0.03	1.065HisIle: 1.065 ± 0.039	0.65HisLys: 0.65 ± 0.033	1.921HisLeu: 1.921 ± 0.052	0.44HisMet: 0.44 ± 0.023	0.698HisAsn: 0.698 ± 0.032	1.5HisPro: 1.5 ± 0.048	0.711HisGln: 0.711 ± 0.03	1.555HisArg: 1.555 ± 0.049	1.385HisSer: 1.385 ± 0.049	1.295HisThr: 1.295 ± 0.041	1.645HisVal: 1.645 ± 0.043	0.277HisTrp: 0.277 ± 0.02	0.506HisTyr: 0.506 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.407IleAla: 6.407 ± 0.089	0.429IleCys: 0.429 ± 0.024	3.227IleAsp: 3.227 ± 0.072	3.011IleGlu: 3.011 ± 0.068	1.536IlePhe: 1.536 ± 0.053	4.195IleGly: 4.195 ± 0.09	1.038IleHis: 1.038 ± 0.036	2.377IleIle: 2.377 ± 0.071	1.532IleLys: 1.532 ± 0.044	3.881IleLeu: 3.881 ± 0.069	0.943IleMet: 0.943 ± 0.036	1.655IleAsn: 1.655 ± 0.052	2.589IlePro: 2.589 ± 0.059	1.344IleGln: 1.344 ± 0.045	2.693IleArg: 2.693 ± 0.065	3.028IleSer: 3.028 ± 0.07	3.151IleThr: 3.151 ± 0.066	4.144IleVal: 4.144 ± 0.086	0.487IleTrp: 0.487 ± 0.024	0.997IleTyr: 0.997 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	4.26LysAla: 4.26 ± 0.085	0.195LysCys: 0.195 ± 0.017	2.272LysAsp: 2.272 ± 0.083	2.287LysGlu: 2.287 ± 0.066	1.082LysPhe: 1.082 ± 0.04	2.844LysGly: 2.844 ± 0.077	0.757LysHis: 0.757 ± 0.028	1.888LysIle: 1.888 ± 0.053	2.19LysLys: 2.19 ± 0.083	3.567LysLeu: 3.567 ± 0.076	0.948LysMet: 0.948 ± 0.035	1.472LysAsn: 1.472 ± 0.055	2.239LysPro: 2.239 ± 0.072	1.551LysGln: 1.551 ± 0.051	2.466LysArg: 2.466 ± 0.069	2.089LysSer: 2.089 ± 0.068	2.244LysThr: 2.244 ± 0.056	2.965LysVal: 2.965 ± 0.068	0.539LysTrp: 0.539 ± 0.031	0.832LysTyr: 0.832 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	11.14LeuAla: 11.14 ± 0.138	0.696LeuCys: 0.696 ± 0.032	5.609LeuAsp: 5.609 ± 0.087	5.187LeuGlu: 5.187 ± 0.079	2.737LeuPhe: 2.737 ± 0.073	7.881LeuGly: 7.881 ± 0.122	1.841LeuHis: 1.841 ± 0.051	4.473LeuIle: 4.473 ± 0.089	3.159LeuLys: 3.159 ± 0.074	8.404LeuLeu: 8.404 ± 0.131	1.984LeuMet: 1.984 ± 0.056	2.767LeuAsn: 2.767 ± 0.062	5.048LeuPro: 5.048 ± 0.076	2.917LeuGln: 2.917 ± 0.064	6.227LeuArg: 6.227 ± 0.108	5.716LeuSer: 5.716 ± 0.094	5.669LeuThr: 5.669 ± 0.094	7.442LeuVal: 7.442 ± 0.109	1.071LeuTrp: 1.071 ± 0.037	1.662LeuTyr: 1.662 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.618MetAla: 2.618 ± 0.057	0.147MetCys: 0.147 ± 0.014	1.212MetAsp: 1.212 ± 0.042	1.167MetGlu: 1.167 ± 0.043	0.747MetPhe: 0.747 ± 0.033	1.761MetGly: 1.761 ± 0.051	0.479MetHis: 0.479 ± 0.026	1.157MetIle: 1.157 ± 0.04	0.857MetLys: 0.857 ± 0.036	2.127MetLeu: 2.127 ± 0.059	0.568MetMet: 0.568 ± 0.027	0.767MetAsn: 0.767 ± 0.028	1.204MetPro: 1.204 ± 0.036	0.751MetGln: 0.751 ± 0.031	1.455MetArg: 1.455 ± 0.043	1.666MetSer: 1.666 ± 0.05	1.602MetThr: 1.602 ± 0.045	1.786MetVal: 1.786 ± 0.049	0.298MetTrp: 0.298 ± 0.02	0.379MetTyr: 0.379 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.309AsnAla: 3.309 ± 0.071	0.252AsnCys: 0.252 ± 0.019	1.642AsnAsp: 1.642 ± 0.053	1.709AsnGlu: 1.709 ± 0.051	0.922AsnPhe: 0.922 ± 0.033	2.672AsnGly: 2.672 ± 0.081	0.736AsnHis: 0.736 ± 0.033	1.446AsnIle: 1.446 ± 0.042	1.257AsnLys: 1.257 ± 0.048	2.688AsnLeu: 2.688 ± 0.06	0.7AsnMet: 0.7 ± 0.03	1.188AsnAsn: 1.188 ± 0.056	2.463AsnPro: 2.463 ± 0.071	1.27AsnGln: 1.27 ± 0.048	2.011AsnArg: 2.011 ± 0.057	2.164AsnSer: 2.164 ± 0.061	1.896AsnThr: 1.896 ± 0.055	2.287AsnVal: 2.287 ± 0.059	0.437AsnTrp: 0.437 ± 0.026	0.81AsnTyr: 0.81 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	5.817ProAla: 5.817 ± 0.119	0.27ProCys: 0.27 ± 0.022	3.079ProAsp: 3.079 ± 0.077	4.135ProGlu: 4.135 ± 0.074	1.523ProPhe: 1.523 ± 0.046	4.522ProGly: 4.522 ± 0.128	1.234ProHis: 1.234 ± 0.042	2.132ProIle: 2.132 ± 0.055	2.06ProLys: 2.06 ± 0.068	4.176ProLeu: 4.176 ± 0.074	1.01ProMet: 1.01 ± 0.039	1.835ProAsn: 1.835 ± 0.055	1.802ProPro: 1.802 ± 0.06	1.954ProGln: 1.954 ± 0.058	2.91ProArg: 2.91 ± 0.061	3.215ProSer: 3.215 ± 0.073	3.241ProThr: 3.241 ± 0.069	4.289ProVal: 4.289 ± 0.074	0.749ProTrp: 0.749 ± 0.034	1.035ProTyr: 1.035 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	4.031GlnAla: 4.031 ± 0.08	0.245GlnCys: 0.245 ± 0.02	1.635GlnAsp: 1.635 ± 0.048	1.973GlnGlu: 1.973 ± 0.052	1.07GlnPhe: 1.07 ± 0.042	2.574GlnGly: 2.574 ± 0.065	0.821GlnHis: 0.821 ± 0.036	1.74GlnIle: 1.74 ± 0.048	1.307GlnLys: 1.307 ± 0.051	3.896GlnLeu: 3.896 ± 0.084	0.821GlnMet: 0.821 ± 0.034	1.034GlnAsn: 1.034 ± 0.034	2.064GlnPro: 2.064 ± 0.063	1.764GlnGln: 1.764 ± 0.058	2.838GlnArg: 2.838 ± 0.069	1.847GlnSer: 1.847 ± 0.054	1.728GlnThr: 1.728 ± 0.045	2.665GlnVal: 2.665 ± 0.056	0.649GlnTrp: 0.649 ± 0.029	0.723GlnTyr: 0.723 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	6.349ArgAla: 6.349 ± 0.1	0.401ArgCys: 0.401 ± 0.025	3.496ArgAsp: 3.496 ± 0.081	4.457ArgGlu: 4.457 ± 0.086	2.112ArgPhe: 2.112 ± 0.05	4.809ArgGly: 4.809 ± 0.089	1.368ArgHis: 1.368 ± 0.042	3.351ArgIle: 3.351 ± 0.074	2.602ArgLys: 2.602 ± 0.07	5.618ArgLeu: 5.618 ± 0.102	1.692ArgMet: 1.692 ± 0.047	2.035ArgAsn: 2.035 ± 0.054	3.12ArgPro: 3.12 ± 0.074	2.409ArgGln: 2.409 ± 0.059	4.911ArgArg: 4.911 ± 0.102	3.677ArgSer: 3.677 ± 0.077	3.579ArgThr: 3.579 ± 0.072	4.808ArgVal: 4.808 ± 0.09	1.004ArgTrp: 1.004 ± 0.038	1.513ArgTyr: 1.513 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	7.024SerAla: 7.024 ± 0.102	0.367SerCys: 0.367 ± 0.023	3.526SerAsp: 3.526 ± 0.073	3.537SerGlu: 3.537 ± 0.065	1.937SerPhe: 1.937 ± 0.042	5.768SerGly: 5.768 ± 0.111	1.296SerHis: 1.296 ± 0.045	2.646SerIle: 2.646 ± 0.061	2.092SerLys: 2.092 ± 0.06	5.222SerLeu: 5.222 ± 0.089	1.405SerMet: 1.405 ± 0.042	1.964SerAsn: 1.964 ± 0.053	3.151SerPro: 3.151 ± 0.077	2.186SerGln: 2.186 ± 0.051	3.559SerArg: 3.559 ± 0.06	4.305SerSer: 4.305 ± 0.107	4.106SerThr: 4.106 ± 0.071	4.45SerVal: 4.45 ± 0.082	0.83SerTrp: 0.83 ± 0.032	1.315SerTyr: 1.315 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	6.591ThrAla: 6.591 ± 0.097	0.448ThrCys: 0.448 ± 0.025	3.41ThrAsp: 3.41 ± 0.083	3.451ThrGlu: 3.451 ± 0.067	1.999ThrPhe: 1.999 ± 0.049	5.353ThrGly: 5.353 ± 0.077	1.339ThrHis: 1.339 ± 0.046	2.966ThrIle: 2.966 ± 0.065	2.176ThrLys: 2.176 ± 0.065	5.2ThrLeu: 5.2 ± 0.086	1.314ThrMet: 1.314 ± 0.043	1.871ThrAsn: 1.871 ± 0.056	3.696ThrPro: 3.696 ± 0.084	1.761ThrGln: 1.761 ± 0.049	3.257ThrArg: 3.257 ± 0.072	3.862ThrSer: 3.862 ± 0.09	4.147ThrThr: 4.147 ± 0.115	5.323ThrVal: 5.323 ± 0.106	0.85ThrTrp: 0.85 ± 0.035	1.302ThrTyr: 1.302 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	9.278ValAla: 9.278 ± 0.125	0.693ValCys: 0.693 ± 0.034	5.188ValAsp: 5.188 ± 0.106	5.357ValGlu: 5.357 ± 0.088	2.558ValPhe: 2.558 ± 0.066	6.286ValGly: 6.286 ± 0.111	1.574ValHis: 1.574 ± 0.048	4.179ValIle: 4.179 ± 0.077	2.803ValLys: 2.803 ± 0.071	7.555ValLeu: 7.555 ± 0.119	1.781ValMet: 1.781 ± 0.056	2.357ValAsn: 2.357 ± 0.054	3.996ValPro: 3.996 ± 0.078	2.36ValGln: 2.36 ± 0.049	4.751ValArg: 4.751 ± 0.091	4.605ValSer: 4.605 ± 0.076	5.0ValThr: 5.0 ± 0.102	7.056ValVal: 7.056 ± 0.121	0.98ValTrp: 0.98 ± 0.036	1.529ValTyr: 1.529 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.4TrpAla: 1.4 ± 0.05	0.131TrpCys: 0.131 ± 0.014	0.735TrpAsp: 0.735 ± 0.03	0.74TrpGlu: 0.74 ± 0.031	0.553TrpPhe: 0.553 ± 0.027	0.956TrpGly: 0.956 ± 0.04	0.326TrpHis: 0.326 ± 0.023	0.712TrpIle: 0.712 ± 0.031	0.511TrpLys: 0.511 ± 0.025	1.417TrpLeu: 1.417 ± 0.043	0.407TrpMet: 0.407 ± 0.024	0.462TrpAsn: 0.462 ± 0.021	0.616TrpPro: 0.616 ± 0.031	0.56TrpGln: 0.56 ± 0.026	1.022TrpArg: 1.022 ± 0.04	0.748TrpSer: 0.748 ± 0.033	0.74TrpThr: 0.74 ± 0.03	1.082TrpVal: 1.082 ± 0.035	0.314TrpTrp: 0.314 ± 0.021	0.286TrpTyr: 0.286 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.244TyrAla: 2.244 ± 0.061	0.185TyrCys: 0.185 ± 0.016	1.311TyrAsp: 1.311 ± 0.045	1.243TyrGlu: 1.243 ± 0.04	0.776TyrPhe: 0.776 ± 0.038	1.94TyrGly: 1.94 ± 0.049	0.446TyrHis: 0.446 ± 0.026	0.891TyrIle: 0.891 ± 0.031	0.661TyrLys: 0.661 ± 0.033	2.142TyrLeu: 2.142 ± 0.05	0.368TyrMet: 0.368 ± 0.02	0.665TyrAsn: 0.665 ± 0.033	1.171TyrPro: 1.171 ± 0.048	0.761TyrGln: 0.761 ± 0.029	1.573TyrArg: 1.573 ± 0.048	1.373TyrSer: 1.373 ± 0.039	1.267TyrThr: 1.267 ± 0.043	1.545TyrVal: 1.545 ± 0.052	0.298TyrTrp: 0.298 ± 0.019	0.538TyrTyr: 0.538 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2160 proteins (755222 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---