Amino acid dipepetide frequency for Wenzhou sobemo-like virus 3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.525AlaAla: 5.525 ± 1.744
1.842AlaCys: 1.842 ± 0.581
4.604AlaAsp: 4.604 ± 1.38
0.921AlaGlu: 0.921 ± 0.593
1.842AlaPhe: 1.842 ± 1.186
4.604AlaGly: 4.604 ± 0.452
0.921AlaHis: 0.921 ± 0.593
0.921AlaIle: 0.921 ± 1.117
5.525AlaLys: 5.525 ± 1.744
8.287AlaLeu: 8.287 ± 2.667
0.921AlaMet: 0.921 ± 0.593
2.762AlaAsn: 2.762 ± 1.992
8.287AlaPro: 8.287 ± 3.339
2.762AlaGln: 2.762 ± 1.133
3.683AlaArg: 3.683 ± 1.535
4.604AlaSer: 4.604 ± 2.033
4.604AlaThr: 4.604 ± 1.95
11.971AlaVal: 11.971 ± 0.603
1.842AlaTrp: 1.842 ± 1.15
1.842AlaTyr: 1.842 ± 0.581
0.0AlaXaa: 0.0 ± 0.0
Cys
0.921CysAla: 0.921 ± 1.117
0.0CysCys: 0.0 ± 0.0
0.921CysAsp: 0.921 ± 0.593
0.921CysGlu: 0.921 ± 0.767
0.0CysPhe: 0.0 ± 0.0
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
1.842CysIle: 1.842 ± 0.581
0.0CysLys: 0.0 ± 0.0
3.683CysLeu: 3.683 ± 4.466
1.842CysMet: 1.842 ± 2.233
0.921CysAsn: 0.921 ± 1.117
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
1.842CysVal: 1.842 ± 0.581
0.0CysTrp: 0.0 ± 0.0
1.842CysTyr: 1.842 ± 0.581
0.0CysXaa: 0.0 ± 0.0
Asp
1.842AspAla: 1.842 ± 0.581
0.0AspCys: 0.0 ± 0.0
3.683AspAsp: 3.683 ± 1.96
6.446AspGlu: 6.446 ± 3.178
3.683AspPhe: 3.683 ± 1.395
4.604AspGly: 4.604 ± 0.452
0.921AspHis: 0.921 ± 0.593
1.842AspIle: 1.842 ± 1.186
0.921AspLys: 0.921 ± 0.767
1.842AspLeu: 1.842 ± 0.581
1.842AspMet: 1.842 ± 1.535
1.842AspAsn: 1.842 ± 1.535
2.762AspPro: 2.762 ± 0.889
1.842AspGln: 1.842 ± 2.233
2.762AspArg: 2.762 ± 1.225
3.683AspSer: 3.683 ± 1.395
1.842AspThr: 1.842 ± 1.15
3.683AspVal: 3.683 ± 1.395
1.842AspTrp: 1.842 ± 1.15
1.842AspTyr: 1.842 ± 0.581
0.0AspXaa: 0.0 ± 0.0
Glu
4.604GluAla: 4.604 ± 0.791
0.0GluCys: 0.0 ± 0.0
4.604GluAsp: 4.604 ± 1.758
0.921GluGlu: 0.921 ± 0.767
0.921GluPhe: 0.921 ± 0.767
3.683GluGly: 3.683 ± 1.395
1.842GluHis: 1.842 ± 1.535
2.762GluIle: 2.762 ± 0.889
4.604GluLys: 4.604 ± 2.685
1.842GluLeu: 1.842 ± 1.15
0.921GluMet: 0.921 ± 0.767
4.604GluAsn: 4.604 ± 1.758
1.842GluPro: 1.842 ± 0.581
2.762GluGln: 2.762 ± 1.779
6.446GluArg: 6.446 ± 1.922
0.921GluSer: 0.921 ± 0.593
1.842GluThr: 1.842 ± 2.233
1.842GluVal: 1.842 ± 0.581
1.842GluTrp: 1.842 ± 1.186
3.683GluTyr: 3.683 ± 1.163
0.0GluXaa: 0.0 ± 0.0
Phe
3.683PheAla: 3.683 ± 1.395
0.921PheCys: 0.921 ± 1.117
1.842PheAsp: 1.842 ± 0.581
1.842PheGlu: 1.842 ± 0.581
0.921PhePhe: 0.921 ± 0.593
2.762PheGly: 2.762 ± 1.225
0.0PheHis: 0.0 ± 0.0
0.921PheIle: 0.921 ± 0.767
2.762PheLys: 2.762 ± 1.225
1.842PheLeu: 1.842 ± 0.956
1.842PheMet: 1.842 ± 0.581
1.842PheAsn: 1.842 ± 1.186
0.921PhePro: 0.921 ± 0.767
2.762PheGln: 2.762 ± 0.622
5.525PheArg: 5.525 ± 1.196
2.762PheSer: 2.762 ± 0.889
0.921PheThr: 0.921 ± 1.117
2.762PheVal: 2.762 ± 0.622
0.0PheTrp: 0.0 ± 0.0
1.842PheTyr: 1.842 ± 0.581
0.0PheXaa: 0.0 ± 0.0
Gly
5.525GlyAla: 5.525 ± 0.269
0.921GlyCys: 0.921 ± 0.767
0.921GlyAsp: 0.921 ± 0.767
2.762GlyGlu: 2.762 ± 2.302
5.525GlyPhe: 5.525 ± 0.269
1.842GlyGly: 1.842 ± 0.581
0.921GlyHis: 0.921 ± 1.117
3.683GlyIle: 3.683 ± 1.163
1.842GlyLys: 1.842 ± 1.186
4.604GlyLeu: 4.604 ± 1.752
1.842GlyMet: 1.842 ± 1.16
1.842GlyAsn: 1.842 ± 1.186
1.842GlyPro: 1.842 ± 1.186
1.842GlyGln: 1.842 ± 0.581
4.604GlyArg: 4.604 ± 0.452
9.208GlySer: 9.208 ± 3.678
1.842GlyThr: 1.842 ± 1.15
3.683GlyVal: 3.683 ± 1.395
1.842GlyTrp: 1.842 ± 1.535
2.762GlyTyr: 2.762 ± 0.889
0.0GlyXaa: 0.0 ± 0.0
His
1.842HisAla: 1.842 ± 0.956
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.0HisGlu: 0.0 ± 0.0
0.0HisPhe: 0.0 ± 0.0
2.762HisGly: 2.762 ± 0.622
0.0HisHis: 0.0 ± 0.0
0.921HisIle: 0.921 ± 1.117
0.921HisLys: 0.921 ± 0.767
0.0HisLeu: 0.0 ± 0.0
1.842HisMet: 1.842 ± 0.581
0.0HisAsn: 0.0 ± 0.0
0.0HisPro: 0.0 ± 0.0
0.0HisGln: 0.0 ± 0.0
2.762HisArg: 2.762 ± 2.302
0.0HisSer: 0.0 ± 0.0
0.921HisThr: 0.921 ± 0.593
4.604HisVal: 4.604 ± 0.791
0.0HisTrp: 0.0 ± 0.0
1.842HisTyr: 1.842 ± 1.535
0.0HisXaa: 0.0 ± 0.0
Ile
1.842IleAla: 1.842 ± 0.581
0.0IleCys: 0.0 ± 0.0
1.842IleAsp: 1.842 ± 0.581
1.842IleGlu: 1.842 ± 1.15
0.921IlePhe: 0.921 ± 0.767
0.921IleGly: 0.921 ± 0.767
2.762IleHis: 2.762 ± 1.133
0.0IleIle: 0.0 ± 0.0
2.762IleLys: 2.762 ± 1.225
6.446IleLeu: 6.446 ± 3.822
3.683IleMet: 3.683 ± 1.019
0.0IleAsn: 0.0 ± 0.0
0.921IlePro: 0.921 ± 0.593
3.683IleGln: 3.683 ± 1.163
1.842IleArg: 1.842 ± 0.956
4.604IleSer: 4.604 ± 0.452
2.762IleThr: 2.762 ± 1.225
1.842IleVal: 1.842 ± 1.535
0.921IleTrp: 0.921 ± 1.117
1.842IleTyr: 1.842 ± 0.956
0.0IleXaa: 0.0 ± 0.0
Lys
5.525LysAla: 5.525 ± 1.196
0.921LysCys: 0.921 ± 0.593
0.0LysAsp: 0.0 ± 0.0
0.921LysGlu: 0.921 ± 0.767
0.921LysPhe: 0.921 ± 0.593
1.842LysGly: 1.842 ± 0.581
1.842LysHis: 1.842 ± 1.535
3.683LysIle: 3.683 ± 1.712
0.921LysLys: 0.921 ± 0.767
7.366LysLeu: 7.366 ± 2.248
0.921LysMet: 0.921 ± 0.759
0.0LysAsn: 0.0 ± 0.0
1.842LysPro: 1.842 ± 0.956
2.762LysGln: 2.762 ± 1.225
0.0LysArg: 0.0 ± 0.0
2.762LysSer: 2.762 ± 0.622
5.525LysThr: 5.525 ± 1.341
3.683LysVal: 3.683 ± 2.238
0.0LysTrp: 0.0 ± 0.0
0.921LysTyr: 0.921 ± 1.117
0.0LysXaa: 0.0 ± 0.0
Leu
3.683LeuAla: 3.683 ± 1.712
0.921LeuCys: 0.921 ± 1.117
1.842LeuAsp: 1.842 ± 1.535
11.05LeuGlu: 11.05 ± 1.483
2.762LeuPhe: 2.762 ± 2.302
7.366LeuGly: 7.366 ± 2.364
2.762LeuHis: 2.762 ± 0.622
5.525LeuIle: 5.525 ± 2.756
4.604LeuLys: 4.604 ± 1.694
13.812LeuLeu: 13.812 ± 3.112
2.762LeuMet: 2.762 ± 0.622
4.604LeuAsn: 4.604 ± 2.822
2.762LeuPro: 2.762 ± 1.992
3.683LeuGln: 3.683 ± 0.393
7.366LeuArg: 7.366 ± 2.248
3.683LeuSer: 3.683 ± 1.019
7.366LeuThr: 7.366 ± 4.748
7.366LeuVal: 7.366 ± 1.385
0.0LeuTrp: 0.0 ± 0.0
5.525LeuTyr: 5.525 ± 1.778
0.0LeuXaa: 0.0 ± 0.0
Met
2.762MetAla: 2.762 ± 0.622
0.921MetCys: 0.921 ± 0.767
0.921MetAsp: 0.921 ± 0.767
1.842MetGlu: 1.842 ± 1.186
1.842MetPhe: 1.842 ± 1.15
0.0MetGly: 0.0 ± 0.0
0.921MetHis: 0.921 ± 0.593
1.842MetIle: 1.842 ± 1.535
0.921MetLys: 0.921 ± 0.767
4.604MetLeu: 4.604 ± 1.419
0.921MetMet: 0.921 ± 0.593
0.921MetAsn: 0.921 ± 0.767
1.842MetPro: 1.842 ± 0.956
0.921MetGln: 0.921 ± 0.767
1.842MetArg: 1.842 ± 1.15
3.683MetSer: 3.683 ± 0.393
0.921MetThr: 0.921 ± 1.117
3.683MetVal: 3.683 ± 2.301
0.0MetTrp: 0.0 ± 0.0
1.842MetTyr: 1.842 ± 1.186
0.0MetXaa: 0.0 ± 0.0
Asn
2.762AsnAla: 2.762 ± 1.779
0.0AsnCys: 0.0 ± 0.0
3.683AsnAsp: 3.683 ± 1.911
0.0AsnGlu: 0.0 ± 0.0
0.0AsnPhe: 0.0 ± 0.0
5.525AsnGly: 5.525 ± 1.341
0.921AsnHis: 0.921 ± 0.593
0.921AsnIle: 0.921 ± 0.767
0.921AsnLys: 0.921 ± 0.593
1.842AsnLeu: 1.842 ± 0.956
0.0AsnMet: 0.0 ± 0.0
0.921AsnAsn: 0.921 ± 0.593
3.683AsnPro: 3.683 ± 1.96
0.0AsnGln: 0.0 ± 0.0
0.921AsnArg: 0.921 ± 0.593
1.842AsnSer: 1.842 ± 1.535
2.762AsnThr: 2.762 ± 2.133
2.762AsnVal: 2.762 ± 1.133
1.842AsnTrp: 1.842 ± 2.233
4.604AsnTyr: 4.604 ± 2.713
0.0AsnXaa: 0.0 ± 0.0
Pro
11.971ProAla: 11.971 ± 3.325
2.762ProCys: 2.762 ± 1.992
0.921ProAsp: 0.921 ± 0.593
2.762ProGlu: 2.762 ± 0.889
0.0ProPhe: 0.0 ± 0.0
6.446ProGly: 6.446 ± 0.835
0.921ProHis: 0.921 ± 0.767
0.0ProIle: 0.0 ± 0.0
0.0ProLys: 0.0 ± 0.0
2.762ProLeu: 2.762 ± 0.622
0.0ProMet: 0.0 ± 0.0
1.842ProAsn: 1.842 ± 1.535
5.525ProPro: 5.525 ± 2.523
0.921ProGln: 0.921 ± 1.117
1.842ProArg: 1.842 ± 1.186
2.762ProSer: 2.762 ± 0.889
3.683ProThr: 3.683 ± 2.372
5.525ProVal: 5.525 ± 1.778
0.0ProTrp: 0.0 ± 0.0
0.921ProTyr: 0.921 ± 0.593
0.0ProXaa: 0.0 ± 0.0
Gln
1.842GlnAla: 1.842 ± 1.186
0.921GlnCys: 0.921 ± 0.767
2.762GlnAsp: 2.762 ± 1.133
2.762GlnGlu: 2.762 ± 1.225
0.0GlnPhe: 0.0 ± 0.0
1.842GlnGly: 1.842 ± 1.186
0.921GlnHis: 0.921 ± 1.117
0.921GlnIle: 0.921 ± 0.767
0.0GlnLys: 0.0 ± 0.0
6.446GlnLeu: 6.446 ± 2.898
0.921GlnMet: 0.921 ± 0.508
0.0GlnAsn: 0.0 ± 0.0
1.842GlnPro: 1.842 ± 1.186
3.683GlnGln: 3.683 ± 0.393
2.762GlnArg: 2.762 ± 0.622
0.0GlnSer: 0.0 ± 0.0
2.762GlnThr: 2.762 ± 1.779
3.683GlnVal: 3.683 ± 0.393
0.0GlnTrp: 0.0 ± 0.0
2.762GlnTyr: 2.762 ± 0.622
0.0GlnXaa: 0.0 ± 0.0
Arg
0.921ArgAla: 0.921 ± 0.593
0.0ArgCys: 0.0 ± 0.0
3.683ArgAsp: 3.683 ± 1.395
3.683ArgGlu: 3.683 ± 1.535
5.525ArgPhe: 5.525 ± 2.424
2.762ArgGly: 2.762 ± 1.225
0.0ArgHis: 0.0 ± 0.0
3.683ArgIle: 3.683 ± 2.238
2.762ArgLys: 2.762 ± 1.779
8.287ArgLeu: 8.287 ± 1.366
1.842ArgMet: 1.842 ± 0.581
0.0ArgAsn: 0.0 ± 0.0
3.683ArgPro: 3.683 ± 1.535
1.842ArgGln: 1.842 ± 1.186
3.683ArgArg: 3.683 ± 1.535
6.446ArgSer: 6.446 ± 0.856
1.842ArgThr: 1.842 ± 2.233
4.604ArgVal: 4.604 ± 2.822
0.0ArgTrp: 0.0 ± 0.0
4.604ArgTyr: 4.604 ± 1.38
0.0ArgXaa: 0.0 ± 0.0
Ser
8.287SerAla: 8.287 ± 1.366
0.0SerCys: 0.0 ± 0.0
5.525SerAsp: 5.525 ± 2.424
1.842SerGlu: 1.842 ± 1.186
2.762SerPhe: 2.762 ± 0.622
7.366SerGly: 7.366 ± 3.688
0.0SerHis: 0.0 ± 0.0
1.842SerIle: 1.842 ± 0.956
5.525SerLys: 5.525 ± 2.867
5.525SerLeu: 5.525 ± 1.778
2.762SerMet: 2.762 ± 1.225
0.0SerAsn: 0.0 ± 0.0
1.842SerPro: 1.842 ± 0.956
1.842SerGln: 1.842 ± 1.186
6.446SerArg: 6.446 ± 3.634
2.762SerSer: 2.762 ± 2.133
9.208SerThr: 9.208 ± 3.678
8.287SerVal: 8.287 ± 4.274
1.842SerTrp: 1.842 ± 0.581
4.604SerTyr: 4.604 ± 2.01
0.0SerXaa: 0.0 ± 0.0
Thr
6.446ThrAla: 6.446 ± 4.15
0.921ThrCys: 0.921 ± 1.117
2.762ThrAsp: 2.762 ± 1.133
0.921ThrGlu: 0.921 ± 1.117
0.921ThrPhe: 0.921 ± 0.593
0.921ThrGly: 0.921 ± 0.767
0.921ThrHis: 0.921 ± 0.767
3.683ThrIle: 3.683 ± 1.712
0.921ThrLys: 0.921 ± 1.117
6.446ThrLeu: 6.446 ± 2.898
2.762ThrMet: 2.762 ± 1.992
3.683ThrAsn: 3.683 ± 1.712
4.604ThrPro: 4.604 ± 1.95
1.842ThrGln: 1.842 ± 0.956
1.842ThrArg: 1.842 ± 1.15
6.446ThrSer: 6.446 ± 2.632
3.683ThrThr: 3.683 ± 1.911
3.683ThrVal: 3.683 ± 1.395
1.842ThrTrp: 1.842 ± 1.186
2.762ThrTyr: 2.762 ± 1.133
0.0ThrXaa: 0.0 ± 0.0
Val
5.525ValAla: 5.525 ± 1.341
2.762ValCys: 2.762 ± 1.992
5.525ValAsp: 5.525 ± 2.451
6.446ValGlu: 6.446 ± 2.263
7.366ValPhe: 7.366 ± 0.787
2.762ValGly: 2.762 ± 0.889
0.921ValHis: 0.921 ± 0.767
3.683ValIle: 3.683 ± 1.163
3.683ValLys: 3.683 ± 1.163
7.366ValLeu: 7.366 ± 1.971
1.842ValMet: 1.842 ± 1.535
6.446ValAsn: 6.446 ± 1.917
4.604ValPro: 4.604 ± 2.713
1.842ValGln: 1.842 ± 0.581
2.762ValArg: 2.762 ± 1.133
14.733ValSer: 14.733 ± 3.73
2.762ValThr: 2.762 ± 1.133
2.762ValVal: 2.762 ± 1.605
0.0ValTrp: 0.0 ± 0.0
0.921ValTyr: 0.921 ± 0.593
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.921TrpCys: 0.921 ± 1.117
1.842TrpAsp: 1.842 ± 1.535
0.0TrpGlu: 0.0 ± 0.0
0.921TrpPhe: 0.921 ± 0.593
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.921TrpLys: 0.921 ± 1.117
0.921TrpLeu: 0.921 ± 0.593
0.0TrpMet: 0.0 ± 0.0
2.762TrpAsn: 2.762 ± 0.622
0.921TrpPro: 0.921 ± 0.593
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
3.683TrpSer: 3.683 ± 0.393
0.921TrpThr: 0.921 ± 0.767
0.921TrpVal: 0.921 ± 1.117
1.842TrpTrp: 1.842 ± 1.15
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.762TyrAla: 2.762 ± 0.889
0.0TyrCys: 0.0 ± 0.0
1.842TyrAsp: 1.842 ± 0.581
4.604TyrGlu: 4.604 ± 2.936
1.842TyrPhe: 1.842 ± 0.581
1.842TyrGly: 1.842 ± 0.581
0.921TyrHis: 0.921 ± 0.767
2.762TyrIle: 2.762 ± 0.889
2.762TyrLys: 2.762 ± 1.133
5.525TyrLeu: 5.525 ± 1.196
2.762TyrMet: 2.762 ± 1.992
0.921TyrAsn: 0.921 ± 0.593
1.842TyrPro: 1.842 ± 0.581
1.842TyrGln: 1.842 ± 1.15
2.762TyrArg: 2.762 ± 1.779
3.683TyrSer: 3.683 ± 1.395
1.842TyrThr: 1.842 ± 1.186
5.525TyrVal: 5.525 ± 1.778
0.921TyrTrp: 0.921 ± 0.593
2.762TyrTyr: 2.762 ± 0.622
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (1087 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski