Amino acid dipepetide frequency for Agaricus bisporus var. burnettii (strain JB137-S8 / ATCC MYA-4627 / FGSC 10392) (White button mushroom)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.961AlaAla: 6.961 ± 0.053	0.958AlaCys: 0.958 ± 0.015	3.679AlaAsp: 3.679 ± 0.029	4.276AlaGlu: 4.276 ± 0.037	3.144AlaPhe: 3.144 ± 0.031	4.738AlaGly: 4.738 ± 0.037	1.835AlaHis: 1.835 ± 0.021	4.16AlaIle: 4.16 ± 0.036	3.807AlaLys: 3.807 ± 0.035	7.412AlaLeu: 7.412 ± 0.046	1.713AlaMet: 1.713 ± 0.02	2.755AlaAsn: 2.755 ± 0.028	4.357AlaPro: 4.357 ± 0.041	2.944AlaGln: 2.944 ± 0.022	4.621AlaArg: 4.621 ± 0.034	6.83AlaSer: 6.83 ± 0.043	4.762AlaThr: 4.762 ± 0.036	4.845AlaVal: 4.845 ± 0.031	1.073AlaTrp: 1.073 ± 0.016	2.109AlaTyr: 2.109 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	0.892CysAla: 0.892 ± 0.016	0.233CysCys: 0.233 ± 0.009	0.687CysAsp: 0.687 ± 0.013	0.564CysGlu: 0.564 ± 0.011	0.541CysPhe: 0.541 ± 0.011	0.917CysGly: 0.917 ± 0.017	0.351CysHis: 0.351 ± 0.009	0.712CysIle: 0.712 ± 0.012	0.53CysLys: 0.53 ± 0.012	1.204CysLeu: 1.204 ± 0.017	0.265CysMet: 0.265 ± 0.007	0.462CysAsn: 0.462 ± 0.012	0.758CysPro: 0.758 ± 0.016	0.517CysGln: 0.517 ± 0.011	0.76CysArg: 0.76 ± 0.013	0.954CysSer: 0.954 ± 0.016	0.691CysThr: 0.691 ± 0.013	0.79CysVal: 0.79 ± 0.013	0.22CysTrp: 0.22 ± 0.007	0.333CysTyr: 0.333 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.305AspAla: 4.305 ± 0.028	0.61AspCys: 0.61 ± 0.011	4.228AspAsp: 4.228 ± 0.044	4.391AspGlu: 4.391 ± 0.033	2.293AspPhe: 2.293 ± 0.028	3.746AspGly: 3.746 ± 0.032	1.288AspHis: 1.288 ± 0.019	3.399AspIle: 3.399 ± 0.027	2.339AspLys: 2.339 ± 0.023	4.946AspLeu: 4.946 ± 0.035	1.175AspMet: 1.175 ± 0.017	1.989AspAsn: 1.989 ± 0.02	3.283AspPro: 3.283 ± 0.028	1.733AspGln: 1.733 ± 0.021	2.804AspArg: 2.804 ± 0.028	4.272AspSer: 4.272 ± 0.03	2.978AspThr: 2.978 ± 0.026	3.813AspVal: 3.813 ± 0.028	0.902AspTrp: 0.902 ± 0.015	1.562AspTyr: 1.562 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	4.673GluAla: 4.673 ± 0.038	0.668GluCys: 0.668 ± 0.012	3.995GluAsp: 3.995 ± 0.037	5.645GluGlu: 5.645 ± 0.061	2.086GluPhe: 2.086 ± 0.021	3.624GluGly: 3.624 ± 0.033	1.39GluHis: 1.39 ± 0.017	3.304GluIle: 3.304 ± 0.027	3.493GluLys: 3.493 ± 0.035	5.242GluLeu: 5.242 ± 0.037	1.42GluMet: 1.42 ± 0.016	2.364GluAsn: 2.364 ± 0.022	2.583GluPro: 2.583 ± 0.026	2.149GluGln: 2.149 ± 0.026	3.956GluArg: 3.956 ± 0.047	4.164GluSer: 4.164 ± 0.032	3.103GluThr: 3.103 ± 0.025	3.64GluVal: 3.64 ± 0.031	0.904GluTrp: 0.904 ± 0.014	1.633GluTyr: 1.633 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	2.932PheAla: 2.932 ± 0.026	0.566PheCys: 0.566 ± 0.012	2.4PheAsp: 2.4 ± 0.028	2.249PheGlu: 2.249 ± 0.02	1.798PhePhe: 1.798 ± 0.024	2.703PheGly: 2.703 ± 0.029	0.998PheHis: 0.998 ± 0.017	2.086PheIle: 2.086 ± 0.025	1.754PheLys: 1.754 ± 0.022	3.701PheLeu: 3.701 ± 0.029	0.847PheMet: 0.847 ± 0.013	1.598PheAsn: 1.598 ± 0.021	2.158PhePro: 2.158 ± 0.023	1.319PheGln: 1.319 ± 0.017	2.019PheArg: 2.019 ± 0.024	3.285PheSer: 3.285 ± 0.029	2.305PheThr: 2.305 ± 0.022	2.62PheVal: 2.62 ± 0.029	0.633PheTrp: 0.633 ± 0.012	1.137PheTyr: 1.137 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	4.354GlyAla: 4.354 ± 0.033	0.771GlyCys: 0.771 ± 0.016	3.312GlyAsp: 3.312 ± 0.029	3.309GlyGlu: 3.309 ± 0.031	2.628GlyPhe: 2.628 ± 0.025	5.264GlyGly: 5.264 ± 0.067	1.621GlyHis: 1.621 ± 0.022	3.516GlyIle: 3.516 ± 0.032	3.516GlyLys: 3.516 ± 0.032	5.535GlyLeu: 5.535 ± 0.04	1.415GlyMet: 1.415 ± 0.02	2.527GlyAsn: 2.527 ± 0.028	3.089GlyPro: 3.089 ± 0.032	2.22GlyGln: 2.22 ± 0.024	3.873GlyArg: 3.873 ± 0.032	5.496GlySer: 5.496 ± 0.04	3.742GlyThr: 3.742 ± 0.035	4.071GlyVal: 4.071 ± 0.036	1.065GlyTrp: 1.065 ± 0.015	1.844GlyTyr: 1.844 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	1.848HisAla: 1.848 ± 0.021	0.357HisCys: 0.357 ± 0.009	1.365HisAsp: 1.365 ± 0.018	1.346HisGlu: 1.346 ± 0.019	1.03HisPhe: 1.03 ± 0.015	1.518HisGly: 1.518 ± 0.019	0.958HisHis: 0.958 ± 0.017	1.485HisIle: 1.485 ± 0.021	1.016HisLys: 1.016 ± 0.015	2.515HisLeu: 2.515 ± 0.025	0.52HisMet: 0.52 ± 0.011	0.926HisAsn: 0.926 ± 0.016	1.995HisPro: 1.995 ± 0.023	1.012HisGln: 1.012 ± 0.017	1.591HisArg: 1.591 ± 0.019	2.269HisSer: 2.269 ± 0.028	1.496HisThr: 1.496 ± 0.02	1.573HisVal: 1.573 ± 0.02	0.357HisTrp: 0.357 ± 0.009	0.758HisTyr: 0.758 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.104IleAla: 4.104 ± 0.034	0.767IleCys: 0.767 ± 0.014	3.037IleAsp: 3.037 ± 0.027	2.98IleGlu: 2.98 ± 0.027	2.173IlePhe: 2.173 ± 0.025	3.191IleGly: 3.191 ± 0.028	1.4IleHis: 1.4 ± 0.015	2.856IleIle: 2.856 ± 0.031	2.467IleLys: 2.467 ± 0.028	5.081IleLeu: 5.081 ± 0.046	1.053IleMet: 1.053 ± 0.016	1.983IleAsn: 1.983 ± 0.02	3.576IlePro: 3.576 ± 0.025	1.998IleGln: 1.998 ± 0.021	3.123IleArg: 3.123 ± 0.03	4.403IleSer: 4.403 ± 0.033	3.06IleThr: 3.06 ± 0.028	3.449IleVal: 3.449 ± 0.029	0.764IleTrp: 0.764 ± 0.013	1.456IleTyr: 1.456 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	3.94LysAla: 3.94 ± 0.039	0.6LysCys: 0.6 ± 0.012	2.757LysAsp: 2.757 ± 0.024	3.534LysGlu: 3.534 ± 0.039	1.612LysPhe: 1.612 ± 0.022	2.938LysGly: 2.938 ± 0.028	1.228LysHis: 1.228 ± 0.017	2.428LysIle: 2.428 ± 0.022	3.454LysLys: 3.454 ± 0.043	4.235LysLeu: 4.235 ± 0.028	1.007LysMet: 1.007 ± 0.016	1.917LysAsn: 1.917 ± 0.022	2.709LysPro: 2.709 ± 0.028	1.772LysGln: 1.772 ± 0.019	3.713LysArg: 3.713 ± 0.031	3.752LysSer: 3.752 ± 0.034	2.768LysThr: 2.768 ± 0.028	2.917LysVal: 2.917 ± 0.025	0.705LysTrp: 0.705 ± 0.015	1.392LysTyr: 1.392 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	7.387LeuAla: 7.387 ± 0.046	1.228LeuCys: 1.228 ± 0.018	5.284LeuAsp: 5.284 ± 0.038	5.525LeuGlu: 5.525 ± 0.043	3.553LeuPhe: 3.553 ± 0.03	5.409LeuGly: 5.409 ± 0.044	2.461LeuHis: 2.461 ± 0.024	4.34LeuIle: 4.34 ± 0.036	4.541LeuLys: 4.541 ± 0.035	8.537LeuLeu: 8.537 ± 0.06	1.844LeuMet: 1.844 ± 0.022	3.44LeuAsn: 3.44 ± 0.027	6.06LeuPro: 6.06 ± 0.038	3.729LeuGln: 3.729 ± 0.034	5.879LeuArg: 5.879 ± 0.041	7.989LeuSer: 7.989 ± 0.05	5.072LeuThr: 5.072 ± 0.034	5.611LeuVal: 5.611 ± 0.039	1.189LeuTrp: 1.189 ± 0.017	2.427LeuTyr: 2.427 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	1.79MetAla: 1.79 ± 0.019	0.233MetCys: 0.233 ± 0.008	1.244MetAsp: 1.244 ± 0.014	1.271MetGlu: 1.271 ± 0.016	0.734MetPhe: 0.734 ± 0.013	1.275MetGly: 1.275 ± 0.02	0.456MetHis: 0.456 ± 0.01	1.017MetIle: 1.017 ± 0.017	1.074MetLys: 1.074 ± 0.017	1.81MetLeu: 1.81 ± 0.021	0.517MetMet: 0.517 ± 0.011	0.839MetAsn: 0.839 ± 0.015	1.285MetPro: 1.285 ± 0.017	0.804MetGln: 0.804 ± 0.013	1.293MetArg: 1.293 ± 0.018	1.919MetSer: 1.919 ± 0.022	1.367MetThr: 1.367 ± 0.017	1.204MetVal: 1.204 ± 0.017	0.248MetTrp: 0.248 ± 0.008	0.496MetTyr: 0.496 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.132AsnAla: 3.132 ± 0.028	0.477AsnCys: 0.477 ± 0.01	2.116AsnAsp: 2.116 ± 0.021	2.136AsnGlu: 2.136 ± 0.022	1.469AsnPhe: 1.469 ± 0.017	2.719AsnGly: 2.719 ± 0.029	1.068AsnHis: 1.068 ± 0.017	2.17AsnIle: 2.17 ± 0.02	1.709AsnLys: 1.709 ± 0.022	3.541AsnLeu: 3.541 ± 0.031	0.818AsnMet: 0.818 ± 0.015	1.641AsnAsn: 1.641 ± 0.025	2.575AsnPro: 2.575 ± 0.021	1.421AsnGln: 1.421 ± 0.02	2.012AsnArg: 2.012 ± 0.021	3.054AsnSer: 3.054 ± 0.027	2.265AsnThr: 2.265 ± 0.026	2.596AsnVal: 2.596 ± 0.026	0.528AsnTrp: 0.528 ± 0.011	1.003AsnTyr: 1.003 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	4.607ProAla: 4.607 ± 0.044	0.493ProCys: 0.493 ± 0.013	3.099ProAsp: 3.099 ± 0.025	3.549ProGlu: 3.549 ± 0.031	2.27ProPhe: 2.27 ± 0.02	3.604ProGly: 3.604 ± 0.029	1.763ProHis: 1.763 ± 0.023	2.973ProIle: 2.973 ± 0.024	2.654ProLys: 2.654 ± 0.028	5.348ProLeu: 5.348 ± 0.042	1.045ProMet: 1.045 ± 0.018	2.382ProAsn: 2.382 ± 0.023	6.39ProPro: 6.39 ± 0.084	2.501ProGln: 2.501 ± 0.032	3.488ProArg: 3.488 ± 0.033	7.038ProSer: 7.038 ± 0.061	4.37ProThr: 4.37 ± 0.04	3.629ProVal: 3.629 ± 0.029	0.699ProTrp: 0.699 ± 0.014	1.625ProTyr: 1.625 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	2.98GlnAla: 2.98 ± 0.024	0.515GlnCys: 0.515 ± 0.012	1.92GlnAsp: 1.92 ± 0.018	2.204GlnGlu: 2.204 ± 0.024	1.397GlnPhe: 1.397 ± 0.019	2.199GlnGly: 2.199 ± 0.025	1.1GlnHis: 1.1 ± 0.018	1.947GlnIle: 1.947 ± 0.021	1.825GlnLys: 1.825 ± 0.023	3.588GlnLeu: 3.588 ± 0.03	0.793GlnMet: 0.793 ± 0.013	1.544GlnAsn: 1.544 ± 0.021	2.349GlnPro: 2.349 ± 0.03	2.125GlnGln: 2.125 ± 0.046	2.456GlnArg: 2.456 ± 0.028	3.024GlnSer: 3.024 ± 0.029	2.216GlnThr: 2.216 ± 0.024	2.11GlnVal: 2.11 ± 0.02	0.533GlnTrp: 0.533 ± 0.011	1.072GlnTyr: 1.072 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.334ArgAla: 4.334 ± 0.038	0.819ArgCys: 0.819 ± 0.013	3.282ArgAsp: 3.282 ± 0.032	3.775ArgGlu: 3.775 ± 0.039	2.278ArgPhe: 2.278 ± 0.023	3.556ArgGly: 3.556 ± 0.032	1.631ArgHis: 1.631 ± 0.021	3.218ArgIle: 3.218 ± 0.028	3.584ArgLys: 3.584 ± 0.033	5.56ArgLeu: 5.56 ± 0.035	1.306ArgMet: 1.306 ± 0.017	2.36ArgAsn: 2.36 ± 0.022	3.436ArgPro: 3.436 ± 0.032	2.455ArgGln: 2.455 ± 0.024	4.935ArgArg: 4.935 ± 0.043	5.1ArgSer: 5.1 ± 0.043	3.369ArgThr: 3.369 ± 0.025	3.54ArgVal: 3.54 ± 0.03	0.957ArgTrp: 0.957 ± 0.014	1.656ArgTyr: 1.656 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	6.282SerAla: 6.282 ± 0.043	0.939SerCys: 0.939 ± 0.014	4.397SerAsp: 4.397 ± 0.032	4.181SerGlu: 4.181 ± 0.03	3.374SerPhe: 3.374 ± 0.031	5.48SerGly: 5.48 ± 0.038	2.25SerHis: 2.25 ± 0.026	4.468SerIle: 4.468 ± 0.033	3.89SerLys: 3.89 ± 0.034	7.928SerLeu: 7.928 ± 0.049	1.739SerMet: 1.739 ± 0.02	3.339SerAsn: 3.339 ± 0.031	6.345SerPro: 6.345 ± 0.07	3.298SerGln: 3.298 ± 0.037	5.151SerArg: 5.151 ± 0.04	10.083SerSer: 10.083 ± 0.098	6.023SerThr: 6.023 ± 0.044	4.883SerVal: 4.883 ± 0.037	1.103SerTrp: 1.103 ± 0.014	2.154SerTyr: 2.154 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	4.496ThrAla: 4.496 ± 0.033	0.762ThrCys: 0.762 ± 0.013	2.755ThrAsp: 2.755 ± 0.022	2.875ThrGlu: 2.875 ± 0.027	2.462ThrPhe: 2.462 ± 0.022	3.8ThrGly: 3.8 ± 0.03	1.472ThrHis: 1.472 ± 0.021	3.267ThrIle: 3.267 ± 0.031	2.585ThrLys: 2.585 ± 0.026	5.66ThrLeu: 5.66 ± 0.043	1.165ThrMet: 1.165 ± 0.017	2.182ThrAsn: 2.182 ± 0.024	4.661ThrPro: 4.661 ± 0.047	2.054ThrGln: 2.054 ± 0.021	3.522ThrArg: 3.522 ± 0.028	5.865ThrSer: 5.865 ± 0.046	4.412ThrThr: 4.412 ± 0.037	3.591ThrVal: 3.591 ± 0.028	0.804ThrTrp: 0.804 ± 0.014	1.61ThrTyr: 1.61 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	4.866ValAla: 4.866 ± 0.035	0.811ValCys: 0.811 ± 0.014	3.887ValAsp: 3.887 ± 0.025	3.881ValGlu: 3.881 ± 0.031	2.49ValPhe: 2.49 ± 0.029	3.788ValGly: 3.788 ± 0.034	1.499ValHis: 1.499 ± 0.017	3.257ValIle: 3.257 ± 0.028	3.096ValLys: 3.096 ± 0.027	5.733ValLeu: 5.733 ± 0.043	1.328ValMet: 1.328 ± 0.016	2.374ValAsn: 2.374 ± 0.026	3.724ValPro: 3.724 ± 0.03	2.298ValGln: 2.298 ± 0.025	3.419ValArg: 3.419 ± 0.029	4.67ValSer: 4.67 ± 0.034	3.505ValThr: 3.505 ± 0.026	4.398ValVal: 4.398 ± 0.043	0.928ValTrp: 0.928 ± 0.015	1.763ValTyr: 1.763 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.009TrpAla: 1.009 ± 0.015	0.184TrpCys: 0.184 ± 0.006	0.945TrpAsp: 0.945 ± 0.015	0.837TrpGlu: 0.837 ± 0.015	0.581TrpPhe: 0.581 ± 0.011	0.867TrpGly: 0.867 ± 0.016	0.326TrpHis: 0.326 ± 0.008	0.785TrpIle: 0.785 ± 0.016	0.883TrpLys: 0.883 ± 0.013	1.304TrpLeu: 1.304 ± 0.018	0.345TrpMet: 0.345 ± 0.009	0.718TrpAsn: 0.718 ± 0.013	0.606TrpPro: 0.606 ± 0.013	0.505TrpGln: 0.505 ± 0.01	0.908TrpArg: 0.908 ± 0.014	1.088TrpSer: 1.088 ± 0.017	0.879TrpThr: 0.879 ± 0.015	0.849TrpVal: 0.849 ± 0.015	0.25TrpTrp: 0.25 ± 0.009	0.414TrpTyr: 0.414 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.088TyrAla: 2.088 ± 0.019	0.39TyrCys: 0.39 ± 0.01	1.666TyrAsp: 1.666 ± 0.022	1.51TyrGlu: 1.51 ± 0.019	1.195TyrPhe: 1.195 ± 0.016	1.83TyrGly: 1.83 ± 0.023	0.841TyrHis: 0.841 ± 0.014	1.535TyrIle: 1.535 ± 0.019	1.16TyrLys: 1.16 ± 0.018	2.627TyrLeu: 2.627 ± 0.024	0.561TyrMet: 0.561 ± 0.01	1.113TyrAsn: 1.113 ± 0.016	1.587TyrPro: 1.587 ± 0.022	1.041TyrGln: 1.041 ± 0.015	1.628TyrArg: 1.628 ± 0.021	2.05TyrSer: 2.05 ± 0.023	1.617TyrThr: 1.617 ± 0.019	1.585TyrVal: 1.585 ± 0.019	0.419TyrTrp: 0.419 ± 0.01	0.886TyrTyr: 0.886 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 11211 proteins (4612704 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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